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AYLDHAATTPMHPAAIEAMAAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTES DNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTWLPTAADGSVSATALREALQSH DDVALVSVMWANNEVGTILPIAEMSVVAMEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPG VGALLLRRDVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEENSARLRLLRDRLVEGVLAE IDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDANGIECSTGSACTAGVAQPSHVLIAMGVDAASAR GSLRLSLGHTSVEADVDAALEVLPGAVARARRAALAAAGASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3025c | iscS | - | 100% (393) | PROBABLE CYSTEINE DESULFURASE ISCS (NIFS PROTEIN HOMOLOG) (NITROGENASE METALLOCLUSTERS BIOSYNTHESIS PROTEIN NIFS) |
| M. tuberculosis H37Rv | Rv1464 | csd | 9e-24 | 28.42% (387) | cysteine desulfurase |
| M. tuberculosis H37Rv | Rv3700c | - | 5e-06 | 25.79% (221) | hypothetical protein Rv3700c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3051c | iscS | 0.0 | 100.00% (393) | cysteine desulfurase IscS |
| M. gilvum PYR-GCK | Mflv_4255 | - | 1e-170 | 77.58% (388) | aminotransferase, class V |
| M. leprae Br4923 | MLBr_01708 | - | 0.0 | 84.91% (391) | putative aminotransferase |
| M. abscessus ATCC 19977 | MAB_3357c | - | 1e-152 | 70.36% (388) | putative aminotransferase/cysteine desulfurase |
| M. marinum M | MMAR_1689 | iscS | 0.0 | 85.71% (392) | cysteine desulfurase IscS |
| M. avium 104 | MAV_3872 | - | 0.0 | 85.97% (392) | cysteine desulfurase |
| M. smegmatis MC2 155 | MSMEG_2357 | - | 1e-172 | 77.38% (389) | cysteine desulfurase |
| M. thermoresistible (build 8) | TH_1185 | - | 1e-171 | 75.70% (391) | PROBABLE CYSTEINE DESULFURASE ISCS (NIFS PROTEIN HOMOLOG) |
| M. ulcerans Agy99 | MUL_1927 | iscS | 0.0 | 85.46% (392) | cysteine desulfurase IscS |
| M. vanbaalenii PYR-1 | Mvan_2105 | - | 1e-163 | 73.71% (388) | aminotransferase, class V |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4255|M.gilvum_PYR-GCK MRWSRERDRGARPRGRYPGTAMSASAAAPRPVYLDHAATTPMRPAAIEAM
Mvan_2105|M.vanbaalenii_PYR-1 ----------------MPG---------PAPVYLDHAATTPMRPGAIEAM
Rv3025c|M.tuberculosis_H37Rv ------------------------------MAYLDHAATTPMHPAAIEAM
Mb3051c|M.bovis_AF2122/97 ------------------------------MAYLDHAATTPMHPAAIEAM
MLBr_01708|M.leprae_Br4923 ----------------MIRQAPIAGILKCVMAYLDHAATTPMHPAAIEAM
MAV_3872|M.avium_104 ------------------------------MVYLDHAATTPMHPAAVEAM
MMAR_1689|M.marinum_M ------------------------------MVYLDHAATTPMHPTAIEAM
MUL_1927|M.ulcerans_Agy99 ------------------------------MVYLDHAATTPMHPTAIEAM
MSMEG_2357|M.smegmatis_MC2_155 -----------------------MTSTAGRQVYLDHAATTPMHPAAIEAM
TH_1185|M.thermoresistible__bu -------------------------MNTPQTVYLDHAATTPMYPAAITAM
MAB_3357c|M.abscessus_ATCC_199 ---------------------------MSRSVYLDHAATTPMRPDAIEAM
.********** * *: **
Mflv_4255|M.gilvum_PYR-GCK TAALATVGNASSLHGSGRTARRRLEESRETLAQLLGARPSEVIFTAGGTE
Mvan_2105|M.vanbaalenii_PYR-1 TAALATVGNAASLHGSGRLARRRLEESRETLARLLGARPSEVIFTAGGTE
Rv3025c|M.tuberculosis_H37Rv AAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTE
Mb3051c|M.bovis_AF2122/97 AAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTE
MLBr_01708|M.leprae_Br4923 TTALGTVGNASSLHTSGRVARRRIEESRELIADKLAARPSEVIFTAGGTE
MAV_3872|M.avium_104 TAVLGTVGNASSLHTSGRAARRRIEESRELVADKLGARPSEVIFTAGGTE
MMAR_1689|M.marinum_M MAVLATVGNASSLHTTGRAARRRLEESRELIAAKLGARPSEVIFTAGGTE
MUL_1927|M.ulcerans_Agy99 TAVLATVGNASSLHTTGRAARRRLEESRELIAAKLGARPSEVIFTAGGTE
MSMEG_2357|M.smegmatis_MC2_155 TAVLAGVGNASSLHGSGRAARRRMEEAREALARLLGARPSEIIFTTGGTE
TH_1185|M.thermoresistible__bu TDVMSTVGNASSLHSSGRVARRRMEEARETLARLLGARPSEVVFTAGGTE
MAB_3357c|M.abscessus_ATCC_199 AATMAQTGNAASLHGAGRDARRRVEESRESIAAALGARPSEVIFTAGGTE
. ***:*** :** ****:**:** :* *.*****::**:****
Mflv_4255|M.gilvum_PYR-GCK SDNLAVKGIYWARRDAEPQRRRIVTTPVEHHAVLDAVQWLADHEGAEVTW
Mvan_2105|M.vanbaalenii_PYR-1 SDNLVVKGIYWARRASSPKRRRIITTPVEHHAVLDAVEWLVEHEDAEVTW
Rv3025c|M.tuberculosis_H37Rv SDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTW
Mb3051c|M.bovis_AF2122/97 SDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTW
MLBr_01708|M.leprae_Br4923 SDNLAVKGIYWARRDAQPCHRRIVTTEVEHHAVLDSVNWLVEHEGAEVTW
MAV_3872|M.avium_104 SDNLAVKGIYWARRDAEPRQRRIVTSEVEHHAVLDSVNWLVEHEGAEVTW
MMAR_1689|M.marinum_M SDNLAVKGMYWARRDAQPARRRIVTTRVEHHAVLDTVDWLVEHEGAEVTW
MUL_1927|M.ulcerans_Agy99 SDNLAVKGMYWARRDAQPARRRIVTTRVEHHAVLDTVDWLVEHEGAEVTW
MSMEG_2357|M.smegmatis_MC2_155 SDNLAVKGIYWARHDADPARRRIITTAVEHHAVLDAVEWLVAHEGAEVTW
TH_1185|M.thermoresistible__bu SDNLAVKGLYWARRAASPGLRRIITTRVEHHAVLDAVDWLVQHEGAEVTW
MAB_3357c|M.abscessus_ATCC_199 SDNLAVKGIYWARRGADARRRRIIASAVEHHAVLDAVQWLADHEGAAVTW
****.***:****: :.. ***::: ********:*:**. **.* ***
Mflv_4255|M.gilvum_PYR-GCK LPVDQYGAVNPADLRVALSE-TADVALVSVMWANNEVGTIQPIAELAAIA
Mvan_2105|M.vanbaalenii_PYR-1 LPVDEFGAVGAADLRTALAD-PDDVALISVMWANNEVGTIMPIHELASVA
Rv3025c|M.tuberculosis_H37Rv LPTAADGSVSATALREALQS-HDDVALVSVMWANNEVGTILPIAEMSVVA
Mb3051c|M.bovis_AF2122/97 LPTAADGSVSATALREALQS-HDDVALVSVMWANNEVGTILPIAEMSVVA
MLBr_01708|M.leprae_Br4923 LPTAADGSVSAFGLREALQQ-HNDVALVSVMWANNEVGTVMPVVELAAVA
MAV_3872|M.avium_104 LPTAADGSVSPAALREVLTR-HDDVALVSVMWANNEVGTVQPVAELAAVA
MMAR_1689|M.marinum_M LPTDADGSVSASALRDALES-HDDVALVSVMWANNEVGTIMPIAELAGVA
MUL_1927|M.ulcerans_Agy99 LPTDADGSVSASALRDALES-HDDVALVSVMWANNEVGTIMPIAELAGVA
MSMEG_2357|M.smegmatis_MC2_155 LPVDRDGAVSPAALREALQAGAHDVALVSVMWANNEVGTIMPIAELAAVA
TH_1185|M.thermoresistible__bu LPVEPDGSVTPATLREALRA-HDDVALVTLMWANNEVGTVSPIAELAAVA
MAB_3357c|M.abscessus_ATCC_199 LPVDQAGTVTPGALRAALAE-HDDVALITVMWANNEVGTINPIYELSSIA
**. *:* . ** .* ****:::*********: *: *:: :*
Mflv_4255|M.gilvum_PYR-GCK TEFGVPMHSDAIQAIGQLPVDFGASGLSAMSVAAHKFGGPAGVGALLLRR
Mvan_2105|M.vanbaalenii_PYR-1 AEFEIPMHSDAIQVVGQLPVDFAASGLSAMSVTAHKFGGPIGVGALLLRR
Rv3025c|M.tuberculosis_H37Rv MEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRR
Mb3051c|M.bovis_AF2122/97 MEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRR
MLBr_01708|M.leprae_Br4923 AEFGVPMHSDAIQAVGQLPVKFGVSGLSAMSVAAHKFGGPPGVGALLLRR
MAV_3872|M.avium_104 AEFGVPMHSDAVQAVGQLPVDFTASGLSAMSVTAHKFGGPPAVGALLLRR
MMAR_1689|M.marinum_M AEFGVPMHSDAVQAVGQVPVDFGACGLAAMSVTAHKFGGPPGAGALLMRR
MUL_1927|M.ulcerans_Agy99 AEFGVPMHSDAVQAVGQIPVDFGACGLAAMSVTAHKFGGPPGAGALLMRR
MSMEG_2357|M.smegmatis_MC2_155 AEFGVPMHSDAVQAVGQIPVNFGASGLAAMSVTAHKFGGPTGVGALLLRR
TH_1185|M.thermoresistible__bu AEFSVPMHSDAVQAVGHLPVDFSASGLSAMSISAHKFGGPTGVGALLIRR
MAB_3357c|M.abscessus_ATCC_199 AEFDVPMHSDAIGAVGQLDVDFALSGLSAISVAAHKFGGPMGVGALLLRR
** :******: .:*:: :.* .**:*:*::.****** ..****:**
Mflv_4255|M.gilvum_PYR-GCK DTACVPQLHGGGQERDVRSGTQDVAGVIGMAVAARDAADTMEPVIARVRD
Mvan_2105|M.vanbaalenii_PYR-1 ETACVPLLHGGGQERDVRSGTQDVPGAVGMAAAAQIAADTMDSAAEKVRA
Rv3025c|M.tuberculosis_H37Rv DVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEENSARLRL
Mb3051c|M.bovis_AF2122/97 DVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEENSARLRL
MLBr_01708|M.leprae_Br4923 DISCVPLLHGGGQERDIRSGTPGVASVVGMAAAAQIAVDGLEINSIRLQV
MAV_3872|M.avium_104 DVACVPLAHGGGQERDIRSGTADVAGAVGMAAAARISVDGLETNSARLRA
MMAR_1689|M.marinum_M DVSCVPLLHGGGQERDIRSGTPDVASAVGMAAAARIAVDGLEANSARLQT
MUL_1927|M.ulcerans_Agy99 DVSCVPLLHGGGQERDIRSGTPDVASAVGIAAAARIAVDGLEANSARLQT
MSMEG_2357|M.smegmatis_MC2_155 DTACVPLLHGGGQERDVRSGTPDVAGVVAMATAAGVAIENLADNSARVRA
TH_1185|M.thermoresistible__bu DAECVPLLHGGGQERDIRSGTPHVAGVVAMAVAAEAAIENLPAVSARIAA
MAB_3357c|M.abscessus_ATCC_199 EIACVPLLHGGGHERDIRSGTPDTAAIVAMSTALVAAVAERCESAAAMAG
: *** ****:***:**** ... :.::.* : :
Mflv_4255|M.gilvum_PYR-GCK LRDRLVAGVLESIDDVDVNGAPGPGRLPGNAHFTFRGCEGDSLLMLLDAK
Mvan_2105|M.vanbaalenii_PYR-1 LRDRLIDGVLDAVDDVDVNGAPGAGRLPGNAHFTFRGCEGDSLLMLLDAK
Rv3025c|M.tuberculosis_H37Rv LRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDAN
Mb3051c|M.bovis_AF2122/97 LRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDAN
MLBr_01708|M.leprae_Br4923 LRDRLIEGVLATIDDVALNGARDRMRLPGNAHFIFRGCEGDVLLMLLDAN
MAV_3872|M.avium_104 LRDRLVDGVLGGIEDVTLNGARDPLRLPGNAHFTFRGCEGDALLMLLDAN
MMAR_1689|M.marinum_M LRDRLVAGVLAEIDDVRLNGARDPLRLPGNAHFTFRGCEGDALLMLLDAN
MUL_1927|M.ulcerans_Agy99 LRDRLVAGVLAEIDDVRLNGARDPLRLPGNAHFTFRGCEGDALLMLLDAN
MSMEG_2357|M.smegmatis_MC2_155 LRDRLIDGVLSAIEDAQLNGARGDARLPGNAHFTFHGCEGDSLLMLLDAK
TH_1185|M.thermoresistible__bu LRDRLIDGVLTGIDDAYLNGARGADRLPGNAHFTFRGCEGDSLLMLLDAN
MAB_3357c|M.abscessus_ATCC_199 LRDSLIDQVLTQIEGATLNGAPGSGRLPGNAHFTFAGCEGDSLLMLLDAN
*** *: ** ::.. :*** . **.***** * ***** *******:
Mflv_4255|M.gilvum_PYR-GCK GIECSTGSACTAGVAQPSHVLTAMGVDPASARGSLRLSLGHTSTEADIEA
Mvan_2105|M.vanbaalenii_PYR-1 GIECSTGSACTAGVAQPSHVLTAMGADPVSARGSLRLSLGHTSTDADIDA
Rv3025c|M.tuberculosis_H37Rv GIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDA
Mb3051c|M.bovis_AF2122/97 GIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDA
MLBr_01708|M.leprae_Br4923 GIECSTGSACTSGVPQPSHVLIAMGADPASARGSLRLSLGHNSVEVDVEE
MAV_3872|M.avium_104 GIECSTGSACTAGVAQPSHVLVAMGVDPASARGSLRLSLGHTSIDADVDA
MMAR_1689|M.marinum_M GIECSTGSACTAGVAQPSHVLIAMGADPASARGSLRLSLGHTTVEADVDA
MUL_1927|M.ulcerans_Agy99 GIECSTGSACTAGVAQPSHVLIAMGADPASARGSLRLSLGHTTVEADVDA
MSMEG_2357|M.smegmatis_MC2_155 GVECSTGSACTAGVAQASHVLIAMGADAVKARGSLRLSLGHTSTEADVDT
TH_1185|M.thermoresistible__bu GIECSTGSACTAGVAQPSHVLIAMGADSASARGSLRLSLGHTSTEADVDA
MAB_3357c|M.abscessus_ATCC_199 GIECSTGSACTAGVARPSHVLIEMGIDPEVARGSLRFTFGHTSVPSDVDR
*:*********:**.:.**** ** *. ******:::**.: *::
Mflv_4255|M.gilvum_PYR-GCK VLEVLPAAVDRARQAALASSGRH----
Mvan_2105|M.vanbaalenii_PYR-1 VLDVLPAAVERARQAALASSGRR----
Rv3025c|M.tuberculosis_H37Rv ALEVLPGAVARARRAALAAAGASR---
Mb3051c|M.bovis_AF2122/97 ALEVLPGAVARARRAALAAAGASR---
MLBr_01708|M.leprae_Br4923 VLRVLPGAVDRARRASLAAAGAGGVGV
MAV_3872|M.avium_104 VLRVLPGAVERARRAALAAAGAS----
MMAR_1689|M.marinum_M ALQVLPAAVARARSAAVAAAGAAW---
MUL_1927|M.ulcerans_Agy99 ALQVLPAAVARARSAAVAAAGAAW---
MSMEG_2357|M.smegmatis_MC2_155 ALEVLPAAVERARQAALASAGTVSR--
TH_1185|M.thermoresistible__bu ALAVLPAAVERARQAALASAG-VDK--
MAB_3357c|M.abscessus_ATCC_199 ALEALHAAVPRARAAALASAGGRS---
.* .* .** *** *::*::*