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MTASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQVLDAEREFLTASNGAVHRGAHQLMEE ATDAYEQGRADIALFVGADTDELVFTKNATEALNLVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQ ELARRTGATLRWYGVTDDGRIDLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSRAHQSGALTVLDACQ SVPHQPVDLHELGVDFAAFSGHKMLGPNGIGVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRF EAGTPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDRGSPVAFVVEG VHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADEVDRLVAGVRRSRHFFGRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1464 | csd | - | 100% (417) | PROBABLE CYSTEINE DESULFURASE CSD |
| M. tuberculosis H37Rv | Rv3025c | iscS | 1e-23 | 28.42% (387) | cysteine desulfurase IscS |
| M. tuberculosis H37Rv | Rv3778c | - | 3e-17 | 25.48% (365) | aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1499 | csd | 0.0 | 100.00% (417) | cysteine desulfurase |
| M. gilvum PYR-GCK | Mflv_3674 | - | 0.0 | 80.29% (416) | SufS subfamily cysteine desulfurase |
| M. leprae Br4923 | MLBr_00596 | - | 0.0 | 85.37% (417) | putative aminotransferase |
| M. abscessus ATCC 19977 | MAB_2746c | - | 0.0 | 75.85% (414) | cysteine desulfurase/aminotransferase |
| M. marinum M | MMAR_2269 | csd | 0.0 | 87.02% (416) | cysteine desulfurase Csd |
| M. avium 104 | MAV_3315 | - | 0.0 | 87.25% (408) | cysteine desulfurase |
| M. smegmatis MC2 155 | MSMEG_3125 | - | 0.0 | 83.70% (411) | cysteine desulfurase |
| M. thermoresistible (build 8) | TH_3033 | - | 0.0 | 86.27% (415) | PUTATIVE cysteine desulfurases, SufS subfamily |
| M. ulcerans Agy99 | MUL_1865 | csd | 0.0 | 86.78% (416) | cysteine desulfurase Csd |
| M. vanbaalenii PYR-1 | Mvan_2736 | - | 0.0 | 80.05% (416) | SufS subfamily cysteine desulfurase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3674|M.gilvum_PYR-GCK MTTART-LDLTVLNRVRADFPILSRVMRGGQQLAYLDSGATSQKPLAVLD
MSMEG_3125|M.smegmatis_MC2_155 MTAAKT-LDVTAI---RADFPILSRVMRGGNQLAYLDSGATSQKPLQVLD
Rv1464|M.tuberculosis_H37Rv MTASVNSLDLAAI---RADFPILKRIMRGGNPLAYLDSGATSQRPLQVLD
Mb1499|M.bovis_AF2122/97 MTASVNSLDLAAI---RADFPILKRIMRGGNPLAYLDSGATSQRPLQVLD
MLBr_00596|M.leprae_Br4923 MTISLTPLDLSAI---RADFPILKRVMRGGNQLAYLDSGATSQRPVQVLD
MAV_3315|M.avium_104 ---------MAAI---RADFPILKRIMRSGNQLAYLDSGATSQRPLQVLD
MMAR_2269|M.marinum_M MTVSVARLDLAAI---RADFPILQRVMRSGNQLAYLDSGATSQRPLQVLD
MUL_1865|M.ulcerans_Agy99 MTVSVARLDLAAI---RADFPILQRVMRSGNQLAYLDSGATSQRPLQVLD
TH_3033|M.thermoresistible__bu MTVAPNRLDLGAI---RADFPILQRVMRGGSQLAYLDSGATAQRPVQVLD
Mvan_2736|M.vanbaalenii_PYR-1 MTASVD-LDVAAI---RADFPILKRVMRGGNTLAYLDSGATSQKPLQVLD
MAB_2746c|M.abscessus_ATCC_199 MTATVP-LDITAI---RNDFPILSRTVRGGKPLAYLDSGATSQRPVQVLD
: .: * *****.* :*.*. *********:*:*: ***
Mflv_3674|M.gilvum_PYR-GCK AERDFLLHSNGAVHRGAHQLMEESTDAYEHGREAIASFVGADSDELVFTK
MSMEG_3125|M.smegmatis_MC2_155 AEREFLLTSNGAVHRGAHQLMEESTDAYEQGRADIAAFVGADPDELVFTK
Rv1464|M.tuberculosis_H37Rv AEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTK
Mb1499|M.bovis_AF2122/97 AEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTK
MLBr_00596|M.leprae_Br4923 AEREFLVTSNGAVHRGAHQLMEEATDAYERGRVDIAAFIGAAADELVFTK
MAV_3315|M.avium_104 AEREFLLTSNGAVHRGAHQLMEESTDAYEQGRADIAAFVGADPDELVFTK
MMAR_2269|M.marinum_M AEREFLTTCNGAVHRGAHQLMEEATDAYEQGRADIAAFVGAEPDELVFTK
MUL_1865|M.ulcerans_Agy99 AEREFLTTCNGAVHRGAHQLMEEATDAYEQGRADIAAFVGAEPDELVFTK
TH_3033|M.thermoresistible__bu AEREFLTTSYGAVHRGAHQLMEEATDAYEEGRADIAAFVGADPDELVFTK
Mvan_2736|M.vanbaalenii_PYR-1 AERQFLTTSYGAVHRGAHQLMEESTDAYEQGRADIAAFVGAAPGELVFTK
MAB_2746c|M.abscessus_ATCC_199 AERRFLTERNAAVHRGAHQLAEEATDAYEGARNAIARFVGVDDGEIVFTK
*** ** .********* **:***** .* ** *:*. .*:****
Mflv_3674|M.gilvum_PYR-GCK NATEAINLVAYALGDKRFENAIGPG-DVIVTTELEHHANLVPWQELVLRT
MSMEG_3125|M.smegmatis_MC2_155 NATEAINLVAYVLGDKRFERAVGPG-DVIVTTEVEHHANLVPWQELAERT
Rv1464|M.tuberculosis_H37Rv NATEALNLVSYVLGDSRFERAVGPG-DVIVTTELEHHANLIPWQELARRT
Mb1499|M.bovis_AF2122/97 NATEALNLVSYVLGDSRFERAVGPG-DVIVTTELEHHANLIPWQELARRT
MLBr_00596|M.leprae_Br4923 NATESLNLVSYVFGDNRFEGTSGDGGDVIVTTELEHHANLIPWQELARRI
MAV_3315|M.avium_104 NATEALNLVSYVVGDNRFERAVGPG-DVIVTTELEHHANLVPWQELARRT
MMAR_2269|M.marinum_M NATESLNLVSYVLGDSRFDRAIGPG-DVIVTTELEHHANLIPWQELARRT
MUL_1865|M.ulcerans_Agy99 NATESLNLVSYVLGDSRFDRAIGPG-DVIVTTELEHHANLIPWQELARRT
TH_3033|M.thermoresistible__bu NATEALNLVAYVLGDDRFDRAVGPG-DVIVTTELEHHANLIPWQELARRT
Mvan_2736|M.vanbaalenii_PYR-1 NATEALNLVSYVLGDDRSGFAVGPG-DVIVVTEMEHHANLIPWQELARRT
MAB_2746c|M.abscessus_ATCC_199 NATESLNLVAYTLGDNRFDRAVGPG-DEIVVTELEHHANLVPWQELCRRT
****::***:*..**.* : * * * **.**:******:***** *
Mflv_3674|M.gilvum_PYR-GCK GATLKWYGVTAEGRIDLDSLVLDERVKVVAFSHHSNVTGAIAPVSELVAR
MSMEG_3125|M.smegmatis_MC2_155 GATLKWYGVTDSGRIDLDSLELDERVKVVAFSHHSNVTGAVAPVAELVSR
Rv1464|M.tuberculosis_H37Rv GATLRWYGVTDDGRIDLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSR
Mb1499|M.bovis_AF2122/97 GATLRWYGVTDDGRIDLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSR
MLBr_00596|M.leprae_Br4923 GATLRWYGVTDDGQIDLDSLQLDERVKVVAFSHHSNVTGAVAPVRELVAR
MAV_3315|M.avium_104 GASLRWYGVTDDGRIDLDSLQLDERVKVVAFSHHSNVTGAVAPVAELVGR
MMAR_2269|M.marinum_M GATLRWYSVTDEGRIDLDSLQLDERVKVVTFTHHSNVTGALAPVAELVSR
MUL_1865|M.ulcerans_Agy99 GATLRWYSVTDEGRIDLDSLQLDERVKVVTFTHHSNVTGALAPVAELVSR
TH_3033|M.thermoresistible__bu GAELRWYSVTDDGRIDLDSLELDERVKVVAFTHHSNVTGAIAPVEELVSR
Mvan_2736|M.vanbaalenii_PYR-1 GATLRWFGLTDDGEVDLDSLKLDERVKVVSFSHHSNVTGVGVPVADMVAR
MAB_2746c|M.abscessus_ATCC_199 GATLRWFGVTDDGRIDVDSLELTEAVKVVAFTHQSNVTGAVAPVAELVRR
** *:*:.:* .*.:*:*** * : ****:*:*:*****. .** ::* *
Mflv_3674|M.gilvum_PYR-GCK ARAVGALVVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPTGIGVLYGR
MSMEG_3125|M.smegmatis_MC2_155 AKAVGALTVLDACQSAPHQPVDLHALDVDYAAFSGHKMLGPTGIGVLYGR
Rv1464|M.tuberculosis_H37Rv AHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGIGVLYGR
Mb1499|M.bovis_AF2122/97 AHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGIGVLYGR
MLBr_00596|M.leprae_Br4923 AKEVGALTVLDACQSVPHQPVDLHGLGVDFAAFSGHKMLGPNGIGVLYAR
MAV_3315|M.avium_104 ARAVGALTVLDACQSVPHQPVDFHALDVDFAAFSGHKMLGPNGIGVLYGR
MMAR_2269|M.marinum_M AKAVGALTVLDACQSVPHQPVDFHKLDVDFAAFSGHKMLGPNGIGVLYGR
MUL_1865|M.ulcerans_Agy99 AKAVGALTVLDACQSVPHQPVDFHKLDVDFAAFSGHKMLGPNGIGELYGR
TH_3033|M.thermoresistible__bu ARAVGALTVLDACQSVPHQPVDLHALGVDYAAWSGHKMLGPNGIGALYGR
Mvan_2736|M.vanbaalenii_PYR-1 AKAVGALTVLDSCQAVPHQPVDFHALDVDFAAFSGHKMLGPTGIGALYGR
MAB_2746c|M.abscessus_ATCC_199 AKAVGALVVLDACQSVPHMSVNFRELGVDYAAFSGHKMLGPSGVGVLYGR
*: ***.***:**:.** .*::: *.**:**:********.*:* **.*
Mflv_3674|M.gilvum_PYR-GCK RALLNALPPFLTGGSMIETVTMEATTFAPAPQRFEAGTPMTSQVVGLGAA
MSMEG_3125|M.smegmatis_MC2_155 RGLLDAMPPFITGGSMIETVTMEKTTFAPAPQRFEAGTPMTSQVVGLAAA
Rv1464|M.tuberculosis_H37Rv RELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAA
Mb1499|M.bovis_AF2122/97 RELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAA
MLBr_00596|M.leprae_Br4923 RELLSVMPPFLTGGSMIETVTMESTTYAPAPQRFEAGTPMTSQVVGLAAA
MAV_3315|M.avium_104 REVLSQLPPFLTGGSMIETVTMESSSYAPVPQRFEAGTPMASQVVGLAAA
MMAR_2269|M.marinum_M RELLAAMPPFLTGGSMIETVTMEASTYAPAPQRFEAGTPMTSQVVGLAAA
MUL_1865|M.ulcerans_Agy99 RELLAAMPPFLTGGSMIETVTMEASTYAPAPQRFEAGTPMTSQVVGLAAA
TH_3033|M.thermoresistible__bu RELLEAMPPFLTGGSMIETVSMEGATYAPAPQRFEAGTPMTSQVVGLAAA
Mvan_2736|M.vanbaalenii_PYR-1 ARLLEQLPPFLTGGSMIETVTMEGATYAPPPQRFEAGTQMISQVVGLGAA
MAB_2746c|M.abscessus_ATCC_199 RALLEAMPPFITGGSMIETVTMEVSTYAPPPQRFEAGVPMTSQVVGLGAA
:* :***:*********:** :::** *******. * ******.**
Mflv_3674|M.gilvum_PYR-GCK ARYLDALGMPAVEEHERELVAAALAGLSEVPGVRVIGPASMDDRGSPVSF
MSMEG_3125|M.smegmatis_MC2_155 ARYLTALGMPAVEAHEAELVAAALEGLAGVPGVRIIGPTAMENRGSPVSF
Rv1464|M.tuberculosis_H37Rv ARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDRGSPVAF
Mb1499|M.bovis_AF2122/97 ARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDRGSPVAF
MLBr_00596|M.leprae_Br4923 ARYLDAIGMKAVEAHERELVAAAVEGLSRIDGVRIIGPKSMENRGSPVSF
MAV_3315|M.avium_104 ARYLGALGMDAVQAHEERLVAAAIEGLSGIDAVRIVGPTSTENRGSPVSF
MMAR_2269|M.marinum_M SRYLDAIGMDVIEAHERDLVAAAIEGLSAIEGVRIIGPTSMENRGSPVSF
MUL_1865|M.ulcerans_Agy99 SRYLDAIGMDVIEAHERDLVAAAIEGLSAIEGVRIIGPTSMENRGSPVSF
TH_3033|M.thermoresistible__bu ARYLSAIGMDAVQAHEAELVAAALEGLSGIEQVRIIGPTSMELRGSPVSF
Mvan_2736|M.vanbaalenii_PYR-1 TRYLGGIGMSAVEEHEHRLVTATLEGLAAIPGVRIIGPATAERR-SPVAF
MAB_2746c|M.abscessus_ATCC_199 VDYLNAVGMEAVAAHEHQLVSAALAGLAGIEGVRIIGPTDNLDRGGAVSF
** .:** .: ** **:*:: **: : **::** * ..*:*
Mflv_3674|M.gilvum_PYR-GCK VVDGVHAHDVGQVLDDDGVAVRVGHHCAWPLHRRFGIAATARASFAVYNT
MSMEG_3125|M.smegmatis_MC2_155 VVDGVHAHDVGQVLDDDGVAVRVGHHCAWPLHRRFGIAATARASFAVYNT
Rv1464|M.tuberculosis_H37Rv VVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNT
Mb1499|M.bovis_AF2122/97 VVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNT
MLBr_00596|M.leprae_Br4923 VVDGVHAHDIGQVLDDDGVAVRVGHHCALPLHRRFALAATARASFAVYNT
MAV_3315|M.avium_104 VVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRRFGLAATARASFAVYNT
MMAR_2269|M.marinum_M VVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRKFGVAATARASFAVYNT
MUL_1865|M.ulcerans_Agy99 VVDGVHAHDVGQVLDDEGVAVRVGHHCALPLHRKFGVAATARASFAVYNT
TH_3033|M.thermoresistible__bu VVDGVHAHDVGQVLDDDGVAVRVGHHCAWPLHQRFGIAATARASFAVYNT
Mvan_2736|M.vanbaalenii_PYR-1 VVDGVHAHDVGQVLDDDGVAVRVGHHCAAPLHRRFGIAATVRASFAVYNT
MAB_2746c|M.abscessus_ATCC_199 VVDGIHAHDLGQVLDDEGVAVRVGHHCAWPLHRRFGIAASARASFAVYNT
**:*:****:****** *********** ***::*.:**:.*********
Mflv_3674|M.gilvum_PYR-GCK VDEVDRLVAGVRRAVEFFGRE
MSMEG_3125|M.smegmatis_MC2_155 LDEVDRLVAGVKRAVEFFA--
Rv1464|M.tuberculosis_H37Rv ADEVDRLVAGVRRSRHFFGRA
Mb1499|M.bovis_AF2122/97 ADEVDRLVAGVRRSRHFFGRA
MLBr_00596|M.leprae_Br4923 VDEVDRLVAGVLRALDFFGRE
MAV_3315|M.avium_104 AEEVDRLVAGVRRALDFFGGA
MMAR_2269|M.marinum_M RDEVNRLLAGVQRSLNFFGRG
MUL_1865|M.ulcerans_Agy99 RDEVNRLLAGVQRSLNFFGRG
TH_3033|M.thermoresistible__bu LDEVDRLVAGVRRAVEFFGDR
Mvan_2736|M.vanbaalenii_PYR-1 LDEVDRLIAGVQRAIEFFGRD
MAB_2746c|M.abscessus_ATCC_199 LDEVDRLTAGVRRAQEFFS--
:**:** *** *: .**.