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MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMTRTDNDTWDLASSVGATATMIATARAL ASRAENPLINDPFAEPLVRAVGIDLFTRLASGELRLEDIGDHATGGRWMIDNIAIRTKFYDDFFGDATTA GIRQVVILAAGLDTRAYRLPWPPGTVVYEIDQPAVIKFKTRALANLNAEPNAERHAVAVDLRNDWPTALK NAGFDPARPTAFSAEGLLSYLPPQGQDRLLDAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSAAEAW RERGFDLDLTELIYFDQRNDVADYLAGSGWQVTTSTGKELFAAQGLPPFADDHITRFADRRYISAVLK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3399 | - | - | 100% (348) | hypothetical protein Rv3399 |
| M. tuberculosis H37Rv | Rv0726c | - | 2e-98 | 59.61% (307) | hypothetical protein Rv0726c |
| M. tuberculosis H37Rv | Rv0731c | - | 7e-89 | 55.08% (305) | hypothetical protein Rv0731c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3432 | - | 0.0 | 99.71% (348) | hypothetical protein Mb3432 |
| M. gilvum PYR-GCK | Mflv_5023 | - | 2e-92 | 56.03% (307) | putative methyltransferase |
| M. leprae Br4923 | MLBr_02640 | - | 9e-56 | 43.56% (303) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 1e-81 | 55.63% (293) | hypothetical protein MAB_3787 |
| M. marinum M | MMAR_1059 | - | 1e-100 | 59.09% (308) | O-methyltransferase |
| M. avium 104 | MAV_4441 | - | 1e-104 | 62.75% (306) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_1482 | - | 6e-94 | 58.76% (291) | methyltransferase |
| M. thermoresistible (build 8) | TH_2706 | - | 3e-83 | 56.29% (286) | PUTATIVE putative methyltransferase |
| M. ulcerans Agy99 | MUL_0818 | - | 6e-99 | 59.09% (308) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1346 | - | 4e-88 | 53.87% (310) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3399|M.tuberculosis_H37Rv MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMTRTDNDT
Mb3432|M.bovis_AF2122/97 MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMTRTDNDT
MMAR_1059|M.marinum_M -------------------------------------MTSTGSTRYDGDS
MUL_0818|M.ulcerans_Agy99 -------------------------------------MTSTGSTRYDGDS
MAV_4441|M.avium_104 -------------------------------------MTST---RYEGDT
Mflv_5023|M.gilvum_PYR-GCK ------------------------------------------MPRTENDT
Mvan_1346|M.vanbaalenii_PYR-1 ------------------------------------------MARTDNDT
MSMEG_1482|M.smegmatis_MC2_155 ------------------------------------------MARTENDT
TH_2706|M.thermoresistible__bu ------------------------------------------MARSESDT
MAB_3787|M.abscessus_ATCC_1997 ------------------------------------------MARTDDDS
MLBr_02640|M.leprae_Br4923 -------------------------------------------MRTHDDT
* ..*:
Rv3399|M.tuberculosis_H37Rv WDLASSVGATATMIATARALASRAENPLINDPFAEPLVRAVGIDLFTRLA
Mb3432|M.bovis_AF2122/97 WDLASSVGATATMIATARALASRAENPLINDPFAEPLVRAVGIDLFTRLA
MMAR_1059|M.marinum_M WDLASSVGVTATMVAAARAMATRAENPLINDPYAEPLVRAVGVDLLTRLA
MUL_0818|M.ulcerans_Agy99 WDLASSVGVTATMVAAARAMATRAENPLINDPYAEPLVRAVGVDLLTRLA
MAV_4441|M.avium_104 WDLASSVGVTATMVAAARAMATRADNPLINDPFAEPLVKAVGVDLLSRLA
Mflv_5023|M.gilvum_PYR-GCK WDLASSVGATATMVAAARAVATRAEDPVIDDPYAEPLVRAVGIDFFAKLA
Mvan_1346|M.vanbaalenii_PYR-1 WDLASSVGATATMVAAARAVATRAPRPVIDDPFAAPLVQAVGVDFFTRLA
MSMEG_1482|M.smegmatis_MC2_155 WDLASSVGATATMVAAARALATNADEPAIDDPFAAPLVRAVGVDFFTKLV
TH_2706|M.thermoresistible__bu WDLTSGVGVTATMVAAARALASREPEPLIDDPFAAPLVRAVGVEFFTRLV
MAB_3787|M.abscessus_ATCC_1997 WDLASSVGATATMVAAQRALASHVPNPLINDPYAEPLVRAVGIEYFTKLA
MLBr_02640|M.leprae_Br4923 WDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAM
**: :.**.**.*:*: ** : . * **:* ** .* : .
Rv3399|M.tuberculosis_H37Rv SGELRLEDIG---DHATGGR----WMIDNIAIRTKFYDDFFGDATTAG--
Mb3432|M.bovis_AF2122/97 SGELRLEDIG---DHATGGR----WMIDNIAIRTKFYDDFFGDATTAG--
MMAR_1059|M.marinum_M TGEFNVADLD---DDPQRPLGPLGDVADNMAVRTRFFDDFFLDATRAG--
MUL_0818|M.ulcerans_Agy99 TGEFNVADLD---DDPQRPLGPIGDVADNMAVRTRFFDDFFLAATRAG--
MAV_4441|M.avium_104 GGELDPAELNDVHDGAAGSAGAMSRMADNMAVRTKFFDEFFLNATKAG--
Mflv_5023|M.gilvum_PYR-GCK SGELTPEDLDVSGDESPVGMS---RFADGMAARTRFFDDFFTDACAAG--
Mvan_1346|M.vanbaalenii_PYR-1 TGELTTEELDTNDAESPVGMS---RFADAMAARTRFFDDFFAEAMRAGPP
MSMEG_1482|M.smegmatis_MC2_155 DDNFDLTALDP---EAAEGLT---RFANGMAARTRFFDDFFLDAARAG--
TH_2706|M.thermoresistible__bu DGDLELPADT---AEERAAAQ---VLTEVMAVRTRFFDDFFTDATRVG--
MAB_3787|M.abscessus_ATCC_1997 SGAFDPEQMAGLVQLGITADG----MANGMASRTWYYDTAFESSTAAG--
MLBr_02640|M.leprae_Br4923 LDPSMVAKVEAIDAEAAAMVE---HMRSYQAVRTNFFDTYFNNAVIDG--
. . . * ** ::* * : *
Rv3399|M.tuberculosis_H37Rv -IRQVVILAAGLDTRAYRLPWPPGTVVYEIDQPAVIKFKTRALANLNAEP
Mb3432|M.bovis_AF2122/97 -IRQVVILAAGLDTRAYRLPWPPGTVVYEIDQPAVIKFKTRALANLNAEP
MMAR_1059|M.marinum_M -LEQVVILASGLDARAYRLPWPPQTVVYEIDLPQVIEFKSRTLADLGAAP
MUL_0818|M.ulcerans_Agy99 -LEQVVILASGRDARAYRLPWPPQTVVYEIDLPQVIDFKSRTLADLGAAP
MAV_4441|M.avium_104 -IAQVVILASGLDARAYRLAWPAGTVVYEVDQPQVIDFKTTALAQLGAAP
Mflv_5023|M.gilvum_PYR-GCK -VRQAVILASGLDARGYRLTWPEGMTLFEIDQPEVIEFKRTTLAGLGATP
Mvan_1346|M.vanbaalenii_PYR-1 PIRQGVILASGLDARAYRLSWPQDMVLFEIDQPEVLTFKAATLADLGVRP
MSMEG_1482|M.smegmatis_MC2_155 -VRQFVILASGLDARAYRLPWPAGSVVFEIDQPDVIEFKTKALADLGALP
TH_2706|M.thermoresistible__bu -ARQAVILASGLDARAYRLTWPDGTVVYEIDQPEVIAFKTRTLAELGAPP
MAB_3787|M.abscessus_ATCC_1997 -VRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFKTDTLAELGASP
MLBr_02640|M.leprae_Br4923 -IRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTP
* ****:* *:*.*** ** .::*:* * *: :* :** .. *
Rv3399|M.tuberculosis_H37Rv NAERHAVAVDLRNDWPTALKNAGFDPARPTAFSAEGLLSYLPPQGQDRLL
Mb3432|M.bovis_AF2122/97 NAERHAVAVDLRNDWPTALKNAGFDPARPTAFSAEGLLSYLPPQGQDRLL
MMAR_1059|M.marinum_M TADRRVVAVDLREDWPAALRAAGFDPNQPTAWSAEGLLGYLPPEAQDRLL
MUL_0818|M.ulcerans_Agy99 TADRRVVAVDLREDWPAALRAAGFDPNQPTAWSAEGLLGYLPPEAQDRLL
MAV_4441|M.avium_104 TAERRVVAVDLRDDWPAALRAAGFDPTRPTAWSAEGLLGYLPPEAQDRLL
Mflv_5023|M.gilvum_PYR-GCK STHLATVAIDLREDWPTALRDAGFDPSVPTAWIAEGLLGYLPPDAQDRLL
Mvan_1346|M.vanbaalenii_PYR-1 STKLATVAVDLRNDWPAALAEAGFDASAPTAWIAEGLLGYLPPDAQDRLL
MSMEG_1482|M.smegmatis_MC2_155 TTDRRAVAVDLRFDWPAALTEAGFDPAEPTAWIAEGLLGYLPPEAQDRLL
TH_2706|M.thermoresistible__bu TAPHRPVAVDLRDDWPAALTAAGFDPTVATAWSAEGLLRYLPPDAQDRLF
MAB_3787|M.abscessus_ATCC_1997 SAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLIYLPPEAQDRLF
MLBr_02640|M.leprae_Br4923 TADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLF
.: *.:*** ***.** ****. *.: ***** ***. .** *:
Rv3399|M.tuberculosis_H37Rv DAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSAAEAWRERGFDLDLT
Mb3432|M.bovis_AF2122/97 DAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSAAEAWRERGFDLDLT
MMAR_1059|M.marinum_M DTVTELSAPGSRLAAECLSSVDPGEEEQIKERMQEVSARWRAHGFDVDMV
MUL_0818|M.ulcerans_Agy99 DTVTELSAPGSRLAAECLSGVDPAEEEQIKERMQEVSARWRAHGFDVDMV
MAV_4441|M.avium_104 DTITELSAPGSRLATESAPNPAPGEEEKLKERMQAISQRWRAHGFDLDMA
Mflv_5023|M.gilvum_PYR-GCK DTIGELSASGSRLAVESVPSQQSADQDEMREKMKDSTDRWRSHGFDLDFS
Mvan_1346|M.vanbaalenii_PYR-1 DTIGELSAPGSRLAVESVPTHHEADQEELREKMKESSDRWRSHGFDVDFS
MSMEG_1482|M.smegmatis_MC2_155 DQIAELSAPGSRVAVEEIPAIEEEDHEEIAARMKDFSDRWRAHGFDLDFT
TH_2706|M.thermoresistible__bu DHITDLSAPGSRLATEDHPGPGAG----LGEKADELGRRWREHGFEVQLS
MAB_3787|M.abscessus_ATCC_1997 ASITELSAPGSRLVCEQVPGLETADFS----KARELTRQFAGETLDLDLE
MLBr_02640|M.leprae_Br4923 TEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDALG-FEQAVDVQ
: *** .**:. : : ::.
Rv3399|M.tuberculosis_H37Rv ELIYFDQ-RNDVADYLAGSGWQVTTSTGKELFAAQG-LPPFADDHITRFA
Mb3432|M.bovis_AF2122/97 ELIYFDQ-RNDVADYLAGSGWQVTTSTGKELFAAQG-LPPFEDDHITRFA
MMAR_1059|M.marinum_M GLVYFGD-RNEAVPYLSDRGWLLTSTPLPELRAANG-LAPAAVDDDGPSV
MUL_0818|M.ulcerans_Agy99 GLVYFGD-RNEAVPYLSDRGWLLTSTPLPELRAANG-LAPAAVDDDGPSV
MAV_4441|M.avium_104 GLVYFGE-RNEAAPYLAGHGWRLNSVTIRDLFAANG-LDPLD-DDDTRMG
Mflv_5023|M.gilvum_PYR-GCK ELVFLGE-RANVPDYLRERGWAVTATPTNDLLTRYG-LAPLD--TDEGFA
Mvan_1346|M.vanbaalenii_PYR-1 ELVFLGE-RADVTDYLRDRGWTVDATPTNQLLTRYG-LAPLD--SDEGFA
MSMEG_1482|M.smegmatis_MC2_155 ELVFLGD-RADVSSYLQGHGWKTTSMTSDELLVHNG-LPRVD--DDAQIG
TH_2706|M.thermoresistible__bu ELFHPGE-RTPVVDYLRGRGWDARARPRAEVFAGYG-REFPDSAALAAMR
MAB_3787|M.abscessus_ATCC_1997 SLVYTQE-RQMAADWLAEHGWTVITEENDELYARLN-LDPPNPLLRSIFP
MLBr_02640|M.leprae_Br4923 ELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGVPMADDKDA
*.. : * . :* ** : : .
Rv3399|M.tuberculosis_H37Rv DRRYISAVLK---------
Mb3432|M.bovis_AF2122/97 DRRYISAVLK---------
MMAR_1059|M.marinum_M DMLYVSGTLYTTPRPDPAP
MUL_0818|M.ulcerans_Agy99 DMLYVSGTLYTTPRPDPAP
MAV_4441|M.avium_104 EMLYTWG-IYE--------
Mflv_5023|M.gilvum_PYR-GCK EVVYVNAAR----------
Mvan_1346|M.vanbaalenii_PYR-1 EVVYVSATR----------
MSMEG_1482|M.smegmatis_MC2_155 SVVYVTATR----------
TH_2706|M.thermoresistible__bu DSSAVTAVRPVVRAGMR--
MAB_3787|M.abscessus_ATCC_1997 NIVYVDATLG---------
MLBr_02640|M.leprae_Br4923 FAEFVTAHRL---------
.