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M. tuberculosis H37Rv Rv2396 (PE_PGRS41)

annotation: PE-PGRS FAMILY PROTEIN
coordinates: 2692799 - 2693884
length: 361

MSFLIASPEALAATATYLTGIGSAISAANAVAAAPTTEILAAGTDEVSTAISALFGAHAQAYQALSAHVA
AFHDQFVHTLTAGAGSYMAAEAAAASPLQALQLELLNAINAPTLALLGRPLIGDGTDAAPGSGGAGGAGG
ILIGNGGTGGASDLAGTGRGGVGGAGGAGGLFGIGGAGGGCGSAVAIGGDGGAGGAGGVFSGGGAGGAGD
AIGGSGGAGGTGGLLGGGGGAGGAGGAGGNGGGASNSASIGGDGGSGGAGGMLYGAGGVGGNGGAAVAIG
GDGGAGGRAGAIGNGGDGGNGGTSNTPGGSGGDGGNGGNAGLIGNGGNGGNAEIVISGGSVAGTGGNGGL
LLGFNGTNGLP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2396PE_PGRS41-100% (361)PE-PGRS FAMILY PROTEIN
M. tuberculosis H37RvRv1818cPE_PGRS33e-10555.81% (396) PE-PGRS family protein
M. tuberculosis H37RvRv0278cPE_PGRS3e-10455.36% (401) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2418PE_PGRS410.099.17% (361) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-3e-5952.46% (244) triple helix repeat-containing collagen
M. leprae Br4923MLBr_01183-4e-1237.36% (91) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-6e-2838.43% (229) hypothetical protein MAB_4284c
M. marinum MMMAR_4224-1e-10354.19% (406) PE-PGRS family protein
M. avium 104MAV_4827-1e-2143.87% (155) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_3202-3e-4545.93% (270) hypothetical protein MSMEG_3202
M. thermoresistible (build 8)TH_4332-1e-3332.59% (359) PUTATIVE -
M. ulcerans Agy99MUL_4524-1e-9752.26% (398) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-3e-5651.82% (247) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Rv2396|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2418|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155      --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -------------------------------MVTFGGGATPTPTSLGAAA
Mvan_1264|M.vanbaalenii_PYR-1       MMFLAPPGGPGPISAAIQLTSTGSEATEPWYVVSFGGSGAPTPNNLAASL
MMAR_4224|M.marinum_M               --------------------------------------------------
MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------------MSIIDFILNLFRDPVEAASYVADPE
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv2396|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2418|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155      --------------------------------------------------
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          VDLSGTSCGLICNGQDGTGQNGGILFGNGGSGWNSDVVGMDGGNGGNGGL
Mvan_1264|M.vanbaalenii_PYR-1       VDLSGTSCGLICNGQDGTGQNGGILFGNGGSGWNSEIAGVSGGNGGNAGL
MMAR_4224|M.marinum_M               --------------------------------------------------
MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGN
MAV_4827|M.avium_104                --------------------------------MNIVLGVSMAPSSIQMVV
                                                                                      

Rv2396|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2418|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155      -------------------------------------------------M
TH_4332|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          FGGNGGNGGNGLGGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG
Mvan_1264|M.vanbaalenii_PYR-1       FGGNGGNGGNGLGSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG
MMAR_4224|M.marinum_M               --------------------------------------------------
MUL_4524|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSP
MAV_4827|M.avium_104                LEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQ
                                                                                      

Rv2396|M.tuberculosis_H37Rv         ------------------------MSFLIASPEALAATATYLTGIGSAIS
Mb2418|M.bovis_AF2122/97            ------------------------MSFLIASPEALAATATYLTGIGSAIN
MSMEG_3202|M.smegmatis_MC2_155      TKHQRLTSAVAASIVATAGVAVSQAPAPASTGTPTAHQTPTSTSTPRWLT
TH_4332|M.thermoresistible__bu      -------------------------MPFITSGAAFVGGAAMLLAGPGGVS
Mflv_5091|M.gilvum_PYR-GCK          APGVAGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAGAVG
Mvan_1264|M.vanbaalenii_PYR-1       APGVAGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAGAVG
MMAR_4224|M.marinum_M               ------------------------MSFLVTAPEILAAAATDLDGIGAAIG
MUL_4524|M.ulcerans_Agy99           ------------------------MSYLVAVPEMLASAALDLDNIGSTIT
MLBr_01183|M.leprae_Br4923          -----------------------MPLFLNAEPQALTAAANTLEGLSAATV
MAB_4284c|M.abscessus_ATCC_199      SGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQG
MAV_4827|M.avium_104                LSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMG
                                                                                      

Rv2396|M.tuberculosis_H37Rv         AANAVAAAPTTEILAAG---------TDEVSTAISALFGAHAQAYQALSA
Mb2418|M.bovis_AF2122/97            AANAVAAAPTTEILAAG---------TDEVSTAISALFGAHAQAYQALSA
MSMEG_3202|M.smegmatis_MC2_155      VTSTPEGAPATPNALYG-------------AILPSTSPGSVTSTGSGIGH
TH_4332|M.thermoresistible__bu      ALEAAGSAPRTVEYEYS-------------LVACDSTLPLMCEAGDSVGG
Mflv_5091|M.gilvum_PYR-GCK          SAGAAGEAGETGTWGNAGLPGKAGDAGGAGAVGAAGAAGTVGTAGATGGT
Mvan_1264|M.vanbaalenii_PYR-1       SAGTAGSAGAPGVWGNAGLPGAAGAAGGAGAIGTAGVAGAAGTAGATGGT
MMAR_4224|M.marinum_M               AANAAAAAPTTAVLAAG---------ADEISAAMASLFTAHAQAYQGLSV
MUL_4524|M.ulcerans_Agy99           AANAAAAAPTTAVLAAG---------ADEISAAVAALFTGHAQAYQWLGA
MLBr_01183|M.leprae_Br4923          ASNAAAAQLTTEIAPPA---------ADDVSILLAHFFSGHGRQYQAHAS
MAB_4284c|M.abscessus_ATCC_199      STAVNGDVRDSNIINAD----------HGSNVGVDQSQTRVGGDYTNVSG
MAV_4827|M.avium_104                YERTAVLLVEPDTATLAVVET------SDGSIPDVYKQQIRAESYGDAAG
                                       .      .                                     . 

Rv2396|M.tuberculosis_H37Rv         HVAAFHDQFVHTLTAGAGSYMAAEAAAASPLQALQLELLN----------
Mb2418|M.bovis_AF2122/97            HVAAFHDQFVHTLTAGAGSYMAAEAAAS-PLQALQLELLN----------
MSMEG_3202|M.smegmatis_MC2_155      REPGISGSPAFTAVRAVRPGSSTARLVFAPKTSTSGTALTVT-PIAVGMV
TH_4332|M.thermoresistible__bu      LGGASHDRSAFSAS-------ALGMASFGPDWNPGGAFLG----------
Mflv_5091|M.gilvum_PYR-GCK          GTGANGGAGGVGGVGGTGAAGAAGGAGGLGETGTTGGAGGVG-GQGTAGG
Mvan_1264|M.vanbaalenii_PYR-1       GVGGNGGAGQAGGIGGTGAAGAAGQAGTAGETGVTGGVGGIG-GQGTEGG
MMAR_4224|M.marinum_M               QVGAFHNQFVQALTGAGGAYAAAEAANVSPLQAAAQDMLTAIRAPAQALL
MUL_4524|M.ulcerans_Agy99           QAGAFHSQFIQALTGSGSAYAAAEAANASPLQTAAQELLAVINTPTQTLL
MLBr_01183|M.leprae_Br4923          QGATNHQDLIQSLL--------TSSSAYAGTETANHDSL-----------
MAB_4284c|M.abscessus_ATCC_199      HGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIGSHN
MAV_4827|M.avium_104                QLSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPE
                                                                                      

Rv2396|M.tuberculosis_H37Rv         ---------------AINAPTLALLGRPLIGD-----------------G
Mb2418|M.bovis_AF2122/97            ---------------AINAPTLALLGRPLIGD-----------------G
MSMEG_3202|M.smegmatis_MC2_155      GNAKVTVAVDSSGRPMIGPGGWLIGNGIEPGQ-----------------N
TH_4332|M.thermoresistible__bu      ---------------LIGPGGLLIGDGLN--------------------G
Mflv_5091|M.gilvum_PYR-GCK          TGGVGGIGGAGSTGAVGGVGGKGIQGGQGLQG-----------------G
Mvan_1264|M.vanbaalenii_PYR-1       TGGVGGVGGVGATGGAGGVGGKGIQGGQGLQG-----------------G
MMAR_4224|M.marinum_M               GRPLIGNGADGAPGQAGGDGGLLYGNGGNGGTSTTAGVAGGAGGSAGLIG
MUL_4524|M.ulcerans_Agy99           GRPLIGNGADGALGQAGGDGGLLYGNGG----------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      QANIGTSTSAGGSAAVGGNAGLAGNAGLAGNAG--------------LAG
MAV_4827|M.avium_104                TALARGAALAAANAPLFASSTAALAYAQDPGT-----------------G
                                                                                      

Rv2396|M.tuberculosis_H37Rv         TDAAPGSGGAG------GAGGILIGNGGTGGAS-------------DLAG
Mb2418|M.bovis_AF2122/97            TDAAPGSGGAG------GAGGILIGNGGTGGAS-------------DLAG
MSMEG_3202|M.smegmatis_MC2_155      GGLLIGNGADGGPGQKGGNGGFLLGNGGRGGDG-------------LAG-
TH_4332|M.thermoresistible__bu      TDAYIDENGVFHEATRGGNGGLLWGNGGKGGNG-------------LDAG
Mflv_5091|M.gilvum_PYR-GCK          KGGDGGAGGKGGDADSMGSAGATGGKGGNGGNG-------------GRGG
Mvan_1264|M.vanbaalenii_PYR-1       QGGDGGTGGTGGDATSMGEAGATGGKGGNGGNG-------------GRGS
MMAR_4224|M.marinum_M               NGGAGGGGGAGAVGGNGGAGGWLFGNGGAGGAGGATPGIGGGGGAGGAGG
MUL_4524|M.ulcerans_Agy99           ------------------AGGWLFGQGGVGGNG-------------GTGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      NAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG-----------LAGNAG
MAV_4827|M.avium_104                AVDQYSLPDYLYVPVDPEPGDDELAYSAVGEED-------------AESP
                                                                                      

Rv2396|M.tuberculosis_H37Rv         -T------GRGGVGGAGGAG-----GLFGIGGAGGGCGSAVAIGG-----
Mb2418|M.bovis_AF2122/97            -T------GRGGVGGAGGAG-----GLFGIGGAGGGCGSAVAIGG-----
MSMEG_3202|M.smegmatis_MC2_155      --------VNGGRAGDGGNA-----GLLGNGGDGGNS-VGGVEGA-----
TH_4332|M.thermoresistible__bu      LY------TVPDPDNPGSTI-----QMYFEASDGADGGRGGFLFG-----
Mflv_5091|M.gilvum_PYR-GCK          LF------GKGGNAGNGADG-----GTGGAGGAGGTGGTGGAGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1       LF------GRGGNAGNGGNG-----GTGGNGGNGGTGGTGGNGGTGGTGG
MMAR_4224|M.marinum_M               IGGAAGLFGNGGAGGVGGDGGLNYYGDGGVAGAGGDGGRGGWLHG-----
MUL_4524|M.ulcerans_Agy99           IG------LDGVAGHIGG-------GNAGNAGNGGTGGSGGLLFG-----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LAG-----NAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG---
MAV_4827|M.avium_104                TVVIEKLFLPEDSEPRRRPVLLVGSGLAVVGISAVLALEIALAIGIR---
                                                                                      

Rv2396|M.tuberculosis_H37Rv         ---------------------------------------DGGAGGAGGVF
Mb2418|M.bovis_AF2122/97            ---------------------------------------DGGAGGAGGVF
MSMEG_3202|M.smegmatis_MC2_155      ---------------------------------------NGGNAGLIGN-
TH_4332|M.thermoresistible__bu      ---------------------------------------NGGDGGNGGNV
Mflv_5091|M.gilvum_PYR-GCK          TGGIGGAGSTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGKGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1       TGGIGGAGSTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGKGGTGGTG
MMAR_4224|M.marinum_M               ---------------------------------------DGGDGGAGGDG
MUL_4524|M.ulcerans_Agy99           ---------------------------------------DGGDGGHGGAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------------------------------LAGNAGLAGNA
MAV_4827|M.avium_104                ---------------------------------------TTGTVALQPTP
                                                                                      

Rv2396|M.tuberculosis_H37Rv         ------SGGGAGGAG--------DAIGGSGGAGGTG-----------GLL
Mb2418|M.bovis_AF2122/97            ------SGGGAGGAG--------DAIGGSGGAGGTG-----------GLL
MSMEG_3202|M.smegmatis_MC2_155      ------GGKGGDGSPNVISNGAHIANAGRGGNGGNG-----------GLL
TH_4332|M.thermoresistible__bu      ------GGKNGADPVTATVAADKSVAGGNGGNGGRG-----------GLL
Mflv_5091|M.gilvum_PYR-GCK          ------GAGGTGGDGGTGGTGGTGGTGGTGGTGGTG-----------GAG
Mvan_1264|M.vanbaalenii_PYR-1       ------GDGGTGGTGGTGGTGGTGGTGGTGGTGGTG-----------GAG
MMAR_4224|M.marinum_M               GRGLPGGDGGSGGAGGGTGLWGSGGAGGQGGTGGTGLNGNAPFADGQHPV
MUL_4524|M.ulcerans_Agy99           ----FGGGNGSGNPIGGQG--GNAGVAGNGGAGGS-------------AA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GLAGNAGLAGNAGLAGNAAVAGNAAVAGNAAVAGNA---------AVGGV
MAV_4827|M.avium_104                NQHLIVPTEQAPAPPPVQASAPQPKISVPEPVAAPKP---------LSPP
                                                                                      

Rv2396|M.tuberculosis_H37Rv         GGGGGAGGAGGAGGNGGGASN-SASIGGDGGSGGAGG-------------
Mb2418|M.bovis_AF2122/97            GGGGGAGGAGGAGGNGGGASN-SASIGGDGGSGGAGG-------------
MSMEG_3202|M.smegmatis_MC2_155      VGSGGDGGRGGDGDGEGPET--AGSHGADGGNGGAGGVFGNGGRGGDG--
TH_4332|M.thermoresistible__bu      FGLGGNGGNGG---WSTTSY--LDARGGNGGNGGLGGVLRPGG-------
Mflv_5091|M.gilvum_PYR-GCK          DGTGGTGGTGGTGGQGGQGG--QGGTGGTGGQGGLGGGGGTGGQGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       DGLGGTGGTGGTGGFGGQGG--QGGTGGTGGQGGLGGVGGTGGTGGTGGT
MMAR_4224|M.marinum_M               ILDGGHGGTGGNGGAAGNGGL-LFGNGGNGGLGGMGGGGGNGLPSTG---
MUL_4524|M.ulcerans_Agy99           MLFG-NGGAGGNGGSGGDG-----GHGGNSALS---------VPGS----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LNTGVSGAIGGSSHVGGAINESLGGSGSVGGSTAVGGGAHTGVGGGVSTG
MAV_4827|M.avium_104                VAAPLPAAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPD
                                                                                      

Rv2396|M.tuberculosis_H37Rv         -------------------------------MLYGAGGVGGNG---GAAV
Mb2418|M.bovis_AF2122/97            -------------------------------MLYGAGGVGGNG---GAAV
MSMEG_3202|M.smegmatis_MC2_155      ----------------------GDANNGTVGTRNGNAAAGKGGNGGSTGI
TH_4332|M.thermoresistible__bu      ----------------------------LLSLLLPSGAASEPG-----GL
Mflv_5091|M.gilvum_PYR-GCK          GGQGGTGGTGGTGGTGGTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGG
Mvan_1264|M.vanbaalenii_PYR-1       GGQGGTGGTGGTGGTGGTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGG
MMAR_4224|M.marinum_M               -----------------------------VGGDGGDGGNGGTAGNGGWLI
MUL_4524|M.ulcerans_Agy99           -----------------------------IGGDAGAGGTGGSAGKSGLLF
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -----------------------VGVGSHVGGGISESLGGSGSVGGSTAV
MAV_4827|M.avium_104                P---------------------VSPPQLLAPPRLSVPQPVQPPVRVPQPP
                                                                                      

Rv2396|M.tuberculosis_H37Rv         AIGGDGGAGGRAGAIG------------NGGDGGNGGTSNTPGGSGGDGG
Mb2418|M.bovis_AF2122/97            AIGGDGGAGGRAGAIG------------NGGDGGNGGTSNTPGGSGGDGG
MSMEG_3202|M.smegmatis_MC2_155      GTGGAGGNGGKA-TGTNAAYGGNGGNGGSGLAGGGNGGDGGDAQSSSNRA
TH_4332|M.thermoresistible__bu      FTGGNGGNGGLA-IAN----------HWVGITDGVPGPDDDAVSSSAYGG
Mflv_5091|M.gilvum_PYR-GCK          STGGAGGAGGQAGTAGKGGLFGGSGSAGKAGATGAAGASGGKGAQGATGA
Mvan_1264|M.vanbaalenii_PYR-1       STGGAGGAGGQAGVAGKGGLFGGSGSAGTAGVTGASGASGGKGAQGATGA
MMAR_4224|M.marinum_M               GNGGTGGQGGAGFAGGTGADNVSAGRPGGAGGTGGIGAGGGNAGLIGTGG
MUL_4524|M.ulcerans_Agy99           GAGGAGGQGGG----------------GGTGGDGGDCAG---ANIGGDGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GGGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGV
MAV_4827|M.avium_104                SPPQVGGTVPQSPPQHQTPPGEGTPPKPDGPGNYGGGHVPTPGAGGSGGS
                                                                                      

Rv2396|M.tuberculosis_H37Rv         NGGNAGLIGNGGNGGNAEIVIS-----GGSVAGTGGNGGLLLGFNGTNGL
Mb2418|M.bovis_AF2122/97            NGGNAGLIGSGGNGGNAEIVIS-----GGSVAGTGGNGGLLLGFNGTNGL
MSMEG_3202|M.smegmatis_MC2_155      RPGQGGQAGRGGFGRDGKTGNP-----GNATDRSATRENVSNRVTGRSTP
TH_4332|M.thermoresistible__bu      HGGHGAGPGSGGNGGSAVANSL-----GNAIAGNGG-------DAGRFVL
Mflv_5091|M.gilvum_PYR-GCK          QGATGAQGATGATGAAGKAGAT-----GAAGAAGAAGSAGTTGAQGSAGT
Mvan_1264|M.vanbaalenii_PYR-1       QGATGAQGATGATGASGAQGSA-----GSAGSAGVAGSAGTTGAQGSAGT
MMAR_4224|M.marinum_M               SGGNGGMGGHGGDSGYGDQTGGQGGNGGMGGAGGAAGNGGLLLGSGSRGG
MUL_4524|M.ulcerans_Agy99           AGGAGGLGGNGTDGGWLYGNGG----GGAGGQGGDGGHGGSPVGFDGKSG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GGGVNTGVGVGSHVGGGISESLG----GSGSVGGSTAVGGGAHTSAINDA
MAV_4827|M.avium_104                GGGHVPTPGAGGSGGSGGGHVPTPGTGGPGGTGGSGGGHVPTPGAGTPGG
                                                                                      

Rv2396|M.tuberculosis_H37Rv         P-------------------------------------------------
Mb2418|M.bovis_AF2122/97            P-------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155      TRS-----------------------------------------------
TH_4332|M.thermoresistible__bu      IGP-----------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          NGANGANGSQGAAGKAGATGTTGATGAAGEDGDAGSGGSGINGGAGGAGG
Mvan_1264|M.vanbaalenii_PYR-1       NGANGANGSQGAAGKAGATGTTGATGAAGDAGDPGSEAVDINGGAGGAGG
MMAR_4224|M.marinum_M               DGGDGGNGGEGRGGFSVPQHGVGGQGGTGGNGSDG-------------GW
MUL_4524|M.ulcerans_Agy99           VGGDGGDGGNAR--------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LGGSGSVGGSTAVG------------------------------------
MAV_4827|M.avium_104                SGGGHLPFPGAG--------------------------------------
                                                                                      

Rv2396|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2418|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155      -------ADKAGSRTSSSSESNSESNSESSSK-TSSKAGGTKSSDTKSGG
TH_4332|M.thermoresistible__bu      -------GGNGGNGGTGLXXXPRPRRRRNHRR-TRRRPNGRRPRPPPGR-
Mflv_5091|M.gilvum_PYR-GCK          AGGEGGEGGDGGKGGAGAEGGAGGGGGAGGSG-AGGAGGAGGSGGSGGSG
Mvan_1264|M.vanbaalenii_PYR-1       AGGEGGEGGAGGAGGDGSEGGAGGSGGAGGSG-TGGAGGAGGSGGSGGSG
MMAR_4224|M.marinum_M               LYGDGGAGGAGGNGGFGGSGVQNGAGGDAGSGGDSRLIGDGGAAGAGGTG
MUL_4524|M.ulcerans_Agy99           IIGNGGNGGNGGNGGVGSTDGDGGQGGAAG-----LLFGQPGSMGT----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----GGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQG
MAV_4827|M.avium_104                STPGGSGGGHLPTPGAGTPGGGLGGFGGGHAPAPGGGLGGGGGHAPAPGG
                                                                                      

Rv2396|M.tuberculosis_H37Rv         ----------------------
Mb2418|M.bovis_AF2122/97            ----------------------
MSMEG_3202|M.smegmatis_MC2_155      GAAGTGSDSKDSE---------
TH_4332|M.thermoresistible__bu      ----------------------
Mflv_5091|M.gilvum_PYR-GCK          GSGGSGGAAGDSDD--------
Mvan_1264|M.vanbaalenii_PYR-1       GAGGSGGAAGDSD---------
MMAR_4224|M.marinum_M               APPGADGHSGADGLLSAALGA-
MUL_4524|M.ulcerans_Agy99           ----------------------
MLBr_01183|M.leprae_Br4923          ----------------------
MAB_4284c|M.abscessus_ATCC_199      HAQGHASETAHTTLPGAEHH--
MAV_4827|M.avium_104                GLGGFGGGHSGGGLGGLGGGHK