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MSINDQRLTRRVEDLYASDAQFAAASPNEAITQAIDQPGVALPQLIRMVMEGYADRPALGQRALRFVTDP DSGRTMVELLPRFETITYRELWARAGTLATALSAEPAIRPGDRVCVLGFNSVDYTTIDIALIRLGAVSVP LQTSAPVTGLRPIVTETEPTMIATSIDNLGDAVEVLAGHAPARLVVFDYHGKVDTHREAVEAARARLAGS VTIDTLAELIERGRALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRKSSGWFEPSGYPS ITLNFMPMSHVGGRQVLYGTLSNGGTAYFVAKSDLSTLFEDLALVRPTELCFVPRIWDMVFAEFHSEVDR RLVDGADRAALEAQVKAELRENVLGGRFVMALTGSAPISAEMTAWVESLLADVHLVEGYGSTEAGMVLND GMVRRPAVIDYKLVDVPELGYFGTDQPYPRGELLVKTQTMFPGYYQRPDVTAEVFDPDGFYRTGDIMAKV GPDQFVYLDRRNNVLKLSQGEFIAVSKLEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRHGIEN LKPVISESLQEVARAAGLQSYEIPRDFIIETTPFTLENGLLTGIRKLARPQLKKFYGERLERLYTELADS QSNELRELRQSGPDAPVLPTLCRAAAALLGSTAADVRPDAHFADLGGDSLSALSLANLLHEIFGVDVPVG VIVSPASDLRALADHIEAARTGVRRPSFASIHGRSATEVHASDLTLDKFIDAATLAAAPNLPAPSAQVRT VLLTGATGFLGRYLALEWLDRMDLVNGKLICLVRARSDEEAQARLDATFDSGDPYLVRHYRELGAGRLEV LAGDKGEADLGLDRVTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNAAGTAELLRLALTGKRKPYIYTS TIAVGEQIPPEAFTEDADIRAISPTRRIDDSYANGYANSKWAGEVLLREAHEQCGLPVTVFRCDMILADT SYTGQLNLPDMFTRLMLSLAATGIAPGSFYELDAHGNRQRAHYDGLPVEFVAEAICTLGTHSPDRFVTYH VMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEWLQRFETSLRALPDRQRHASLLPLLHNYREPAK PICGSIAPTDQFRAAVQEAKIGPDKDIPHLTAAIIAKYISNLRLLGLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2590 | fadD9 | - | 100% (1168) | PROBABLE FATTY-ACID-CoA LIGASE FADD9 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) |
| M. tuberculosis H37Rv | Rv0101 | nrp | 0.0 | 39.24% (1180) | peptide synthetase |
| M. tuberculosis H37Rv | Rv2187 | fadD15 | 3e-29 | 24.91% (574) | long-chain-fatty-acid-CoA ligase fadD15 (fatty-acid-CoA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2621 | fadD9 | 0.0 | 99.83% (1168) | fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_2962 | - | 8e-32 | 25.34% (588) | AMP-dependent synthetase and ligase |
| M. leprae Br4923 | MLBr_00484 | fadD9 | 0.0 | 68.23% (1174) | putative acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4714c | - | 0.0 | 55.20% (1172) | fatty-acid-coa ligase FadD |
| M. marinum M | MMAR_2117 | fadD9 | 0.0 | 75.89% (1174) | fatty-acid-CoA ligase FadD9 |
| M. avium 104 | MAV_3471 | - | 0.0 | 69.96% (1175) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2956 | - | 0.0 | 69.34% (1171) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_1879 | fadD9 | 1e-159 | 55.27% (550) | PROBABLE FATTY-ACID-CoA LIGASE FADD9 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_1722 | - | 0.0 | 75.55% (1174) | fatty-acid-CoA ligase FadD9 |
| M. vanbaalenii PYR-1 | Mvan_2578 | - | 0.0 | 66.89% (1175) | thioester reductase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2590|M.tuberculosis_H37Rv --------------MS--INDQR-LTRRVEDLYASDAQFAAASPNEAITQ
Mb2621|M.bovis_AF2122/97 --------------MS--INDQR-LTRRVEDLYASDAQFAAASPNEAITQ
MMAR_2117|M.marinum_M --------------MSPITREER-LERRIQDLYANDPQFAAAKPATAITA
MUL_1722|M.ulcerans_Agy99 --------------MSPITREER-LERRIQDLYANDPQFAAAKPVTAITA
MLBr_00484|M.leprae_Br4923 MWRQQSISHRKESVMSTITKQEKQLARRVDDLTANDPQFAAAKPDPAVAA
MAV_3471|M.avium_104 --------------MSTATHDER-LDRRVHELIATDPQFAAAQPDPAITA
MSMEG_2956|M.smegmatis_MC2_155 --------------MTIETREDR-FNRRIDHLFETDPQFAAARPDEAISA
Mvan_2578|M.vanbaalenii_PYR-1 --------------MSTDTREDR-LARRIADLYATDPQFAAAAPDDAISH
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 ------MTETISTAAVPTTDLEEQVKRRIEQVVSNDPQLAALLPEDSVTE
Mflv_2962|M.gilvum_PYR-GCK --------------------------MTAREFTVPAPFTVEERDNIVGAV
Rv2590|M.tuberculosis_H37Rv AIDQPGVALPQLIRMVMEGYADRPALGQRALRFVTDPDSGRTMVELLPRF
Mb2621|M.bovis_AF2122/97 AIDQPGVALPQLIRMVMEGYADRPALGQRALRFVTDPDSGRTMVELLPRF
MMAR_2117|M.marinum_M AIERPGLPLPQIIETVMTGYADRPALAQRSVEFVTDAGTGHTTLRLLPHF
MUL_1722|M.ulcerans_Agy99 AIERPGLPLPQIIETVMTGYADRPALAQRSVEFVTDAGTGHTTLRLLPHF
MLBr_00484|M.leprae_Br4923 ALAQPGLRLPQIIQTALDGYAERPALGQRVAEFTKDPKTGRTSMELLPSF
MAV_3471|M.avium_104 ALEQPGLRLPQIIRTVLDGYADRPALGQRVVEFVTDAKTGRTSAQLLPRF
MSMEG_2956|M.smegmatis_MC2_155 AAADPELRLPAAVKQILAGYADRPALGKRAVEFVTD-EEGRTTAKLLPRF
Mvan_2578|M.vanbaalenii_PYR-1 AIDQPGTHLPVIVQTVLDGYAERPALGQRAVRFVTDPATGRTTTELLPRF
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 AVNEPDLPLVEVIRRLLEGYGDRPALGQRAFEFVTG-DDGATVIALKPEY
Mflv_2962|M.gilvum_PYR-GCK FTHERDDPDHVIFQRLVDG-----------------------------KW
Rv2590|M.tuberculosis_H37Rv ETITYRELWARAGTLATALSAEPAIRPGDRVCVLGFNSVDYTTIDIALIR
Mb2621|M.bovis_AF2122/97 ETITYRELWARAGTLATALSAEPAIRPGDRVCVLGFNSVDYTTIDIALIR
MMAR_2117|M.marinum_M ETISYGELWDRISALADVLSTEQTVKPGDRVCLLGFNSVDYATIDMTLAR
MUL_1722|M.ulcerans_Agy99 ETISYGELWDRISALADVLSTEQTVKPSDRVCLLGFNSVDYATIDMTLAR
MLBr_00484|M.leprae_Br4923 ETITYRQLGDRVGALARAWRHD-LLHAGYRVCVLGFNSVDYAIIDMALGV
MAV_3471|M.avium_104 ETITYGEVAQRVSALGRALSDD-AVHPGDRVCVLGFNSVDYATIDMALGA
MSMEG_2956|M.smegmatis_MC2_155 DTITYRQLAGRIQAVTNAWHNH-PVNAGDRVAILGFTSVDYTTIDIALLE
Mvan_2578|M.vanbaalenii_PYR-1 ETITYAELSRRIHAVTAALT---DVHPGDRVAVLGFTSIDYTTVDMALAM
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 TTVSYRELWERAEAIAAAWHEQ-GIRDGDFVAQLGFTSTDFASLDVAGLR
Mflv_2962|M.gilvum_PYR-GCK IDVTARQAAGQIRSAARGLIAE-GVQAGDRVALLSATRYEWPILDFAILS
Rv2590|M.tuberculosis_H37Rv LGAVSVPLQTSAPVTGLRPIVTETEPTMIATSIDNLGDAVEV-LAGHAP-
Mb2621|M.bovis_AF2122/97 LGAVSVPLQTSAPVTGLRPIVTETEPTMIATSIDNLGDAVEV-LAGHAP-
MMAR_2117|M.marinum_M LGAVAVPLQTSAAITQLQPIVAETQPTMIAASVDALADATELALSGQTA-
MUL_1722|M.ulcerans_Agy99 LGAVAVPLQTSAAITQLQPIVAETQPTMIAASVDALADATELALSGQTA-
MLBr_00484|M.leprae_Br4923 IGAVAVPLQTSAAITQLQSIVTETEPSMIATSVNQLPDTVELIL-SGQAP
MAV_3471|M.avium_104 IGAVSVPLQTSAAISSLQPIVAETEPTLIASSVNQLSDAVQLITGAEQAP
MSMEG_2956|M.smegmatis_MC2_155 LGAVSVPLQTSAPVAQLQPIVAETEPKVIASSVDFLADAVALVESGPAP-
Mvan_2578|M.vanbaalenii_PYR-1 LGAVAVPLQTSAPATTVRPIVAETEPVVIASSVDALTDAVGLALDAPTV-
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 LGTVSVPLQTGASLQQRNAILEETRPAVFAASIEYLDAAVDSVLATPSV-
Mflv_2962|M.gilvum_PYR-GCK IGAVTVPIYETSSAEQVQFVLADSGAVAAIAETDAHAAHIEAQRDTLPAL
Rv2590|M.tuberculosis_H37Rv ARLVVFDYHGKVDTHREAVEAARARLAGS---VTIDTLAELIER-----G
Mb2621|M.bovis_AF2122/97 ARLVVFDYHGKVDTHREAVEAARARLAGS---VTIDTLAELIER-----G
MMAR_2117|M.marinum_M TRVLVFDHHRQVDAHRAAVESARERLAGS---AVVETLAEAIARGDVPRG
MUL_1722|M.ulcerans_Agy99 TRVLVFDHHRQVDAHRAAVESARERLAGS---AVVETLAEAIARGDVPRG
MLBr_00484|M.leprae_Br4923 AKLVVFDYHPEVDEQHDAVATARARLADSS--VVVESLTEVLGRG---KT
MAV_3471|M.avium_104 TRLVVFDYHPQVDDQREAVQDAAARLSGTG--VAVQTLAELLERG---KD
MSMEG_2956|M.smegmatis_MC2_155 SRLVVFDYSHEVDDQREAFEAAKGKLAGTG--VVVETITDALDRG----R
Mvan_2578|M.vanbaalenii_PYR-1 TRLVVFDHRAGVDDHRDALISASDRLRAANSPIEVETITDIVARG----S
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 RLLSVFDYHAEVDSQREALEAVRARLESAGRTIVVEALAEALARG-----
Mflv_2962|M.gilvum_PYR-GCK RRIYVIDGSVPALDELAEAGASVD--------------------------
Rv2590|M.tuberculosis_H37Rv RALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRKSSGWF
Mb2621|M.bovis_AF2122/97 RALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRKSSGWF
MMAR_2117|M.marinum_M ASAGSAPGTDVSDDSLALLIYTSGSTGAPKGAMYPRRNVATFWRKRT-WF
MUL_1722|M.ulcerans_Agy99 ASAGSAPGTDVSDDSLALLIYTSGSTGAPKGAMYPRRNVATFWRKRT-WF
MLBr_00484|M.leprae_Br4923 LPATPIPVADDSADPLALLIYTSGSTGAPKGAMYLQSNVGKMWRRSDGNW
MAV_3471|M.avium_104 LPAVAEPPADE--DSLALLIYTSGSTGAPKGAMYPQSNVGKMWRRGSKNW
MSMEG_2956|M.smegmatis_MC2_155 SLADAPLYVPDEADPLTLLIYTSGSTGTPKGAMYPESKTATMWQAGSKAR
Mvan_2578|M.vanbaalenii_PYR-1 KLPVRAQFS-ADGDALSLLIYTSGSTGAPKGAMYPQHLVANSWRRLARSF
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 RDLPAAPLPSADPDALRLLIYTSGSTGTPKGAMYPQWLVANLW--QKKWL
Mflv_2962|M.gilvum_PYR-GCK AAAVDERVASIRSTDAATLIYTSGTTGRPKGCQLTHSNLLYEIRGAKACF
Rv2590|M.tuberculosis_H37Rv EPS---GYPSITLNFMPMSHVGGRQVLYGTLSNGGTAYFVAKSDLSTLFE
Mb2621|M.bovis_AF2122/97 EPS---GYPSITLNFMPMSHVGGRQVLYGTLSNGGTAYYVAKSDLSTLFE
MMAR_2117|M.marinum_M EGG---YEPSITLNFMPMSHVMGRQILYGTLCNGGTAYFVAKSDLSTLFE
MUL_1722|M.ulcerans_Agy99 EGG---YEPSITLNFMPMSHVMGRQILYGTLCNGGTAYFVVKSDLSTLFE
MLBr_00484|M.leprae_Br4923 FGP---TAASITLNFMPMSHVMGRGILYGTLGNGGTAYFAARSDLSTLLE
MAV_3471|M.avium_104 FGE---SAASITLNFMPMSHVMGRSILYGTLGNGGTAYFAARSDLSTLLE
MSMEG_2956|M.smegmatis_MC2_155 WDETLGVMPSITLNFMPMSHVMGRGILCSTLASGGTAYFAARSDLSTFLE
Mvan_2578|M.vanbaalenii_PYR-1 WGD-LGVFPAITLNFMPMSHVMGRGLLYGTLDAGGTAYFAARSDLSTFLE
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 TDD---VIPSIGVNFMPMSHLAGRLTLMGTLSGGGTAYYIASSDLSTFFE
Mflv_2962|M.gilvum_PYR-GCK PEH--LAKGEKLLVFLPLAHVLARALTIGAFSNGVTLGFTS--DIKNLVP
Rv2590|M.tuberculosis_H37Rv DLALVRPTELCFVPRIWDMVFAEFHSEVDRRLVD---GADRAALEAQVKA
Mb2621|M.bovis_AF2122/97 DLALVRPTELCFVPRIWDMVFAEFHSEVDRRLVD---GADRAALEAQVKA
MMAR_2117|M.marinum_M DLALVRPTELTFVPRVWDMVFDEFQSEVDRRLVD---GADRVALEAQVKA
MUL_1722|M.ulcerans_Agy99 DLALVRPTELTFVPRVWDMVFDEFQSEVDRRLVD---GADRVALEAQVKA
MLBr_00484|M.leprae_Br4923 DLKLVRPTELNFVPRIWETLYDESKRAVDRRLANSGSA-DRAAIKAEVMD
MAV_3471|M.avium_104 DLELVRPTELNFVPRIWETLYGEFQRQVERRLSEAGDAGERRAVEAEVLA
MSMEG_2956|M.smegmatis_MC2_155 DLALVRPTQLNFVPRIWDMLFQEYQSRLDNRRAE----GSEDRAEAAVLE
Mvan_2578|M.vanbaalenii_PYR-1 DLALVRPTQLSFVPRIWDTIHAEVSQELERRPSD----ATE------VIA
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 DIALIRPSEVLFVPRVVEMVFQRFQAELDRSLAP---GESNSEIAERIKV
Mflv_2962|M.gilvum_PYR-GCK MFAVFQPTLVVSVPRVFEKVYN----------------------------
Rv2590|M.tuberculosis_H37Rv ELRENVLGGRFVMALTGSAPISAEMTAWVESLLADVHLVEGYGSTEAGMV
Mb2621|M.bovis_AF2122/97 ELRENVLGGRFVMALTGSAPISAEMTAWVESLLADVHLVEGYGSTEAGMV
MMAR_2117|M.marinum_M EIRNDVLGGRYTSALTGSAPISDEMKAWVEELL-DMHLVEGYGSTEAGMI
MUL_1722|M.ulcerans_Agy99 EIRNDVLGGRYTSALTGSAPISDEMKAWVEELL-DMHLVEGYGSTEAGMI
MLBr_00484|M.leprae_Br4923 EQRQSLLGGRYIAAMTGSAPTSPELKHGVESLL-EMHLLEGYGSTEAGMV
MAV_3471|M.avium_104 EQRQYLLGGRFTFAMTGSAPISPELRNWVESLL-EMHLMDGYGSTEAGMV
MSMEG_2956|M.smegmatis_MC2_155 EVRTQLLGGRFVSALTGSAPISAEMKSWVEDLL-DMHLLEGYGSTEAGAV
Mvan_2578|M.vanbaalenii_PYR-1 DLRRSLLGGRYVTAMTGSAPLSPEMRAFVENLL-DVHLIDGYGSTEAGAV
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 RIREQDFGGRVLSAGSGSAPLSPEMTEFMESLL-QVPLRDGYGSTEAGGV
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
Rv2590|M.tuberculosis_H37Rv LNDGMVRRPAVIDYKLVDVPELGYFGTDQPYPRGELLVKTQTMFPGYYQR
Mb2621|M.bovis_AF2122/97 LNDGMVRRPAVIDYKLVDVPELGYFGTDQPYPRGELLVKTQTMFPGYYQR
MMAR_2117|M.marinum_M LIDGAIRRPAVLDYKLVDVPDLGYFLTDRPHPRGELLVKTDSLFPGYYQR
MUL_1722|M.ulcerans_Agy99 LIDGAIRRPAVLDYKLVDVPDLGYFLTDRPHPRGELLVKTDSLFPGYYQR
MLBr_00484|M.leprae_Br4923 LFDGEVQRPPVIDYKLVDVPDLGYFSTDQPYPRGELLLKTQNMFPGYYKR
MAV_3471|M.avium_104 LFDGEIQRPPVVDYKLVDVPDLGYFSTDRPHPRGELLLRTENMFPGYYKR
MSMEG_2956|M.smegmatis_MC2_155 FIDGQIQRPPVIDYKLVDVPDLGYFATDRPYPRGELLVKSEQMFPGYYKR
Mvan_2578|M.vanbaalenii_PYR-1 FVDGRVQRPPVIDYKLVDVADLGYFSTDRPHPRGELLVKSETLFPGYYKR
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 WRDGVLQRPPVTDYKLVDVPELGYFTTDSPHPRGELRLKSETMFPGYYKR
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
Rv2590|M.tuberculosis_H37Rv PDVTAEVFDPDGFYRTGDIMAKVGPDQFVYLDRRNNVLKLSQGEFIAVSK
Mb2621|M.bovis_AF2122/97 PDVTAEVFDPDGFYRTGDIMAKVGPDQFVYLDRRNNVLKLSQGEFIAVSK
MMAR_2117|M.marinum_M AEVTADVFDADGFYRTGDIMAEVGPEQFVYLDRRNNVLKLSQGEFVTVSK
MUL_1722|M.ulcerans_Agy99 AEVTADVFDADGFYRTGDIMAEVGPEQFVYLDRRNNVLKLSQGEFVTVSK
MLBr_00484|M.leprae_Br4923 PEVTATVFDSDGYYQTGDIVAEVGPDRLVYVDRRNNVLKLAQGQFVTVAK
MAV_3471|M.avium_104 AETTAGVFDEDGYYRTGDVFAEIAPDRLVYVDRRNNVLKLAQGEFVTLAK
MSMEG_2956|M.smegmatis_MC2_155 PEITAEMFDEDGYYRTGDIVAELGPDHLEYLDRRNNVLKLSQGEFVTVSK
Mvan_2578|M.vanbaalenii_PYR-1 PDVTAEMFDEDGYYRTGDIVAETGADQLTYLDRRNNVLKLSQGEFVTVSR
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_4714c|M.abscessus_ATCC_199 PETTADVFDDEGYYKTGDVVAELGPDHLKYLDRVKNVLKLAQGEFVAVSK
Mflv_2962|M.gilvum_PYR-GCK ---------------TAELNAETGGKGKIFTAAANTAIEYS---------
Rv2590|M.tuberculosis_H37Rv LEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRHG--IENLKPVI
Mb2621|M.bovis_AF2122/97 LEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRHG--IENLKPVI
MMAR_2117|M.marinum_M LEAVFGDSPLVRQIYIYGNSARAYLLAVIVPTQEALDAVP--VEELKARL
MUL_1722|M.ulcerans_Agy99 LEAVFGDSPLVRQIYIYGNSARAYLLAVIVPTQEALDAVP--VEELKARL
MLBr_00484|M.leprae_Br4923 LEAAFSNSPLVRQIYIYGNSAHPYLLAVVVPTEDALATND--IEVLKPLI
MAV_3471|M.avium_104 LEAVFGNSPLIRQIYVYGNSAQPYLLAVVVPTEEALASGD--PETLKPKI
MSMEG_2956|M.smegmatis_MC2_155 LEAVFGDSPLVRQIYVYGNSARSYLLAVVVPTEEALSRWD--GDELKSRI
Mvan_2578|M.vanbaalenii_PYR-1 LEAVFGNSPLVRQIYVYGNSARPYLLAVVVPTEAALA-----GADAKAAV
TH_1879|M.thermoresistible__bu -------------------------------------------------V
MAB_4714c|M.abscessus_ATCC_199 LEAAYTGSPLVRQIFVYGNSERSFLLAVVVPTPEVLERYADSPDALKPLI
Mflv_2962|M.gilvum_PYR-GCK ---------------------------------KALDSGG----------
Rv2590|M.tuberculosis_H37Rv SESLQEVARAAG-LQSYEIPRDFIIETTPFTLENGLLTGIRKLARPQLKK
Mb2621|M.bovis_AF2122/97 SESLQEVARAAG-LQSYEIPRDFIIETTPFTLENGLLTGIRKLARPQLKK
MMAR_2117|M.marinum_M GDSLQEVAKAAG-LQSYEIPRDFIIETTPWTLENGLLTGIRKLARPQLKK
MUL_1722|M.ulcerans_Agy99 GDSLQEVAKAAG-LQSYEIPRDFIIETTPWTLQNGLLTGIRKLARPQLKK
MLBr_00484|M.leprae_Br4923 IDSLQKVAKEAD-LQSYEVPRDLIVETTPFSLENGLLTGIRKLAWPKLKQ
MAV_3471|M.avium_104 ADSLQQVAKEAG-LQSYEVPRDFIIETTPFSLENGLLTGIRKLAWPKLKQ
MSMEG_2956|M.smegmatis_MC2_155 SDSLQDAARAAG-LQSYEIPRDFLVETTPFTLENGLLTGIRKLARPKLKA
Mvan_2578|M.vanbaalenii_PYR-1 AESLQDVAKATG-LQSYEIPRDFLLETTPFTLENGLLTGIRKLARPRLRE
TH_1879|M.thermoresistible__bu GLSXQARARLADRLPAYMVPAAVVVLDRIPLTVNGKLD-RRALPAPEYQR
MAB_4714c|M.abscessus_ATCC_199 QDSLQQVAKDAE-LQSYEIPRDFIVETVPFTVESGLLSDARKLLRPKLKD
Mflv_2962|M.gilvum_PYR-GCK ----------------------------PGLVLKLKHALFDKLVYGKLRA
. * . :
Rv2590|M.tuberculosis_H37Rv FYGERLERLYTELADSQSNELRELRQSGPDAPVLPTLCRAAAALLGSTAA
Mb2621|M.bovis_AF2122/97 FYGERLERLYTELADSQSNELRELRQSGPDAPVLPTLCRAAAALLGSTAA
MMAR_2117|M.marinum_M HYGELLEQIYTDLAHGQADELRSLRQSGADAPVLVTVCRAAAALLGGSAS
MUL_1722|M.ulcerans_Agy99 HYGELLEQIYTDLAHGQADELRSLRQSGADAPVLVTVCRAAAALLGGSAS
MLBr_00484|M.leprae_Br4923 HYGARLEQLYADLVEGQANALHVLKQSVANAPVLQTVSRAVGTILGVATT
MAV_3471|M.avium_104 HYGERLEQMYADLAAGQADELAELRRNGAQAPVLQTVSRAAGAMLGSAAS
MSMEG_2956|M.smegmatis_MC2_155 HYGERLEQLYTDLAEGQANELRELRRNGADRPVVETVSRAAVALLGASVT
Mvan_2578|M.vanbaalenii_PYR-1 RYGEQLEALYTMLSEEQADELRELRRSGGERPALETVGRAAGALLGTTAG
TH_1879|M.thermoresistible__bu AD----------------------RYRAPETAVEKTLTEIFAHVLG--LE
MAB_4714c|M.abscessus_ATCC_199 HYGERLEALYAELAESQNERLRQLAREAATRPVLETVTDAAAALLGASSS
Mflv_2962|M.gilvum_PYR-GCK ALGGR-----------------------------CHAAISGGAPLGARLG
**
Rv2590|M.tuberculosis_H37Rv DVRPDAHFADLGGDSLSALSLANLLHEIFGVDVPVGVIVSPASDLRALAD
Mb2621|M.bovis_AF2122/97 DVRPDAHFADLGGDSLSALSLANLLHEIFGVDVPVGVIVSPASDLRALAD
MMAR_2117|M.marinum_M DVQPDAHFTDLGGDSLSALSFTNLLHEIFDIEVPVGVIVSPANDLQALAD
MUL_1722|M.ulcerans_Agy99 DVQPDAHFTDLGGDSLSALSFTNLLHEIFDIDVPVGVIVSPANDLQALAD
MLBr_00484|M.leprae_Br4923 DLPSNAHFTDLGGDSLSALTFGSLLRELFDIDVPVGVIVSPVNNLVAIAD
MAV_3471|M.avium_104 DLSPDAHFTDLGGDSLSALTFGNLLREIFDVDVPVGVIVSPANDLAAIAS
MSMEG_2956|M.smegmatis_MC2_155 DLRSDAHFTDLGGDSLSALSFSNLLHEIFDVDVPVGVIVSPATDLAGVAA
Mvan_2578|M.vanbaalenii_PYR-1 ELEPSAHFTDLGGDSLSALTFANLLRDIFDVDVPVGVIVSPATDLQALAD
TH_1879|M.thermoresistible__bu RVGVDDSFFDLGGDSISAMRAVAAINTALDTDVAVRTLFEAP-TVRRLSR
MAB_4714c|M.abscessus_ATCC_199 DLAPDVRFIDLGGDSLSALSYSELLRDIFEVDVPVGVINSVANDLAAIAR
Mflv_2962|M.gilvum_PYR-GCK HFYRGVGLSIYEGYGLTETSAAITVNRVGDLRVGS---------------
. . : * .:: :. *
Rv2590|M.tuberculosis_H37Rv HIE-----AAR-TGVRRPSFASIHGRS---ATEVHASDLTLDKFIDAATL
Mb2621|M.bovis_AF2122/97 HIE-----AAR-TGVRRPSFASIHGRS---ATEVHASDLTLDKFIDAATL
MMAR_2117|M.marinum_M YVE-----AARKPGSSRPTFASVHGASNGQVTEVHAGDLSLDKFIDAATL
MUL_1722|M.ulcerans_Agy99 YVE-----AARKPGSSRPTFASVHGASNEQVTEVHAGDLSLDKFIDAATL
MLBr_00484|M.leprae_Br4923 YIE-----RER-QGTKRPTFIAIHGRD---AGKVHASDLTLDKFIDVSTL
MAV_3471|M.avium_104 YIE-----AER-QGSKRPTFASVHGRD---ATVVRAADLTLDKFLDADTL
MSMEG_2956|M.smegmatis_MC2_155 YIE-----GELR-GSKRPTYASVHG---RDATEVRARDLALGKFIDAKTL
Mvan_2578|M.vanbaalenii_PYR-1 YVE-----SARRHGSVRPTFESVHGHSGRPGTEVHARDLTLDEFVDAATL
TH_1879|M.thermoresistible__bu QLEGGADTAPQGADLGAVTYESVHGAT---ATEVRAADLTLDRFIDAATL
MAB_4714c|M.abscessus_ATCC_199 HIE-----AQRTGAATQPTFASVHGKD---ATVITAGELTLDKFLDESLL
Mflv_2962|M.gilvum_PYR-GCK ----------------------------------------VGKLVPGNSM
:..:: :
Rv2590|M.tuberculosis_H37Rv AAAPNLPAPSAQVRTVLLTGATGFLGRYLALEWLDRMDLVNGKLICLVRA
Mb2621|M.bovis_AF2122/97 AAAPNLPAPSAQVRTVLLTGATGFLGRYLALEWLDRMDLVNGKLICLVRA
MMAR_2117|M.marinum_M AEAPRLPAANTQVRTVLLTGATGFLGRYLALEWLERMDLVDGKLICLVRA
MUL_1722|M.ulcerans_Agy99 AEAPRLPAANTQVRTVLLTGATGFLGRYLALEWLERMDLVDGKLICLVRA
MLBr_00484|M.leprae_Br4923 TAAPVLAQPGTEVRTVLLTGATGFLGRYLALKWLERMDLVEGKVIALVRA
MAV_3471|M.avium_104 ASAPNLPKPATEVRTVLLTGATGFLGRYLALEWLERMDMVDGKVIALVRA
MSMEG_2956|M.smegmatis_MC2_155 SAAPGLPRSGTEIRTVLLTGATGFLGRYLALEWLERMDLVDGKVICLVRA
Mvan_2578|M.vanbaalenii_PYR-1 AHAPTLPGPRAEVRTVLLTGATGFLGRYLALEWLERMALVGGKLICLVRA
TH_1879|M.thermoresistible__bu RTAADLPRPTGQVQTVLLTGATGFLGRYLLLEWLRRLRRVDDTVICLVRG
MAB_4714c|M.abscessus_ATCC_199 KAAKDVQPATADVKTVLVTGGNGWLGRWLVLDWLERLAPNGGKVYALIRG
Mflv_2962|M.gilvum_PYR-GCK RLG--------EDGELLVRGGVVFNG-YWGNEEETRAVFTDGWFHTGDLG
. : :*: *. : * : . * . . .
Rv2590|M.tuberculosis_H37Rv RSDEEAQARLDATFDSGDPYLVRHYRELGAGRLEVLAGDKGEADLGLDRV
Mb2621|M.bovis_AF2122/97 RSDEEAQARLDATFDSGDPYLVRHYRELGAGRLEVLAGDKGEADLGLDRV
MMAR_2117|M.marinum_M KSDTEARARLDKTFDSGDPELLAHYRALAGDHLEVLAGDKGEADLGLDRQ
MUL_1722|M.ulcerans_Agy99 KSDTEARARLEKTFDSGAPELLAHYRALAGDHLEVLAGDKGEADLGLDRQ
MLBr_00484|M.leprae_Br4923 KSNEDARARLDKTFDSGDPKLLAHYQELATDHLEVIAGDKGEVDLELDRQ
MAV_3471|M.avium_104 RSDEEARARLDKTFDSGDPKLLAHYQQLAADHLEVIAGDKGEANLGLRQD
MSMEG_2956|M.smegmatis_MC2_155 RSDDEARARLDATFDTGDATLLEHYRALAADHLEVIAGDKGEADLGLDHD
Mvan_2578|M.vanbaalenii_PYR-1 KDDAAARVRLDSTFDSGDPELLRHYRRLAADHLEVIAGDKADADLGLDAR
TH_1879|M.thermoresistible__bu RSDADARQRLEAVFDT-DPALRRHFRELAAERLQVIAGDKGQPNLGLDVQ
MAB_4714c|M.abscessus_ATCC_199 ADAEAARARLDAVYESGDPKLSAHYRQLAQQSLEVIAGDFGDQDLGLSQE
Mflv_2962|M.gilvum_PYR-GCK AIDDDG------------------FLTIVGRKKEIIVTAGGKN-------
. : : :::. ..
Rv2590|M.tuberculosis_H37Rv TWQRLADTVDLIVDPAALVNHVLPYSQLFGPNAAGTAELLRLALTGKRKP
Mb2621|M.bovis_AF2122/97 TWQRLADTVDLIVDPAALVNHVLPYSQLFGPNAAGTAELLRLALTGKRKP
MMAR_2117|M.marinum_M TWQRLADTVDLIVDPAALVNHVLPYSQLFGPNALGTAELLRLALTSKIKP
MUL_1722|M.ulcerans_Agy99 TWQRLADTVDLIVDPAALVNHVLPYSQLFGPNALGTAELLRLALTSKIKP
MLBr_00484|M.leprae_Br4923 TWRRLADTVDLIVDPAALVNHVLPYSELFGPNTLGTAELIRIALTSKQKP
MAV_3471|M.avium_104 VWQRLADTVDVIVDPAALVNHVLPYSELFGPNALGTAELIRLALTSKQKP
MSMEG_2956|M.smegmatis_MC2_155 TWQRLADTVDLIVDPAALVNHVLPYSQMFGPNALGTAELIRIALTTTIKP
Mvan_2578|M.vanbaalenii_PYR-1 TWQRLADTVDLIVDPAALVNHVLPYRQLFAPNVLGTAELLRIALTTRMKP
TH_1879|M.thermoresistible__bu TWRRLAERVDLIVDSAAFVNSVLPYRELFGPNVVGTAELIRFALTAKLKP
MAB_4714c|M.abscessus_ATCC_199 VWQKLAKDVDLIVHSGALVNHVLPYSQLFGPNVAGTAEIIKLAISERLKP
Mflv_2962|M.gilvum_PYR-GCK ------------VAPAQLEDRLRAHPLISQAMAVGDQQPFIAALIT----
* .. : : : .: : . . * : : *:
Rv2590|M.tuberculosis_H37Rv YIYTSTIAVGEQIPPEAFTEDADIRAISPTRRIDDSYANGYANSKWAGEV
Mb2621|M.bovis_AF2122/97 YIYTSTIAVGEQIPPEAFTEDADIRAISPTRRIDDSYANGYANSKWAGEV
MMAR_2117|M.marinum_M YSYTSTIGVADQIPPSAFTEDADIRVISATRAVDDSYANGYSNSKWAGEV
MUL_1722|M.ulcerans_Agy99 YSYTSTIGVADQIPPSAFTEDADIRVISATRAVDDSYANGYSNSKWAGEV
MLBr_00484|M.leprae_Br4923 YIYVSTIGVGNQIEPAKFTEDSDIRVISPTRNINNNYANGYGNSKWAGEV
MAV_3471|M.avium_104 YTYVSTIGVGDQIEPGKFVENADIRQMSATRAINDSYANGYGNSKWAGEV
MSMEG_2956|M.smegmatis_MC2_155 YVYVSTIGVGQGISPEAFVEDADIREISATRRVDDSYANGYGNSKWAGEV
Mvan_2578|M.vanbaalenii_PYR-1 FVYVSTIGVGAGIEPARFTEDADIRQISATRRIDDSYANGYGNSKWAGEV
TH_1879|M.thermoresistible__bu YNFVSTSDIGRQIEPDLFTEDADIRTISPTRTVDASYANGYGNSKWAGEV
MAB_4714c|M.abscessus_ATCC_199 VTYLSTVGIADQIPVTEFEEDSDVRVMSAERQINDGYANGYGNSKWAGEV
Mflv_2962|M.gilvum_PYR-GCK ------------VDTEAFPGWKERHHKASDASVADLADD-----------
: * : : :. : :
Rv2590|M.tuberculosis_H37Rv LLREAHEQCGLPVTVFRCDMILADTSYTGQLNLPDMFTRLMLSLAATGIA
Mb2621|M.bovis_AF2122/97 LLREAHEQCGLPVTVFRCDMILADTSYTGQLNLPDMFTRLMLSLAATGIA
MMAR_2117|M.marinum_M LLREAHDLCGLPVAVFRCDMILADTTWAGQLNVPDMFTRMILSLAATGIA
MUL_1722|M.ulcerans_Agy99 LLREAHVLCGLPVAVFRCDMILADTTWAGQLNVPDMFTRMILSLAATGIA
MLBr_00484|M.leprae_Br4923 LLREAHDLCGLPVTVFRCDMILADTSYAGQLNVPDMFTRMMLSLAATGIA
MAV_3471|M.avium_104 LLREAHDLCGLPVAVFRCDMILADTTYAGQLNLPDMFTRLMLSLVATGIA
MSMEG_2956|M.smegmatis_MC2_155 LLREAHDWCGLPVSVFRCDMILADTTYSGQLNLPDMFTRLMLSLVATGIA
Mvan_2578|M.vanbaalenii_PYR-1 LLREAHDLCGLPVSVFRCDMILADTTYAGQLNLPDMFTRLIFSLVATGVA
TH_1879|M.thermoresistible__bu LLREAHDLCGLPVAVFRSGMILVDPTYAGQLNVTDTVSRMVLSIVATGVA
MAB_4714c|M.abscessus_ATCC_199 LLREAHDLAGLPVRVFRSDMILAHSDYHGQLNVTDVFTRSIQSLLLTGVA
Mflv_2962|M.gilvum_PYR-GCK ---------------------------------PDLLAEIELAVKDANQA
.* .:. :: :. *
Rv2590|M.tuberculosis_H37Rv PGSFYELDAHGNRQRAHYDGLPVEFVAEAICTLGTH---SPDR-----FV
Mb2621|M.bovis_AF2122/97 PGSFYELDAHGNRQRAHYDGLPVEFVAEAICTLGTH---SPDR-----FV
MMAR_2117|M.marinum_M PGSFYELAADGARQRAHYDGLPVEFIAEAISTLGAQ---SQDG-----FH
MUL_1722|M.ulcerans_Agy99 PGSFYELAADGARQRAHYDGLPVEFIAEAISTLGAQ---SQDG-----FH
MLBr_00484|M.leprae_Br4923 PGSFYELDAESNRQRAHYDGLPVEFIAEAISTLGDQSLHDRDG-----FT
MAV_3471|M.avium_104 PGSFYELDADGNRQRAHYDGLPVEFIAAAISTLGSQITDSDTG-----FQ
MSMEG_2956|M.smegmatis_MC2_155 PGSFYELDADGNRQRAHYDGLPVEFIAEAISTIGSQ---VTDG-----FE
Mvan_2578|M.vanbaalenii_PYR-1 PESFYHLATDGTRQRAHYDGLPVEFIAEAISTLGSD---VASG-----FR
TH_1879|M.thermoresistible__bu PKSFYRLGDDGSRQRAHFDGLPVDFVAEAVATLGWQIARTATGSPAGDFR
MAB_4714c|M.abscessus_ATCC_199 PASFYELDADGNRQRAHYDGVPGDFTAASITAIGGVN--VVDG-----YR
Mflv_2962|M.gilvum_PYR-GCK VS------------------------------------------------
Rv2590|M.tuberculosis_H37Rv TYHVMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEWLQRFETSLR
Mb2621|M.bovis_AF2122/97 TYHVMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEWLQRFETSLR
MMAR_2117|M.marinum_M TYHVMNPYDDGIGLDEFVDWLNE----SGCPIQRIADYGDWLQRFETALR
MUL_1722|M.ulcerans_Agy99 TYHVMNPYDDGIGLDEFVDWLNE----SGCPIQRIADYGDWLQRFETALR
MLBr_00484|M.leprae_Br4923 TYHVMNPHDDGIGMDEFVDWLID----AGCPIQRINDYDEWLRRFEISLR
MAV_3471|M.avium_104 TYHVMNPYDDGIGLDEYVDWLVD----AGYSIERIADYSEWLRRFETSLR
MSMEG_2956|M.smegmatis_MC2_155 TFHVMNPYDDGIGLDEYVDWLIE----AGYPVHRVDDYATWLSRFETALR
Mvan_2578|M.vanbaalenii_PYR-1 TYHVMNPHDDGIGLDEYVDWLID----AGHPIRRVGDYPTWLQRFTVAIT
TH_1879|M.thermoresistible__bu TYHVMNPHDDGIGIDEYVDWLIE----AGHPIERIDDFGEWLRRFEAGLH
MAB_4714c|M.abscessus_ATCC_199 SFDVFNPHHDGVSMDTFVDWLID----AGYKIARIDDYDQWLARFELALK
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
Rv2590|M.tuberculosis_H37Rv ALPDRQRHASLLPLLHNYRE------PAKPICGSIAPTDQFRAAVQEAKI
Mb2621|M.bovis_AF2122/97 ALPDRQRHTSLLPLLHNYRE------PAKPICGSIAPTDQFRAAVQEAKI
MMAR_2117|M.marinum_M ALPDRQRHSSLLPLLHNYRQ------PERPVRGSIAPTDRFRAAVQEAKI
MUL_1722|M.ulcerans_Agy99 ALPDRQRHSSLLPLLHNYRQ------PERPVRGSIAPTDRFRAAVQEAKI
MLBr_00484|M.leprae_Br4923 ALPERQRHSSLLPLLHNYQK------PEKPLHGSLAPTIRFRTAVQNANI
MAV_3471|M.avium_104 ALPDRQRQYSLLPLLHNYRT------PEKPINGSIAPTDVFRAAVQEAKI
MSMEG_2956|M.smegmatis_MC2_155 ALPERQRQASLLPLLHNYQQ------PSPPVCGAMAPTDRFRAAVQDAKI
Mvan_2578|M.vanbaalenii_PYR-1 ALPERQRQASLLPLLHNYQH------PETPIRGSIAPTDRFREAVQDAKI
TH_1879|M.thermoresistible__bu ALPERQRQHSVLQMLTLLRQQGGEPQPPEPRHGSDAPADRFEAAVKRAGI
MAB_4714c|M.abscessus_ATCC_199 GLPEQQRQQSVLPLLKMYEK------PQPAIDGSALPTAEFSRAVHEAKV
Mflv_2962|M.gilvum_PYR-GCK -KAEAIRKFRILPVDFTEDT------------GELTPTLKVKRKVVAEKF
.: *: :* : * *: . * .
Rv2590|M.tuberculosis_H37Rv GPDKDIPHLTAAIIAKYISNLRLLGLL
Mb2621|M.bovis_AF2122/97 GPDKDIPHLTAAIIAKYISNLRLLGLL
MMAR_2117|M.marinum_M GPDKDIPHVGAPIIVKYVSDLRLLGLL
MUL_1722|M.ulcerans_Agy99 GPDKDIPHVGAPIIVKYVSDLRLLGLL
MLBr_00484|M.leprae_Br4923 GQDKDIPHISPAIIAKYVSDLQLLGLV
MAV_3471|M.avium_104 GPDKDIPHVSPPVIVKYITDLQLLGLL
MSMEG_2956|M.smegmatis_MC2_155 GPDKDIPHVTADVIVKYISNLQMLGLL
Mvan_2578|M.vanbaalenii_PYR-1 GPDKDIPHVTPQIVIKYVTDLQRLGLL
TH_1879|M.thermoresistible__bu NGGQGIPHVTPEVIVRYVTDLRQLGLL
MAB_4714c|M.abscessus_ATCC_199 GDSGEIPHVTKELILKYASDIQLLGLV
Mflv_2962|M.gilvum_PYR-GCK AADIEALYAKG----------------
. :