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MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGV EGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAA YGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVG LFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRT VGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGE CTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQ LAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2247 | accD6 | - | 100% (473) | ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 |
| M. tuberculosis H37Rv | Rv3280 | accD5 | e-101 | 43.20% (456) | propionyl-CoA carboxylase beta chain |
| M. tuberculosis H37Rv | Rv3799c | accD4 | 5e-74 | 37.38% (428) | propionyl-CoA carboxylase beta chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2271 | accD6 | 0.0 | 100.00% (473) | acetyl/propionyl-CoA carboxylase beta subunit AccD6 |
| M. gilvum PYR-GCK | Mflv_2775 | - | 0.0 | 87.87% (470) | propionyl-CoA carboxylase |
| M. leprae Br4923 | MLBr_01657 | - | 0.0 | 92.81% (473) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_1876c | - | 0.0 | 86.89% (473) | propionyl-CoA carboxylase beta chain 6 |
| M. marinum M | MMAR_3340 | accD6 | 0.0 | 96.83% (473) | acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 |
| M. avium 104 | MAV_2190 | - | 0.0 | 95.77% (473) | propionyl-CoA carboxylase beta chain |
| M. smegmatis MC2 155 | MSMEG_4329 | - | 0.0 | 89.03% (474) | propionyl-CoA carboxylase beta chain |
| M. thermoresistible (build 8) | TH_2704 | - | 0.0 | 89.94% (477) | PUTATIVE propionyl-CoA carboxylase beta chain |
| M. ulcerans Agy99 | MUL_1302 | accD6 | 0.0 | 96.62% (473) | acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 |
| M. vanbaalenii PYR-1 | Mvan_3758 | - | 0.0 | 88.49% (469) | propionyl-CoA carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2775|M.gilvum_PYR-GCK MTTIENPPAPGAVNESLDPRDPLLRLATFFDDGSVELLHERDKSGVLAGA
Mvan_3758|M.vanbaalenii_PYR-1 MTTIENPPAPESVNESLDPRDPLLRLATFFDDGTVELLHERDKSGILAAS
MSMEG_4329|M.smegmatis_MC2_155 MTIM----APEAAAESLDPRDPLLRLSTFFDDGSVELLHERDRSGVLAAA
Rv2247|M.tuberculosis_H37Rv MTIM----APEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAA
Mb2271|M.bovis_AF2122/97 MTIM----APEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAA
MMAR_3340|M.marinum_M MTIM----APEAVGESLDPRDPLLRLSNFFDDGTVVLLHERDRSGVLAAS
MUL_1302|M.ulcerans_Agy99 MTIM----APEAVGESLDPRDPLLRLSNFFDDGTVVLLHERDRSGVLAAS
MLBr_01657|M.leprae_Br4923 MTIT----APKVVGKSIDPRDPLLRLSNFFDDGRVEPLHERNQSGVFAAT
MAV_2190|M.avium_104 MTIT----APETVGESLDPRDPLLRLSNFFDDGSVALLHERDRSGVLAAA
TH_2704|M.thermoresistible__bu MTIM----APEAVGESLDPRDPLLRLSTFFDDGSIELLHERDRSGVLAAA
MAB_1876c|M.abscessus_ATCC_199 MTIL----APEAIDESLDPRDPLLRLNTFFDDGSVELLHERDRSGVLAAA
** ** :*:********* .***** : ****::**::*.:
Mflv_2775|M.gilvum_PYR-GCK GTVNGVRTIAFCTDGTVMGGAMGVEGCKHIVDAYDVAIDEQSPIVGIWHS
Mvan_3758|M.vanbaalenii_PYR-1 GSVNGVRTIAFCTDGTVMGGAMGVDGCAHIVNAYDLAIEEQSPIVGIWHS
MSMEG_4329|M.smegmatis_MC2_155 GTVNGVRTVAFCTDGTVMGGAMGVEGCAHIVDAYDTAIEEQSPIVGIWHS
Rv2247|M.tuberculosis_H37Rv GTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHS
Mb2271|M.bovis_AF2122/97 GTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHS
MMAR_3340|M.marinum_M GTVNGVRTIAFCTDGTVMGGAMGVEGCAHIVNAYDTAIDEQSPIVGIWHS
MUL_1302|M.ulcerans_Agy99 GTVNGVRTIAFCTDGTVMGGAMGVEGCAHIVNAYDTAIDEQSPIVGIWHS
MLBr_01657|M.leprae_Br4923 GTVNGLRTIAFCTDGTVMGGAMGIEGCAHIVNAYDTAIEEQSPIVGIWHS
MAV_2190|M.avium_104 GTVNGVRTIAFCTDGTVMGGAMGIEGCSHIVDAYDTAIEEQSPIVGIWHS
TH_2704|M.thermoresistible__bu GTVNGVRTIAFCTDGTVMGGAMGTDGCRHIVDAYDTAIEEQSPIVGIWHS
MAB_1876c|M.abscessus_ATCC_199 GTVNGVRTIAFCTDGTVMGGAMGVEGCRHIVNAYDTAIEEQSPIVGIWHS
*:***:**:************** :** ***:*** **::**********
Mflv_2775|M.gilvum_PYR-GCK GGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALT
Mvan_3758|M.vanbaalenii_PYR-1 GGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALT
MSMEG_4329|M.smegmatis_MC2_155 GGARLAEGVKALHAVGLMFEAMIRASGYVPQISVVVGFAAGGAAYGPALT
Rv2247|M.tuberculosis_H37Rv GGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALT
Mb2271|M.bovis_AF2122/97 GGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALT
MMAR_3340|M.marinum_M GGARLAEGVRALHAVGQVFEAMIRASGYVPQVSVVVGFAAGGAAYGPALT
MUL_1302|M.ulcerans_Agy99 GGARLAEGVRALHAVGQVFEAMIRASGYVPQVSVVVGFAAGGAAYGPALT
MLBr_01657|M.leprae_Br4923 GGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALT
MAV_2190|M.avium_104 GGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALT
TH_2704|M.thermoresistible__bu GGARLAEGVRALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALT
MAB_1876c|M.abscessus_ATCC_199 GGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALT
*********:****** :**********:**:******************
Mflv_2775|M.gilvum_PYR-GCK DVIVMAPDSKVFVTGPDVVRSVTGEDVDMVSLGGPEAHHKKSGVCHIVAD
Mvan_3758|M.vanbaalenii_PYR-1 DVIVMAPDSKVFVTGPDVVRSVTGEDVDMVSLGGPEAHHKKSGVCHIVAD
MSMEG_4329|M.smegmatis_MC2_155 DVIVMAPDSKIFVTGPDVVRSVTGEDVDMVSLGGPEAHHKKSGVCHIVAD
Rv2247|M.tuberculosis_H37Rv DVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVAD
Mb2271|M.bovis_AF2122/97 DVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVAD
MMAR_3340|M.marinum_M DVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVAD
MUL_1302|M.ulcerans_Agy99 DVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVAD
MLBr_01657|M.leprae_Br4923 DVVIMAPEGRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVAN
MAV_2190|M.avium_104 DVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVAD
TH_2704|M.thermoresistible__bu DVVIMAPEGRVFVTGPDVVRSVTGEDVDMASLGGPDTHHKKSGVCHIVAD
MAB_1876c|M.abscessus_ATCC_199 DVIIMAPESRVFVTGPDVVRSVTGEDVDMATLGGPDAHHKKSGVCHIVAD
**::***:.::******************.:****::************:
Mflv_2775|M.gilvum_PYR-GCK DELDAYERGRRLVGLFCQQGHFDRTKAEAGDTDLKALLPESARRAYDVHP
Mvan_3758|M.vanbaalenii_PYR-1 DELDAYERGRRLVGLFCQQGHFDRSKAEAGDTDLKALLPESARRAYDVHP
MSMEG_4329|M.smegmatis_MC2_155 DELDAYERGRRLVGLFCQQGHFDRSKAEAGDSDLHALLPDSARRAYDVHP
Rv2247|M.tuberculosis_H37Rv DELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRP
Mb2271|M.bovis_AF2122/97 DELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRP
MMAR_3340|M.marinum_M DELDAYERGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESARRAYDVHP
MUL_1302|M.ulcerans_Agy99 DELDAYERGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESARRAYDVHP
MLBr_01657|M.leprae_Br4923 DELDAYERGRRLVGLFCQQGHFDRSKAEAGDTNIQALLPESSRRAYDVHP
MAV_2190|M.avium_104 DELDAYERGRRLVGLFCQQGHFDRTKAEAGDTDIHALLPESARRAYDVRP
TH_2704|M.thermoresistible__bu DELDAYERGRRLVGLFCQQGHFDRAKAEAGESDLHALLPESPRRAYDVHP
MAB_1876c|M.abscessus_ATCC_199 DELDAYARGRKLVGFFCQQGVFDRGRAEADHTDLRALLPESAKRAYDVHP
****** ***:***:***** *** :***..::::****:*.:*****:*
Mflv_2775|M.gilvum_PYR-GCK LVEALLDEG---VPFEEFQSRWAPSIVVGLGRLAGRTVGVIANNPLRLGG
Mvan_3758|M.vanbaalenii_PYR-1 LIEALLDEG---VPFEEFQSRWAPSIVVGLGRLAGRTVGVIANNPLRLGG
MSMEG_4329|M.smegmatis_MC2_155 LVHALLDEG---VPFEEFQAKWAPSIVVGLGRLAGRTIGVIANNPLRLGG
Rv2247|M.tuberculosis_H37Rv IVTAILDAD---TPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGG
Mb2271|M.bovis_AF2122/97 IVTAILDAD---TPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGG
MMAR_3340|M.marinum_M IVTAILDAD---TPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGG
MUL_1302|M.ulcerans_Agy99 IVTAILDAD---TPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGG
MLBr_01657|M.leprae_Br4923 VVTAILDEN---TPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGG
MAV_2190|M.avium_104 IVTAILDDE---TPFDEFQANWAPSMVIGLGRLSGRTVGVLANNPLRLGG
TH_2704|M.thermoresistible__bu IVTELLDKEDGVSTFEEFQAKWAPSMVVGLGRLSGRTVGVLANNPLRLGG
MAB_1876c|M.abscessus_ATCC_199 IVNALLDGD---DPFEEFQGKWAPSMVIGLGRLAGRTVGVLANNPLRLGG
:: :** .*:***..****:*:*****:***:**:*********
Mflv_2775|M.gilvum_PYR-GCK CLNSESAEKSARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAK
Mvan_3758|M.vanbaalenii_PYR-1 CLNSESAEKSARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAK
MSMEG_4329|M.smegmatis_MC2_155 CLNSESAEKSARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAK
Rv2247|M.tuberculosis_H37Rv CLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAK
Mb2271|M.bovis_AF2122/97 CLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAK
MMAR_3340|M.marinum_M CLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAK
MUL_1302|M.ulcerans_Agy99 CLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAK
MLBr_01657|M.leprae_Br4923 CLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAK
MAV_2190|M.avium_104 CLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAK
TH_2704|M.thermoresistible__bu CLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAK
MAB_1876c|M.abscessus_ATCC_199 CLNSESAEKAARFVRLCNAFGIPLIVLVDVPGYLPGVGQEWGGVVRRGAK
*********:*******:******:*:**********.************
Mflv_2775|M.gilvum_PYR-GCK LLHAFGESSVPRVTLVTRKIYGGAYIAMNSRSLNATKVFAWPEAEVAVMG
Mvan_3758|M.vanbaalenii_PYR-1 LLHAFGESSVPRVTLVTRKIYGGAYIAMNSRSLNATKVFAWPEAEVAVMG
MSMEG_4329|M.smegmatis_MC2_155 LLHAFGESTVPRVTLVTRKIYGGAYIAMNSRSLNATKVFAWPDAEVAVMG
Rv2247|M.tuberculosis_H37Rv LLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMG
Mb2271|M.bovis_AF2122/97 LLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMG
MMAR_3340|M.marinum_M LLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMG
MUL_1302|M.ulcerans_Agy99 LLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMG
MLBr_01657|M.leprae_Br4923 LLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMG
MAV_2190|M.avium_104 LLHAFGEATVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMG
TH_2704|M.thermoresistible__bu LLHAFGEASVPRVTLVTRKIYGGAYIAMNSRSLNATKVFAWPDAEVAVMG
MAB_1876c|M.abscessus_ATCC_199 LLHAFGEATVPRVTLVTRKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMG
*******.:********** *************.********:*******
Mflv_2775|M.gilvum_PYR-GCK AKAAVGILHKKKLAAVEDPAEREALHEELAVEHERIAGGVDSAIEIGVVD
Mvan_3758|M.vanbaalenii_PYR-1 AKAAVGILHKKKLAAAPD-HERESLHEALALEHERIAGGVDSAIEIGVVD
MSMEG_4329|M.smegmatis_MC2_155 AKAAVGILHKKKLAAVEDPAEREALHEQLAVEHEKIAGGVDSAIEIGVVD
Rv2247|M.tuberculosis_H37Rv AKAAVGILHKKKLAAAPE-HEREALHDQLAAEHERIAGGVDSALDIGVVD
Mb2271|M.bovis_AF2122/97 AKAAVGILHKKKLAAAPE-HEREALHDQLAAEHERIAGGVDSALDIGVVD
MMAR_3340|M.marinum_M AKAAVGILHKKKLAAAAE-HEREALHDELAAEHERIAGGVDSAIDIGVVD
MUL_1302|M.ulcerans_Agy99 AKAAVGILHKKKLAAAAE-HEREALHDELAAEHERIAGGVDSAIDIGVVD
MLBr_01657|M.leprae_Br4923 AKAAVGILHKRKLAAAPN-DEREALHDDLAAEHERIAGGVDSAIDIGVVD
MAV_2190|M.avium_104 AKAAVGILHKKKLAAAPE-HEREALHDQLAAEHEKIAGGVDSAIEIGVVD
TH_2704|M.thermoresistible__bu AKAAVGILHKKKLAAVEDPVEREALHEQLAVEHEKIAGGVDSAIEIGVVD
MAB_1876c|M.abscessus_ATCC_199 AKAAVGILHKKQLAAAAP-EEREALHEELALEHERIAGGVDRAIEIGVVD
**********::***. ***:**: ** ***:****** *::*****
Mflv_2775|M.gilvum_PYR-GCK EKIDPSHTRSRLTQALAEAPMRRGRHKNIPL
Mvan_3758|M.vanbaalenii_PYR-1 EKIDPSHTRSKLTQALAEAPMRRGRHKNIPL
MSMEG_4329|M.smegmatis_MC2_155 EKIDPSHTRSKLTEALAEAPHRRGRHKNIPL
Rv2247|M.tuberculosis_H37Rv EKIDPAHTRSKLTEALAQAPARRGRHKNIPL
Mb2271|M.bovis_AF2122/97 EKIDPAHTRSKLTEALAQAPARRGRHKNIPL
MMAR_3340|M.marinum_M EKIDPAHTRSRLTEALAQAPARRGRHKNIPL
MUL_1302|M.ulcerans_Agy99 EKIDPAHTRSRLTEVLAQAPARRGRHKNIPL
MLBr_01657|M.leprae_Br4923 EKINPAHTRSKLTEALAQSPVRRGRHKNIPL
MAV_2190|M.avium_104 EKIDPAHTRSKLTEALAQAPARRGRHKNIPL
TH_2704|M.thermoresistible__bu EKIDPSLTRSKLAQALAEAPARRGRHKNIPL
MAB_1876c|M.abscessus_ATCC_199 EEIEPSQTRAVLTRALAEAPSRRGRHKNIPL
*:*:*: **: *:..**::* **********