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QQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHAHTHYLDNGGGPRGTDVVGVDSAFLVHN DRTYPTLCRLFAELGVATQESEMSMSVRADDIGLEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAA ARLLREETDNAEDKPETLEAFLSRHHFSQYFVDYFITPLVAAVWSCGGADALRYPARYLFVFLDHHGMLS VFGSPTWRTVTGGSANYVQAIAAQLDEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQALL LLDEPTPAERAVLGAIAYSTNSAQLHTDESVLPRHHRARASWNYLVTPGQHQVVVSYDISRLMRLDGGRR YLVTLGGHDRVDPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVFAGAYHGWGFHEDGAASGLRAAR RLGADWPAAIPQEAMVAC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0449c | - | - | 100% (439) | hypothetical protein Rv0449c |
| M. tuberculosis H37Rv | Rv2677c | hemY | 9e-07 | 25.91% (328) | protoporphyrinogen oxidase |
| M. tuberculosis H37Rv | Rv3727 | - | 7e-06 | 27.54% (138) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0457c | - | 0.0 | 100.00% (439) | hypothetical protein Mb0457c |
| M. gilvum PYR-GCK | Mflv_4501 | - | 2e-07 | 27.81% (302) | amine oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 3e-05 | 37.08% (89) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2985c | - | 4e-07 | 24.33% (374) | protoporphyrinogen oxidase |
| M. marinum M | MMAR_0770 | - | 0.0 | 82.07% (435) | oxidoreductase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_2921 | - | 1e-09 | 28.81% (295) | PUTATIVE putative flavin-containing monoamine oxidase AofH_1 |
| M. ulcerans Agy99 | MUL_1404 | - | 0.0 | 80.92% (435) | oxidoreductase |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4501|M.gilvum_PYR-GCK -------MAEVVVVGAGFAGLAAARELSRLG---RDVVVVEGRDRVGGRS
TH_2921|M.thermoresistible__bu ----------VVVVGAGLAGLTAARTLRRAG---VDVVVLEARDRVGGRT
Rv0449c|M.tuberculosis_H37Rv MQQS--LRRSVAVVGSGVAGLTAAYILSGR----DRVTLYEADGRLGGHA
Mb0457c|M.bovis_AF2122/97 MQQS--LRRSVAVVGSGVAGLTAAYILSGR----DRVTLYEADGRLGGHA
MMAR_0770|M.marinum_M MQQKTLTQRSIAVIGSGVAGLTAAYLLSGR----DRVTLYEADTRLGGHA
MUL_1404|M.ulcerans_Agy99 MQQKTLTQRSIAVIGSGVAGLTAAYLLSGR----DRVTLYEADTRLGGHA
MLBr_01044|M.leprae_Br4923 MT-----SRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVL
MAB_2985c|M.abscessus_ATCC_199 MTPQPSGSPSIAIVGGGISGLTAAYRLRRELGDDARISLYDPAGQLGGIL
::*.*.:**:** * : : : ::**
Mflv_4501|M.gilvum_PYR-GCK YTGSVGGVP-------VDFGATFVGPTQDAVLALAAELGVESVPTYGEGK
TH_2921|M.thermoresistible__bu LNHFLEHGPDPENDAVVELGGQWIGPGHQRIRALIDELGLSTFDTYDRGA
Rv0449c|M.tuberculosis_H37Rv HTHYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEM
Mb0457c|M.bovis_AF2122/97 HTHYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEM
MMAR_0770|M.marinum_M HTHCLDAGDG----TFVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEM
MUL_1404|M.ulcerans_Agy99 HTHCLDAGDG----TFVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEM
MLBr_01044|M.leprae_Br4923 RTECVGGQP-------MDLGAEAFLLRRPEVPALLAELGLSERQRATTDA
MAB_2985c|M.abscessus_ATCC_199 RTITLGEHR-------IDIGAEAFITRRPEVLDLLDELGLADRTLDTTGA
. : : ... . * :.
Mflv_4501|M.gilvum_PYR-GCK NLIRWRGRVRSYRSTIPRLSILELLDVSRIQWRFDRISKRVPVDQPWASP
TH_2921|M.thermoresistible__bu KLWEHNGRVRRYTGEIPRANPLHLADLQIALTRLERMARRIDPAAPWAAP
Rv0449c|M.tuberculosis_H37Rv SMSVRADDIGLEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARL
Mb0457c|M.bovis_AF2122/97 SMSVRADDIGLEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARL
MMAR_0770|M.marinum_M SMSVRADDIGLEYAGALGPRGLFACSAALRPRYLMMLAEILRFHRAASRL
MUL_1404|M.ulcerans_Agy99 SMSVRADDIGLEYAGALGPRGLFACSAALRPRYLMMLAEILRFHRAASRL
MLBr_01044|M.leprae_Br4923 RPLIYSQQR---LHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRP
MAB_2985c|M.abscessus_ATCC_199 RPLIYAGGG---LHPLPARTVNGIPASASSVVGLVDEETVARIDSEPQRD
:
Mflv_4501|M.gilvum_PYR-GCK LAGQLDD------ISLDAWLRSVHAG-ASTRDLMAIMARVTWGAEPGDVS
TH_2921|M.thermoresistible__bu RAAQWDR------QTVAGWIDRHVRT-AVGRAFIELVCEAVWAADAADLS
Rv0449c|M.tuberculosis_H37Rv LREETDN-AEDKPETLEAFLSRHHFSQYFVDYFITPLVAAVWSCGGADA-
Mb0457c|M.bovis_AF2122/97 LREETDN-AEDKPETLEAFLSRHHFSQYFVDYFITPLVAAVWSCGGADA-
MMAR_0770|M.marinum_M LREDTAGSAGDDLETLEAFLKRHHFSSFFVDYFITPLVAAVWSCAAGDA-
MUL_1404|M.ulcerans_Agy99 LREDTAGSAGDDLETLEAFLKRHRFSSFFVDYFITPLVAAVWSCTAGDA-
MLBr_01044|M.leprae_Br4923 LSWEPGS------DPAMAELVADRFGEQAVARLVDPLLGGVYAGSAATIG
MAB_2985c|M.abscessus_ATCC_199 MHWTVGA------EPTVADLVALRFGPQVVARLVDPLLGGVYAGSAATTG
. . : :: : .:. .
Mflv_4501|M.gilvum_PYR-GCK MLHAVRYVNAAGGLNR----------MLDVEGGAQQDRFPAGTQKIADLM
TH_2921|M.thermoresistible__bu LLHLLTYTSSNQGLSQ----------LITTRGGAQQSRIIGGAQQISTAM
Rv0449c|M.tuberculosis_H37Rv LRYPARYLFVFLDHHG----------MLSVFGSPTWRTVTGGSANYVQAI
Mb0457c|M.bovis_AF2122/97 LRYPARYLFVFLDHHG----------MLSVFGSPTWRTVTGGSANYVQAI
MMAR_0770|M.marinum_M LRYPARYLFVFLEHHG----------MLSVFGSPTWRTVTGGSVNYVRAI
MUL_1404|M.ulcerans_Agy99 LRYPARYLFVFLEHHG----------MLSVFGSPTWRTVTGGSVNYVRAI
MLBr_01044|M.leprae_Br4923 LRAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDEL
MAB_2985c|M.abscessus_ATCC_199 LRTAAPGIARALDEGAGSLLAAARQALPPISDSGIFGAVDGGYAVLVEEL
: : . . .* :
Mflv_4501|M.gilvum_PYR-GCK AAELGDRVVVGAPVRRITRNPDRTVTVTTAGAEYQAGAVIVAVPPEHRSG
TH_2921|M.thermoresistible__bu ADELGDAVRLGAPVREIRTRDG--VQVVADTATVRAERVVVAMSPTLAGR
Rv0449c|M.tuberculosis_H37Rv AAQL-DEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQA-L
Mb0457c|M.bovis_AF2122/97 AAQL-DEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQA-L
MMAR_0770|M.marinum_M ASSL-DEVRTGAAVHSLRRTADGVVIRAGGDAPRCFDAAVVAVHPDQA-L
MUL_1404|M.ulcerans_Agy99 ASSL-DEVRTGAAVHSLRRTADGVVIRAGGDAPRCFDAAVVAVHPDQA-L
MLBr_01044|M.leprae_Br4923 VRRS-RLQWVAATVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVR
MAB_2985c|M.abscessus_ATCC_199 WSRA-RAEHVQVAVTGIERDGAGWAVTGEGGLTDAVDAVIVAVPAPRAAA
..* : .::*: .
Mflv_4501|M.gilvum_PYR-GCK IEFDPPLPAEHRELSRHWPQGRLSKAYAAYETPFWRADGHSGESLSDEGP
TH_2921|M.thermoresistible__bu LHYDEPLPADRDQLTQRMPNGSVVKCMAIYDEPFWRADGLSGQGVGFTGP
Rv0449c|M.tuberculosis_H37Rv LLLDEPTPAERAVLG--------AIAYSTNSAQLHTDESVLPR----HHR
Mb0457c|M.bovis_AF2122/97 LLLDEPTPAERAVLG--------AIAYSTNSAQLHTDESVLPR----HHR
MMAR_0770|M.marinum_M LLLDDPTTWERNVLG--------AIPYSTNRALLHTDESVLPR----HHR
MUL_1404|M.ulcerans_Agy99 LLLDDPTTWERNVLG--------AIPYSTNRALLHTDGSVLPR----HHR
MLBr_01044|M.leprae_Br4923 LLQQIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVASGERLRA
MAB_2985c|M.abscessus_ATCC_199 ILEAVAPESAAAARTIPVASSVVVALTLPGDAPIPANSGVLVASGEALHT
: . : .
Mflv_4501|M.gilvum_PYR-GCK VFITFDCSPG--DDGPGVLLGFTD---PRSFDPLPGEQRREIALAGFSAL
TH_2921|M.thermoresistible__bu VKVFFDNSPP--SGRPGVLLGFLEGSQARELGRADTRTRREAVIGCFARM
Rv0449c|M.tuberculosis_H37Rv ARASWNYLVT--PGQHQVVVSYDIS----RLMRLDGGRRYLVTLGGHDRV
Mb0457c|M.bovis_AF2122/97 ARASWNYLVT--PGQHQVVVSYDIS----RLMRLDGGRRYLVTLGGHDRV
MMAR_0770|M.marinum_M ARASWNYLVA--PGQDHVVVSYDVS----RLMRIGGNRRFVVTLGGHDRV
MUL_1404|M.ulcerans_Agy99 ARASWNYLVA--TGQDHVVVSYDVS----RLMRIRGNRRFVVTLGGHDRV
MLBr_01044|M.leprae_Br4923 KAVTLSSRKWGLQG-DTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAA
MAB_2985c|M.abscessus_ATCC_199 KAITFSTSKWGLRGRSTQVVRLSYGRFGDTVARATTDEQLRHWAVADLEA
. . :: . .
Mflv_4501|M.gilvum_PYR-GCK FGAAAAHPIDYVDHCWGAEPFSPGGPTAAVPPGAWTAHGRWLRAPVDGIF
TH_2921|M.thermoresistible__bu FGPRAARPVDYVEKVWAADQWTRGCYGAFLPPNTWTQVGPALRRAVGPIH
Rv0449c|M.tuberculosis_H37Rv DPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVFAGAYHG---WGFH
Mb0457c|M.bovis_AF2122/97 DPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVFAGAYHG---WGFH
MMAR_0770|M.marinum_M DPRSVIAEMTYSHPLYTPESVAAQRVLPTLDDDRVVFAGAYHG---WGFH
MUL_1404|M.ulcerans_Agy99 DTRSVIAEMTYSHPLYTPESVVAQRVLPTLDDDRVVFAGAYHG---WGFH
MLBr_01044|M.leprae_Br4923 VFDVTVDPVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMD
MAB_2985c|M.abscessus_ATCC_199 VLGAGIVPVNSAVARWIDAMPQYGPGHAEVVDAIRSGLPSGIAVAGSYLD
: : . : :
Mflv_4501|M.gilvum_PYR-GCK WAGTETADSWTGFLDGAVRSGLRAADEAHRELARA-
TH_2921|M.thermoresistible__bu WAGAETAVRSMGYMDGAVASGERAAAEVLTALGSGA
Rv0449c|M.tuberculosis_H37Rv EDGAASGLRAARRLGADWPAAIPQEAMVAC------
Mb0457c|M.bovis_AF2122/97 EDGAASGLRAARRLGADWPAAIPQEAMVAC------
MMAR_0770|M.marinum_M EDGAASGLRAARRLGADWPARTRPEAMLSC------
MUL_1404|M.ulcerans_Agy99 EDGAASGLRAARRLGADWPARTRPEAMLSC------
MLBr_01044|M.leprae_Br4923 GIGVPACISAAGRAIEALQAEVAR------------
MAB_2985c|M.abscessus_ATCC_199 GIGVPACVASASQAAQASVARWRHG-----------
*. : :