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TVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFMEIGALCRTPGDP NALYGDGVVTGHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDA VTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMFVTGPDVIKDVTGEDV SLDELGGADHQASYGNIHQVVESEAAAYQYVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPD SDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMSGAIDNEASDKAARFI RFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLT ADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAERGFIDAVIDPH ETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3799c | accD4 | - | 100% (522) | PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 4 ACCD4 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) |
| M. tuberculosis H37Rv | Rv3280 | accD5 | e-136 | 47.74% (530) | propionyl-CoA carboxylase beta chain |
| M. tuberculosis H37Rv | Rv2247 | accD6 | 6e-74 | 37.38% (428) | acetyl/propionyl-CoA carboxylase beta subunit AccD6 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3829c | accD4 | 0.0 | 100.00% (522) | propionyl-CoA carboxylase beta chain |
| M. gilvum PYR-GCK | Mflv_1170 | - | 0.0 | 83.63% (513) | carboxyl transferase |
| M. leprae Br4923 | MLBr_00102 | accD4 | 0.0 | 91.09% (516) | putative acyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_0181 | - | 0.0 | 75.49% (514) | propionyl-CoA carboxylase, beta subunit (PccB) |
| M. marinum M | MMAR_5363 | accD4_1 | 0.0 | 90.52% (517) | propionyl-CoA carboxylase beta chain 4 AccD4_1 |
| M. avium 104 | MAV_0220 | - | 0.0 | 85.11% (517) | propionyl-CoA carboxylase beta chain |
| M. smegmatis MC2 155 | MSMEG_6391 | - | 0.0 | 81.48% (513) | propionyl-CoA carboxylase beta chain |
| M. thermoresistible (build 8) | TH_1608 | - | 0.0 | 84.21% (513) | PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 4 ACCD4 (PCCASE) |
| M. ulcerans Agy99 | MUL_4982 | accD4_1 | 0.0 | 90.12% (516) | propionyl-CoA carboxylase beta chain 4 AccD4_1 |
| M. vanbaalenii PYR-1 | Mvan_5639 | - | 0.0 | 83.82% (513) | carboxyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1170|M.gilvum_PYR-GCK ---------MTERTTAELLAELREKLELAKEPGGEKAVAKREKKGIPSAR
Mvan_5639|M.vanbaalenii_PYR-1 ---------MTERTTAELLAELREKLELAKEPGGEKAVAKREKKGIPSAR
Rv3799c|M.tuberculosis_H37Rv ----MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSAR
Mb3829c|M.bovis_AF2122/97 ----MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSAR
MLBr_00102|M.leprae_Br4923 ---------MIMKSTAEKLAELRVRLELANEPGGEKAAAKRDKKNIPSAR
MMAR_5363|M.marinum_M MTDTAPGPAPVVHSTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSAR
MUL_4982|M.ulcerans_Agy99 ----------MVHSTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSAR
MAV_0220|M.avium_104 --MTEMAPAPIQHTTAEKLAELYRRLELAKEPGGEKAAAKRDKKGIPSAR
TH_1608|M.thermoresistible__bu --VSQESGLRPPKTTAEQLAELREKLEQAKEPGGAKAAAKRDAKGIPSPR
MSMEG_6391|M.smegmatis_MC2_155 ---------MTNKTTAELLAELREKLELAKEPGGEKAVAKREKKGIPSAR
MAB_0181|M.abscessus_ATCC_1997 ---------MPPHTTAEKLADLRERIALTREPGDAKAIARRDKKGIPSAR
::*** **:* :: :.***. ** *:*: *.***.*
Mflv_1170|M.gilvum_PYR-GCK ARIHSLLDPGSFLEIGALAKTPGDPDALYGDGVVTGHGTINGRPVGVFSH
Mvan_5639|M.vanbaalenii_PYR-1 ARIHALLDPGSFLEIGALAKTPGDPDALYGDGVVTGHGTINGRPVGVFSH
Rv3799c|M.tuberculosis_H37Rv ARIYELVDPGSFMEIGALCRTPGDPNALYGDGVVTGHGLINGRPVGVFSH
Mb3829c|M.bovis_AF2122/97 ARIYELVDPGSFMEIGALCRTPGDPNALYGDGVVTGHGLINGRPVGVFSH
MLBr_00102|M.leprae_Br4923 ARIYALVDPGTFLEIGALTRTPGDPNALYGDGVVTGHGLINGRQVGVFSH
MMAR_5363|M.marinum_M ARVHALVDPGTFFETGALCKTPGDPGALYGDGVVTGHAMIDGRPVGVFSH
MUL_4982|M.ulcerans_Agy99 ARVHALVDPGTFFETGALCKTPGDPGALYGDGVVTGHAMIDGRPVGVFSH
MAV_0220|M.avium_104 ARIHALVDPGTFLETGALAKTPNDPNALYGDGCVTGHAMIDGRPVGLFSH
TH_1608|M.thermoresistible__bu ARIHALLDPGSFVEIGMLAKTPGDPNALYGDGVVTGHGTIDGRPVGVFSH
MSMEG_6391|M.smegmatis_MC2_155 ARINALLDPGSFIEIGALAKTPGDPNALYGDGVVTGRGTIDGRPVGVFSH
MAB_0181|M.abscessus_ATCC_1997 ARIDALLDKGSFLELDAFARTPGDANAPYTDGVVTGLGRIDGRPVAVFSH
**: *:* *:*.* . : :**.*..* * ** *** . *:** *.:***
Mflv_1170|M.gilvum_PYR-GCK DQTVFQGSVGEMFGRKVAKLMEWVAMVGCPIIGINDSAGARIQDTATSLA
Mvan_5639|M.vanbaalenii_PYR-1 DQTVFQGSVGEMFGRKVARLMEWVAMVGCPIIGINDSAGARIQDTATSLA
Rv3799c|M.tuberculosis_H37Rv DQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDAVTSLA
Mb3829c|M.bovis_AF2122/97 DQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDAVTSLA
MLBr_00102|M.leprae_Br4923 DQTVFGGTVGEMFGRKVARLMEWCAMAGCPIVGINDSGGARIQDAVTSLA
MMAR_5363|M.marinum_M DQTVFQGSVGEMFGRKVARLMEWCSMVGCPIIGINDSAGARIQDTATSLA
MUL_4982|M.ulcerans_Agy99 DQTVFQGSVGEMFGRKVARLMEWCSMVGCPIIGINDSAGARIQDTATSLA
MAV_0220|M.avium_104 DQTVFQGTVGEMFGRKVARLMEWCAMVGCPIIGIQDSGGARIQDAVTSLA
TH_1608|M.thermoresistible__bu DQTVFGGSVGEMFGRKVSRLMEWVAMVGCPIIGINDSGGARIQDLATSLA
MSMEG_6391|M.smegmatis_MC2_155 DQTVFQGSVGEMFGRKVARLMEWVAMVGCPIIGINDSAGARIQDAVTSLA
MAB_0181|M.abscessus_ATCC_1997 DQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGINDSAGARIQDTATSLA
****: *:*********::**** : ***::**:**.****** .****
Mflv_1170|M.gilvum_PYR-GCK WYAELGRRHELLRGLVPEISLIFGKCAGGAVYSPIQTDLVVAVRDQGYMF
Mvan_5639|M.vanbaalenii_PYR-1 WYAELGRRHELLRGLVPEISLIFGKCAGGAVYSPIQTDLVVAVRDQGYMF
Rv3799c|M.tuberculosis_H37Rv WYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMF
Mb3829c|M.bovis_AF2122/97 WYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMF
MLBr_00102|M.leprae_Br4923 WYAELGRRHELLSGIVPQISIVLGKCAGGAVYSPIQTDLVVAVRGQGYMF
MMAR_5363|M.marinum_M WYAELGRRHEILSGQVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMF
MUL_4982|M.ulcerans_Agy99 WYAELGRRHEILSGQVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMF
MAV_0220|M.avium_104 WYAELGRRHEALSGLVPQISLIFGKCAGGAVYSPIQDDLLVSVRDQGYFF
TH_1608|M.thermoresistible__bu WYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDLIVAVRDQGYMF
MSMEG_6391|M.smegmatis_MC2_155 WYAELGRRHEMLRGLVPEISLIFGKCAGGAVYSPIQTDLLVAVRDQGYMF
MAB_0181|M.abscessus_ATCC_1997 WYAELGRRHELLRGTVPEISIILGKCAGGAVYSPIQTDLLVAVRDQGYMF
********** * * **:**:::************* **:*:**.***:*
Mflv_1170|M.gilvum_PYR-GCK VTGPDVIKDVTGEDVTLDELGGADAQARYGNIHQVVESEAAAFQYVRDYL
Mvan_5639|M.vanbaalenii_PYR-1 VTGPDVIKDVTGEDVTLDELGGADAQARYGNIHQVVESEAAAFQYVRDYL
Rv3799c|M.tuberculosis_H37Rv VTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQYVRDFL
Mb3829c|M.bovis_AF2122/97 VTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQYVRDFL
MLBr_00102|M.leprae_Br4923 VTGPDVIKDVTGEEVSLDELGGVDSQAKYGNIHQVVESEAAAFGYVRDFL
MMAR_5363|M.marinum_M VTGPDVIKDVTGEDVSLDELGGADSQARYGNIHQVVEDEAAAFQYVRDFL
MUL_4982|M.ulcerans_Agy99 VTGPDVIKDVTGEDVSLDELGGADSQARYGNIHQVVEDEAAAFQYVRDFL
MAV_0220|M.avium_104 VTGPDVIREVTGEEVTLDELGGSDAQARYGNIHHVVNTEAEAFQYVREYL
TH_1608|M.thermoresistible__bu VTGPDVIKDVTGEEVTLDELGGADAQARYGNIHTVVNSEKEAFQYVRDYL
MSMEG_6391|M.smegmatis_MC2_155 ITGPDVIKDVTGEDVTFDELGGADEQAKRGNIHKVVNSEAEAYQYVRDYL
MAB_0181|M.abscessus_ATCC_1997 ITGPDVIKDVTGEDVSFDELGGADVQAQRGNIHKVVEDEAAAFQYVRDYL
:******::****:*::***** * ** **** **: * *: ***::*
Mflv_1170|M.gilvum_PYR-GCK SFLPANTFDDAPIVNPGLEPEITPHDLELDAIVPDSDNQAYDMMEILLRI
Mvan_5639|M.vanbaalenii_PYR-1 SFLPGNAFDDAPIVNPGLEPEVTPHDLELDAIVPDADNQAYDMMEILLRI
Rv3799c|M.tuberculosis_H37Rv SFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRI
Mb3829c|M.bovis_AF2122/97 SFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRI
MLBr_00102|M.leprae_Br4923 SFLPPNCFDKAPIVNPGLEPEIMAHDLELDSIVPDSDNTAYDMREVLLRI
MMAR_5363|M.marinum_M SFLPSDCFGDPPVVNPGLEPEITPSDLELDSIVPDSDNTAYDMHEILLRI
MUL_4982|M.ulcerans_Agy99 SFLPSDCFGDPPVVNPGLEPEITPSDLELDSIVPDSDNTAYDMHEILLRI
MAV_0220|M.avium_104 SFLPSNCFDQPPIVNPGLEPEITPTDLELDSIVPDSDNMSYDMHEILLRI
TH_1608|M.thermoresistible__bu GFLPANTFDDAPIVNPGLEPEITPHDLELDSIVPDNDNTAYDMHEILLRI
MSMEG_6391|M.smegmatis_MC2_155 SFLPSNHFDNPPIVNPGMEPEITPHDLELDSIVPDADNMAYDMHEILLRI
MAB_0181|M.abscessus_ATCC_1997 SFLPSNTFDYPPIVNPGLEPEITEDDLYLDTFIPDSDNQGYDMMEILLRI
.*** : *. .*:****:***: ** **:::** ** .*** *:****
Mflv_1170|M.gilvum_PYR-GCK FDDGDVFQVAEQAGPAIITAFARVDGRPVGVIANQPMYMSGAIDNEASDK
Mvan_5639|M.vanbaalenii_PYR-1 FDDGDVFQVGEQAGPAIITAFARVDGRPVGIIANQPMYMSGAIDNEASDK
Rv3799c|M.tuberculosis_H37Rv FDDGDFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMSGAIDNEASDK
Mb3829c|M.bovis_AF2122/97 FDDGDFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMSGAIDNEASDK
MLBr_00102|M.leprae_Br4923 FDDGHFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHLSGAIDNEASDK
MMAR_5363|M.marinum_M FDDGDFLDVAAQAGQAIITGYARVDGRPVGVVANQPMHMSGAIDNEASDK
MUL_4982|M.ulcerans_Agy99 FDDGDFLDVAAQASQAIITGYARVDGRPVGVVANQPMHMSGAIDNEASDK
MAV_0220|M.avium_104 FDDGDFLEVAAQHGPAIITGYARVDGHPVGVIANQPMHLSGSIDNEASDK
TH_1608|M.thermoresistible__bu FDDGDFLEVAGQAGQAIITGFARVDGRPVGVVANQPMVLSGAIDNEASDK
MSMEG_6391|M.smegmatis_MC2_155 FDDGDVFEIAEQRGPAMITAFARVDGHPVGVIANQPMVLSGAIDNEASDK
MAB_0181|M.abscessus_ATCC_1997 FDDGDIFEISEQRGPAMITAFARVDGHPVGVIANQPLQMAGAVDTDASDK
****..:::. * . *:**.:*****:.**::****: ::*::*.:****
Mflv_1170|M.gilvum_PYR-GCK AARFVRFCDSFNTPLVFVVDTPGFMPGVEQEKGGIIKRGGRFLNAVVEAS
Mvan_5639|M.vanbaalenii_PYR-1 AARFVRFCDSFNTPLVFVVDTPGFMPGVEQEKGGIIKRGGRFLNAVVEAD
Rv3799c|M.tuberculosis_H37Rv AARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEAD
Mb3829c|M.bovis_AF2122/97 AARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEAD
MLBr_00102|M.leprae_Br4923 AARFIRFCDAFNIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEAD
MMAR_5363|M.marinum_M AARFVRFCDAFKIPLVFVVDTPGFLPGAEQEKNGIIKRGGRFLYAVVEAD
MUL_4982|M.ulcerans_Agy99 AARFVRFCDAFKIPLVFVVDTPGFLPGAEQEKNGIIKRGGRFLYAVVEAD
MAV_0220|M.avium_104 AARFIRFCDAFNIPLVFVVDTPGFLPGAEEEKRGIIKRGGRFLYSVVEAD
TH_1608|M.thermoresistible__bu AARFVRFCDAFNTPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEAD
MSMEG_6391|M.smegmatis_MC2_155 AASFIRFCDSYNLPLVFVVDTPGAMPGVAEEKGGIIKRGGRFFNAIVEAD
MAB_0181|M.abscessus_ATCC_1997 AASFIRFCDAYNLPLVFVVDTPGALPGVSEEKNGIIKKGGRFFNAVVEAD
** *:**.*::. ********** :**. :** ****:****: ::***.
Mflv_1170|M.gilvum_PYR-GCK VAKVTITIRKSYGGAYAVMGSKQLTSDFNFAWPTARIAVIGADGAAQLLV
Mvan_5639|M.vanbaalenii_PYR-1 VPKVTITIRKSYGGAYAVMGSKQLTADFNFAWPTARIAVIGAEGAAQLLV
Rv3799c|M.tuberculosis_H37Rv VPKVTITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVIGADGAAQLLM
Mb3829c|M.bovis_AF2122/97 VPKVTITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVIGADGAAQLLM
MLBr_00102|M.leprae_Br4923 VPKVTITIRKSYGGAYAVMGSKQLAADLNFAWPTARIAVIGADGAAQLLM
MMAR_5363|M.marinum_M VPKVTITIRKSYGGAYAVMGSKQLTADFNFAWPTARIAVIGADGAAQLLM
MUL_4982|M.ulcerans_Agy99 VPKVTITIRKSYGGAYAVMGSKQLTADFNFAWPTARIAVIGADGAAQLLM
MAV_0220|M.avium_104 VPKVTITVRKSYGGAYAVMGSRQLTADFNFAWPTARIAVIGAEGAAQLLM
TH_1608|M.thermoresistible__bu VPKVTITVRKSYGGAYAVMGSKQLTSDFNFLWPTARIAVIGAEGAAQLIM
MSMEG_6391|M.smegmatis_MC2_155 VPKVTVIIRKAYGGGYAVMGSKQLSADLNFAWPTARIAVIGAEGAAQLLV
MAB_0181|M.abscessus_ATCC_1997 VPKVTIITRKAYGGGYAVMGSKQLSADLNYVWPTARIAVIGAEGAAQLLV
*.***: **:***.******:**::*:*: ***********:*****::
Mflv_1170|M.gilvum_PYR-GCK KRFPDPTAPEVQKIKADFIEGYNANLAVPWIAAERGFIDGVIEPHETRLL
Mvan_5639|M.vanbaalenii_PYR-1 KRFPDPTAPEVQKIRADFIEGYNANLATPWIAAERGFIDGVVEPHETRLL
Rv3799c|M.tuberculosis_H37Rv KRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAERGFIDAVIDPHETRLL
Mb3829c|M.bovis_AF2122/97 KRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAERGFIDAVIDPHETRLL
MLBr_00102|M.leprae_Br4923 KRFPDPSSPDVQAIRKTFVDNYNLNMAIPWIAAERGFIDAVVEPHQTRLL
MMAR_5363|M.marinum_M KRFPDPTTPEAQKIKRDFIEGYNLNMAIPWIAAERGFIDAVVDPHQTRLL
MUL_4982|M.ulcerans_Agy99 KRFPDPTTPEAQKIKRDFIEGYNLNMAIPWIAAERGYIDAVVDPHQTRLL
MAV_0220|M.avium_104 KRFPDPTTPEAQQIKKDFIEGYNLNMAIPWTAAERGFIDAVIDPHETRLL
TH_1608|M.thermoresistible__bu KRFPDPNAPEVQEIRRQFIEGYNRDMATPYVAAERGYVDAVIEPHETRLK
MSMEG_6391|M.smegmatis_MC2_155 KRFPDPNAPEVQKIRDDFIEGYNLNMATPWIAAERGYIDAVIQPHETRLL
MAB_0181|M.abscessus_ATCC_1997 KRFPDPTAPEVQKIRADFIEGYNKNLATPWIAAERGYIDGVIEPHQTRLL
******.:*:.* *: *::.** ::* *: *****::*.*::**:***
Mflv_1170|M.gilvum_PYR-GCK LRKCLHLLADKQ-INRVHRKHGLTPI
Mvan_5639|M.vanbaalenii_PYR-1 LRKCMHLLRDKQ-INRVQRKHGLTPI
Rv3799c|M.tuberculosis_H37Rv LRKSMHLLRDKQLWWRVGRKHGLIPV
Mb3829c|M.bovis_AF2122/97 LRKSMHLLRDKQLWWRVGRKHGLIPV
MLBr_00102|M.leprae_Br4923 LRKSLHLLRDKQQWWRVGRKHGLIPL
MMAR_5363|M.marinum_M LRKSMHLLRDKQLWWRVGRKHGLIPV
MUL_4982|M.ulcerans_Agy99 LRKSMHLLRDKQLWWRVGRKHGLIPV
MAV_0220|M.avium_104 LRKSLKLLRDKQLWFRVARKHGLIPV
TH_1608|M.thermoresistible__bu LRSAMRLLRDKQ-IQRVQRKHGLIPI
MSMEG_6391|M.smegmatis_MC2_155 LRKSLRLLRDKQNGPKVQRKHGLLPL
MAB_0181|M.abscessus_ATCC_1997 LRKSLKLLRDKQKHDRMQRKHGLTPI
**..::** *** :: ***** *: