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MTSTLPDARPAVAALNPLEDYLAACKQACDREIVRLYGSGERGSNGLYQLILDYPLRGGKALRPALSIAT CLGLGGHLEAILPTAATLELYHNAFLIHDDIEDESWWRRGKPTLHIDHGVPVAVNVGDAMLSLSLQPLLD NVERVGLGPALRILRAVATMTRKTVDGQALELDWVHSNTWRLDDADYLEMVELKTSWYSFITPLQAGAVA AGSTPDRMAPLESLGRHLGAAFQITDDLLNLRADPQEYGKEIGGDLWEGKRTLMLLHTLRHAEPGDQQRA VQILSRRRPSPDAEFDLTELLDRLTAGGQLSVSGRTEIEARLRRHHHSEVKSLNDIRWLYELMHRVGSLN HARDVAVRQARQAAAVLAGLDWFPRSRHRDMLAALVDYVHGRAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4802 | - | - | 100% (395) | polyprenyl synthetase |
| M. avium 104 | MAV_2321 | - | 2e-24 | 31.82% (286) | polyprenyl synthetase |
| M. avium 104 | MAV_4581 | - | 2e-19 | 29.43% (333) | polyprenyl synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3431c | idsA1 | 8e-30 | 32.96% (267) | multifunctional dimethylallyltransferase/farnesyl |
| M. gilvum PYR-GCK | Mflv_2975 | - | 7e-24 | 30.90% (288) | polyprenyl synthetase |
| M. tuberculosis H37Rv | Rv3398c | idsA1 | 8e-30 | 32.96% (267) | multifunctional dimethylallyltransferase/farnesyl |
| M. leprae Br4923 | MLBr_02277 | - | 1e-20 | 27.98% (336) | polyprenyl diphosphate synthase component |
| M. abscessus ATCC 19977 | MAB_1992c | - | 1e-25 | 31.00% (300) | polyprenyl synthetase |
| M. marinum M | MMAR_5095 | idsA1 | 9e-25 | 35.02% (217) | multifunctional geranylgeranyl pyrophosphate synthetase |
| M. smegmatis MC2 155 | MSMEG_4240 | - | 2e-22 | 30.99% (284) | polyprenyl synthetase |
| M. thermoresistible (build 8) | TH_0708 | idsA2 | 2e-24 | 31.25% (288) | PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 |
| M. ulcerans Agy99 | MUL_3516 | idsA2 | 2e-21 | 28.47% (281) | geranylgeranyl pyrophosphate synthetase IdsA2 |
| M. vanbaalenii PYR-1 | Mvan_3536 | - | 1e-25 | 32.28% (285) | polyprenyl synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2975|M.gilvum_PYR-GCK MDAAAPSAVELVNAVNEELREYLRGRRRDAAYIGTDYAVLTEALEEFVLR
Mvan_3536|M.vanbaalenii_PYR-1 MDASAPSAVELAAAVTEQLRDYLRARRRDAAYIGAGYAVLTEAVEEFVLR
TH_0708|M.thermoresistible__bu --------VELANAVTDELRDYLRQRREDSAYIGSDYTHMTAALEEFVLR
MSMEG_4240|M.smegmatis_MC2_155 MDTAAPSAVELAGAVTEQLREYLRERRSDCAYIGPVYAELTAGVEEFVLR
MUL_3516|M.ulcerans_Agy99 ----------------------MRDRRSQAAYIGDDYGALTAWLEEFVLS
MAB_1992c|M.abscessus_ATCC_199 -----------------------------------------------MLR
Mb3431c|M.bovis_AF2122/97 ------MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADR
Rv3398c|M.tuberculosis_H37Rv ------MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADR
MMAR_5095|M.marinum_M ------MAMSQMARPVRASTTPARIT----LLLNDIRLLIEPKQRAVIDN
MAV_4802|M.avium_104 ----------MMTSTLPDARPAVAALNPLEDYLAACKQACDREIVRLYGS
MLBr_02277|M.leprae_Br4923 -MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLHLFAA
Mflv_2975|M.gilvum_PYR-GCK GGKRLRPAFAYWG-FRAVAG-TEP--EPHIMRLFSALELLHACALVHDDL
Mvan_3536|M.vanbaalenii_PYR-1 GGKRLRPAFAYWG-WRAVAG-TEP--GPEALRLFSALELLHACALVHDDV
TH_0708|M.thermoresistible__bu GGKRIRPAFAYWG-WRAVAD-EPAPVPPEIMRLFAALELLHACALVHDDV
MSMEG_4240|M.smegmatis_MC2_155 GGKRVRPAFAYWG-WRSVIEPADAVAGPDVLRLFSALELLQACALIHDDV
MUL_3516|M.ulcerans_Agy99 GGKRLRPIFAYRG-WPAVTT-EDP--DPDLLLLFSALELLHAWALIHDDV
MAB_1992c|M.abscessus_ATCC_199 GGKRLRPAFAYWG-WRAITDDPDP-WNPEVLRVCAALELLHTCALIHDDV
Mb3431c|M.bovis_AF2122/97 LDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSA
Rv3398c|M.tuberculosis_H37Rv LDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSA
MMAR_5095|M.marinum_M LSPELRLCAGFHIGWWEPDGRDSSVRHGKAVRPALSITCARAAGGAMDAA
MAV_4802|M.avium_104 GERGSNGLYQLILDYPLRGG--------KALRPALSIATCLGLGGHLEAI
MLBr_02277|M.leprae_Br4923 GGKRFRPLFTVLS-------------------------AQIGPRPDAPEV
.
Mflv_2975|M.gilvum_PYR-GCK IDASATRRGLPTVHRIFSERHR----SNNWLGSSDQFGLSAAILLGDLSL
Mvan_3536|M.vanbaalenii_PYR-1 IDASATRRGLPTVHRIFAERHR----SNNWLGSSEQFGLSAAILLGDVAL
TH_0708|M.thermoresistible__bu IDASATRRGLPTVHRLFADTHR----SRGWRGSAEQFGLSAAILLGDLAL
MSMEG_4240|M.smegmatis_MC2_155 IDDSATRRGLPTVHRLFTEQHH----ERGWLGSERQFGLSAAILAGDLAL
MUL_3516|M.ulcerans_Agy99 IDASSTRRGRPMAHIHFAALHR----DRNWLGPAQQFGISAAILIGDVAQ
MAB_1992c|M.abscessus_ATCC_199 IDSSATRRGEPTIHVEFAALHR----ENGWSGSPEQFGISAAILLGDLAL
Mb3431c|M.bovis_AF2122/97 IPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAML
Rv3398c|M.tuberculosis_H37Rv IPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAML
MMAR_5095|M.marinum_M IPAAVAVELVHDCSLLHDDIMDGDVTRRHRPAAWVVYGVPMAILTGDALL
MAV_4802|M.avium_104 LPTAATLELYHNAFLIHDDIEDESWWRRGKPTLHIDHGVPVAVNVGDAML
MLBr_02277|M.leprae_Br4923 IIAGAVIELVHLASLYHDDVMDEAEVRRGAPSANLRWSNSVAILAGDYLF
: . . . . . . *: **
Mflv_2975|M.gilvum_PYR-GCK VWADDIIA---EAPIDDAAHRRVQRVWAAIRTEVLGGQYLDIVNEASGSE
Mvan_3536|M.vanbaalenii_PYR-1 VWADDIVA---SAEIGVEAHRRVQRVWAAIRTEVLGGQYLDIVNEATGAE
TH_0708|M.thermoresistible__bu VWADDAVG---SAGLSVDAHRRVRRVWADIRTEVLGGQYLDIVNESSGAD
MSMEG_4240|M.smegmatis_MC2_155 SWADDIVA---GADLPVDAHRRVQTVWRHIRTEVLGGQYLDIVTESSGDE
MUL_3516|M.ulcerans_Agy99 AWADDIISRVSQSSLSPDAQRRVQRVWSDIRTEVLGGQYLDIVAEASAAD
MAB_1992c|M.abscessus_ATCC_199 TWADDMVV---GAQLSPEAHVRARGVWSILRSEVLGGQYLDILSESSGDE
Mb3431c|M.bovis_AF2122/97 SLAHEVLL-----DCDSPHVGAALRAISEATRELIRGQAADTAFESRTDV
Rv3398c|M.tuberculosis_H37Rv SLAHEVLL-----DCDSPHVGAALRAISEATRELIRGQAADTAFESRTDV
MMAR_5095|M.marinum_M VLALDLVH-----EGAS---GSALR---KAALELCAGQSADLAFEQRTKV
MAV_4802|M.avium_104 SLSLQPLLDN-VERVGLGPALRILRAVATMTRKTVDGQALELDWVHSNTW
MLBr_02277|M.leprae_Br4923 ATASRLVS---------QLGLDAVRIIADTFAQLVTGQMRETRGVPEGAD
: : : ** :
Mflv_2975|M.gilvum_PYR-GCK TVASA--LTVNIYKTASYTISRPLQLGAAAAGDRPEILEAFHELGTSLGV
Mvan_3536|M.vanbaalenii_PYR-1 TVASA--LTVNIYKTASYTISRPLQLGAAAAADCPEVLSAFHELGTSLGV
TH_0708|M.thermoresistible__bu SVASA--MTVNTYKTASYTVTRPLQLGAAAAADRPDVLATFHEVGNDLGV
MSMEG_4240|M.smegmatis_MC2_155 SVASA--LNVNTFKTASYTVARPLQLGAAAAADRPDVQELFHRIGNDLGV
MUL_3516|M.ulcerans_Agy99 SITSA--MTVATFKTACYTVSRPLQLGAAAAADRPDVQEAFHQFGTDLGV
MAB_1992c|M.abscessus_ATCC_199 SVETA--LRVIRFKTAGYTVQRPLQLGVAIAGENAEISRLLGDVGLDIGI
Mb3431c|M.bovis_AF2122/97 ALDEC--LKMAEGKTAALMAAS-AEVGALLAGAPRSVREALVAYGRHIGL
Rv3398c|M.tuberculosis_H37Rv ALDEC--LKMAEGKTAALMAAS-AEVGALLAGAPRSVREALVAYGRHIGL
MMAR_5095|M.marinum_M WLPEC--LQMAQQKTGALFGVA-CQLGALAAGADSLVADQYAQFGRHLGL
MAV_4802|M.avium_104 RLDDADYLEMVELKTSWYSFITPLQAGAVAAGSTPDRMAPLESLGRHLGA
MLBr_02277|M.leprae_Br4923 SIEQY--LKVVYEKTG-CLIGSAGRLGGLFAGAHAEQVERLSRLGSIVGT
: : : **. . * *. * :*
Mflv_2975|M.gilvum_PYR-GCK AFQLRDDVLGVYGDPAVTGKPSGDDLRSGKRTVLLAEAVELADRHDPP--
Mvan_3536|M.vanbaalenii_PYR-1 AFQLRDDVLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEKHDQI--
TH_0708|M.thermoresistible__bu AFQLRDDVLGVFGDPAVTGKPSGDDLRSGKRTVLLAEAVELAEQRDPA--
MSMEG_4240|M.smegmatis_MC2_155 AFQLRDDVLGVFGDPAVTGKPSGDDLRSGKRTVLLAEALELADASDPA--
MUL_3516|M.ulcerans_Agy99 AFQLRDDVLGVFGDPAMTGKPSGDDLRSGKRTVLIAEAAALADRSDPK--
MAB_1992c|M.abscessus_ATCC_199 AFQLRDDVLGVFGDPKVTGKPAGDDLRSGKRTVLLAEALRLARQRDSA--
Mb3431c|M.bovis_AF2122/97 AFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRR--
Rv3398c|M.tuberculosis_H37Rv AFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRR--
MMAR_5095|M.marinum_M SFQLVDDILGIWGSESVTGKPVFSDLQSRKKSLPVVAALSSGTAAGAK--
MAV_4802|M.avium_104 AFQITDDLLNLRADPQEYGKEIGGDLWEGKRTLMLLHTLRHAEPGDQQRA
MLBr_02277|M.leprae_Br4923 AFQISDDIIDIDSDYTKSGKLPGTDVREGVRTLPILYALRETGPDSER--
:**: **::.: . ** *: . ::: : : .
Mflv_2975|M.gilvum_PYR-GCK -------------------------------------AAQLLRTSIGTDL
Mvan_3536|M.vanbaalenii_PYR-1 -------------------------------------AAKLLRTSIGTDL
TH_0708|M.thermoresistible__bu -------------------------------------AAELLRTAIGTEL
MSMEG_4240|M.smegmatis_MC2_155 -------------------------------------AAALLRRSVGTEL
MUL_3516|M.ulcerans_Agy99 -------------------------------------AANLLRSAVGSEL
MAB_1992c|M.abscessus_ATCC_199 -------------------------------------AEDLLHSWIGTPL
Mb3431c|M.bovis_AF2122/97 -------------------------------------LAAWLVDETGSQT
Rv3398c|M.tuberculosis_H37Rv -------------------------------------LAAWLVDETGSQT
MMAR_5095|M.marinum_M -------------------------------------LETLLG---GTEA
MAV_4802|M.avium_104 VQILSRRRPSPDAEFDLTELLDRLTAGGQLSVSGRTEIEARLRRHHHSEV
MLBr_02277|M.leprae_Br4923 -----------------------------------------LRALLAGPV
*
Mflv_2975|M.gilvum_PYR-GCK S-DAQVKELCLVIEAVGALAAVESRIDTLTRRALDIMNSAPIDVRA--KA
Mvan_3536|M.vanbaalenii_PYR-1 T-DAQVKEVCLVIESVGALAAVESRIDTLTRRALDILNSAPIDVQA--KA
TH_0708|M.thermoresistible__bu S-DEQVTEVCGAIEKVGALRAVEDRIETLTTRALRRLDAAPIHEAA--KV
MSMEG_4240|M.smegmatis_MC2_155 S-DTQVRELCDAIESVGALAAVEQRIETLTRDALDVLAAANVHPQA--KA
MUL_3516|M.ulcerans_Agy99 T-DSQVGELREVIVRVGALAAAENRNAGLTRRALATLESIPINASA--KA
MAB_1992c|M.abscessus_ATCC_199 T-DQQVAEMCSLIVDLGALGAVESRIEEHTHRALDQLAGADIADDA--RA
Mb3431c|M.bovis_AF2122/97 ASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRP--AA
Rv3398c|M.tuberculosis_H37Rv ASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRP--AA
MMAR_5095|M.marinum_M LSDHELSYAADLIEDAGGRAWAEGEALRHRGLALDALAAAEPEPTA--AE
MAV_4802|M.avium_104 KSLNDIRWLYELMHRVGSLNHARDVAVRQARQAAAVLAGLDWFPRSRHRD
MLBr_02277|M.leprae_Br4923 DNDAEVVEALALLRASPGMARARQVLAHYADQASGELAQLPDGPSR---D
:: : . . . :
Mflv_2975|M.gilvum_PYR-GCK GLAELARLAANRSA
Mvan_3536|M.vanbaalenii_PYR-1 GLAELARMAANRSA
TH_0708|M.thermoresistible__bu GLSELARSAANRSA
MSMEG_4240|M.smegmatis_MC2_155 GLSELARSAANRTA
MUL_3516|M.ulcerans_Agy99 GLSALARTATDRSA
MAB_1992c|M.abscessus_ATCC_199 ALSDLVRLVSNRSA
Mb3431c|M.bovis_AF2122/97 ELQDLAHYIVDRQA
Rv3398c|M.tuberculosis_H37Rv ELQDLAHYIVDRQA
MMAR_5095|M.marinum_M DLLALAELMTVRAA
MAV_4802|M.avium_104 MLAALVDYVHGRAR
MLBr_02277|M.leprae_Br4923 ALATLVDYTTNRHG
* *. *