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TSVTEPSAEHEIDIHTTAGKLADLRKRAAEAQHPVGETAVEKVHAKGKLTARERILALLDEGSFVELDAL AKHRSKNFGLEHNRPTGDGVVTGYGTIDGRDVCVFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIG INDGAGARIQEGVVSLGLYSRIFHNNIKASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITG PDVIKTVTGEDVTMEELGGAHTHMAKSGTVHYVASGEQDALDYVRDLLSYLPPNNYAEPPRYPAPHADAP IEESLTDEDLELDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAGNIVIGFGRVDGRPVGIVANQPT QFAGCLDINASEKAARFIRTCDCFNIPIVLLVDVPGFLPGTDQEYNGIIRRGAKLLYAYGEATVAKVTVI TRKSYGGAYCVMGSKDMGADVVVAWPTAQIAVMGASGAVGFVYRQQLREAAANGEDVDALRLKLQQEYED TLVNPYIAAERGYVDAVILPSHTRGYVATALKLLERKVVQTPPKKHGNIPL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1677 | - | - | 100% (542) | carboxyl transferase |
| M. vanbaalenii PYR-1 | Mvan_5639 | - | e-133 | 49.24% (528) | carboxyl transferase |
| M. vanbaalenii PYR-1 | Mvan_3758 | - | 2e-98 | 42.98% (456) | propionyl-CoA carboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3308 | accD5 | 0.0 | 86.70% (549) | propionyl-CoA carboxylase beta chain |
| M. gilvum PYR-GCK | Mflv_4774 | - | 0.0 | 96.66% (539) | carboxyl transferase |
| M. tuberculosis H37Rv | Rv3280 | accD5 | 0.0 | 86.89% (549) | propionyl-CoA carboxylase beta chain |
| M. leprae Br4923 | MLBr_00731 | accD5 | 0.0 | 83.24% (549) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_3631 | - | 0.0 | 85.63% (536) | propionyl-CoA carboxylase beta chain 5 AccD5 |
| M. marinum M | MMAR_1256 | accD5 | 0.0 | 87.91% (546) | propionyl-CoA carboxylase beta chain 5 AccD5 |
| M. avium 104 | MAV_4250 | - | 0.0 | 88.10% (546) | propionyl-CoA carboxylase beta chain |
| M. smegmatis MC2 155 | MSMEG_1813 | - | 0.0 | 92.80% (542) | propionyl-CoA carboxylase beta chain |
| M. thermoresistible (build 8) | TH_4304 | - | 0.0 | 90.57% (530) | PUTATIVE propionyl-CoA carboxylase beta chain |
| M. ulcerans Agy99 | MUL_2632 | accD5 | 0.0 | 87.36% (546) | propionyl-CoA carboxylase beta chain 5 AccD5 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1677|M.vanbaalenii_PYR-1 MTSVTE-------PSAEHEIDIHTTAGKLADLRKRAAEAQHPVGETAVEK
Mflv_4774|M.gilvum_PYR-GCK ---MTE-------PEASHEIDIHTTAGKLADLRKRAEEALHPVGEAAVEK
MSMEG_1813|M.smegmatis_MC2_155 MTSVTE-------PSAEHQVDIHTTAGKLADLKRRTEETLHPVGEAAVDK
Mb3308|M.bovis_AF2122/97 MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEK
Rv3280|M.tuberculosis_H37Rv MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEK
MLBr_00731|M.leprae_Br4923 MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEK
MMAR_1256|M.marinum_M MTSVTD---HTAEPAAEHTIDIHTTAGKLAELHKRRAESLHPVGEGAIEK
MUL_2632|M.ulcerans_Agy99 MTSVTD---HTAEPAAEHTIDIHTTAGKLAELHKRRAESLHPVGEGAIEK
MAV_4250|M.avium_104 MTSVTD---HTAEPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEK
TH_4304|M.thermoresistible__bu ------------------VVDLRTTAGKLADLRRRKAEAQFPVGEAAVEK
MAB_3631|M.abscessus_ATCC_1997 -MTTTESDSHTAADAAAPQPDIHTTAGKLADLRRRNEEALHPVGEAAVDK
:::*******:*::* *: .*** *.:*
Mvan_1677|M.vanbaalenii_PYR-1 VHAKGKLTARERILALLDEGSFVELDALAKHRSKNFGLEHNRPTGDGVVT
Mflv_4774|M.gilvum_PYR-GCK VHAKGKLTARERILALLDEGSFVELDALAKHRSKNFGLEKNRPTGDGVVT
MSMEG_1813|M.smegmatis_MC2_155 VHAKGKLTARERILALLDEGSFVELDALAKHRSTNFGLEKNRPLGDGVIT
Mb3308|M.bovis_AF2122/97 VHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVT
Rv3280|M.tuberculosis_H37Rv VHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVT
MLBr_00731|M.leprae_Br4923 VHAKGKFTARERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVT
MMAR_1256|M.marinum_M VHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFGLESNRPVGDGVVT
MUL_2632|M.ulcerans_Agy99 VHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFGLESNRPVGDGVVT
MAV_4250|M.avium_104 VHAKGKLTARERILALLDEDSFVELDALARHRSKNFGLENNRPLGDGVIT
TH_4304|M.thermoresistible__bu VHAKGKLTARERVLALLDEGSFVELDQLARHRSTNFGLADKRPLGDGVVT
MAB_3631|M.abscessus_ATCC_1997 IHAKGKLTARERIFALLDEGSFVELDALARHRSTNFGLESKRPLGDGVVT
:*****:*****: ****:.****** **:***.**.* :** ****:*
Mvan_1677|M.vanbaalenii_PYR-1 GYGTIDGRDVCVFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
Mflv_4774|M.gilvum_PYR-GCK GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MSMEG_1813|M.smegmatis_MC2_155 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
Mb3308|M.bovis_AF2122/97 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
Rv3280|M.tuberculosis_H37Rv GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MLBr_00731|M.leprae_Br4923 GYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MMAR_1256|M.marinum_M GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAVKTGRPLIGIN
MUL_2632|M.ulcerans_Agy99 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAVKTGRPLIGIN
MAV_4250|M.avium_104 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
TH_4304|M.thermoresistible__bu GYGTIDGREVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MAB_3631|M.abscessus_ATCC_1997 GFGTIDGRDVCIFSQDVSVFGGSLGEVYGEKIVKVMDLAIKTGRPLIGIN
*:******:**:****.:***************** :**:**********
Mvan_1677|M.vanbaalenii_PYR-1 DGAGARIQEGVVSLGLYSRIFHNNIKASGVIPQISLIMGAAAGGHVYSPA
Mflv_4774|M.gilvum_PYR-GCK DGAGARIQEGVVSLGLYSKIFHNNIKASGVIPQISLIMGAAAGGHVYSPA
MSMEG_1813|M.smegmatis_MC2_155 DGAGARIQEGVVSLGLYSRIFHNNIKASGVIPQISLIMGAAAGGHVYSPA
Mb3308|M.bovis_AF2122/97 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
Rv3280|M.tuberculosis_H37Rv DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
MLBr_00731|M.leprae_Br4923 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
MMAR_1256|M.marinum_M DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
MUL_2632|M.ulcerans_Agy99 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
MAV_4250|M.avium_104 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
TH_4304|M.thermoresistible__bu DGAGARIQEGVVSLSLYSRIFHNNIRASGVIPQISLIMGAAAGGHVYSPA
MAB_3631|M.abscessus_ATCC_1997 EGAGARIQEGVVSLGLYGQIFHRNVIASGVIPQISLIMGPAAGGHVYSPA
:*************.**.:**:.*: *************.**********
Mvan_1677|M.vanbaalenii_PYR-1 LTDFVIMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTVHY
Mflv_4774|M.gilvum_PYR-GCK LTDFVIMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTVHY
MSMEG_1813|M.smegmatis_MC2_155 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
Mb3308|M.bovis_AF2122/97 LTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHTHMAKSGTAHY
Rv3280|M.tuberculosis_H37Rv LTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHTHMAKSGTAHY
MLBr_00731|M.leprae_Br4923 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
MMAR_1256|M.marinum_M LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMVKSGTAHY
MUL_2632|M.ulcerans_Agy99 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEEIGGAHTHMVKSGTAHY
MAV_4250|M.avium_104 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTLHY
TH_4304|M.thermoresistible__bu LTDFVIMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
MAB_3631|M.abscessus_ATCC_1997 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
*****:**********************:*****:*******.**** **
Mvan_1677|M.vanbaalenii_PYR-1 VASGEQDALDYVRDLLSYLPPNNYAEPPRYPAPHAD-APIEESLTDEDLE
Mflv_4774|M.gilvum_PYR-GCK VASGEQDALDYVRDLLSYLPPNNYAEPPRYPAPIS--GPIEENLTDEDLE
MSMEG_1813|M.smegmatis_MC2_155 VASGEQDAFDYVRDLLSYLPPNNYADPPLYPVAIPE-GSIEETLTDEDLE
Mb3308|M.bovis_AF2122/97 AASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPT-GPIEENLTDEDLE
Rv3280|M.tuberculosis_H37Rv AASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPT-GPIEENLTDEDLE
MLBr_00731|M.leprae_Br4923 VASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPH-GSIEDNLTAKDLE
MMAR_1256|M.marinum_M VASGEQDAFEYVRELLSYLPPNNATDAPRYPAPAPE-GPIEENLTDEDLE
MUL_2632|M.ulcerans_Agy99 VASGEQDAFEYVRELLSYLPPNNATDAPRYPAPAPE-GPIEENLTDEDLE
MAV_4250|M.avium_104 VASGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPA-GAIEDNLTDEDLE
TH_4304|M.thermoresistible__bu VASGEQDAFDYVRDLLSYLPPNNYADPPRYPAPVQH-GAIEDNLTDTDLE
MAB_3631|M.abscessus_ATCC_1997 VASGEQDAFDYVRDILSYLPSNNASEPPRYPGPEPTDGAIEDHLTEEDLE
.*******:::**::*****.** ::.* * . ..**: ** ***
Mvan_1677|M.vanbaalenii_PYR-1 LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAGNIVIGFGRVDGRP
Mflv_4774|M.gilvum_PYR-GCK LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAGNIVVGFGRVDGRP
MSMEG_1813|M.smegmatis_MC2_155 LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAGNIVVGFGRVEGRP
Mb3308|M.bovis_AF2122/97 LDTLIPDSPNQPYDMHEVITRLLDD-EFLEIQAGYAQNIVVGFGRIDGRP
Rv3280|M.tuberculosis_H37Rv LDTLIPDSPNQPYDMHEVITRLLDD-EFLEIQAGYAQNIVVGFGRIDGRP
MLBr_00731|M.leprae_Br4923 LDTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRIDDRP
MMAR_1256|M.marinum_M LDTLIPDSPNQPYDMHEVITRILDEDEFLEIQAGYAQNIVVGFGRIEGRP
MUL_2632|M.ulcerans_Agy99 LDTLIPDSPNQPYDMHEVITRILDEDEFLEIQAGYAQNIVVGFGRIEGRP
MAV_4250|M.avium_104 LDTLIPDSPNQPYDMHEVITRILDDDEFLEIQGGYAQNIVVGFGRIDGRP
TH_4304|M.thermoresistible__bu LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAQNIIVGFGRVDGRP
MAB_3631|M.abscessus_ATCC_1997 LDTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAQNIIVGFGRIDGRS
******************:**:**: ****:*.*** **::*:**::.*.
Mvan_1677|M.vanbaalenii_PYR-1 VGIVANQPTQFAGCLDINASEKAARFIRTCDCFNIPIVLLVDVPGFLPGT
Mflv_4774|M.gilvum_PYR-GCK VGIVANQPTQFAGCLDINASEKAARFIRTCDCYNIPIVLLVDVPGFLPGT
MSMEG_1813|M.smegmatis_MC2_155 VGIVANQPTQFAGCLDINASEKAARFIRTCDCFNIPIVLLVDVPGFLPGT
Mb3308|M.bovis_AF2122/97 VGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
Rv3280|M.tuberculosis_H37Rv VGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
MLBr_00731|M.leprae_Br4923 VGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGT
MMAR_1256|M.marinum_M VGIVANQPTHFAGCLDIDASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
MUL_2632|M.ulcerans_Agy99 VGIVANQPTHFAGCLDIDASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
MAV_4250|M.avium_104 VGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIIMLVDVPGFLPGT
TH_4304|M.thermoresistible__bu VGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGT
MAB_3631|M.abscessus_ATCC_1997 VGIVANQPTQFAGCLDINASEKAARFIRTCDCFGIPIITLEDVPGFLPGT
******** :*******:********:*.***:.***: * *********
Mvan_1677|M.vanbaalenii_PYR-1 DQEYNGIIRRGAKLLYAYGEATVAKVTVITRKSYGGAYCVMGSKDMGADV
Mflv_4774|M.gilvum_PYR-GCK DQEYNGIIRRGAKLLYAYGEATVAKVTVITRKSYGGAYCVMGSKDMGADV
MSMEG_1813|M.smegmatis_MC2_155 DQEYNGIIRRGAKLLYAYGEATVAKVTVITRKSYGGAYCVMGSKDMGADV
Mb3308|M.bovis_AF2122/97 DQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDA
Rv3280|M.tuberculosis_H37Rv DQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDV
MLBr_00731|M.leprae_Br4923 EQEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGCDV
MMAR_1256|M.marinum_M GQEYNGIIRRGAKLLYAYGEATVPKVTVITRKAYGGAYCVMGSKDMGCDV
MUL_2632|M.ulcerans_Agy99 GQEYNGIIRRGAKLLYAYGEATVPKVTVITRKAYGGAYCVMGSKDMGCDV
MAV_4250|M.avium_104 GQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDV
TH_4304|M.thermoresistible__bu DQEYNGIIRRGAKLLYAYGEATVAKITVITRKAYGGAYCVMGSKDMGADV
MAB_3631|M.abscessus_ATCC_1997 EQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYDVMGSKHMGADV
***:**********:*******.*:******:***** *****.**.*.
Mvan_1677|M.vanbaalenii_PYR-1 VVAWPTAQIAVMGASGAVGFVYRQQLREAAANGEDVDALRLKLQQEYEDT
Mflv_4774|M.gilvum_PYR-GCK VVAWPTAQIAVMGASGAVGFVYRGQLKEAAANGEDVDALRLKLQQEYEDT
MSMEG_1813|M.smegmatis_MC2_155 VVAWPTAQIAVMGASGAVGFVYRQQLKEAAKNGEDVDALRLELQQTYEDT
Mb3308|M.bovis_AF2122/97 NLAWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDT
Rv3280|M.tuberculosis_H37Rv NLAWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDT
MLBr_00731|M.leprae_Br4923 NLAWPTAQIAVMGASGAVGFVYRKELAQAAKNGANVDELRLQLQQEYEDT
MMAR_1256|M.marinum_M NLAWPTAQIAVMGASGAVGFVYRQQLKEAAEAGKDVDALRLQLQQEYEDT
MUL_2632|M.ulcerans_Agy99 NLAWPTAQIAVMGASGAVGFVYRQQLKKAAEAGKDVDALLLQLQQEYEDT
MAV_4250|M.avium_104 NIAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGEDVDALRLQLQQEYEDT
TH_4304|M.thermoresistible__bu CVAWPTAQIAVMGASGAVGFVYRPQLAEAAKKGEDVDALRLRLQQEYEDT
MAB_3631|M.abscessus_ATCC_1997 NVAWPTAQIAVMGASGAVGFVYRSQLAEAAKNGDDVDALRLQLQAEYEDT
:***:***************** :* :** * ::* * *.** ****
Mvan_1677|M.vanbaalenii_PYR-1 LVNPYIAAERGYVDAVILPSHTRGYVATALKLLERKVVQTPPKKHGNIPL
Mflv_4774|M.gilvum_PYR-GCK LVNPYIAAERGYVDAVIPPSHTRGYVATALKLLERKVVQTPPKKHGNIPL
MSMEG_1813|M.smegmatis_MC2_155 LVNPYIAAERGYVDAVIPPSHTRGYVANALRLLERKIVQMPPKKHGNIPL
Mb3308|M.bovis_AF2122/97 LVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL
Rv3280|M.tuberculosis_H37Rv LVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL
MLBr_00731|M.leprae_Br4923 LVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLPPKKHGNIPL
MMAR_1256|M.marinum_M LVNPYIAAERGYVDAVIPPSYTRGYIGTALRLLERKIAQQPPKKHGNIPL
MUL_2632|M.ulcerans_Agy99 LVNPYIAAERGYVDAVIPPSYTRGYIGTALRLLERKIAQQPPKKHGNIPL
MAV_4250|M.avium_104 LVNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPPKKHGNIPL
TH_4304|M.thermoresistible__bu LVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLERKIAQVPPKKHGNIPL
MAB_3631|M.abscessus_ATCC_1997 LVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLDRKIVRLPPKKHGNIPL
*****:*********** **:****:..:*:**:**:.: *******:**