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VVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIGSSAGLMAAAA SPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMTLTATNLLGQNTPAIEANQAA YSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQ LAQPAQGVVPSSKLGGLWTAVSPHLSPLSNVSSIANNHMSMMGTGVSMTNTLHSMLKGLAPAAAQAVETA AENGVWAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAA QTAPGHMLGGLPLGHSVNAGSGINNALRVPARAYAIPRTPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3478 | PPE60 | - | 100% (393) | PE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1361c | PPE19 | 0.0 | 85.61% (396) | PPE family protein |
| M. tuberculosis H37Rv | Rv1196 | PPE18 | e-176 | 81.27% (395) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3505 | PPE60 | 0.0 | 100.00% (393) | PE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 8e-28 | 29.63% (378) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-74 | 40.48% (420) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 2e-28 | 37.71% (175) | PPE-family protein |
| M. marinum M | MMAR_4240 | - | 1e-110 | 53.13% (399) | PPE family protein, PPE18 |
| M. avium 104 | MAV_2924 | - | 1e-73 | 40.86% (421) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-27 | 33.64% (220) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 4e-31 | 39.69% (194) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0947 | - | 1e-109 | 52.63% (399) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-28 | 36.63% (202) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3478|M.tuberculosis_H37Rv ------------MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASD
Mb3505|M.bovis_AF2122/97 ------------MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASD
MMAR_4240|M.marinum_M -------------MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVD
MUL_0947|M.ulcerans_Agy99 -------------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVD
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MAV_2924|M.avium_104 -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
: : .** :* : *.*...::.*. * :. :
Rv3478|M.tuberculosis_H37Rv LFSAASAFQSVVWGLTVGSWIGSSAGLMAAAASPYVAWMSVTAGQAQLTA
Mb3505|M.bovis_AF2122/97 LFSAASAFQSVVWGLTVGSWIGSSAGLMAAAASPYVAWMSVTAGQAQLTA
MMAR_4240|M.marinum_M LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATRAELAA
MUL_0947|M.ulcerans_Agy99 LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
MAV_2924|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
:* . : : : * :: ** *: : . *
Rv3478|M.tuberculosis_H37Rv AQVRVAAAAYETAYRLTVPPPVIAENRTELMTLTATNLLGQNTPAIEANQ
Mb3505|M.bovis_AF2122/97 AQVRVAAAAYETAYRLTVPPPVIAENRTELMTLTATNLLGQNTPAIEANQ
MMAR_4240|M.marinum_M NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MUL_0947|M.ulcerans_Agy99 NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MAV_2924|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
: :* ** :* . : *: * :*.:* *: * :
Rv3478|M.tuberculosis_H37Rv AAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGGL-------
Mb3505|M.bovis_AF2122/97 AAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGGL-------
MMAR_4240|M.marinum_M AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGL-------
MUL_0947|M.ulcerans_Agy99 AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGL-------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
MAV_2924|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASAS-KVTPFQKAPQVTNPSGQ-------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR---
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR---
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS---
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD---
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARS---
* * . * * * :* * . .*
Rv3478|M.tuberculosis_H37Rv -----LEQAVAVEEAIDTAAANQLMNN------VPQALQQL--AQPA-QG
Mb3505|M.bovis_AF2122/97 -----LEQAVAVEEAIDTAAANQLMNN------VPQALQQL--AQPA-QG
MMAR_4240|M.marinum_M -----VNQTAAVGQAIDSAAAGQLMSN------VPQALQQL--AAPAPQG
MUL_0947|M.ulcerans_Agy99 -----VKQTAAVGQAIDSAAAGQLMSN------VPQALQQL--AATAPQG
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
MAV_2924|M.avium_104 -----AAQSAAVSTATANSTSTNTTKALQS---LAQPASSSTTATKAATT
Mflv_0325|M.gilvum_PYR-GCK -------AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFE
Mvan_0415|M.vanbaalenii_PYR-1 -------AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFE
MSMEG_0619|M.smegmatis_MC2_155 -------ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-
TH_3569|M.thermoresistible__bu -------AMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFG
MAB_0669|M.abscessus_ATCC_1997 -------DQSDVPGSPDQ---------------IMKMLQGFQQWFEKMG-
: .
Rv3478|M.tuberculosis_H37Rv VVP---SSKLGGLWTAVSPHLSP--LSNVSSIANNHMSMMGTGVSMTNTL
Mb3505|M.bovis_AF2122/97 VVP---SSKLGGLWTAVSPHLSP--LSNVSSIANNHMSMMGTGVSMTNTL
MMAR_4240|M.marinum_M AST---ATAPKSLLQSVTSSFSLSNLSTIVGMENTHLSMANSGASIFKTM
MUL_0947|M.ulcerans_Agy99 AST---ATAPKSLLQSVTSSFSSSNLSTIVGMENTHLSMANSGASILKTM
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSP--INDTLSMINNHAGMANAGLSLVNGM
MAV_2924|M.avium_104 AASTTSTDPLSEIWFLLTGQTSLP--TNLGTLVNGYSPFAG-LFYNTEGL
Mflv_0325|M.gilvum_PYR-GCK PIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 PIFDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 AILDFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWP
TH_3569|M.thermoresistible__bu PIVDFLRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWP
MAB_0669|M.abscessus_ATCC_1997 -FNPATSAVLAVIMLFLYDLLWYPY-----YASYLLPFLIPALSGLSG-L
.
Rv3478|M.tuberculosis_H37Rv HSMLKGLAPAAAQAVETAAENGVWAMSSLGSQLGSSLGSSGLGAGVAAN-
Mb3505|M.bovis_AF2122/97 HSMLKGLAPAAAQAVETAAENGVWAMSSLGSQLGSSLGSSGLGAGVAAN-
MMAR_4240|M.marinum_M GDSVKGFIPSASKAAETAVEH---AARNAVSMVGGG-GPAGIGGWAPQGG
MUL_0947|M.ulcerans_Agy99 GDSVKGFIPSASKAAETAVEH---AARNAVSMVGGG-GPAGIGGWAPQGG
MLBr_01182|M.leprae_Br4923 GSAMKSLAPTTTKAAESAFKA----MGSAVQSTGRGLLGSSSGGHVTAQ-
MAV_2924|M.avium_104 PYFSTGMANTFTQIAKSVGAIGGAAPAAAKALPGLGGLGGMLGGGAAAAH
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPS
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPT
MSMEG_0619|M.smegmatis_MC2_155 TWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAA
TH_3569|M.thermoresistible__bu TWAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAA
MAB_0669|M.abscessus_ATCC_1997 AALMHLRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPS
Rv3478|M.tuberculosis_H37Rv -------------LGRAASVG-SLSVPPAWAAANQAVTPAARALPLTSLT
Mb3505|M.bovis_AF2122/97 -------------LGRAASVG-SLSVPPAWAAANQAVTPAARALPLTSLT
MMAR_4240|M.marinum_M -------------VGQALSVG-GLKVPQAWAEANQSVVPAARALPISPVT
MUL_0947|M.ulcerans_Agy99 -------------VGQALSVG-GLKVPQAWAEANQAVVPAARALPISPVT
MLBr_01182|M.leprae_Br4923 -------------LGRAASIG-SLRVPQTWTTASQPVTAATRALSPARVA
MAV_2924|M.avium_104 PV---------AALGGAGSIGGKLSVPVAWSGA-PATPALGHAIPVSSIS
Mflv_0325|M.gilvum_PYR-GCK RPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVV
Mvan_0415|M.vanbaalenii_PYR-1 RADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAV
MSMEG_0619|M.smegmatis_MC2_155 PRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAV
TH_3569|M.thermoresistible__bu P-------------------VRAEPQNPLPLTXXX---------------
MAB_0669|M.abscessus_ATCC_1997 GG---------------SSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLV
Rv3478|M.tuberculosis_H37Rv SAAQTA--PGHMLGG-LPLGHSV-NAGSG---INNALRVPARAYAIPRTP
Mb3505|M.bovis_AF2122/97 SAAQTA--PGHMLGG-LPLGHSV-NAGSG---INNALRVPARAYAIPRTP
MMAR_4240|M.marinum_M GAVEGA--HGAPLPG-MPFGQLAGNGGNG---VSGVLRVTPKAYVMPRPP
MUL_0947|M.ulcerans_Agy99 GAVEGA--HGAPLPG-MPFGQLAGNGGNG---VSGVLRVTPKAYVMPRPP
MLBr_01182|M.leprae_Br4923 VATESE--SAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNP
MAV_2924|M.avium_104 AAPEAAGGPGNLLGG-MPLAGAG-AGGHG----AAGPKYGFRPTVMARPP
Mflv_0325|M.gilvum_PYR-GCK AGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEE
Mvan_0415|M.vanbaalenii_PYR-1 AGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDE
MSMEG_0619|M.smegmatis_MC2_155 ANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQ
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 P---PGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKNKAE
Rv3478|M.tuberculosis_H37Rv AAG-----------------------------------------------
Mb3505|M.bovis_AF2122/97 AAG-----------------------------------------------
MMAR_4240|M.marinum_M AAG-----------------------------------------------
MUL_0947|M.ulcerans_Agy99 AAG-----------------------------------------------
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
MAV_2924|M.avium_104 FAG-----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK IKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDE
Mvan_0415|M.vanbaalenii_PYR-1 IAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAA
MSMEG_0619|M.smegmatis_MC2_155 IEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDV
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 AGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAGTAPAAAS
Rv3478|M.tuberculosis_H37Rv --------------------------------------------------
Mb3505|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4240|M.marinum_M --------------------------------------------------
MUL_0947|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAV_2924|M.avium_104 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK QAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 QAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MSMEG_0619|M.smegmatis_MC2_155 TAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 THVAATVRLS-SDEARQVIPMLPSTWDAD-----------------GGDQ
Rv3478|M.tuberculosis_H37Rv -
Mb3505|M.bovis_AF2122/97 -
MMAR_4240|M.marinum_M -
MUL_0947|M.ulcerans_Agy99 -
MLBr_01182|M.leprae_Br4923 -
MAV_2924|M.avium_104 -
Mflv_0325|M.gilvum_PYR-GCK P
Mvan_0415|M.vanbaalenii_PYR-1 Q
MSMEG_0619|M.smegmatis_MC2_155 R
TH_3569|M.thermoresistible__bu -
MAB_0669|M.abscessus_ATCC_1997 N