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MDGDAHDLEDTPLAQRWREARPPAAGVHVDSAACSRQSVAVIEATAQHARHEAEVGGYVAAEAAAPVLDA GRAAVRVLAGMPDAEVVFTTGSNNALDILLADWPGERTLACLQGEFGPNLAIMARHGFEVRTLPLEESGR LDVNAIGAALAHDPPALVHFTVLGSHSGVVQPARAMASACHGHGIPLIVDAAQGFAHIDVAGIGADALYS SSRKWTAGPRGVGVLATKPGFLSEATRQRISHTEANVGMHVGFSVALGEHVAAGVEAVQARLREVGAATR RALADVRGWRVLEALDEPSAITTLRPPDGVDAQDVRARLIAEHSIVATYLGTERAPREMNRPALRVSPHV DVTAADLGRVAEALAEVTPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1319 | - | - | 100% (370) | aminotransferase, class V |
| M. gilvum PYR-GCK | Mflv_3674 | - | 2e-12 | 24.17% (331) | SufS subfamily cysteine desulfurase |
| M. gilvum PYR-GCK | Mflv_4255 | - | 6e-09 | 25.65% (386) | aminotransferase, class V |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3726c | - | 1e-122 | 60.65% (371) | hypothetical protein Mb3726c |
| M. tuberculosis H37Rv | Rv3700c | - | 1e-122 | 60.65% (371) | hypothetical protein Rv3700c |
| M. leprae Br4923 | MLBr_00596 | - | 1e-12 | 24.26% (338) | putative aminotransferase |
| M. abscessus ATCC 19977 | MAB_0373 | - | 1e-103 | 55.21% (355) | aminotransferase |
| M. marinum M | MMAR_5211 | csdB | 1e-117 | 59.09% (374) | selenocysteine lyase, CsdB |
| M. avium 104 | MAV_0403 | - | 1e-112 | 56.84% (373) | pyridoxal-phosphate-dependent transferase |
| M. smegmatis MC2 155 | MSMEG_6246 | - | 1e-113 | 56.64% (369) | pyridoxal-phosphate-dependent transferase |
| M. thermoresistible (build 8) | TH_1723 | - | 2e-89 | 55.03% (318) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4284 | csdB | 1e-116 | 58.56% (374) | selenocysteine lyase, CsdB |
| M. vanbaalenii PYR-1 | Mvan_5482 | - | 1e-159 | 78.37% (356) | aminotransferase, class V |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1319|M.gilvum_PYR-GCK -MDGDAHDLEDTPLAQRWREARPPAAG----VHVDSAACSRQSVAVIEAT
Mvan_5482|M.vanbaalenii_PYR-1 -----------MTLAEQWRAARPPVAG----VHVDSAACSRQSFAVIEAA
Mb3726c|M.bovis_AF2122/97 MRRSGANSPAGDSLADRWRAARPPVAG----LHLDSAACSRQSFAALDAA
Rv3700c|M.tuberculosis_H37Rv MRRSGANSPAGDSLADRWRAARPPVAG----LHLDSAACSRQSFAALDAA
MAV_0403|M.avium_104 -------MSGGTPLADTWRSARPPAAG----LHLDSAACSRQSFAVIEAT
MMAR_5211|M.marinum_M ---------MTDTLADRWRAARPPAAG----LHLDSAACSRQSLEVLQAV
MUL_4284|M.ulcerans_Agy99 ---------MTDTLADRWRAARPPATG----LHLDSAACSRQSLEVLRAV
MSMEG_6246|M.smegmatis_MC2_155 -----------MMLAQQWRDARPKVAG----LHLDSGACSRQSFAVIDAT
TH_1723|M.thermoresistible__bu --------------------------------------------------
MAB_0373|M.abscessus_ATCC_1997 -----------MSLRDRWRHARPPVLG----VHLDSAACSRQSIETLRAV
MLBr_00596|M.leprae_Br4923 -MTISLTPLDLSAIRADFPILKRVMRGGNQLAYLDSGATSQRPVQVLDAE
Mflv_1319|M.gilvum_PYR-GCK AQHARH---EAEVGGYVAAEAAAPVLDAGRAAVRVLAGMPDAEVVFTTGS
Mvan_5482|M.vanbaalenii_PYR-1 AQHARH---EAEVGGYVAAEAAAPALDAGRTAVRALTGMSDAVVHFTTGS
Mb3726c|M.bovis_AF2122/97 AQHARH---EAEVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGS
Rv3700c|M.tuberculosis_H37Rv AQHARH---EAEVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGS
MAV_0403|M.avium_104 AQHARN---EAELGGYVAAEAAAPVLDAGRFAFTALTGMTDAEAVFTTGS
MMAR_5211|M.marinum_M AAHGLH---EAEVGGYVAAEAAAPVLDAGRAAVATLCGVPDARVVFTTGS
MUL_4284|M.ulcerans_Agy99 AAHGLH---EAEVGGYVAAEAAAPVLDAGRAAVATLCGVPDARVVFTTGS
MSMEG_6246|M.smegmatis_MC2_155 TAHARH---EAEVGGYVAAEAATPALDAGRAAVASLIGFAASDVVYTSGS
TH_1723|M.thermoresistible__bu ------------------------VLHAGRAAVAHLVGMDAADVVFTTGS
MAB_0373|M.abscessus_ATCC_1997 AQHAEH---EAQIGGYVAQEAATPVLEAGRAAVRQLTGMPEAHVQFTTGA
MLBr_00596|M.leprae_Br4923 REFLVTSNGAVHRGAHQLMEEATDAYERGRVDIAAFIGAAADELVFTKNA
. . ** . : * :*..:
Mflv_1319|M.gilvum_PYR-GCK NNALDILLADWPGE--RTLACLQG------------EFGPNLAIMARHGF
Mvan_5482|M.vanbaalenii_PYR-1 NHALDILLGDWTGA--RTLACLPG------------EFGPNLAIMARHGF
Mb3726c|M.bovis_AF2122/97 LHALDLLLGSWPGEN-RTLACLPG------------EYGPNLAVMAAHGF
Rv3700c|M.tuberculosis_H37Rv LHALDLLLGSWPGEN-RTLACLPG------------EYGPNLAVMAAHGF
MAV_0403|M.avium_104 LHALDLLLGSWPAER-RTLACLPG------------EYGPNLAVMAAHGF
MMAR_5211|M.marinum_M LHALDLLLGSWPRES-RTLACLPG------------EYGPNLAVMAAHGF
MUL_4284|M.ulcerans_Agy99 LHALDLLLGSWPRES-RTLACLPG------------EYGPNLAVMAAHGF
MSMEG_6246|M.smegmatis_MC2_155 NHAIDLLLSSWPGK--RTLACLPG------------EYGPNLSAMAANGF
TH_1723|M.thermoresistible__bu NHALDLLLSSWPQP--RSLACLPG------------EFGPNLAIMAANGF
MAB_0373|M.abscessus_ATCC_1997 ADALRTLLQAWPADSGRVVACLPG------------EFGPNLMIMNHFGF
MLBr_00596|M.leprae_Br4923 TESLNLVSYVFGDNRFEGTSGDGGDVIVTTELEHHANLIPWQELARRIGA
.:: : : . : * : * *
Mflv_1319|M.gilvum_PYR-GCK EVRTLPLEESGRLDVNAIGAALAHDPPALVHFTVLGSHSGVVQPARAMAS
Mvan_5482|M.vanbaalenii_PYR-1 SIKVLPVDEFGRLDVNAVGAALSSHQPALVHFTVLGSHSGIVQPVRDMAS
Mb3726c|M.bovis_AF2122/97 DVRPLPTLQDGRVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQ
Rv3700c|M.tuberculosis_H37Rv DVRPLPTLQDGRVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQ
MAV_0403|M.avium_104 DRWLLPTLADGRVALDDAALALQTDPPDLVHLTTIGSHSGVVQPVSMIAR
MMAR_5211|M.marinum_M EVRLLPTLDDGRLALDDAAYELEEDPPELVHLTPVASHRGTVQPLAMMAE
MUL_4284|M.ulcerans_Agy99 EVRLLPTLDDGRLALDDAAYELEEDPPELVHLTPVASHRGTVQPLAMMAE
MSMEG_6246|M.smegmatis_MC2_155 QVRALPVDDDGRVLVDEASHELSAHPVALVHLTALASHRGIAQPAAELVE
TH_1723|M.thermoresistible__bu EVRALPVDEIGRVRPDRAEHLLRTDPPALVHLTALASHRGIAQPAARIAE
MAB_0373|M.abscessus_ATCC_1997 TPVWLPVDGDGRADVDGIEVFLRHEKIDLLHLTVVGSHRGTVQPAAEVVA
MLBr_00596|M.leprae_Br4923 TLRWYGVTDDGQIDLDSLQLDER---VKVVAFSHHSNVTGAVAPVRELVA
*: : :: :: .. * . * :.
Mflv_1319|M.gilvum_PYR-GCK ACHGHGIPLIVDAAQGFAHIDVAGIGADALYSSSR-KWTAGPRGVGVLAT
Mvan_5482|M.vanbaalenii_PYR-1 ACRGHGIPLIVDAAQGFAHLDVAGIGADALYSSSR-KWTAGPRGVGVLAS
Mb3726c|M.bovis_AF2122/97 LCTELKLPLVVDAAQGLGHVDCA-VGADVTYASSR-KWIAGPRGVGVLAV
Rv3700c|M.tuberculosis_H37Rv LCTELKLPLVVDAAQGLGHVDCA-VGADVTYASSR-KWIAGPRGVGVLAV
MAV_0403|M.avium_104 LCRELGLPLVVDAAQALGQVDCT-AGADVTYSSSR-KWIAGPRGVGMLAV
MMAR_5211|M.marinum_M LCRELGLPLVVDAAQGMGQIDCA-VGADVTYSSSR-KWLAGPRGVGVLAM
MUL_4284|M.ulcerans_Agy99 LCRELGLPLVVDAAQGMGQIDCA-VGADVTYSSSR-KWLAGPRGVGVLAM
MSMEG_6246|M.smegmatis_MC2_155 ACHNAGIPVVIDAAQALGHLDCN-VGADAVYSSSR-KWLAGPRGVGVLAV
TH_1723|M.thermoresistible__bu LCRAYRVPLVIDAAQALGHLDCA-VGADAVYSSSR-KWLAGPRGVGVLAI
MAB_0373|M.abscessus_ATCC_1997 LARAAGVPVVVDAAQALGHIDCT-YGADAMYAPSR-KWLAGPRGVGVLAV
MLBr_00596|M.leprae_Br4923 RAKEVGALTVLDACQSVPHQPVDLHGLGVDFAAFSGHKMLGPNGIGVLYA
. ::**.*.. : * .. ::. : **.*:*:*
Mflv_1319|M.gilvum_PYR-GCK KPGFLSEATR----------------------QRISHTEANVGMHVGFSV
Mvan_5482|M.vanbaalenii_PYR-1 RPGLLADDTR----------------------IRLNHAETNVGLQVGFSV
Mb3726c|M.bovis_AF2122/97 RPELMERLRARLPAPDWMP--------PLTVAQQLGFGEANVAARVGFSV
Rv3700c|M.tuberculosis_H37Rv RPELMERLRARLPAPDWMP--------PLTVAQQLGFGEANVAARVGFSV
MAV_0403|M.avium_104 RRELMENLHPRLAAPDWAP--------GSTVAQQLEFGEANIAARVGFSL
MMAR_5211|M.marinum_M RPEVLDRLTPRLAPPDWSPDS-----PSTSVAQILEFGEANIAARVGFSL
MUL_4284|M.ulcerans_Agy99 RPEVLDRLTPRLAPPDWSPDS-----PSTSVAQILEFGEANIAARVGFSL
MSMEG_6246|M.smegmatis_MC2_155 RPELAERLQPRIPPSDWPIP--------MSVLEKLELGEHNAAARVGFSV
TH_1723|M.thermoresistible__bu RPELAERLCPRLPPPDWPVAR------TLRVLDRLAHGEANIAARVGFSV
MAB_0373|M.abscessus_ATCC_1997 NP-VLEHLLP----------------------QWAGHVEAHVAGWVGLSV
MLBr_00596|M.leprae_Br4923 RRELLSVMPPFLTGGSMIETVTMESTTYAPAPQRFEAGTPMTSQVVGLAA
. . . **::
Mflv_1319|M.gilvum_PYR-GCK ALGEHVAAGVEAVQARLREVGAATRRALADVRGWRVLEALDEPSAITTLR
Mvan_5482|M.vanbaalenii_PYR-1 AVGEYVAAGPDAVQSRLREVGAATRTALADVPGWRVVEHVTEPSAITTLQ
Mb3726c|M.bovis_AF2122/97 ALGEHLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLA
Rv3700c|M.tuberculosis_H37Rv ALGEHLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLA
MAV_0403|M.avium_104 ALGEYLGYGPAAVCARLAELGGLSRGVLTDVTGWAVVEEAEEPSAITTLA
MMAR_5211|M.marinum_M AVGEHLEYGPALIRARLAELGAAARRVLADVDGWLVVEEVDEPSAITTLA
MUL_4284|M.ulcerans_Agy99 AVGEHLEYGPALIRARLAELGAAARRVLADVDGWLVVEEVDEPSAITTLA
MSMEG_6246|M.smegmatis_MC2_155 AVGEHLAAGPTAVRERLAEVGRLSRQVLAEVDGWRVVEPVDQPTAITTLE
TH_1723|M.thermoresistible__bu AVGEHLAAGPAAVRARLAEVGRQTHAVLAQVPGWRVVEPPDEPTAITTLE
MAB_0373|M.abscessus_ATCC_1997 AVGQHLAAGPGQIQGALAERGRAARKILGELKDWRVIESVDEPSAITTLE
MLBr_00596|M.leprae_Br4923 AARYLDAIGMKAVEAHERELVAAAVEGLSRIDGVRIIGPKSMENRGSPVS
* * : * : * : . :: . :.:
Mflv_1319|M.gilvum_PYR-GCK PPDGVDAQDVRARLIAEHSIVATYLGTERAPREMN---RPALRVSPHVDV
Mvan_5482|M.vanbaalenii_PYR-1 STDGIDPLDVRTRLIAEHQIVTTYLGLERAPREMS---HPALRVSPHVDV
Mb3726c|M.bovis_AF2122/97 PIDGADPAAVRAWLLSQRRIVTTYAGVERAPLELP---APVLRISPHVDN
Rv3700c|M.tuberculosis_H37Rv PIDGADPAAVRAWLLSQRRIVTTYAGVERAPLELP---APVLRISPHVDN
MAV_0403|M.avium_104 PTDGADPRAVRDWLLAERRILTTFVGVQRAPLRLT---APVLRISPHLDT
MMAR_5211|M.marinum_M PIDGADPAAVREWLLEQRRILTTYAGIARAPQELT---APVLRVAPHVDT
MUL_4284|M.ulcerans_Agy99 PIDGADPAAEREWLLEQRRILTTYAGIARAPQELT---APVLRVAPHVDT
MSMEG_6246|M.smegmatis_MC2_155 STDGADPASVRSWLIAERGIVTTACELARAPFEMR---TPVLRISPHVDV
TH_1723|M.thermoresistible__bu PTAGADPAAVR-RTLIERGIVTTAAEPARAPFELR---TPVLRLSPHIDT
MAB_0373|M.abscessus_ATCC_1997 PVGDIDVIAVRARLIEEHAIVTTGAEMVRAPFEMT---KPVLRVSPHVDG
MLBr_00596|M.leprae_Br4923 FVVDGVHAHDIGQVLDDDGVAVRVGHHCALPLHRRFALAATARASFAVYN
. : : : . * . .. * : :
Mflv_1319|M.gilvum_PYR-GCK TAADLGRVAEALAEVTPG-----
Mvan_5482|M.vanbaalenii_PYR-1 TDADLAALADALATVTR------
Mb3726c|M.bovis_AF2122/97 TADDLDAFAEALVAATAATSGER
Rv3700c|M.tuberculosis_H37Rv TADDLDAFAEALVAATAATSGER
MAV_0403|M.avium_104 TAEDLETFAEALIAATAATSA--
MMAR_5211|M.marinum_M TAEDLENFAEALIEATAATTAT-
MUL_4284|M.ulcerans_Agy99 TAEDLENFAEALIEATAATTAT-
MSMEG_6246|M.smegmatis_MC2_155 TVDELEQFAAALREAP-------
TH_1723|M.thermoresistible__bu TTAELEQFAAALADVTAALR---
MAB_0373|M.abscessus_ATCC_1997 TDEELELLAGVLASARRV-----
MLBr_00596|M.leprae_Br4923 TVDEVDRLVAGVLRALDFFGRE-
* :: .. : .