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M. tuberculosis H37Rv Rv1886c (fbpB)

annotation: SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR ALPHA-ANTIGEN)
coordinates: 2134890 - 2135867
length: 325

TDVSRKIRAWGRRLMIGTAAAVVLPGLVGLAGGAATAGAFSRPGLPVEYLQVPSPSMGRDIKVQFQSGGN
NSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFL
TSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDA
GGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQ
DAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv1886c fbpB - 100% (325) SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR ALPHA-ANTIGEN)
M. tuberculosis H37Rv Rv3804c fbpA e-157 78.86% (317) secreted antigen 85-A FBPA (Mycolyl transferase 85A)
M. tuberculosis H37Rv Rv0129c fbpC e-132 71.61% (310) secreted antigen 85-C FBPC (85C) (antigen 85 complex C)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1918c fbpB 0.0 100.00% (325) secreted antigen 85-B fbpB (85B) (antigen 85 complex B)
M. gilvum PYR-GCK Mflv_4459 - 1e-140 72.52% (313) putative esterase
M. leprae Br4923 MLBr_02028 fbpB 1e-162 83.02% (324) antigen 85A, mycolyltransferase
M. abscessus ATCC 19977 MAB_1579 - 1e-111 61.78% (314) antigen 85-B precursor
M. marinum M MMAR_2777 fbpB 1e-177 88.89% (324) secreted antigen 85-B FbpB
M. avium 104 MAV_2816 - 1e-171 85.49% (324) antigen 85-B
M. smegmatis MC2 155 MSMEG_2078 - 1e-139 72.50% (320) antigen 85-C
M. thermoresistible (build 8) TH_2078 fbpA 1e-127 67.08% (322) SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A)
M. ulcerans Agy99 MUL_2970 fbpB 1e-176 87.96% (324) secreted antigen 85-B FbpB
M. vanbaalenii PYR-1 Mvan_1902 - 1e-141 72.52% (313) putative esterase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4459|M.gilvum_PYR-GCK          -MRLLDRIRG---PWARRLGIATLAALLLPGVVGLTGGSVTAGAFSRPGL
Mvan_1902|M.vanbaalenii_PYR-1       -MRLLDRIRG---PWARRLGIAALAAVLLPGVVGLTGGSATAGAFSRPGL
MSMEG_2078|M.smegmatis_MC2_155      -MTFIDKIRG---HWARRMTVAAVAALLLPGLVGVVGGSATAGAFSRPGL
TH_2078|M.thermoresistible__bu      -MKLVAKLRGAARALPRRLTVAALAAALLPGLVGAFGGSATAGAFSRPGL
Rv1886c|M.tuberculosis_H37Rv        MTDVSRKIRA----WGRRLMIGTAAAVVLPGLVGLAGGAATAGAFSRPGL
Mb1918c|M.bovis_AF2122/97           MTDVSRKIRA----WGRRLMIGTAAAVVLPGLVGLAGGAATAGAFSRPGL
MMAR_2777|M.marinum_M               MTDVSGKIRT----WGRRLLIGAAAAITLPGLVGLAGGAPAAKAFSRPGL
MUL_2970|M.ulcerans_Agy99           MTDVSGKIRT----WGRRLLIGAAAAITLPGLVGVAGGAPAAKAFSRPGL
MAV_2816|M.avium_104                MTDLSEKVRA----WGRRLLVGAAAAVTLPGLIGLAGGAATANAFSRPGL
MLBr_02028|M.leprae_Br4923          MIDVSGKIRA----WGRWLLVG--AAATLPSLISLAGGAATASAFSRPGL
MAB_1579|M.abscessus_ATCC_1997      -MEFLQKMRG---ATARLAAVAAVAAAILPGLIGVTGGSAIAGAFSRPGL
                                       .  ::*       *   :.  **  **.::.  **:  * *******

Mflv_4459|M.gilvum_PYR-GCK          PVEYLMVPSPSMGRDIKVQFQSGGPNSPALYLLDGLRAQDDFNGWDINTQ
Mvan_1902|M.vanbaalenii_PYR-1       PVEYLMVPSPSMGRDIKIQFQSGGPNSPALYLLDGLRAQDDFNGWDINTQ
MSMEG_2078|M.smegmatis_MC2_155      PVEYLMVPSPSMGRDIKVQFQSGGPGSHAVYLLDGLRAQDDFNGWDINTN
TH_2078|M.thermoresistible__bu      PVEYLMVPSAAMGRDIKVQFQSGGEGSPGVYLLDGLRARDDFNGWDIETA
Rv1886c|M.tuberculosis_H37Rv        PVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTP
Mb1918c|M.bovis_AF2122/97           PVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTP
MMAR_2777|M.marinum_M               PVEYLQVPSAAMGRSIKVQFQSGGDNSPAVYLLDGLRAQDDYNGWDINTP
MUL_2970|M.ulcerans_Agy99           PVEYLQVPSAAMGRSIKVQFQSGGDNSPAVYLLDGLRAQDDYNGWDINTP
MAV_2816|M.avium_104                PVEYLQVPSAGMGRDIKVQFQSGGNGSPAVYLLDGLRAQDDYNGWDINTP
MLBr_02028|M.leprae_Br4923          PVEYLQVPSEAMGRSIKVQFQNGGNGSPAVYLLDGLRAQDDYNGWDINTS
MAB_1579|M.abscessus_ATCC_1997      PVEYLQVPSPAMGRDIVVEFQPGGP--HAVYLLDGQRAREDYNGWDIETT
                                    ***** *** .***.* ::** **    .:***** **::*:*****:* 

Mflv_4459|M.gilvum_PYR-GCK          AFEWYLDSGISVVMPVGGQSSFYSNWYKPACGKNGCLTYNWETFLTQELP
Mvan_1902|M.vanbaalenii_PYR-1       AFEWYLDSGISVIMPVGGQSSFYSNWYKPACGKSGCLTYNWETFLTQELP
MSMEG_2078|M.smegmatis_MC2_155      AFEMFLDSGLSVVMPVGGQSSFYSDWYQPACGNNGCVTYKWETFLTSELP
TH_2078|M.thermoresistible__bu      AFEWYYESGLSVIMPVGGQSSFYSDWYSPACGNNGCQTYKWETFLTQELP
Rv1886c|M.tuberculosis_H37Rv        AFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELP
Mb1918c|M.bovis_AF2122/97           AFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELP
MMAR_2777|M.marinum_M               AFEWYYQSGLSVIMPVGGQSSFYANWYQPACGKAGCSTYKWETFLTSELP
MUL_2970|M.ulcerans_Agy99           AFEWYYQSGLSVIMPVGGQSSFYANWYQPACGKSGCSTYKWETFLTSELP
MAV_2816|M.avium_104                AFEWYYQSGLSVIMPVGGQSSFYADWYQPACGKAGCSTYKWETFLTSELP
MLBr_02028|M.leprae_Br4923          AFEWYYQSGLSVVMPVGGQSSFYSDWYSPACGKAGCTTYKWETFLTSELP
MAB_1579|M.abscessus_ATCC_1997      AFEDYYQSGISVVMPVGGQSSNYTDWYNPAKGKDGVWTYKWETFLTTELP
                                    *** : :**:*::******** *::**.** *: *  **:****** ***

Mflv_4459|M.gilvum_PYR-GCK          AWLQANRDVRPTNNAAVGLSMAGGSSLVLAAHHPGQFSYAGSMSGFLNPS
Mvan_1902|M.vanbaalenii_PYR-1       GWLQANRDVKPTGSAAVGLSMAGGSSLVLAAHHPGQFVWAGSMSGFLNPS
MSMEG_2078|M.smegmatis_MC2_155      EWLAANRDVAATGNAAIGLSMAGSAALILAAYHPDRFIYAGSMSGFLNPS
TH_2078|M.thermoresistible__bu      AYLASNYGVDRNRNAAVGLSMAGSAALVLAIYYPQQFQYAASLSGFLNLS
Rv1886c|M.tuberculosis_H37Rv        QWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPS
Mb1918c|M.bovis_AF2122/97           QWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPS
MMAR_2777|M.marinum_M               EWLSANRSVKPTGSAAVGISMSGSSAMILAVYHPQQFVYAGSLSALLDPS
MUL_2970|M.ulcerans_Agy99           EWLSANRSVKPTGSAAIGISMSGSSAMILAVYHPQQFVYAGSLSALLDPS
MAV_2816|M.avium_104                SYLASNKGVKRTGSAAVGISMSGSSAMILAVNHPDQFIYAGSLSALLDPS
MLBr_02028|M.leprae_Br4923          KWLSANRSVKSTGSAVVGLSMAGSSALILAAYHPDQFIYAGSLSALMDSS
MAB_1579|M.abscessus_ATCC_1997      QWLGVNKGISPAANAVVGLSMAGPSALTLAIYHPQQFVYAGALSAPLHPS
                                     :*  *  :    .*.:*:**:* ::: **  :* :* :*.::*. :. *

Mflv_4459|M.gilvum_PYR-GCK          EGWWPGLINISMGDAGGYKANDMWGPAET-DPAWQYNDPMVQIPNLVANN
Mvan_1902|M.vanbaalenii_PYR-1       EGWWPGLINISMGDAGGYKANDMWGPAET-DPAWQYNDPMVQIPRLVANN
MSMEG_2078|M.smegmatis_MC2_155      EGWWPFLINISMGDAGGYKANDMWGPTEDPNSAWKRNDPMVQIPRLVANN
TH_2078|M.thermoresistible__bu      EGWWPMLVGLAMGDAGGYDPNDMWGRTEDPNSAWKRNDPMVNIDKLVANN
Rv1886c|M.tuberculosis_H37Rv        QGMGPSLIGLAMGDAGGYKAADMWGPSSD--PAWERNDPTQQIPKLVANN
Mb1918c|M.bovis_AF2122/97           QGMGPSLIGLAMGDAGGYKAADMWGPSSD--PAWERNDPTQQIPKLVANN
MMAR_2777|M.marinum_M               QGMGPSLIGLAMGDAGGYKAGDMWGPSSD--PAWQRNDPTIQIPALVSNN
MUL_2970|M.ulcerans_Agy99           QGMGPFLIGLAMGDAGGYKAGDMWGPSSD--PAWQRNDPTIQIPALVSNN
MAV_2816|M.avium_104                QGMGPSLIGLAMGDAGGYKADAMWGPSSD--PAWQRNDPSLHIPELVGHN
MLBr_02028|M.leprae_Br4923          QGIEPQLIGLAMGDAGGYKAADMWGPPND--PAWQRNDPILQAGKLVANN
MAB_1579|M.abscessus_ATCC_1997      D--QKWQIRVAMSDAGGFNADDMWGPDSD--PAWARNDPFLHIDQLIANN
                                    :      : ::*.****:..  ***  .   .**  ***  :   *:.:*

Mflv_4459|M.gilvum_PYR-GCK          SRIWVYCGNGTPNELGG----GD-LPATFLEGLTIRTNRTFQDNYLAAGG
Mvan_1902|M.vanbaalenii_PYR-1       SRIWVYCGNGQPNELGG----GD-LPATFLEGLTIRTNRTFQDNYIAAGG
MSMEG_2078|M.smegmatis_MC2_155      TRIWVYCGNGQPNELGG----GD-LPATFLEGLTIRTNETFRDNYIAAGG
TH_2078|M.thermoresistible__bu      TRIWVFCGDGTPADIGAGVPEGDNFNAKFLESFTLRTNKTFQQEYIAAGG
Rv1886c|M.tuberculosis_H37Rv        TRLWVYCGNGTPNELGG-----ANIPAEFLENFVRSSNLKFQDAYNAAGG
Mb1918c|M.bovis_AF2122/97           TRLWVYCGNGTPNELGG-----ANIPAEFLENFVRSSNLKFQDAYNAAGG
MMAR_2777|M.marinum_M               TRLWVYCGNGTPSELGG-----ANLPAEFLENFVRSSNLKFQDAYNAAGG
MUL_2970|M.ulcerans_Agy99           TRLWVYCGNGTPSELGG-----ASLPAEFLENFVRSSNLKFQDAYNAAGG
MAV_2816|M.avium_104                TRLWVYCGNGTPSELGG-----ANMPAEFLENFVRSSNLKFQDAYNGAGG
MLBr_02028|M.leprae_Br4923          THLWVYCGNGTPSELGG-----TNVPAEFLENFVHGSNLKFQDAYNGAGG
MAB_1579|M.abscessus_ATCC_1997      TRLWIYCGSGDATDLDKDRNGLEVISGGVIEGQVIDSDKKFAEAYGSAGG
                                    :::*::**.* . ::.        . . .:*. .  :: .* : * .***

Mflv_4459|M.gilvum_PYR-GCK          KNGVFNFPNNGTHNWAYWGRELQAMKPDLQAHLLG------
Mvan_1902|M.vanbaalenii_PYR-1       TNGVFNFPNNGTHNWAYWGRELQAMKPDLQAHLL-------
MSMEG_2078|M.smegmatis_MC2_155      NNGVFNFPNNGTHNWAYWGRELQAMVPDLQRVLG-------
TH_2078|M.thermoresistible__bu      KNGVFNFPDAGTHSWGYWGQQLQQMKPDIQRVLGVSAA---
Rv1886c|M.tuberculosis_H37Rv        HNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG-----
Mb1918c|M.bovis_AF2122/97           HNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG-----
MMAR_2777|M.marinum_M               HNAVFNFNDNGTHSWEYWGAQLNAMKGDLQASLGAA-----
MUL_2970|M.ulcerans_Agy99           HNAVFNFNDNGTHSWEYWGAQLNAMKGDLQTSLGAA-----
MAV_2816|M.avium_104                HNAVFNFNANGTHSWEYWGAQLNAMKPDLQGTLGASPGGGG
MLBr_02028|M.leprae_Br4923          HNAVFNLNADGTHSWEYWGAQLNAMKPDLQNTLMAVPRSG-
MAB_1579|M.abscessus_ATCC_1997      ANAHFEFPKGGIHNWTYWGNQLRAMKADLVGYLTKPGTAAV
                                     *. *::   * *.* *** :*. *  *:   *

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv1886c	fbpB	-	100% (325)	SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR ALPHA-ANTIGEN)
M. tuberculosis H37Rv	Rv3804c	fbpA	e-157	78.86% (317)	secreted antigen 85-A FBPA (Mycolyl transferase 85A)
M. tuberculosis H37Rv	Rv0129c	fbpC	e-132	71.61% (310)	secreted antigen 85-C FBPC (85C) (antigen 85 complex C)