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MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEKVHAKGKLTARERIYALLDED SFVELDALAKHRSTNFNLGEKRPLGDGVVTGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAI KTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQ TSQMFITGPDVIKTVTGEEVTMEELGGAHTHMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRY QAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITRLLDDEFLEIQAGYAQNIVVGFGRIDGRPVG IVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTDQEYNGIIRRGAKLLYAYGEAT VPKITVITRKAYGGAYCVMGSKDMGCDVNLAWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLR LQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3280 | accD5 | - | 100% (548) | PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 5 ACCD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) |
| M. tuberculosis H37Rv | Rv3799c | accD4 | e-136 | 47.74% (530) | propionyl-CoA carboxylase beta chain |
| M. tuberculosis H37Rv | Rv2247 | accD6 | e-101 | 43.20% (456) | acetyl/propionyl-CoA carboxylase beta subunit AccD6 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3308 | accD5 | 0.0 | 99.82% (548) | propionyl-CoA carboxylase beta chain |
| M. gilvum PYR-GCK | Mflv_4774 | - | 0.0 | 88.27% (537) | carboxyl transferase |
| M. leprae Br4923 | MLBr_00731 | accD5 | 0.0 | 88.71% (549) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_3631 | - | 0.0 | 83.39% (548) | propionyl-CoA carboxylase beta chain 5 AccD5 |
| M. marinum M | MMAR_1256 | accD5 | 0.0 | 92.35% (549) | propionyl-CoA carboxylase beta chain 5 AccD5 |
| M. avium 104 | MAV_4250 | - | 0.0 | 91.07% (549) | propionyl-CoA carboxylase beta chain |
| M. smegmatis MC2 155 | MSMEG_1813 | - | 0.0 | 87.43% (549) | propionyl-CoA carboxylase beta chain |
| M. thermoresistible (build 8) | TH_4304 | - | 0.0 | 89.06% (530) | PUTATIVE propionyl-CoA carboxylase beta chain |
| M. ulcerans Agy99 | MUL_2632 | accD5 | 0.0 | 91.80% (549) | propionyl-CoA carboxylase beta chain 5 AccD5 |
| M. vanbaalenii PYR-1 | Mvan_1677 | - | 0.0 | 86.89% (549) | carboxyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4774|M.gilvum_PYR-GCK ---MTE-------PEASHEIDIHTTAGKLADLRKRAEEALHPVGEAAVEK
Mvan_1677|M.vanbaalenii_PYR-1 MTSVTE-------PSAEHEIDIHTTAGKLADLRKRAAEAQHPVGETAVEK
MSMEG_1813|M.smegmatis_MC2_155 MTSVTE-------PSAEHQVDIHTTAGKLADLKRRTEETLHPVGEAAVDK
Rv3280|M.tuberculosis_H37Rv MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEK
Mb3308|M.bovis_AF2122/97 MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEK
MLBr_00731|M.leprae_Br4923 MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEK
MMAR_1256|M.marinum_M MTSVTD---HTAEPAAEHTIDIHTTAGKLAELHKRRAESLHPVGEGAIEK
MUL_2632|M.ulcerans_Agy99 MTSVTD---HTAEPAAEHTIDIHTTAGKLAELHKRRAESLHPVGEGAIEK
MAV_4250|M.avium_104 MTSVTD---HTAEPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEK
TH_4304|M.thermoresistible__bu ------------------VVDLRTTAGKLADLRRRKAEAQFPVGEAAVEK
MAB_3631|M.abscessus_ATCC_1997 -MTTTESDSHTAADAAAPQPDIHTTAGKLADLRRRNEEALHPVGEAAVDK
:::*******:*::* *: .*** *.:*
Mflv_4774|M.gilvum_PYR-GCK VHAKGKLTARERILALLDEGSFVELDALAKHRSKNFGLEKNRPTGDGVVT
Mvan_1677|M.vanbaalenii_PYR-1 VHAKGKLTARERILALLDEGSFVELDALAKHRSKNFGLEHNRPTGDGVVT
MSMEG_1813|M.smegmatis_MC2_155 VHAKGKLTARERILALLDEGSFVELDALAKHRSTNFGLEKNRPLGDGVIT
Rv3280|M.tuberculosis_H37Rv VHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVT
Mb3308|M.bovis_AF2122/97 VHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVT
MLBr_00731|M.leprae_Br4923 VHAKGKFTARERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVT
MMAR_1256|M.marinum_M VHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFGLESNRPVGDGVVT
MUL_2632|M.ulcerans_Agy99 VHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFGLESNRPVGDGVVT
MAV_4250|M.avium_104 VHAKGKLTARERILALLDEDSFVELDALARHRSKNFGLENNRPLGDGVIT
TH_4304|M.thermoresistible__bu VHAKGKLTARERVLALLDEGSFVELDQLARHRSTNFGLADKRPLGDGVVT
MAB_3631|M.abscessus_ATCC_1997 IHAKGKLTARERIFALLDEGSFVELDALARHRSTNFGLESKRPLGDGVVT
:*****:*****: ****:.****** **:***.**.* :** ****:*
Mflv_4774|M.gilvum_PYR-GCK GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
Mvan_1677|M.vanbaalenii_PYR-1 GYGTIDGRDVCVFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MSMEG_1813|M.smegmatis_MC2_155 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
Rv3280|M.tuberculosis_H37Rv GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
Mb3308|M.bovis_AF2122/97 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MLBr_00731|M.leprae_Br4923 GYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MMAR_1256|M.marinum_M GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAVKTGRPLIGIN
MUL_2632|M.ulcerans_Agy99 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAVKTGRPLIGIN
MAV_4250|M.avium_104 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
TH_4304|M.thermoresistible__bu GYGTIDGREVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MAB_3631|M.abscessus_ATCC_1997 GFGTIDGRDVCIFSQDVSVFGGSLGEVYGEKIVKVMDLAIKTGRPLIGIN
*:******:**:****.:***************** :**:**********
Mflv_4774|M.gilvum_PYR-GCK DGAGARIQEGVVSLGLYSKIFHNNIKASGVIPQISLIMGAAAGGHVYSPA
Mvan_1677|M.vanbaalenii_PYR-1 DGAGARIQEGVVSLGLYSRIFHNNIKASGVIPQISLIMGAAAGGHVYSPA
MSMEG_1813|M.smegmatis_MC2_155 DGAGARIQEGVVSLGLYSRIFHNNIKASGVIPQISLIMGAAAGGHVYSPA
Rv3280|M.tuberculosis_H37Rv DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
Mb3308|M.bovis_AF2122/97 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
MLBr_00731|M.leprae_Br4923 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
MMAR_1256|M.marinum_M DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
MUL_2632|M.ulcerans_Agy99 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
MAV_4250|M.avium_104 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
TH_4304|M.thermoresistible__bu DGAGARIQEGVVSLSLYSRIFHNNIRASGVIPQISLIMGAAAGGHVYSPA
MAB_3631|M.abscessus_ATCC_1997 EGAGARIQEGVVSLGLYGQIFHRNVIASGVIPQISLIMGPAAGGHVYSPA
:*************.**.:**:.*: *************.**********
Mflv_4774|M.gilvum_PYR-GCK LTDFVIMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTVHY
Mvan_1677|M.vanbaalenii_PYR-1 LTDFVIMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTVHY
MSMEG_1813|M.smegmatis_MC2_155 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
Rv3280|M.tuberculosis_H37Rv LTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHTHMAKSGTAHY
Mb3308|M.bovis_AF2122/97 LTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHTHMAKSGTAHY
MLBr_00731|M.leprae_Br4923 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
MMAR_1256|M.marinum_M LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMVKSGTAHY
MUL_2632|M.ulcerans_Agy99 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEEIGGAHTHMVKSGTAHY
MAV_4250|M.avium_104 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTLHY
TH_4304|M.thermoresistible__bu LTDFVIMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
MAB_3631|M.abscessus_ATCC_1997 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
*****:**********************:*****:*******.**** **
Mflv_4774|M.gilvum_PYR-GCK VASGEQDALDYVRDLLSYLPPNNYAEPPRYPAPIS--GPIEENLTDEDLE
Mvan_1677|M.vanbaalenii_PYR-1 VASGEQDALDYVRDLLSYLPPNNYAEPPRYPAPHAD-APIEESLTDEDLE
MSMEG_1813|M.smegmatis_MC2_155 VASGEQDAFDYVRDLLSYLPPNNYADPPLYPVAIPE-GSIEETLTDEDLE
Rv3280|M.tuberculosis_H37Rv AASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPT-GPIEENLTDEDLE
Mb3308|M.bovis_AF2122/97 AASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPT-GPIEENLTDEDLE
MLBr_00731|M.leprae_Br4923 VASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPH-GSIEDNLTAKDLE
MMAR_1256|M.marinum_M VASGEQDAFEYVRELLSYLPPNNATDAPRYPAPAPE-GPIEENLTDEDLE
MUL_2632|M.ulcerans_Agy99 VASGEQDAFEYVRELLSYLPPNNATDAPRYPAPAPE-GPIEENLTDEDLE
MAV_4250|M.avium_104 VASGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPA-GAIEDNLTDEDLE
TH_4304|M.thermoresistible__bu VASGEQDAFDYVRDLLSYLPPNNYADPPRYPAPVQH-GAIEDNLTDTDLE
MAB_3631|M.abscessus_ATCC_1997 VASGEQDAFDYVRDILSYLPSNNASEPPRYPGPEPTDGAIEDHLTEEDLE
.*******:::**::*****.** ::.* * . ..**: ** ***
Mflv_4774|M.gilvum_PYR-GCK LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAGNIVVGFGRVDGRP
Mvan_1677|M.vanbaalenii_PYR-1 LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAGNIVIGFGRVDGRP
MSMEG_1813|M.smegmatis_MC2_155 LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAGNIVVGFGRVEGRP
Rv3280|M.tuberculosis_H37Rv LDTLIPDSPNQPYDMHEVITRLLDD-EFLEIQAGYAQNIVVGFGRIDGRP
Mb3308|M.bovis_AF2122/97 LDTLIPDSPNQPYDMHEVITRLLDD-EFLEIQAGYAQNIVVGFGRIDGRP
MLBr_00731|M.leprae_Br4923 LDTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRIDDRP
MMAR_1256|M.marinum_M LDTLIPDSPNQPYDMHEVITRILDEDEFLEIQAGYAQNIVVGFGRIEGRP
MUL_2632|M.ulcerans_Agy99 LDTLIPDSPNQPYDMHEVITRILDEDEFLEIQAGYAQNIVVGFGRIEGRP
MAV_4250|M.avium_104 LDTLIPDSPNQPYDMHEVITRILDDDEFLEIQGGYAQNIVVGFGRIDGRP
TH_4304|M.thermoresistible__bu LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAQNIIVGFGRVDGRP
MAB_3631|M.abscessus_ATCC_1997 LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAQNIIVGFGRIDGRS
******************:**:**: ****:*.*** **::*:**::.*.
Mflv_4774|M.gilvum_PYR-GCK VGIVANQPTQFAGCLDINASEKAARFIRTCDCYNIPIVLLVDVPGFLPGT
Mvan_1677|M.vanbaalenii_PYR-1 VGIVANQPTQFAGCLDINASEKAARFIRTCDCFNIPIVLLVDVPGFLPGT
MSMEG_1813|M.smegmatis_MC2_155 VGIVANQPTQFAGCLDINASEKAARFIRTCDCFNIPIVLLVDVPGFLPGT
Rv3280|M.tuberculosis_H37Rv VGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
Mb3308|M.bovis_AF2122/97 VGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
MLBr_00731|M.leprae_Br4923 VGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGT
MMAR_1256|M.marinum_M VGIVANQPTHFAGCLDIDASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
MUL_2632|M.ulcerans_Agy99 VGIVANQPTHFAGCLDIDASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
MAV_4250|M.avium_104 VGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIIMLVDVPGFLPGT
TH_4304|M.thermoresistible__bu VGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
MAB_3631|M.abscessus_ATCC_1997 VGIVANQPTQFAGCLDINASEKAARFIRTCDCFGIPIITLEDVPGFLPGT
******** :*******:********:*.***:.***: * *********
Mflv_4774|M.gilvum_PYR-GCK DQEYNGIIRRGAKLLYAYGEATVAKVTVITRKSYGGAYCVMGSKDMGADV
Mvan_1677|M.vanbaalenii_PYR-1 DQEYNGIIRRGAKLLYAYGEATVAKVTVITRKSYGGAYCVMGSKDMGADV
MSMEG_1813|M.smegmatis_MC2_155 DQEYNGIIRRGAKLLYAYGEATVAKVTVITRKSYGGAYCVMGSKDMGADV
Rv3280|M.tuberculosis_H37Rv DQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDV
Mb3308|M.bovis_AF2122/97 DQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDA
MLBr_00731|M.leprae_Br4923 EQEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGCDV
MMAR_1256|M.marinum_M GQEYNGIIRRGAKLLYAYGEATVPKVTVITRKAYGGAYCVMGSKDMGCDV
MUL_2632|M.ulcerans_Agy99 GQEYNGIIRRGAKLLYAYGEATVPKVTVITRKAYGGAYCVMGSKDMGCDV
MAV_4250|M.avium_104 GQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDV
TH_4304|M.thermoresistible__bu DQEYNGIIRRGAKLLYAYGEATVAKITVITRKAYGGAYCVMGSKDMGADV
MAB_3631|M.abscessus_ATCC_1997 EQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYDVMGSKHMGADV
***:**********:*******.*:******:***** *****.**.*.
Mflv_4774|M.gilvum_PYR-GCK VVAWPTAQIAVMGASGAVGFVYRGQLKEAAANGEDVDALRLKLQQEYEDT
Mvan_1677|M.vanbaalenii_PYR-1 VVAWPTAQIAVMGASGAVGFVYRQQLREAAANGEDVDALRLKLQQEYEDT
MSMEG_1813|M.smegmatis_MC2_155 VVAWPTAQIAVMGASGAVGFVYRQQLKEAAKNGEDVDALRLELQQTYEDT
Rv3280|M.tuberculosis_H37Rv NLAWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDT
Mb3308|M.bovis_AF2122/97 NLAWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDT
MLBr_00731|M.leprae_Br4923 NLAWPTAQIAVMGASGAVGFVYRKELAQAAKNGANVDELRLQLQQEYEDT
MMAR_1256|M.marinum_M NLAWPTAQIAVMGASGAVGFVYRQQLKEAAEAGKDVDALRLQLQQEYEDT
MUL_2632|M.ulcerans_Agy99 NLAWPTAQIAVMGASGAVGFVYRQQLKKAAEAGKDVDALLLQLQQEYEDT
MAV_4250|M.avium_104 NIAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGEDVDALRLQLQQEYEDT
TH_4304|M.thermoresistible__bu CVAWPTAQIAVMGASGAVGFVYRPQLAEAAKKGEDVDALRLRLQQEYEDT
MAB_3631|M.abscessus_ATCC_1997 NVAWPTAQIAVMGASGAVGFVYRSQLAEAAKNGDDVDALRLQLQAEYEDT
:***:***************** :* :** * ::* * *.** ****
Mflv_4774|M.gilvum_PYR-GCK LVNPYIAAERGYVDAVIPPSHTRGYVATALKLLERKVVQTPPKKHGNIPL
Mvan_1677|M.vanbaalenii_PYR-1 LVNPYIAAERGYVDAVILPSHTRGYVATALKLLERKVVQTPPKKHGNIPL
MSMEG_1813|M.smegmatis_MC2_155 LVNPYIAAERGYVDAVIPPSHTRGYVANALRLLERKIVQMPPKKHGNIPL
Rv3280|M.tuberculosis_H37Rv LVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL
Mb3308|M.bovis_AF2122/97 LVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL
MLBr_00731|M.leprae_Br4923 LVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLPPKKHGNIPL
MMAR_1256|M.marinum_M LVNPYIAAERGYVDAVIPPSYTRGYIGTALRLLERKIAQQPPKKHGNIPL
MUL_2632|M.ulcerans_Agy99 LVNPYIAAERGYVDAVIPPSYTRGYIGTALRLLERKIAQQPPKKHGNIPL
MAV_4250|M.avium_104 LVNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPPKKHGNIPL
TH_4304|M.thermoresistible__bu LVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLERKIAQVPPKKHGNIPL
MAB_3631|M.abscessus_ATCC_1997 LVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLDRKIVRLPPKKHGNIPL
*****:*********** **:****:..:*:**:**:.: *******:**