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TPSDPLKQQRSLSFGSEAAAYERGRPSYPPEAIDWLLPDGAHDVLDLGAGTGKLTTRLVERGLNVIAVDP LAEMLELLSNSLPDTPALLGTAEEIPLPDNSVDAVLVAQAWHWFDPELAVKEVSRVLRPGGRLGLVWNVR DERLGWVKDLGNIIGHEDPFAHEVTLPAPFTDLERHHVEWTSYLTPQALIDLVASRSYCITSPEQVRTRT LGQVRELLSTHPALANSNGLALPYVTVCMRATLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1650 | - | - | 100% (245) | methyltransferase type 11 |
| M. smegmatis MC2 155 | MSMEG_2632 | - | 2e-10 | 38.54% (96) | SAM-dependent methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1893 | - | 6e-07 | 31.13% (106) | UbiE/COQ5 methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3374 | - | 1e-106 | 77.82% (239) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4877 | - | 1e-113 | 82.92% (240) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3342 | - | 1e-106 | 77.82% (239) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_01723 | - | 7e-07 | 30.95% (126) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_3689 | - | 1e-112 | 84.26% (235) | putative methyltransferase |
| M. marinum M | MMAR_1183 | - | 1e-108 | 81.09% (238) | methyltransferase |
| M. avium 104 | MAV_4317 | - | 1e-107 | 78.99% (238) | putative methyltransferase |
| M. thermoresistible (build 8) | TH_1968 | - | 1e-113 | 83.76% (234) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_1436 | - | 1e-109 | 81.09% (238) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1552 | - | 1e-118 | 86.19% (239) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4877|M.gilvum_PYR-GCK ----------------------MTAE---SDRRSLSFGAEAA--------
Mvan_1552|M.vanbaalenii_PYR-1 ----------------------MTER---PDR-SLSFGAEAA--------
MSMEG_1650|M.smegmatis_MC2_155 ----------------------MTPSDPLKQQRSLSFGSEAA--------
TH_1968|M.thermoresistible__bu ----------------------------------LSFGAEAA--------
Mb3374|M.bovis_AF2122/97 ----------------------MTCS---RRDMSLSFGSAVG--------
Rv3342|M.tuberculosis_H37Rv ----------------------MTCS---RRDMSLSFGSAVG--------
MMAR_1183|M.marinum_M ----------------------MSGS---AQDPSLSFGSAAA--------
MUL_1436|M.ulcerans_Agy99 ---------------------MVSGS---AQDPSLSFGSAAA--------
MAV_4317|M.avium_104 ----------------------MTRS---RHDRSLSFGSAAA--------
MAB_3689|M.abscessus_ATCC_1997 ----------------------MPDA---QAEPSLSFGSQAA--------
MLBr_01723|M.leprae_Br4923 MTRSTEISANAVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSI
* .. .
Mflv_4877|M.gilvum_PYR-GCK AYERGRPSYPPEAIDWLLADSGSRRL---EVLDLGAGTGKLTTRLVERGL
Mvan_1552|M.vanbaalenii_PYR-1 AYERGRPSYPPEAIDWLLPEHAH------DVLDLGAGTGKLTTRLAERGL
MSMEG_1650|M.smegmatis_MC2_155 AYERGRPSYPPEAIDWLLPDGAH------DVLDLGAGTGKLTTRLVERGL
TH_1968|M.thermoresistible__bu AYERGRPSYPPEAIDWLLPSDAR------DVLDLGAGTGKLTTRLVERGL
Mb3374|M.bovis_AF2122/97 AYERGRPSYPPEAIDWLLPAAAR------RVLDLGAGTGKLTTRLVERGL
Rv3342|M.tuberculosis_H37Rv AYERGRPSYPPEAIDWLLPAAAR------RVLDLGAGTGKLTTRLVERGL
MMAR_1183|M.marinum_M AYERGRPSYPPEAIDWLLPAGAR------DVLDLGAGTGKLTTRLVERGL
MUL_1436|M.ulcerans_Agy99 AYERGRPSYPPEAIDWLLPAGAR------DVLDLGAGTGKLTTRLVERGL
MAV_4317|M.avium_104 AYERGRPSYPPEAIDWLLPVGAR------QVLDLGAGTGKLTTRLVERGL
MAB_3689|M.abscessus_ATCC_1997 AYERGRPSYPPEAIDWLLPPGAH------DVLDLGAGTGKLTTRLVERGL
MLBr_01723|M.leprae_Br4923 SYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQSGV
:*:: .* ..:* ::. .*:**.*** : .* : *:
Mflv_4877|M.gilvum_PYR-GCK D--VVAVDPIPEMLDLLRTSLP----DTPALLGTAEEIPLPDDSVDAVLV
Mvan_1552|M.vanbaalenii_PYR-1 A--VVAVDPIPEMLELLSTSLP----DTPALLGTAEEIPLPDDSVDAVLV
MSMEG_1650|M.smegmatis_MC2_155 N--VIAVDPLAEMLELLSNSLP----DTPALLGTAEEIPLPDNSVDAVLV
TH_1968|M.thermoresistible__bu N--VTAVDPIPEMLELLSKSLP----DTPALLGTAEEIPLPDNSVDAVLV
Mb3374|M.bovis_AF2122/97 D--VVAVDPIPEMLDVLRAALP----QTVALLGTAEEIPLDDNSVDAVLV
Rv3342|M.tuberculosis_H37Rv D--VVAVDPIPEMLDVLRAALP----QTVALLGTAEEIPLDDNSVDAVLV
MMAR_1183|M.marinum_M D--VVAVDPIPEMLEVLRASLP----RTLALLGTAEEIPLEDNSVDAVLV
MUL_1436|M.ulcerans_Agy99 D--VVAVDPIPEMLEVLRASLP----RTLALLGTAEEIPLEDNSVDAVLV
MAV_4317|M.avium_104 D--VVAVDPIPDMLEVLRSSLP----ETRALLGTAEEIPLEDNSVDVVLV
MAB_3689|M.abscessus_ATCC_1997 N--VVAVDPLAEMLEVLSNSLP----DTPALLGTAEEIPLPDNSVDAVLV
MLBr_01723|M.leprae_Br4923 ARRGSVTDLSPGMVKIATRNGQSLGLDINGRVADAEGIPYDDNTFDLVVG
..* . *:.: . :. ** ** *::.* *:
Mflv_4877|M.gilvum_PYR-GCK AQAWHWF-DETRAVKEIARVLRPGGSLGLVWNNRDE---------RLGWV
Mvan_1552|M.vanbaalenii_PYR-1 AQAWHWF-DPERAVKEVARVLRPGGRLGLVWNNRDE---------RLGWV
MSMEG_1650|M.smegmatis_MC2_155 AQAWHWF-DPELAVKEVSRVLRPGGRLGLVWNVRDE---------RLGWV
TH_1968|M.thermoresistible__bu AQAWHWF-DVDRAVREVARVLRPGGRLGLVWNTRDE---------RMGWV
Mb3374|M.bovis_AF2122/97 AQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
Rv3342|M.tuberculosis_H37Rv AQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
MMAR_1183|M.marinum_M AQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
MUL_1436|M.ulcerans_Agy99 AQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
MAV_4317|M.avium_104 AQAWHWV-DPERAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
MAB_3689|M.abscessus_ATCC_1997 AQAWHWV-DPERAIPEVARVLRPGGRLGLVWNVRDE---------RLGWV
MLBr_01723|M.leprae_Br4923 HAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFADLTWK
. * . * :: *: ***:*** : :. : * : *
Mflv_4877|M.gilvum_PYR-GCK KDLGDIIGHEGDPWSQSV-ELPAPFTGVERHHVEWTSYLTPQALIDLVAS
Mvan_1552|M.vanbaalenii_PYR-1 KDLGEIIGHEVDPFAQTV-ELPGPFTDVEHHRVEWTSYLTPQALIDLVAS
MSMEG_1650|M.smegmatis_MC2_155 KDLGNIIGHE-DPFAHEV-TLPAPFTDLERHHVEWTSYLTPQALIDLVAS
TH_1968|M.thermoresistible__bu KELGRIIGDEHDPLSKTV-TLPEPFTDVQRHQVEWTNYLTPQALIDLVAS
Mb3374|M.bovis_AF2122/97 RELGEIIGRDGDPVRDRV-TLPEPFTTVQRHQVEWTNYLTPQALIDLVAS
Rv3342|M.tuberculosis_H37Rv RELGEIIGRDGDPVRDRV-TLPEPFTTVQRHQVEWTNYLTPQALIDLVAS
MMAR_1183|M.marinum_M RELGRIIGRDSDPVRDKV-TLPEPFTGVARHHVEWTNYLTPQALIDLVAS
MUL_1436|M.ulcerans_Agy99 RELGRIIGRDSDPVRDKV-TLPEPFTGVARHHVEWTNYLTPQALIDLVAS
MAV_4317|M.avium_104 RELGRIIGSDGD-GRTHV-ALPEPFTDLAHHEVEWTNYLTPQALIDLVAS
MAB_3689|M.abscessus_ATCC_1997 SDLGHIIGHENAADSADVGALPAPFTGQERHQVEWTNYLTPQALLDMVAS
MLBr_01723|M.leprae_Br4923 VTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLETMATN
: : : . * : *:.* :.:.
Mflv_4877|M.gilvum_PYR-GCK R--SYCITSPERVRARTLDR-VRELLTTHP---------ALANSSGLALP
Mvan_1552|M.vanbaalenii_PYR-1 R--SYCITSPEQVRARTLDR-VRELLATHP---------ALASSSGLALP
MSMEG_1650|M.smegmatis_MC2_155 R--SYCITSPEQVRTRTLGQ-VRELLSTHP---------ALANSNGLALP
TH_1968|M.thermoresistible__bu R--SYCITSPAKVRARTLER-VRELLATHP---------ALANNSGLALP
Mb3374|M.bovis_AF2122/97 R--SYCITSPAQVRTKTLDR-VRQLLATHP---------ALANSNGLALP
Rv3342|M.tuberculosis_H37Rv R--SYCITSPAQVRTKTLDR-VRQLLATHP---------ALANSNGLALP
MMAR_1183|M.marinum_M R--SYCITSPAEVRTKTLDQ-VRELLATHP---------ALANSAGLALP
MUL_1436|M.ulcerans_Agy99 R--SYCITSPAEVRTKTLDQ-VRELLATHP---------ALANSAGLALP
MAV_4317|M.avium_104 R--SYCITSPTEVRTRTLDQ-VRHLLATHP---------ALANSTGLALP
MAB_3689|M.abscessus_ATCC_1997 R--SYCITAPEAARKKTLQQ-VRELLATHP---------ALAQSAGLALP
MLBr_01723|M.leprae_Br4923 AGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSWKTLS
* . * :* : :* * :* . :*.
Mflv_4877|M.gilvum_PYR-GCK YVTVCVRATLA----------------
Mvan_1552|M.vanbaalenii_PYR-1 YVTVCTRATLS----------------
MSMEG_1650|M.smegmatis_MC2_155 YVTVCMRATLA----------------
TH_1968|M.thermoresistible__bu YITVCIRATLA----------------
Mb3374|M.bovis_AF2122/97 YVTVCVRATLA----------------
Rv3342|M.tuberculosis_H37Rv YVTVCVRATLA----------------
MMAR_1183|M.marinum_M YVTVCVSATLAA---------------
MUL_1436|M.ulcerans_Agy99 YVTVCVSATLAA---------------
MAV_4317|M.avium_104 YVTRCTRATLAG---------------
MAB_3689|M.abscessus_ATCC_1997 YVTVSIRATLNR---------------
MLBr_01723|M.leprae_Br4923 WVDANVWRRVIPKSWFYNIIITGVKPS
:: :