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M. tuberculosis H37Rv Rv3398c (idsA1)

annotation: PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA1 (GGPP SYNTHETASE) (GGPPSASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE): DIMETHYLALLYLTRANSFERASE (PRENYLTRANSFERASE) (GERANYL-DIPHOSPHATE SYNTHASE) + GERANYLTRANSTRANSFERASE (FARNESYL-DIPHOSPHATE SYNTHASE) (FARNESYL-PYROPHOSPHATE SYNTHETASE) (FARNESYL DIPHOSPHATE SYNTHETASE) (FPP SYNTHETASE) + FARNESYLTRANSTRANSFERASE (GERANYLGERANYL-DIPHOSPHATE SYNTHASE)
coordinates: 3815027 - 3816106
length: 359

RGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNC
GKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGD
AMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAE
VGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSA
GRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLA
HYIVDRQA*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv3398cidsA1-100% (359)PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA1 (GGPP SYNTHETASE) (GGPPSASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE): DIMETHYLALLYLTRANSFERASE (PRENYLTRANSFERASE) (GERANYL-DIPHOSPHATE SYNTHASE) + GERANYLTRANSTRANSFERASE (FARNESYL-DIPHOSPHATE SYNTHASE) (FARNESYL-PYROPHOSPHATE SYNTHETASE) (FARNESYL DIPHOSPHATE SYNTHETASE) (FPP SYNTHETASE) + FARNESYLTRANSTRANSFERASE (GERANYLGERANYL-DIPHOSPHATE SYNTHASE)
M. tuberculosis H37RvRv3383cidsB4e-5440.74% (297) polyprenyl synthetase IdsB
M. tuberculosis H37RvRv0562grcC18e-2729.69% (293) polyprenyl-diphosphate synthase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3431cidsA10.0100.00% (359) multifunctional dimethylallyltransferase/farnesyl
M. gilvum PYR-GCKMflv_5253-5e-2631.21% (298) trans-hexaprenyltranstransferase
M. leprae Br4923MLBr_02277-6e-2629.41% (289) polyprenyl diphosphate synthase component
M. abscessus ATCC 19977MAB_1992c-1e-2728.89% (315) polyprenyl synthetase
M. marinum MMMAR_5095idsA12e-7647.09% (327) multifunctional geranylgeranyl pyrophosphate synthetase
M. avium 104MAV_4802-9e-3032.96% (267) polyprenyl synthetase
M. smegmatis MC2 155MSMEG_1133-2e-2630.24% (291) bifunctional short chain isoprenyl diphosphate synthase
M. thermoresistible (build 8)TH_1767-6e-2931.49% (289) bifunctional short chain isoprenyl diphosphate synthase
M. ulcerans Agy99MUL_3197idsB1e-3336.58% (257) polyprenyl synthetase IdsB
M. vanbaalenii PYR-1Mvan_1577-2e-2629.97% (307) polyprenyl synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       MPSGTTLSSEPALRPAVMEKRRRLLHRIALCAIAAPRRIVAIAALVMVGA
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       AIFGVPVAGSLAAGGFQDPGSESARATRVLTETFGRGDMQLVFAVTDPAG
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       VDSASARAAGLAIATLVGEDPAVADVVSTWTVAPEAAAALISADGRSGLV
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       VAELTGDENTAPRIAQALVDEVATTVQPRHETVAVLAGGSSIVYSQINSQ
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       TLRDVLLMEAIAIPLTFLVLVWVFKGLLAAALPVAVGGLAIVASMSVLRL
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       VAMWTDVSIFALNLTTALGLALAVDYTLLIVSRFRDEVAAGAPRDRALVT
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       TMVTAGRTVLFSALTVALSMAAMLLFPMYFLKSFAYAGLATVALCAVAAI
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       VVTPAVIALFGDRLDAFDIRRMLRRTPAAEPRGEQMFWYRSTKFVMRRAL
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       PVGLAGTALLVSLGLPFLGVSWGLPDDRVLPSSATAHRVGDMLRTEFSDN
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       SEAAVTVLVPDAEGLTPQDFERYAAEASTIEDVSMVSAPTGTFADGRRVG
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       PPAGGAGVQGGIAYLTVGSTTASFSPESERQLDRLRALPGPGGRPVQMTG
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       IAQINRDSVESIMARLPIVLGIIAVITFVLLFLLTGSLVLPVKALVLNAL
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       SLTAAFGALVWIFQDGNLGALGTTPTGTLVVNMPVLLFCIAFGLSMDYEV
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       FLLARIREFWLAGGRRDNDESVALGLAHTGRVVTAAALIMSISFGALIAA
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------------
TH_1767|M.thermoresistible__bu      --------------------------------------------------
MLBr_02277|M.leprae_Br4923          --------------------------------------------------
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       QVSFMRMFGLGLMLAVLIDATLVRMVLLPAFMHLMGRWNWWAPAPLARWH
Rv3398c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb3431c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_5095|M.marinum_M               --------------------------------------------------
MUL_3197|M.ulcerans_Agy99           --------------------------------------------------
MAV_4802|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          --------------------------------------MRTPANVVAGVD
MSMEG_1133|M.smegmatis_MC2_155      --------------------------------------------MVAGVD
TH_1767|M.thermoresistible__bu      --------------------------------------------VVAGVD
MLBr_02277|M.leprae_Br4923          -------------------------------------------MVVAGIN
MAB_1992c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_1577|M.vanbaalenii_PYR-1       ARRTGTAEQNANPTKSGAAIASNGRRRPRHGWVERGGGPQLSRGDGAGAQ
Rv3398c|M.tuberculosis_H37Rv        ----------------------MRGTDEKYGLPPQPDSDRMTRRTLPVLG
Mb3431c|M.bovis_AF2122/97           ----------------------MRGTDEKYGLPPQPDSDRMTRRTLPVLG
MMAR_5095|M.marinum_M               ----------------------MAMSQMARPVRASTTPARIT----LLLN
MUL_3197|M.ulcerans_Agy99           -----------------------------MTADGTCESDVPAAVVQLFLS
MAV_4802|M.avium_104                ---------------------------------MMTSTLPDARPAVAALN
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          FGDAQFAQDVRDGVARIEALMSEELG--------RADALMSEAVNHLFQA
MSMEG_1133|M.smegmatis_MC2_155      FGDPAFAADVRDGVARIEDLMSDELG--------KADELMAEAVQHLFQA
TH_1767|M.thermoresistible__bu      LGDPDFAAGVRDGVARIEDLMSSELG--------KADDLMAEAVQHLFRA
MLBr_02277|M.leprae_Br4923          FGDAAFAATVQDRVVRIEQLMDAELR--------DTDEVMTESVLHLFAA
MAB_1992c|M.abscessus_ATCC_199      -----------------------------------------------MLR
Mvan_1577|M.vanbaalenii_PYR-1       LAEPGLMAWRDTVRTAVREHLEDFVRGECARRLDGGGVDVAAELLCGFLD
Rv3398c|M.tuberculosis_H37Rv        LAHELITPTLRQMADRLDPHMRPVVS--------YHLGWSDERGRPVNNN
Mb3431c|M.bovis_AF2122/97           LAHELITPTLRQMADRLDPHMRPVVS--------YHLGWSDERGRPVNNN
MMAR_5095|M.marinum_M               DIRLLIEPKQRAVIDNLSPELRLCAG--------FHIGWWEPDGRDSSVR
MUL_3197|M.ulcerans_Agy99           SARAACDPVLRRAVESMPEPLATMAG--------YYLGWWDIDRSALAGS
MAV_4802|M.avium_104                PLEDYLAACKQACDREIVRLYGSGER---------GSNGLYQLILDYPLR
                                                                                      

Mflv_5253|M.gilvum_PYR-GCK          GGKRFRPLFTVLSAQLGPEPD---AWQVTVAGAVIELVHLATLYHDDVMD
MSMEG_1133|M.smegmatis_MC2_155      GGKRFRPLFTVLSAQLGPEPD---AWQVTVAGAVIELVHLATLYHDDVMD
TH_1767|M.thermoresistible__bu      GGKRFRPLFTVLSAQLGPEPD---AWQVTVAGAVIELVHLATLYHDDVMD
MLBr_02277|M.leprae_Br4923          GGKRFRPLFTVLSAQIGPRPD---APEVIIAGAVIELVHLASLYHDDVMD
MAB_1992c|M.abscessus_ATCC_199      GGKRLRPAFAYWGWRAITDDPDPWNPEVLRVCAALELLHTCALIHDDVID
Mvan_1577|M.vanbaalenii_PYR-1       GGKYVRSTYMYLGWLCGERE----DTAALRASASLELLHTFALIQDDVMD
Rv3398c|M.tuberculosis_H37Rv        CGKAIRPALVFVAAEAAGADP----HSAIPGAVSVELVHNFSLVHDDLMD
Mb3431c|M.bovis_AF2122/97           CGKAIRPALVFVAAEAAGADP----HSAIPGAVSVELVHNFSLVHDDLMD
MMAR_5095|M.marinum_M               HGKAVRPALSITCARAAGGAM----DAAIPAAVAVELVHDCSLLHDDIMD
MUL_3197|M.ulcerans_Agy99           SGTFVRAALVWAAAAACGGDA----GNAAPIAAAVELVHSGTLLHDDVMA
MAV_4802|M.avium_104                GGKALRPALSIATCLGLGGHL----EAILPTAATLELYHNAFLIHDDIED
                                     *. .*.                         . :** *   * :**:  

Mflv_5253|M.gilvum_PYR-GCK          EAQVRRGAPSAN----------------ARWGNNIAILAGDYLFATASRL
MSMEG_1133|M.smegmatis_MC2_155      EAQMRRGAQSAN----------------ARWGNNIAILAGDYLFATASRL
TH_1767|M.thermoresistible__bu      DAEMRRGAPSAN----------------AKWGNSIAILAGDYLFATASRL
MLBr_02277|M.leprae_Br4923          EAEVRRGAPSAN----------------LRWSNSVAILAGDYLFATASRL
MAB_1992c|M.abscessus_ATCC_199      SSATRRGEPTIHVEFAALHRENGWSGSPEQFGISAAILLGDLALTWADDM
Mvan_1577|M.vanbaalenii_PYR-1       SSPMRRARPSAHVALGRWHRDRALSGSASRFGESAAILLGDLCLVWAEEM
Rv3398c|M.tuberculosis_H37Rv        RDEHRRHRPTVW----------------ALWGDAMALLAGDAMLSLAHEV
Mb3431c|M.bovis_AF2122/97           RDEHRRHRPTVW----------------ALWGDAMALLAGDAMLSLAHEV
MMAR_5095|M.marinum_M               GDVTRRHRPAAW----------------VVYGVPMAILTGDALLVLALDL
MUL_3197|M.ulcerans_Agy99           GEVTRGGRRAVW----------------SIWGIDNAILLGDALQTAAIRT
MAV_4802|M.avium_104                ESWWRRGKPTLH----------------IDHGVPVAVNVGDAMLSLSLQP
                                        *    :                     .   *:  **     :   

Mflv_5253|M.gilvum_PYR-GCK          TSR--LGPEAVRIIADT------FALLVTGQMRETRGAADQVDSVD--HY
MSMEG_1133|M.smegmatis_MC2_155      VSR--LGPDAVRVIADT------FAQLVTGQMRETRGAADHVDSVD--HY
TH_1767|M.thermoresistible__bu      VSR--LGPEAVRVIADT------FAQLVTGQMRETRGAADGADPIE--HY
MLBr_02277|M.leprae_Br4923          VSQ--LGLDAVRIIADT------FAQLVTGQMRETRGVPEGADSIE--QY
MAB_1992c|M.abscessus_ATCC_199      VVG--AQLSPEAHVRARGVWSILRSEVLGGQYLDILSESSGDESVE--TA
Mvan_1577|M.vanbaalenii_PYR-1       LRR--SGVDADALARVWPRYDAMRTELAIGQLSDLLNSCQTFPTLP--EV
Rv3398c|M.tuberculosis_H37Rv        LLD--CDSP-HVGAALRAI-SEATRELIRGQAADTAFESRTDVALD--EC
Mb3431c|M.bovis_AF2122/97           LLD--CDSP-HVGAALRAI-SEATRELIRGQAADTAFESRTDVALD--EC
MMAR_5095|M.marinum_M               VHE--GAS----GSALR----KAALELCAGQSADLAFEQRTKVWLP--EC
MUL_3197|M.ulcerans_Agy99           LTD--LPDPGVAVRAVMRL-ETSCLDLCIGRFEDCAFECGQAGPVD--SY
MAV_4802|M.avium_104                LLDNVERVGLGPALRILRAVATMTRKTVDGQALELDWVHSNTWRLDDADY
                                                                 *:  :          :     

Mflv_5253|M.gilvum_PYR-GCK          LKVVYEKTA-CLISASGRFGATFSGSDEAQIERLAKLGGIVGTAFQISDD
MSMEG_1133|M.smegmatis_MC2_155      LKVVYEKTA-CLIAASGRFGATFSGANDEQIERLSRLGGIVGTAFQIADD
TH_1767|M.thermoresistible__bu      LKVVYEKTA-CLISASGRFGATFSGADEEQVERLARLGGIVGTAFQISDD
MLBr_02277|M.leprae_Br4923          LKVVYEKTG-CLIGSAGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDD
MAB_1992c|M.abscessus_ATCC_199      LRVIRFKTAGYTVQRPLQLGVAIAGENAEISRLLGDVGLDIGIAFQLRDD
Mvan_1577|M.vanbaalenii_PYR-1       LDVLRRKSGNYTVRRPLELGAAMAGCSADVADALSGYGAAIGEAFQLRDD
Rv3398c|M.tuberculosis_H37Rv        LKMAEGKTA-ALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDD
Mb3431c|M.bovis_AF2122/97           LKMAEGKTA-ALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDD
MMAR_5095|M.marinum_M               LQMAQQKTG-ALFGVACQLGALAAGADSLVADQYAQFGRHLGLSFQLVDD
MUL_3197|M.ulcerans_Agy99           ERMAAGKTA-ALIGCCCGLGALAADAGDATITALERFGRELGLAFQCVN-
MAV_4802|M.avium_104                LEMVELKTSWYSFITPLQAGAVAAGSTPDRMAPLESLGRHLGAAFQITDD
                                      :   *:.   .      *   :.            *  :* :**  : 

Mflv_5253|M.gilvum_PYR-GCK          IIDIDSDADESGKVPGTDLREGVHTLPVLYALRETGPD------------
MSMEG_1133|M.smegmatis_MC2_155      IIDIDSDPDESGKTPGTDLREGVHTLPVLYALRETGPD------------
TH_1767|M.thermoresistible__bu      IIDIESESTESGKTPGTDLREGVHTLPVLYALRETGPE------------
MLBr_02277|M.leprae_Br4923          IIDIDSDYTKSGKLPGTDVREGVRTLPILYALRETGPD------------
MAB_1992c|M.abscessus_ATCC_199      VLGVFGDPKVTGKPAGDDLRSGKRTVLLAEALRLARQRDS----------
Mvan_1577|M.vanbaalenii_PYR-1       ILGVFGSPSLTGKSVRSDLEDGKATSIVVAAYELAGPR------------
Rv3398c|M.tuberculosis_H37Rv        LLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRR---------
Mb3431c|M.bovis_AF2122/97           LLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRR---------
MMAR_5095|M.marinum_M               ILGIWGSESVTGKPVFSDLQSRKKSLPVVAALSSGTAAGAK---------
MUL_3197|M.ulcerans_Agy99           -----------------DLGRRNATLTVAAALNSRSEAAIE---------
MAV_4802|M.avium_104                LLNLRADPQEYGKEIGGDLWEGKRTLMLLHTLRHAEPGDQQRAVQILSRR
                                                     *:     :  :  :                   

Mflv_5253|M.gilvum_PYR-GCK          -------------------------------ADRLRELLAGPVTDDADVA
MSMEG_1133|M.smegmatis_MC2_155      -------------------------------ADRLRELLAGPIERDEDVA
TH_1767|M.thermoresistible__bu      -------------------------------AERLRELVSRPVEDDADLA
MLBr_02277|M.leprae_Br4923          -------------------------------SERLRALLAGPVDNDAEVV
MAB_1992c|M.abscessus_ATCC_199      ------------------------------AAEDLLHSWIGTPLTDQQVA
Mvan_1577|M.vanbaalenii_PYR-1       ------------------------------LRRQLAELMQSPEIGAADVD
Rv3398c|M.tuberculosis_H37Rv        ------------------------------LAAWLVDETGSQTASDDELA
Mb3431c|M.bovis_AF2122/97           ------------------------------LAAWLVDETGSQTASDDELA
MMAR_5095|M.marinum_M               ------------------------------LETLLG---GTEALSDHELS
MUL_3197|M.ulcerans_Agy99           ------------------------------PAALCH---SGSFMATGDID
MAV_4802|M.avium_104                RPSPDAEFDLTELLDRLTAGGQLSVSGRTEIEARLRRHHHSEVKSLNDIR
                                                                                   :: 

Mflv_5253|M.gilvum_PYR-GCK          EALRLLRGSQGIRKAKETVIGYAQEAQRELDQLPDVPG---RQALASLVD
MSMEG_1133|M.smegmatis_MC2_155      EALALLRRSPGLTKAKETVASYAAQAREELSHLPECPG---RQALAVLVD
TH_1767|M.thermoresistible__bu      EALDLLRRSPGMAQATETVREYATEARSVLAQLPAGPG---RDALATLID
MLBr_02277|M.leprae_Br4923          EALALLRASPGMARARQVLAHYADQASGELAQLPDGPS---RDALATLVD
MAB_1992c|M.abscessus_ATCC_199      EMCSLIVDLGALGAVESRIEEHTHRALDQLAGADIADDA--RAALSDLVR
Mvan_1577|M.vanbaalenii_PYR-1       RWRTLIRASGAVQWIEEQIARRHDAALRFLDGAAIPAAP--RAALAEMAV
Rv3398c|M.tuberculosis_H37Rv        AVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRP--AAELQDLAH
Mb3431c|M.bovis_AF2122/97           AVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRP--AAELQDLAH
MMAR_5095|M.marinum_M               YAADLIEDAGGRAWAEGEALRHRGLALDALAAAEPEPTA--AEDLLALAE
MUL_3197|M.ulcerans_Agy99           RAATLVDVAAGR----HAVQRCADQRIQATVAALPDAVR--SRDLIALSQ
MAV_4802|M.avium_104                WLYELMHRVGSLNHARDVAVRQARQAAAVLAGLDWFPRSRHRDMLAALVD
                                        *:    .                                 *  :  

Mflv_5253|M.gilvum_PYR-GCK          YTVNRHG
MSMEG_1133|M.smegmatis_MC2_155      YTISREG
TH_1767|M.thermoresistible__bu      FTVNRHG
MLBr_02277|M.leprae_Br4923          YTTNRHG
MAB_1992c|M.abscessus_ATCC_199      LVSNRSA
Mvan_1577|M.vanbaalenii_PYR-1       ACTQRAA
Rv3398c|M.tuberculosis_H37Rv        YIVDRQA
Mb3431c|M.bovis_AF2122/97           YIVDRQA
MMAR_5095|M.marinum_M               LMTVRAA
MUL_3197|M.ulcerans_Agy99           LICCRER
MAV_4802|M.avium_104                YVHGRAR
                                        *