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VRQMRAALAALATGLLVLAPVAGCGGGVLSPDVVLVNGGEPPNPLIPTGTNDSNGGRIIDRLFAGLMSYD AVGKPSLEVAQSIESADNVNYRITVKPGWKFTDGSPVTAHSFVDAWNYGALSTNAQLQQHFFSPIEGFDD VAGAPGDKSRTTMSGLRVVNDLEFTVRLKAPTIDFTLRLGHSSFYPLPDSAFRDMAAFGRNPIGNGPYKL ADGPAGPAWEHNVRIDLVPNPDYHGNRKPRNKGLRFEFYANLDTAYADLLSGNLDVLDTIPPSALTVYQR DLGDHATSGPAAINQTLDTPLRLPHFGGEEGRLRRLALSAAINRPQICQQIFAGTRSPARDFTARSLPGF DPNLPGNEVLDYDPQRARRLWAQADAISPWSGRYAIAYNADAGHRDWVDAVANSIKNVLGIDAVAAPQPT FAGFRTQITNRAIDSAFRAGWRGDYPSMIEFLAPLFTAGAGSNDVGYINPEFDAALAAAEAAPTLTESHE LVNDAQRILFHDMPVVPLWDYISVVGWSSQVSNVTVTWNGLPDYENIVKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3666c | dppA | - | 100% (541) | PROBABLE PERIPLASMIC DIPEPTIDE-BINDING LIPOPROTEIN DPPA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3690c | dppA | 0.0 | 99.45% (541) | periplasmic dipeptide-binding lipoprotein DppA |
| M. gilvum PYR-GCK | Mflv_2761 | - | 5e-12 | 23.94% (376) | extracellular solute-binding protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0426 | - | 7e-77 | 34.67% (548) | peptide ABC transporter DppA |
| M. marinum M | MMAR_5154 | dppA | 0.0 | 82.41% (540) | periplasmic dipeptide-binding lipoprotein DppA |
| M. avium 104 | MAV_0464 | - | 0.0 | 83.36% (535) | extracellular solute-binding protein, family protein 5 |
| M. smegmatis MC2 155 | MSMEG_4545 | - | 2e-14 | 22.60% (500) | extracellular solute-binding protein, family protein 5 |
| M. thermoresistible (build 8) | TH_4152 | - | 2e-16 | 25.24% (527) | PUTATIVE extracellular solute-binding protein, family 5 |
| M. ulcerans Agy99 | MUL_4240 | dppA | 0.0 | 82.44% (541) | periplasmic dipeptide-binding lipoprotein DppA |
| M. vanbaalenii PYR-1 | Mvan_0438 | - | 3e-13 | 22.71% (480) | extracellular solute-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2761|M.gilvum_PYR-GCK -----------------------------------------MARTAVGAA
TH_4152|M.thermoresistible__bu -------------------------------------------------V
Rv3666c|M.tuberculosis_H37Rv ---------------------------------------------MVRQM
Mb3690c|M.bovis_AF2122/97 ---------------------------------------------MVRRM
MMAR_5154|M.marinum_M ----------------------------------------------MRRM
MUL_4240|M.ulcerans_Agy99 MPLMAWGERRRDIANAPIAIRTAPMTMSRVPGALLGGAAGGSMVAVMRRM
MAV_0464|M.avium_104 --------------------------------------------------
MAB_0426|M.abscessus_ATCC_1997 ----------------------------------------------MRLR
MSMEG_4545|M.smegmatis_MC2_155 -------------------------------------MKTTRRVLGTLIA
Mvan_0438|M.vanbaalenii_PYR-1 ----------------------------------------MHIFRRALII
Mflv_2761|M.gilvum_PYR-GCK VLAVCALVLSLTGCNTGERVDLGDGAGGALIAAIAGEPDQLDPHKTTAYF
TH_4152|M.thermoresistible__bu SNLVAVLLIAATGCAPGQRVDLGDLSG-NLIAAIAGEPDQLDPHKTSAYF
Rv3666c|M.tuberculosis_H37Rv RAALAALATGLLVLAPVAGCGGGVLSPDVVLVNGGEPPNPLIPTGTNDSN
Mb3690c|M.bovis_AF2122/97 RAALAALATGLLVLAPVAGCGGGVLSPDVVLVNGGEPPNPLIPTGTNDSN
MMAR_5154|M.marinum_M RATLAVVAV-LLAVSPVAACGGGVLSPDLVLVNGGEPPNPLIPTGTNDSY
MUL_4240|M.ulcerans_Agy99 RATLAVVAV-LLAVSPVAACGGGVLSPDLVLVNGGEPPNPLIPTGTNDSY
MAV_0464|M.avium_104 MAVLATAAAALLVVASLAGCGGGVLSPDLVVVNGGEPPNPLVPTGTNDSQ
MAB_0426|M.abscessus_ATCC_1997 RLAIVLLVGIVAVLPAGCGDLVTPAPPGYFSMYITEPEHTLVPGNTTENQ
MSMEG_4545|M.smegmatis_MC2_155 TTALVVAACGTNTSESASTADPDSLYGGTLRIASVEDIDALDPLIAYSAE
Mvan_0438|M.vanbaalenii_PYR-1 ACVASLAAFGVAACGSDDSSGGGGGSGGDITVNATSFPDYIDPQLSYTVE
. . . : * :
Mflv_2761|M.gilvum_PYR-GCK SFEVLENVFDTLVEPDQ-------DLQMKPALAESWEVSP-DQLTWTFRL
TH_4152|M.thermoresistible__bu SFQVLENVFDTLVEPDE-------DLRMRPALAESWQVSA-DQRVWTFRL
Rv3666c|M.tuberculosis_H37Rv GGRIIDRLFAGLMSYD---------AVGKPSLEVAQSIESADNVNYRITV
Mb3690c|M.bovis_AF2122/97 GGRIIDRLFAGLMSYD---------AVGKPSLEVAQSIESADNVNYRITV
MMAR_5154|M.marinum_M GGRIIDRLFAGLVSYD---------AKGKPSLEVAQSIDTTDNVNYRILL
MUL_4240|M.ulcerans_Agy99 GGRIIDRLFAGLVSYD---------AKGKPSLEVAQSIDTTDNVNYRILL
MAV_0464|M.avium_104 GGRILDRLFAGLMSYD---------AAGNPAPEVAQSIESGDNVNYRIVL
MAB_0426|M.abscessus_ATCC_1997 GGRILRSLFTALVEFNN-------ETAAVEYTGVAESITSHDNVNWTIKL
MSMEG_4545|M.smegmatis_MC2_155 SWQVIRATTRQLVTYPGSKEGIGDDTTVVPDLAESWDVSP-DRKTYTFHL
Mvan_0438|M.vanbaalenii_PYR-1 GWEVLWNVYTPLLTYRHARGK--EGTEVVPALAEALPDISPDGKTYKLKL
. .:: *: : . * : : :
Mflv_2761|M.gilvum_PYR-GCK RPGVTFHDGT--PLAAEDVVFSYRR---------IIDEQLANSDKFS---
TH_4152|M.thermoresistible__bu RPGVTFHDGS--PLTADDVVFSYRR---------IIDEHLTNVDRLS---
Rv3666c|M.tuberculosis_H37Rv KPGWKFTDGS--PVTAHSFVDAWNYGA-LSTNAQLQQHFFSPIEGFDDVA
Mb3690c|M.bovis_AF2122/97 KPGWKFTDGS--PVTAHSFVDAWNYGA-LSTNAQLQQHFFSPIEGFDDVA
MMAR_5154|M.marinum_M KPGWRFTDGS--PVTAHSFVDAWNYGA-LSTNAQLQQHFFSPIEGYEEVA
MUL_4240|M.ulcerans_Agy99 KPGWGFTDGS--PVTAHSFVDAWNYGA-LSTNAQLQQHFFSPIEGYEEVA
MAV_0464|M.avium_104 KPGWRFTDGS--PVTAHSFVDAWNYGA-LSTNAQLQQSFFSPIDGYDALA
MAB_0426|M.abscessus_ATCC_1997 KPGWTFHNGE--PVTAQSYVDAWNYTA-LSTNAQGSSSFLANVDGFDDLQ
MSMEG_4545|M.smegmatis_MC2_155 RDNITFSGASNREITAHDFVYAVKRFPDPNAQVSAITYFNATFDGFEEYA
Mvan_0438|M.vanbaalenii_PYR-1 RPNMKYSDGT--PIKASDFTYAIQRLFKTDSGGSVFYNVIAGATEYADGA
: . : .. : * . . : . :
Mflv_2761|M.gilvum_PYR-GCK ---------------------SVQAVEAPDPS-TVVIRVDRPTPNMLTNL
TH_4152|M.thermoresistible__bu ---------------------AVTEVTAVDPL-TVRITVARPTPNLLTNL
Rv3666c|M.tuberculosis_H37Rv GAPGDKSR------------TTMSGLRVVNDL-EFTVRLKAPTIDFTLRL
Mb3690c|M.bovis_AF2122/97 GAPGDKSR------------TTMSGLRVVNDL-EFTVRLKAPTIDFTLRL
MMAR_5154|M.marinum_M GEPGEGKP------------TTMSGLHVVNNR-EFTVRLRAPTIDFMLSL
MUL_4240|M.ulcerans_Agy99 GEPGEGKP------------TTMSGLHVVNNR-EFTVRLRAPTIDFMLSL
MAV_0464|M.avium_104 A--GQPQQ------------TTMTGLRVVNDL-EFTVRLKAPTVDFKLRL
MAB_0426|M.abscessus_ATCC_1997 GDPAHKIAP---------RATQMRGLHVVDDV-TFTVRLNTPFAIYPMTL
MSMEG_4545|M.smegmatis_MC2_155 AEFAKVPTGDLAAVKQFIDTHEIRGFKALDDK-TLQLTLTEPASDILDIL
Mvan_0438|M.vanbaalenii_PYR-1 AD-------------------TITGITTDDGTGDITIQLTEPNGTFDNLL
: . . : . : : * *
Mflv_2761|M.gilvum_PYR-GCK GGFKGMAIVSRA----NVESGRIATHPVGTGPFSFLGQ------KSGDSI
TH_4152|M.thermoresistible__bu GGFKGMAIVQRA----NVETGRIATHPVGTGPFEFRGA------RSGDSI
Rv3666c|M.tuberculosis_H37Rv GHSSFYPLPDSA----FRDMAAFGRNPIGNGPYKLADGPAGPAWEHNVRI
Mb3690c|M.bovis_AF2122/97 GHSSFYPLPDSA----FRDMAAFGRNPIGNGPYKLADGPAGPAWEHNVRI
MMAR_5154|M.marinum_M GHSSFYPLPEAA----FKDMAAFGRNPIGNGPYRLDSGGEEPAWEHNVKI
MUL_4240|M.ulcerans_Agy99 GHSSFYPLPEAA----FKDMAAFGRNPIGNGPYRLDSGGEEPAWEHNVKI
MAV_0464|M.avium_104 GHSAFYPLPQAA----FRDMAAFGRHPIGNGPYQLAGGPDGPAWEHNVRI
MAB_0426|M.abscessus_ATCC_1997 GYTAFLPLPKAF----FRDPVKFGVHPIGNGPFKADG-----DWVRGVGF
MSMEG_4545|M.smegmatis_MC2_155 TLNFVTPLPEEVTSKYFADSLEFRKNYVSSGPYHIES------YDQGKQL
Mvan_0438|M.vanbaalenii_PYR-1 GLMFAAPIPQST----PLDADATNNPPPASGPFMFTTVDAPRTLTMERNP
.: . : ..**:
Mflv_2761|M.gilvum_PYR-GCK SLRANPDYWAG-PPGVAGVTFRFIP----EPSTALSALQAGEVDWTD---
TH_4152|M.thermoresistible__bu TLVANDDHWAG-PPRLNGVTFRFIS----EPATALSALQAGEIDWTD---
Rv3666c|M.tuberculosis_H37Rv DLVPNPDYHGNRKPRNKGLRFEFYA----NLDTAYADLLSGNLDVLD---
Mb3690c|M.bovis_AF2122/97 DLVPNPDYHGNRKPRNKGLRFEFYA----NLDTAYADLLSGNLDVLD---
MMAR_5154|M.marinum_M DLVPNPDYRGNRKPRNKGLRFEFYA----NLETAYSDLLSGNLDVLD---
MUL_4240|M.ulcerans_Agy99 DLVPNPDYRGNRKPRNKGLRFEFYA----NLETAYSDLLSGNLDVLD---
MAV_0464|M.avium_104 DLRPNPDYHGNRKPRNKGLRFEFYA----NLDTAYADLLSGNLDVLD---
MAB_0426|M.abscessus_ATCC_1997 TLSRYDQYAGEKKAKAKGLIWRVYT----EGLTAYTDMQAGALDIQL---
MSMEG_4545|M.smegmatis_MC2_155 TLARVPEYNSEGDPRKAYADKIVFDTTVASADAASQQLQTGTADIALYVR
Mvan_0438|M.vanbaalenii_PYR-1 QFQTVKDAGADEVADAGVDKITLIENK--NQSAQVTDIMQNKVDFMMD--
: : . . . . : : . *
Mflv_2761|M.gilvum_PYR-GCK SVPPQRVSQLRDDESLQLTVTPSNDYWYLALN----QARAPWNDVR---V
TH_4152|M.thermoresistible__bu AIPTQRVTQLRNDDSLTLAVTPSNDYWYLALN----HARAPWHDLR---V
Rv3666c|M.tuberculosis_H37Rv TIPPSALTVYQRDLGDHATSGPAAINQTLDTP----LRLPHFGGEEGRLR
Mb3690c|M.bovis_AF2122/97 TIPPSALTVYQRDLGDHATSGPAAINQTLDTP----LRLPHFGGEEGRLR
MMAR_5154|M.marinum_M TIPSSALTVYGRDLGDNATSGPAAINQTLDTP----LRLAHFGGEEGRLR
MUL_4240|M.ulcerans_Agy99 TIPSSALTVYGRDLGDNATSGPAAINQTLDTP----LRLAHFGGEEGRLR
MAV_0464|M.avium_104 TIPPSALPVYRRDLGERVTAGPAAINQSLDTP----LRLPHFGGEEGRLR
MAB_0426|M.abscessus_ATCC_1997 DLPDAAYENAKAEFGSAYLERPRPDITSLGFP----MYDPRYRDVR---V
MSMEG_4545|M.smegmatis_MC2_155 SFPANVIAQYKRTDPDHLHSSASGSAVFISWNNPAEPATPAQAALKDLKV
Mvan_0438|M.vanbaalenii_PYR-1 PVPSDRLQEVKSRYSDRFRMEDSINTYYMFMN----TERAPFNDVR---V
.* : . .
Mflv_2761|M.gilvum_PYR-GCK RQAIAYAIDRDAIVQATSYG-TAAANQLAIPEGNPWFTPYDRYREDGEE-
TH_4152|M.thermoresistible__bu RRAIAFGIDREAIVTATGYG-TATANQLAIPPGDFWYTHYDRYRYD----
Rv3666c|M.tuberculosis_H37Rv RLALSAAINRPQICQQIFAG-TRSPARDFTARSLPGFDPNLPGNEVLDY-
Mb3690c|M.bovis_AF2122/97 RLALSAAINRPQICQQIFAG-TRSPARDFTARSLPGFDPNLPGNEVLDY-
MMAR_5154|M.marinum_M RLALSAAIDRPQICQQIFNG-TRSAARDFTARSLPGFDPHIPGNEALDF-
MUL_4240|M.ulcerans_Agy99 RLALSAAIDRPQICQQIFNG-TRSAARDFTARSLPGFDPHIPGNEALDF-
MAV_0464|M.avium_104 RLALSAAINRAQICRQIFAD-TRSPARDFTARSLPGFDPNIAGSDALDF-
MAB_0426|M.abscessus_ATCC_1997 RQAISMAIDREAITQVIFSG-TRTPATSYGSAVVYGYRKGACG-KLCEL-
MSMEG_4545|M.smegmatis_MC2_155 RQAVNYSLNRADVVRGLGGPDSAIPSNEILTSTTLGFNDENPYPTPEDKG
Mvan_0438|M.vanbaalenii_PYR-1 RQAINYAIDPEALNRIFGGR--LHPTQQVLPPGMPGYQEYKLYPGP----
* *: .:: : . . :
Mflv_2761|M.gilvum_PYR-GCK GLETARDLLRQANAT----PGDLDMLVTTEYPETVTAAQIVADNLAPLGI
TH_4152|M.thermoresistible__bu -LDRARALLDEARAAGVDPPRRLDMLVTGDYPQTVTAAQIIADNVAPLGI
Rv3666c|M.tuberculosis_H37Rv DPQRARRLWAQADAIS-PWSGRYAIAYNADAGHRDWVDAVANSIKNVLGI
Mb3690c|M.bovis_AF2122/97 DPQRARRLWAQADAIS-PWSGRYAIAYNADAGHRDWVDAVANSIKNVLGI
MMAR_5154|M.marinum_M NPQRARQLWAQANAIS-PWSGSYAIAYNADSGHQEWVDTVANSIKNVLGI
MUL_4240|M.ulcerans_Agy99 NPQRARQLWAQANAIS-PWSGSYAIAYNADSGHQEWVDAVANSIKNVLGI
MAV_0464|M.avium_104 DPERARRLWAQADAIS-AWSGSYPIAYNADAGHQDWVDAVANGIKNVLGI
MAB_0426|M.abscessus_ATCC_1997 HVDEANKLLDEAHFDR-NKPIELWYSS-SSTGALSWVQAIGNQLQSNLKV
MSMEG_4545|M.smegmatis_MC2_155 DPDKAKALLADSGHKDLTLSAAYRNTPEFEKIATSVQNALARSGITLRLV
Mvan_0438|M.vanbaalenii_PYR-1 DMDKARALIAEANPAD-----RDITVWTDDEPDRKRIGEYYHDLLTQLGF
: *. * :: . .
Mflv_2761|M.gilvum_PYR-GCK TVNIRTVDFATWLDEQ---NSGNFDMLMMGWLGNID------PDDFYYAQ
TH_4152|M.thermoresistible__bu TVDIRTVDFATWLDEQ---NNGTFDMLMMGWLGNID------PDDYYYAQ
Rv3666c|M.tuberculosis_H37Rv DAVAAPQPTFAGFRTQIT-NRAIDSAFRAGWRGDYP------SMIEFLAP
Mb3690c|M.bovis_AF2122/97 DAVAAPQPTFAGFRTQIT-NRAIDSAFRAGWQGDYP------SMIGFLAP
MMAR_5154|M.marinum_M EAMGAPQPTFAGLRTQIT-NRTIDTAFRAGWQGDFP------SMIEFLAP
MUL_4240|M.ulcerans_Agy99 EAMGAPQPTFAGLRTQIT-NRTIDTAFRAGWQGDFP------SMIEFLAP
MAV_0464|M.avium_104 DALGAPQPTFAGFRTQIT-NRSIGSAFRSGWQGDYP------SMIEFLAP
MAB_0426|M.abscessus_ATCC_1997 PYLLKSLP-WSQFLPLQD-GKGMTGPFRSGWVMDYP------SIYNFLES
MSMEG_4545|M.smegmatis_MC2_155 PIAGDSWGAFRAYLADKS-NLDQWDLAITTWTPDWQGNSARMTLGGWLNS
Mvan_0438|M.vanbaalenii_PYR-1 NATLKVIAGDVYWTTVGNQSTPDVDTGFADWFQDFP------HPDDFFRP
. * : :
Mflv_2761|M.gilvum_PYR-GCK HHTDG-----TSNAQKFSNPEVDRLLDAGRVETDEQTRKAGYARAATLIA
TH_4152|M.thermoresistible__bu HHTDG-----ASNAQRFSDPEVDRLLDAARAEPDRDRRKALYDRAATLIA
Rv3666c|M.tuberculosis_H37Rv LFTAG----AGSNDVGYINPEFDAALAAAEAAPTLTESHELVNDAQRILF
Mb3690c|M.bovis_AF2122/97 LFTAG----AGSNDVGYINPEFDAALAAAEAAPTLTESHELVNDAQRILF
MMAR_5154|M.marinum_M LYGTG----AGSNDVGYSNQEFDDALAAAAAAPTLQEADRLANVAQRILF
MUL_4240|M.ulcerans_Agy99 LYGTG----AGSNDVGYSNQEFDDALAAAAAAPTLQEADRLANVAQRILF
MAV_0464|M.avium_104 LFATG----AGSNDVGYSSPRFDAALATAEAAPDLPQAAALANDAQRILF
MAB_0426|M.abscessus_ATCC_1997 LYGTVALPPNGSNYVFYSNPAFDELLRQGNNEPTVELATKAYQKAEDLLF
MSMEG_4545|M.smegmatis_MC2_155 DFAPG----GTWNGVTYHNPQLNAAAARAFAAADP---TADWKEANRIAS
Mvan_0438|M.vanbaalenii_PYR-1 LLHGD------SILPTNGNNLSRANIAENNAKMDELVTKQITDEGVEQQY
. .
Mflv_2761|M.gilvum_PYR-GCK DEVSYIYLYNPSVIQAWNPALSGYEARRDG-AVRFRSASLDSDGNV----
TH_4152|M.thermoresistible__bu DRVSYLFLYNPAVVQAWSPDLSGYRARRDA-AVRFRDASLNRDGLNRDGP
Rv3666c|M.tuberculosis_H37Rv HDMPVVPLWDYISVVGWSSQVSNVTVTWNG-LPDYENIVKA---------
Mb3690c|M.bovis_AF2122/97 HDMPVVPLWDYISVVGWSSQVSNVTVTWNG-LPDYENIVKA---------
MMAR_5154|M.marinum_M HDMPTIPLWDYIAVVGWSTEVSNVQVTWNG-LPDYENLVKA---------
MUL_4240|M.ulcerans_Agy99 HDMPTIPLWDYIAVVGWSTEVSNVQVTWNG-LPDYENLVKA---------
MAV_0464|M.avium_104 HDMPVVPLWNYISVVGWSGEVSHVTVTWNG-LPDYENIVKA---------
MAB_0426|M.abscessus_ATCC_1997 KDLPAAPLFYEVNQAVHSKRVRNVKIGIQD-CIEYADVEVVQ--------
MSMEG_4545|M.smegmatis_MC2_155 ADLAWFPLIERVKTIPTSDRVTNWTWQSLGNNADITNISVNS--------
Mvan_0438|M.vanbaalenii_PYR-1 ADLDRAYMEQAVWAPYGNEQFTTFLSERMDFDKSYHHLLFKQDFTSFALK
: : . .
Mflv_2761|M.gilvum_PYR-GCK -
TH_4152|M.thermoresistible__bu P
Rv3666c|M.tuberculosis_H37Rv -
Mb3690c|M.bovis_AF2122/97 -
MMAR_5154|M.marinum_M -
MUL_4240|M.ulcerans_Agy99 -
MAV_0464|M.avium_104 -
MAB_0426|M.abscessus_ATCC_1997 -
MSMEG_4545|M.smegmatis_MC2_155 -
Mvan_0438|M.vanbaalenii_PYR-1 -