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TYTGSIRCEGDTWDLASSVGATATMVAAARAMATRAANPLINDQFAEPLVRAVGVDVLTRLASGELTASD IDDPERPNASMVRMAEHHAVRTKFFDEFFMDATRAGIRQVVILASGLDSRAYRLAWPAQTVVYEIDQPQV MEFKTRTLAELGATPTADRRVVTADLRADWPTALGAAGFDPTQPTAWSAEGLLRYLPPEAQDRLLDNVTA LSVPDSRFATESIRNFKPHHEERMRERMTILANRWRAYGFDLDMNELVYFGDRNEPASYLSDNGWLLTEI KSQDLLTANGFQPFEDEEVPLPDFFYVSARLQRKHRQYPAHRKPAPSWRHTACPVNELSKSAAYTMTRSD AHQASTTAPPPPGLTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0726c | - | - | 100% (367) | hypothetical protein Rv0726c |
| M. tuberculosis H37Rv | Rv0731c | - | e-106 | 60.88% (317) | hypothetical protein Rv0731c |
| M. tuberculosis H37Rv | Rv3399 | - | 2e-98 | 59.61% (307) | hypothetical protein Rv3399 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0747c | - | 0.0 | 100.00% (367) | hypothetical protein Mb0747c |
| M. gilvum PYR-GCK | Mflv_5023 | - | 8e-93 | 56.25% (304) | putative methyltransferase |
| M. leprae Br4923 | MLBr_02640 | - | 1e-61 | 47.89% (284) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 5e-78 | 50.98% (306) | hypothetical protein MAB_3787 |
| M. marinum M | MMAR_1059 | - | 1e-119 | 67.18% (323) | O-methyltransferase |
| M. avium 104 | MAV_4441 | - | 1e-115 | 66.99% (306) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_1482 | - | 5e-95 | 58.69% (305) | methyltransferase |
| M. thermoresistible (build 8) | TH_2706 | - | 2e-84 | 60.22% (269) | PUTATIVE putative methyltransferase |
| M. ulcerans Agy99 | MUL_0818 | - | 1e-117 | 66.25% (323) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1346 | - | 2e-90 | 55.52% (308) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0726c|M.tuberculosis_H37Rv MTYTGSIRCEGDTWDLASSVGATATMVAAARAMATRAANPLINDQFAEPL
Mb0747c|M.bovis_AF2122/97 MTYTGSIRCEGDTWDLASSVGATATMVAAARAMATRAANPLINDQFAEPL
MMAR_1059|M.marinum_M MTSTGSTRYDGDSWDLASSVGVTATMVAAARAMATRAENPLINDPYAEPL
MUL_0818|M.ulcerans_Agy99 MTSTGSTRYDGDSWDLASSVGVTATMVAAARAMATRAENPLINDPYAEPL
MAV_4441|M.avium_104 MTST---RYEGDTWDLASSVGVTATMVAAARAMATRADNPLINDPFAEPL
Mflv_5023|M.gilvum_PYR-GCK -----MPRTENDTWDLASSVGATATMVAAARAVATRAEDPVIDDPYAEPL
Mvan_1346|M.vanbaalenii_PYR-1 -----MARTDNDTWDLASSVGATATMVAAARAVATRAPRPVIDDPFAAPL
MSMEG_1482|M.smegmatis_MC2_155 -----MARTENDTWDLASSVGATATMVAAARALATNADEPAIDDPFAAPL
TH_2706|M.thermoresistible__bu -----MARSESDTWDLTSGVGVTATMVAAARALASREPEPLIDDPFAAPL
MAB_3787|M.abscessus_ATCC_1997 -----MARTDDDSWDLASSVGATATMVAAQRALASHVPNPLINDPYAEPL
MLBr_02640|M.leprae_Br4923 ------MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLL
* ..*:**: :.**.**.**** ** : . * * :* *
Rv0726c|M.tuberculosis_H37Rv VRAVGVDVLTRLASGELTASDID----DPERPNASMVRMAEHHAVRTKFF
Mb0747c|M.bovis_AF2122/97 VRAVGVDVLTRLASGELTASDID----DPERPNASMVRMAEHHAVRTKFF
MMAR_1059|M.marinum_M VRAVGVDLLTRLATGEFNVADLD---DDPQRPLGPLGDVADNMAVRTRFF
MUL_0818|M.ulcerans_Agy99 VRAVGVDLLTRLATGEFNVADLD---DDPQRPLGPIGDVADNMAVRTRFF
MAV_4441|M.avium_104 VKAVGVDLLSRLAGGELDPAELNDVHDGAAGSAGAMSRMADNMAVRTKFF
Mflv_5023|M.gilvum_PYR-GCK VRAVGIDFFAKLASGELTPEDLDVS--GDESPVG-MSRFADGMAARTRFF
Mvan_1346|M.vanbaalenii_PYR-1 VQAVGVDFFTRLATGELTTEELDTN--DAESPVG-MSRFADAMAARTRFF
MSMEG_1482|M.smegmatis_MC2_155 VRAVGVDFFTKLVDDNFDLTALDP-----EAAEG-LTRFANGMAARTRFF
TH_2706|M.thermoresistible__bu VRAVGVEFFTRLVDGDLELPADT------AEERAAAQVLTEVMAVRTRFF
MAB_3787|M.abscessus_ATCC_1997 VRAVGIEYFTKLASGAFDPEQMAG----LVQLGITADGMANGMASRTWYY
MLBr_02640|M.leprae_Br4923 VTNTGAGALWEAMLDPSMVAKVEAI---DAEAAAMVEHMRSYQAVRTNFF
* .* : . . . . * ** ::
Rv0726c|M.tuberculosis_H37Rv DEFFMDATRAG---IRQVVILASGLDSRAYRLAWPAQTVVYEIDQPQVME
Mb0747c|M.bovis_AF2122/97 DEFFMDATRAG---IRQVVILASGLDSRAYRLAWPAQTVVYEIDQPQVME
MMAR_1059|M.marinum_M DDFFLDATRAG---LEQVVILASGLDARAYRLPWPPQTVVYEIDLPQVIE
MUL_0818|M.ulcerans_Agy99 DDFFLAATRAG---LEQVVILASGRDARAYRLPWPPQTVVYEIDLPQVID
MAV_4441|M.avium_104 DEFFLNATKAG---IAQVVILASGLDARAYRLAWPAGTVVYEVDQPQVID
Mflv_5023|M.gilvum_PYR-GCK DDFFTDACAAG---VRQAVILASGLDARGYRLTWPEGMTLFEIDQPEVIE
Mvan_1346|M.vanbaalenii_PYR-1 DDFFAEAMRAGPPPIRQGVILASGLDARAYRLSWPQDMVLFEIDQPEVLT
MSMEG_1482|M.smegmatis_MC2_155 DDFFLDAARAG---VRQFVILASGLDARAYRLPWPAGSVVFEIDQPDVIE
TH_2706|M.thermoresistible__bu DDFFTDATRVG---ARQAVILASGLDARAYRLTWPDGTVVYEIDQPEVIA
MAB_3787|M.abscessus_ATCC_1997 DTAFESSTAAG---VRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVIT
MLBr_02640|M.leprae_Br4923 DTYFNNAVIDG---IRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLA
* * : * * ****** *:*.*** ** .::*:* *.*:
Rv0726c|M.tuberculosis_H37Rv FKTRTLAELGATPTADRRVVTADLRADWPTALGAAGFDPTQPTAWSAEGL
Mb0747c|M.bovis_AF2122/97 FKTRTLAELGATPTADRRVVTADLRADWPTALGAAGFDPTQPTAWSAEGL
MMAR_1059|M.marinum_M FKSRTLADLGAAPTADRRVVAVDLREDWPAALRAAGFDPNQPTAWSAEGL
MUL_0818|M.ulcerans_Agy99 FKSRTLADLGAAPTADRRVVAVDLREDWPAALRAAGFDPNQPTAWSAEGL
MAV_4441|M.avium_104 FKTTALAQLGAAPTAERRVVAVDLRDDWPAALRAAGFDPTRPTAWSAEGL
Mflv_5023|M.gilvum_PYR-GCK FKRTTLAGLGATPSTHLATVAIDLREDWPTALRDAGFDPSVPTAWIAEGL
Mvan_1346|M.vanbaalenii_PYR-1 FKAATLADLGVRPSTKLATVAVDLRNDWPAALAEAGFDASAPTAWIAEGL
MSMEG_1482|M.smegmatis_MC2_155 FKTKALADLGALPTTDRRAVAVDLRFDWPAALTEAGFDPAEPTAWIAEGL
TH_2706|M.thermoresistible__bu FKTRTLAELGAPPTAPHRPVAVDLRDDWPAALTAAGFDPTVATAWSAEGL
MAB_3787|M.abscessus_ATCC_1997 FKTDTLAELGASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGL
MLBr_02640|M.leprae_Br4923 YKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGL
:* :** *. *:: *. *** ***.** ****. *.* ****
Rv0726c|M.tuberculosis_H37Rv LRYLPPEAQDRLLDNVTALSVPDSRFATESIRNFKPHHEERMRERMTILA
Mb0747c|M.bovis_AF2122/97 LRYLPPEAQDRLLDNVTALSVPDSRFATESIRNFKPHHEERMRERMTILA
MMAR_1059|M.marinum_M LGYLPPEAQDRLLDTVTELSAPGSRLAAECLSSVDPGEEEQIKERMQEVS
MUL_0818|M.ulcerans_Agy99 LGYLPPEAQDRLLDTVTELSAPGSRLAAECLSGVDPAEEEQIKERMQEVS
MAV_4441|M.avium_104 LGYLPPEAQDRLLDTITELSAPGSRLATESAPNPAPGEEEKLKERMQAIS
Mflv_5023|M.gilvum_PYR-GCK LGYLPPDAQDRLLDTIGELSASGSRLAVESVPSQQSADQDEMREKMKDST
Mvan_1346|M.vanbaalenii_PYR-1 LGYLPPDAQDRLLDTIGELSAPGSRLAVESVPTHHEADQEELREKMKESS
MSMEG_1482|M.smegmatis_MC2_155 LGYLPPEAQDRLLDQIAELSAPGSRVAVEEIPAIEEEDHEEIAARMKDFS
TH_2706|M.thermoresistible__bu LRYLPPDAQDRLFDHITDLSAPGSRLATEDHPGPGAG----LGEKADELG
MAB_3787|M.abscessus_ATCC_1997 LIYLPPEAQDRLFASITELSAPGSRLVCEQVPGLETAD----FSKARELT
MLBr_02640|M.leprae_Br4923 LMYLPATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVS
* ***. *** *: : **. .**.. * :
Rv0726c|M.tuberculosis_H37Rv NRWRAYGFDLDMNELVYFGD-RNEPASYLSDNGWLLTEIKSQDLLTANG-
Mb0747c|M.bovis_AF2122/97 NRWRAYGFDLDMNELVYFGD-RNEPASYLSDNGWLLTEIKSQDLLTANG-
MMAR_1059|M.marinum_M ARWRAHGFDVDMVGLVYFGD-RNEAVPYLSDRGWLLTSTPLPELRAANG-
MUL_0818|M.ulcerans_Agy99 ARWRAHGFDVDMVGLVYFGD-RNEAVPYLSDRGWLLTSTPLPELRAANG-
MAV_4441|M.avium_104 QRWRAHGFDLDMAGLVYFGE-RNEAAPYLAGHGWRLNSVTIRDLFAANG-
Mflv_5023|M.gilvum_PYR-GCK DRWRSHGFDLDFSELVFLGE-RANVPDYLRERGWAVTATPTNDLLTRYG-
Mvan_1346|M.vanbaalenii_PYR-1 DRWRSHGFDVDFSELVFLGE-RADVTDYLRDRGWTVDATPTNQLLTRYG-
MSMEG_1482|M.smegmatis_MC2_155 DRWRAHGFDLDFTELVFLGD-RADVSSYLQGHGWKTTSMTSDELLVHNG-
TH_2706|M.thermoresistible__bu RRWREHGFEVQLSELFHPGE-RTPVVDYLRGRGWDARARPRAEVFAGYG-
MAB_3787|M.abscessus_ATCC_1997 RQFAGETLDLDLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLN-
MLBr_02640|M.leprae_Br4923 DALG-FEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGR
::. *.. : * :* .** : .
Rv0726c|M.tuberculosis_H37Rv FQPFE-DEEVPLPDFFYVSARLQRKHRQYPAHRKPAPSWRHTACPVNELS
Mb0747c|M.bovis_AF2122/97 FQPFE-DEEVPLPDFFYVSARLQRKHRQYPAHRKPAPSWRHTACPVNELS
MMAR_1059|M.marinum_M LAPAAVDDDGPSVDMLYVSGTLYTTPRPDPAP------------------
MUL_0818|M.ulcerans_Agy99 LAPAAVDDDGPSVDMLYVSGTLYTTPRPDPAP------------------
MAV_4441|M.avium_104 LDPLD-DDDTRMGEMLYTWG-IYE--------------------------
Mflv_5023|M.gilvum_PYR-GCK LAPLD--TDEGFAEVVYVNAAR----------------------------
Mvan_1346|M.vanbaalenii_PYR-1 LAPLD--SDEGFAEVVYVSATR----------------------------
MSMEG_1482|M.smegmatis_MC2_155 LPRVD--DDAQIGSVVYVTATR----------------------------
TH_2706|M.thermoresistible__bu REFPDSAALAAMRDSSAVTAVRPVVRAGMR--------------------
MAB_3787|M.abscessus_ATCC_1997 LDPPNPLLRSIFPNIVYVDATLG---------------------------
MLBr_02640|M.leprae_Br4923 WGDGVPMADDKDAFAEFVTAHRL---------------------------
. .
Rv0726c|M.tuberculosis_H37Rv KSAAYTMTRSDAHQASTTAPPPPGLTG
Mb0747c|M.bovis_AF2122/97 KSAAYTMTRSDAHQASTTAPPPPGLTG
MMAR_1059|M.marinum_M ---------------------------
MUL_0818|M.ulcerans_Agy99 ---------------------------
MAV_4441|M.avium_104 ---------------------------
Mflv_5023|M.gilvum_PYR-GCK ---------------------------
Mvan_1346|M.vanbaalenii_PYR-1 ---------------------------
MSMEG_1482|M.smegmatis_MC2_155 ---------------------------
TH_2706|M.thermoresistible__bu ---------------------------
MAB_3787|M.abscessus_ATCC_1997 ---------------------------
MLBr_02640|M.leprae_Br4923 ---------------------------