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PSTDKAVVVEGIKKSFGAVTALRDVSFDVGRGEVLGLLGPNGAGKTTTVNILSTLIKPDSGRAMIAGHDV VTDPAGVRRALMLTGQHAALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVGAGDRAVGNYSG GMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTDFKEAGIATLLTTQYLEEADLLSDRIIVI DKGTVIAEGTADQLKERTGGTYCEIVPRQLSQLREVARILGPLLPAAHRDALSDTSDRISMPAPDGPNTL MQALHLLSEADIELSDIALRRPSLDEVFLALTGDHPKARDESEDPLVAADAYA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3389 | - | - | 100% (334) | daunorubicin resistance ABC transporter ATPase subunit |
| M. gilvum PYR-GCK | Mflv_1936 | - | 2e-71 | 47.15% (316) | daunorubicin resistance ABC transporter ATPase subunit |
| M. gilvum PYR-GCK | Mflv_3680 | - | 3e-41 | 34.38% (317) | ABC transporter related |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2961 | drrA | 1e-118 | 66.88% (317) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. tuberculosis H37Rv | Rv2936 | drrA | 1e-117 | 66.88% (317) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. leprae Br4923 | MLBr_02352 | - | 1e-120 | 67.51% (317) | putative antibiotic resistance efflux protein |
| M. abscessus ATCC 19977 | MAB_2752 | - | 2e-35 | 34.11% (299) | ABC transporter ATP-binding protein |
| M. marinum M | MMAR_1771 | drrA | 1e-118 | 66.14% (319) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. avium 104 | MAV_3250 | - | 6e-89 | 55.84% (308) | daunorubicin resistance ATP-binding protein DrrA |
| M. smegmatis MC2 155 | MSMEG_6509 | - | 2e-43 | 40.09% (227) | ABC-type drug export system, ATP-binding protein |
| M. thermoresistible (build 8) | TH_2745 | - | 1e-30 | 28.76% (306) | PUTATIVE ABC transporter related |
| M. ulcerans Agy99 | MUL_2014 | drrA | 1e-118 | 66.14% (319) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. vanbaalenii PYR-1 | Mvan_3122 | - | 1e-168 | 90.12% (334) | daunorubicin resistance ABC transporter ATPase subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3389|M.gilvum_PYR-GCK ---------MPSTDKAVVVEGIKKSFG--AVTALRDVSFDVGRGEVLGLL
Mvan_3122|M.vanbaalenii_PYR-1 ---------MTRSDKAVVVAGIKKSFG--SVQALRDVSFEVERGEVLGLL
MMAR_1771|M.marinum_M ---------MRNNDLAVEVRGVRKAFG--DVVALNDISFEVGRGEVIGLL
MUL_2014|M.ulcerans_Agy99 ---------MRNNDLAVEVRGVRKAFG--DVVALNDISFEVGRGEVIGLL
Mb2961|M.bovis_AF2122/97 ---------MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLL
Rv2936|M.tuberculosis_H37Rv ---------MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLL
MLBr_02352|M.leprae_Br4923 ---------MRNNDKAVMVRGVRKTYGKGKIIALDDVSFDVDRGEVIGLL
MAV_3250|M.avium_104 -----------MSAPAIEVEGLTKKFG-GSTLALAGVDFSVPAGTVCGLL
MAB_2752|M.abscessus_ATCC_1997 ---------------------------------MDSLDLEVHAAQVFALL
MSMEG_6509|M.smegmatis_MC2_155 MTDHMPEPTLPDRTPAIDCDGLTHRYG--QFTAVEDLTLQVRAGETLGLL
TH_2745|M.thermoresistible__bu ---MTTTSPRFDAEPAVEIHGLKKSFG--RTRAVDGLDLRVERGSVAGFL
: .: : * . . .:*
Mflv_3389|M.gilvum_PYR-GCK GPNGAGKTTTVNILSTLIKPDSGRAMIAGHDVVTDPAGVRRALMLTGQHA
Mvan_3122|M.vanbaalenii_PYR-1 GPNGAGKTTTVNILSTLIKPDSGRALIAGHDVVTDPAGVRRALMLTGQHA
MMAR_1771|M.marinum_M GPNGAGKTTMVDILSTLTRPDAGSAHVAGSDVVAQPAGVRRSIMVTGQQV
MUL_2014|M.ulcerans_Agy99 GPNGAGKTTMVDILSTLTRPDAGSAHVAGYDVVAQPAGVRRSIMVTGQQV
Mb2961|M.bovis_AF2122/97 GPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQV
Rv2936|M.tuberculosis_H37Rv GPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQV
MLBr_02352|M.leprae_Br4923 GPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSIMVTGQQV
MAV_3250|M.avium_104 GHNGAGKTTTINILSTLIRPTSGRARVAGYDVVRQPAEVRASIGMAGQFT
MAB_2752|M.abscessus_ATCC_1997 GPNGAGKTTTVELCEGFLHPDEGTVEVLGMDPVAKNSAVRSRIGVMLQGG
MSMEG_6509|M.smegmatis_MC2_155 GPNGAGKTTAVRVLTTLTPVQQGRVRIFGLDTRAHTMDIRHNIGYVPQQL
TH_2745|M.thermoresistible__bu GPNGSGKSTTIRVLLGLLRADGGTARLLGGDPWHDAVELHRRLAYVPGDV
* **:**:* : : : * . : * * . :: :
Mflv_3389|M.gilvum_PYR-GCK ALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVGAGDRAVGNY
Mvan_3122|M.vanbaalenii_PYR-1 ALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVQAADRPVGTY
MMAR_1771|M.marinum_M AVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTY
MUL_2014|M.ulcerans_Agy99 AVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTY
Mb2961|M.bovis_AF2122/97 AVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTY
Rv2936|M.tuberculosis_H37Rv AVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTY
MLBr_02352|M.leprae_Br4923 AVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAGKRRVGTY
MAV_3250|M.avium_104 GMDPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAADRRLSTY
MAB_2752|M.abscessus_ATCC_1997 GAYPTARASEMLGLVASYS-----ANPLDPQWLLDTLGLTDAARTPYRRL
MSMEG_6509|M.smegmatis_MC2_155 SIEAALTGRQNVELFARLYDVPRSERADRVAAALEAMQLLDVADTVAGTY
TH_2745|M.thermoresistible__bu TLWPNLTGGQAIDFLAGLR---DNFDTKRRDELIERFELD--PDKKARTY
. : : :.. :: : *
Mflv_3389|M.gilvum_PYR-GCK SGGMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTDFK-EAG
Mvan_3122|M.vanbaalenii_PYR-1 SGGMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTDFK-EAG
MMAR_1771|M.marinum_M SGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFK-KLG
MUL_2014|M.ulcerans_Agy99 SGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFK-KLG
Mb2961|M.bovis_AF2122/97 SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-KLG
Rv2936|M.tuberculosis_H37Rv SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-KLG
MLBr_02352|M.leprae_Br4923 SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-QIG
MAV_3250|M.avium_104 SGGMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVSSLR-VQG
MAB_2752|M.abscessus_ATCC_1997 SGGQQQRLALACALVGRPELVFLDEPTAGMDAHARLVVWELIDCLR-RDG
MSMEG_6509|M.smegmatis_MC2_155 SGGMVRRLELAQALVNRPLLLILDEPTVGLDPIARDSVWTQVRAMQAEFG
TH_2745|M.thermoresistible__bu SKGNRQKVALVAAFSTNAEIYILDEPTSGLDPLMDKAFQMCVREAA-DNG
* * ::: :. .: . : :***** *:*. . : *
Mflv_3389|M.gilvum_PYR-GCK IATLLTTQYLEEADLLSDRIIVIDKGTVIAEGTADQLKERTGGTYCEIVP
Mvan_3122|M.vanbaalenii_PYR-1 IATLLTTQYLEEADLLSDRIIVIDKGTVIAEGTADELKERTGGTYCEIVP
MMAR_1771|M.marinum_M IATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVP
MUL_2014|M.ulcerans_Agy99 IATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVP
Mb2961|M.bovis_AF2122/97 IATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVP
Rv2936|M.tuberculosis_H37Rv IATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVP
MLBr_02352|M.leprae_Br4923 IATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGETFCEIVP
MAV_3250|M.avium_104 ISVLLTTQYLEEADVLSDSIVVIDHGRVIASGTSEELKRAVGTSYCQVTP
MAB_2752|M.abscessus_ATCC_1997 VSVVLTTHHMKEAEELADQLMIIDHGSVVAAGTPSELMQSGAENQLRFAA
MSMEG_6509|M.smegmatis_MC2_155 MTVLLTTHYMGEADALCDRVALMHHGRLQAVGSPDELKRAVSS-------
TH_2745|M.thermoresistible__bu AAVLLSSHILAEVERLCDSVTIIRSGRTVRAGRLDELRHLMRTTVKVRTR
:.:*::: : *.: *.* : :: * * .:* .
Mflv_3389|M.gilvum_PYR-GCK RQLSQLREVARILGPLLPAAHRDALSDTSDRISMPAPDGPNTLMQALHLL
Mvan_3122|M.vanbaalenii_PYR-1 RNLADIPEVARVLGPLLPDANRAALTDTSDRISMPAPDGPNTLMQALHLL
MMAR_1771|M.marinum_M RHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTLIEAARRI
MUL_2014|M.ulcerans_Agy99 RHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTLIEAARKI
Mb2961|M.bovis_AF2122/97 RDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRI
Rv2936|M.tuberculosis_H37Rv RDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRI
MLBr_02352|M.leprae_Br4923 RDLKDLGTVVAALGSLLPERSRAMLTPTSDRITMPAPDGTQTLIEAARRI
MAV_3250|M.avium_104 ANPAELPQVAAALTGLEG----IEIDSDTGSVSVFAPDGVATLVEVFRRV
MAB_2752|M.abscessus_ATCC_1997 PPRLDLTLLTSALP-----EGYKATEVTPGEYRVEGVVDPQVLATVTAWC
MSMEG_6509|M.smegmatis_MC2_155 -----------------------QASDDAGETTLEDVFRHYAGSDLEGGA
TH_2745|M.thermoresistible__bu APIDALRTAP--------YIHEFSTDDGLHTFSVDRTDLDRTMTELT---
:
Mflv_3389|M.gilvum_PYR-GCK SEADIELSDIALRRPSLDEVFLALTGDHPKARDESEDPLVAADAYA
Mvan_3122|M.vanbaalenii_PYR-1 SEANIELMDIALRRPSLDEVFLALTGDHPRTRDGEADAVVAADAYA
MMAR_1771|M.marinum_M DEANIELADIALRRPSLDDVFLSMTTDPSEAH--ALSHVASGAML-
MUL_2014|M.ulcerans_Agy99 DEANIELADIALRRPSLDDVFLSMTTDPSEAH--VLSHVASGAML-
Mb2961|M.bovis_AF2122/97 DEARIELADIALRRPSLDDVFLAMTTDPTES----LTHLVSGSAR-
Rv2936|M.tuberculosis_H37Rv DEARIELADIALRRPSLDHVFLAMTTDPTES----LTHLVSGSAR-
MLBr_02352|M.leprae_Br4923 DEVSVELADIALRRPSLDDVFLSMTTDPSES----LSHLAAGAMR-
MAV_3250|M.avium_104 DALGLELADISLRKPSLDEAFLHLT-----------ERTVARS---
MAB_2752|M.abscessus_ATCC_1997 ARMDVLTTDLRVEKRSLEDVFLDLTGRELR----------------
MSMEG_6509|M.smegmatis_MC2_155 DPRRSGLGEVRSTRRTARRVS-------------------------
TH_2745|M.thermoresistible__bu ---TLGIEELTVTPASLEDLFLREYQEVPR----------------
:: :