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MKLFSKMRGALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAFSRPGLPVEYLQVPSASMGREIK VQFQPGGAKAVYLLDGLRARDDFSGWDIETTAFEDYYQSGISMVMPVGGQSSFYTDWYNPAKGKDGVWTY KWETFTTQELPAYLAANKGISQTGNAVVGLSMGASAALTLSIYHPQLFVYAGALSGFLNPSDMKFQIGLA MGDAGGFSASDMWGPDSDPAWQRNDPFLNIQKIIDNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGM AIGSNKKFVEAYTAAGGKNAHIEFPPGGIHNWTYWGQQLRAMKPDMVAYLQSH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0176 | - | - | 100% (333) | antigen 85-A precursor |
| M. abscessus ATCC 19977 | MAB_0177 | - | e-159 | 79.28% (333) | antigen 85-A/B/C precursor |
| M. abscessus ATCC 19977 | MAB_1579 | - | e-141 | 72.12% (330) | antigen 85-B precursor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3834c | fbpA | 1e-117 | 63.64% (330) | secreted antigen 85-A FBPA (Mycolyl transferase 85A) |
| M. gilvum PYR-GCK | Mflv_3335 | - | 1e-115 | 60.06% (328) | putative esterase |
| M. tuberculosis H37Rv | Rv3804c | fbpA | 1e-117 | 63.64% (330) | secreted antigen 85-A FBPA (Mycolyl transferase 85A) |
| M. leprae Br4923 | MLBr_00097 | fbpA | 1e-112 | 60.18% (334) | antigen 85A, mycolytransferase |
| M. marinum M | MMAR_5368 | fbpA | 1e-113 | 61.82% (330) | secreted antigen 85-A FbpA |
| M. avium 104 | MAV_0214 | - | 1e-110 | 59.88% (334) | antigen 85-A |
| M. smegmatis MC2 155 | MSMEG_3580 | - | 1e-116 | 61.49% (322) | antigen 85-C |
| M. thermoresistible (build 8) | TH_2078 | fbpA | 1e-115 | 61.14% (332) | SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) |
| M. ulcerans Agy99 | MUL_4987 | fbpA | 1e-113 | 61.52% (330) | secreted antigen 85-A FbpA |
| M. vanbaalenii PYR-1 | Mvan_3061 | - | 1e-117 | 61.89% (328) | putative esterase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5368|M.marinum_M MKLVDRFRGAVT-GTPRRLMVGAVGAALLSGLVGFVGG---SATASAFSR
MUL_4987|M.ulcerans_Agy99 MKLVDRFRGAAT-GTSRRLMVGAVGAALLSGLVGFVGG---SATASAFSR
MAV_0214|M.avium_104 MTLVDRLRGAVA-GMPRRLVVGAAGAALLSGLIGAVGG---SATAGAFSR
Mb3834c|M.bovis_AF2122/97 MQLVDRVRGAVT-GMSRRLVVGAVGAALVSGLVGAVGG---TATAGAFSR
Rv3804c|M.tuberculosis_H37Rv MQLVDRVRGAVT-GMSRRLVVGAVGAALVSGLVGAVGG---TATAGAFSR
MLBr_00097|M.leprae_Br4923 MKFVDRFRGAVA-GMLRRLVVEAMGVALLSALIGVVG----SAPAEAFSR
Mflv_3335|M.gilvum_PYR-GCK MKWKEKARGTRK-SLVRRVAAAALAAAALPGLIGVAGG---SATAGAFSR
Mvan_3061|M.vanbaalenii_PYR-1 MKLKEKWRGTAR-AAMRRVAAAALAAVALPGLIGFAGG---SATAGAFSR
MSMEG_3580|M.smegmatis_MC2_155 MRGIAAWK------ALRRFVIGALAALMLPGLIGFAGG---SASAGAFSR
TH_2078|M.thermoresistible__bu MKLVAKLRGAAR-ALPRRLTVAALAAALLPGLVGAFGG---SATAGAFSR
MAB_0176|M.abscessus_ATCC_1997 MKLFSKMRGALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAFSR
* : **. * .. :..: * * :. * ****
MMAR_5368|M.marinum_M PGLPVEYLQVPSAAMGRNIKVQFQSGGANSPALYLLDGMRAQDDFSGWDI
MUL_4987|M.ulcerans_Agy99 PGLPVEYLQVPSVAMGRNIKVQFQSGGANSPALYLLDGMRAQDDFSGWDI
MAV_0214|M.avium_104 PGLPVEYLQVPSAAMGRDIKVQFQSGGANSPALYLLDGMRAQDDFNGWDI
Mb3834c|M.bovis_AF2122/97 PGLPVEYLQVPSPSMGRDIKVQFQSGGANSPALYLLDGLRAQDDFSGWDI
Rv3804c|M.tuberculosis_H37Rv PGLPVEYLQVPSPSMGRDIKVQFQSGGANSPALYLLDGLRAQDDFSGWDI
MLBr_00097|M.leprae_Br4923 PGLPVEYLQVPSPSMGRDIKVQFQNGGANSPALYLLDGLRAQDDFSGWDI
Mflv_3335|M.gilvum_PYR-GCK PGLPVEYLDVFSPSMNRDIRIQFQGGG--PHAVYLLDGLRAQEDYNGWDI
Mvan_3061|M.vanbaalenii_PYR-1 PGLPVEYLDVFSPSMGRDIRVQFQGGG--PRAVYLLDGLRAQEDYNGWDI
MSMEG_3580|M.smegmatis_MC2_155 PGLPVEYLDVFSPSMNRDIRVQFQGGG--PHAVYLLDGLRAQDDYNGWDI
TH_2078|M.thermoresistible__bu PGLPVEYLMVPSAAMGRDIKVQFQSGGEGSPGVYLLDGLRARDDFNGWDI
MAB_0176|M.abscessus_ATCC_1997 PGLPVEYLQVPSASMGREIKVQFQPGG--AKAVYLLDGLRARDDFSGWDI
******** * * :*.*:*::*** ** . .:*****:**::*:.****
MMAR_5368|M.marinum_M NTPAFEWYYQSGISVAMPVGGQSSFYSDWYNPACGKAGCTTYKWETFLTS
MUL_4987|M.ulcerans_Agy99 NTPAFEWYYQSGISVAMPVGGQSSFYSDWYNPACGKAGCTTYKWETFLTS
MAV_0214|M.avium_104 NTPAFEWYNQSGISVAMPVGGQSSFYSDWYKPACGKAGCTTYKWETFLTS
Mb3834c|M.bovis_AF2122/97 NTPAFEWYDQSGLSVVMPVGGQSSFYSDWYQPACGKAGCQTYKWETFLTS
Rv3804c|M.tuberculosis_H37Rv NTPAFEWYDQSGLSVVMPVGGQSSFYSDWYQPACGKAGCQTYKWETFLTS
MLBr_00097|M.leprae_Br4923 NTTAFEWYYQSGISVVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTS
Mflv_3335|M.gilvum_PYR-GCK NTPAFEWFYQSGLSTIMPVGGQSSFYSDWYQPSRGNGQNYTYKWETFLTQ
Mvan_3061|M.vanbaalenii_PYR-1 NTPAFEWFYQSGLSTIMPVGGQSSFYTDWYQPSRGNGQNYTYKWETFLSQ
MSMEG_3580|M.smegmatis_MC2_155 NTPAFEWFYQSGLSTIMPVGGQSSFYTDWYQPSKGNGQDYTYKWETFLTQ
TH_2078|M.thermoresistible__bu ETAAFEWYYESGLSVIMPVGGQSSFYSDWYSPACGNNGCQTYKWETFLTQ
MAB_0176|M.abscessus_ATCC_1997 ETTAFEDYYQSGISMVMPVGGQSSFYTDWYNPAKGKDGVWTYKWETFTTQ
:*.*** : :**:* **********:***.*: *: ******* :.
MMAR_5368|M.marinum_M ELPQYLSANKGVKPTGSGVVGLSMAGSSALILAAYHPDQFVYSGSLSALL
MUL_4987|M.ulcerans_Agy99 ELPQYLSANKGVKPTGSGVVGLSMAGSSALILAAYHPDQFVYSGSLSALL
MAV_0214|M.avium_104 ELPQYLSAQKQVKPTGSGVVGLSMAGSSALILAAYHPDQFVYAGSLSALL
Mb3834c|M.bovis_AF2122/97 ELPGWLQANRHVKPTGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSGLL
Rv3804c|M.tuberculosis_H37Rv ELPGWLQANRHVKPTGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSGLL
MLBr_00097|M.leprae_Br4923 ELPQYLQSNKQIKPTGSAAVGLSMAGLSALTLAIYHPDQFIYVGSMSGLL
Mflv_3335|M.gilvum_PYR-GCK ELPAWLEANRGVSRTGNAVVGLSMAGSASLTYAIHHPQQFIYAASLSGFL
Mvan_3061|M.vanbaalenii_PYR-1 ELPAWLEANRGVSRTGNAVVGLSMAGSAALTYAIYHPQQFIYAASLSGFL
MSMEG_3580|M.smegmatis_MC2_155 ELPAWLEANRGVSRTGNAVVGLSMAGSAALTYAIYHPEQFIYASTLSGFL
TH_2078|M.thermoresistible__bu ELPAYLASNYGVDRNRNAAVGLSMAGSAALVLAIYYPQQFQYAASLSGFL
MAB_0176|M.abscessus_ATCC_1997 ELPAYLAANKGISQTGNAVVGLSMGASAALTLSIYHPQLFVYAGALSGFL
*** :* :: :. . ...*****.. ::* : ::*: * * .::*.:*
MMAR_5368|M.marinum_M DPSQGMGPSLIGLAMGDAGGYKASDMWGPKDDP--AWARNDPMLQVGKLV
MUL_4987|M.ulcerans_Agy99 DPSQGIGPSLIGLAMGDAGGYKASDMWGPKDDP--AWARNDPMLQVGKLV
MAV_0214|M.avium_104 DPSQGMGPSLIGLAMGDAGGYKAADMWGPKEDP--AWARNDPSLQVGKLV
Mb3834c|M.bovis_AF2122/97 DPSQAMGPTLIGLAMGDAGGYKASDMWGPKEDP--AWQRNDPLLNVGKLI
Rv3804c|M.tuberculosis_H37Rv DPSQAMGPTLIGLAMGDAGGYKASDMWGPKEDP--AWQRNDPLLNVGKLI
MLBr_00097|M.leprae_Br4923 DPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDP--AWKRNDPTVNVGTLI
Mflv_3335|M.gilvum_PYR-GCK NPSEGWWPMLIGLAMNDAGGFNAESMWGPSSDP--AWKRNDPMVNINQLV
Mvan_3061|M.vanbaalenii_PYR-1 NPSEGWWPMLIGLAMNDAGGFNAESMWGPSSDP--AWKRNDPMVNINQLV
MSMEG_3580|M.smegmatis_MC2_155 NPSEGWWPMLIGLAMNDAGGYNAESMWGPSTDP--AWKRNDPMVNINQLV
TH_2078|M.thermoresistible__bu NLSEGWWPMLVGLAMGDAGGYDPNDMWGRTEDPNSAWKRNDPMVNIDKLV
MAB_0176|M.abscessus_ATCC_1997 NPSD--MKFQIGLAMGDAGGFSASDMWGPDSDP--AWQRNDPFLNIQKII
: *: :****.****:.. .*** ** ** **** ::: ::
MMAR_5368|M.marinum_M ANNTRIWVYCGNGKPSDLGG-----DNLPAKFLEGFVRTSNMKFQAAYNA
MUL_4987|M.ulcerans_Agy99 ANNTRIWVYCGNGKPSDLGG-----DNLPAKFLEGFVRTSNMKFQAAYNA
MAV_0214|M.avium_104 ANNTRIWVYCGNGKPSDLGG-----DNLPAKFLEGFVRTSNLKFQDAYNG
Mb3834c|M.bovis_AF2122/97 ANNTRVWVYCGNGKPSDLGG-----NNLPAKFLEGFVRTSNIKFQDAYNA
Rv3804c|M.tuberculosis_H37Rv ANNTRVWVYCGNGKPSDLGG-----NNLPAKFLEGFVRTSNIKFQDAYNA
MLBr_00097|M.leprae_Br4923 ANNTRIWMYCGNGKPTELGG-----NNLPAKLLEGLVRTSNIKFQDGYNA
Mflv_3335|M.gilvum_PYR-GCK ANNTRIWIYCGTGTPSDLDSGTPGQNLMAAQFLEGFTLRTNVAFRDNYIA
Mvan_3061|M.vanbaalenii_PYR-1 ANNTRIWIYCGTGTPSDLDNGTPGNNLMAAQFLEGFTLRTNIAFRDNYIA
MSMEG_3580|M.smegmatis_MC2_155 ANNTRLWVYCGTGTPSELDAGVSGGNLLAAQFLEGLTLRTNLTFRDQYIA
TH_2078|M.thermoresistible__bu ANNTRIWVFCGDGTPADIGAGVPEGDNFNAKFLESFTLRTNKTFQQEYIA
MAB_0176|M.abscessus_ATCC_1997 DNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGMAIGSNKKFVEAYTA
*.**:*::** * .:::. : : . :**.:. :* * * .
MMAR_5368|M.marinum_M AGGHNAVWNFDDNGTHSWEYWGAQLNAMKPDLQHTLGATP----------
MUL_4987|M.ulcerans_Agy99 AGGHNAVWNFDDNGTHSWEYWGAQLNAMRPDLQHTLGATP----------
MAV_0214|M.avium_104 AGGHNAVWNFDANGTHDWPYWGAQLQAMKPDLQSVLGATPGAGPATAAAT
Mb3834c|M.bovis_AF2122/97 GGGHNGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATP----------
Rv3804c|M.tuberculosis_H37Rv GGGHNGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATP----------
MLBr_00097|M.leprae_Br4923 GGGHNAVFNFPDSGTHSWEYWGEQLNDMKPDLQQYLGATP----------
Mflv_3335|M.gilvum_PYR-GCK AGGNNGVFNFPTSGTHSWGYWGQQLQQMKPDIQRVLGAQATA--------
Mvan_3061|M.vanbaalenii_PYR-1 AGGTNGVFNFPTSGTHSWGYWGQQLQQMKPDIQRVLGAQATV--------
MSMEG_3580|M.smegmatis_MC2_155 AGGTNAVFNFPPNGTHTWNYWGQQLLEMKPDIQRVLGAQSAT--------
TH_2078|M.thermoresistible__bu AGGKNGVFNFPDAGTHSWGYWGQQLQQMKPDIQRVLGVSAA---------
MAB_0176|M.abscessus_ATCC_1997 AGGKNAHIEFPPGGIHNWTYWGQQLRAMKPDMVAYLQSH-----------
.** *. :* * * * *** ** *:**: *
MMAR_5368|M.marinum_M NTGDT-QGA
MUL_4987|M.ulcerans_Agy99 NTGDT-QGA
MAV_0214|M.avium_104 NAGNG-QGT
Mb3834c|M.bovis_AF2122/97 NTGPAPQGA
Rv3804c|M.tuberculosis_H37Rv NTGPAPQGA
MLBr_00097|M.leprae_Br4923 -------GA
Mflv_3335|M.gilvum_PYR-GCK ---------
Mvan_3061|M.vanbaalenii_PYR-1 ---------
MSMEG_3580|M.smegmatis_MC2_155 ---------
TH_2078|M.thermoresistible__bu ---------
MAB_0176|M.abscessus_ATCC_1997 ---------