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SFVIAAPEVIAAAATDLASLGSSISAANAAAAANTTALMAAGADEVSTAIAALFGAHGQAYQALSAQAQA FHAQFVQALTSGGGAYAAAEAAAVSPLLDPINEFFLANTGRPLIGNGANGAPGTGANGGDGGWLIGNGGA GGSGAAGVNGGAGGNGGAGGNGGAGGLIGNGGAGGAGGVASSGIGGSGGAGGNAMLFGAGGAGGAGGGVV ALTGGAGGAGGAGGNAGLLFGAAGVGGAGGFTNGSALGGAGGAGGAGGLFATGGVGGSGGAGSSGGAGGA GGAGGLFGAGGTGGHGGFADSSFGGVGGAGGAGGLFGAGGEGGSGGHSLVAGGDGGAGGNAGMLALGAAG GAGGIGGDGGTLTAGGIGGAGGAGGNAGLLFGSGGSGGAGGFGFADGGQGGPGGNAGTVFGSGGAGGNGG VGQGFAGGIGGAGGTPGLIGNGGNGGNGGASAVTGGNGGIGGTGVLIGNGGNGGSGGIGAGKAGVGGVSG LLLGLDGFNAPASTSPLHTLQQNVLNVVNEPFQTLTGRPLIGNGANGTPGTGADGGAGGWLFGNGANGTP GTGAAGGAGGWLFGNGGNGGHGATNTAATATGGAGGAGGILFGTGGNGGTGGIATGAGGIGGAGGAGGVS LLIGSGGTGGNGGNSIGVAGIGGAGGRGGDAGLLFGAAGTGGHGAAGGVPAGVGGAGGNGGLFANGGAGG AGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGGLFGAGGTGGAAGSGGSGITTGGGGHGGNAGL LSLGASGGAGGSGGASSLAGGAGGTGGNGALLFGFRGAGGAGGHGGAALTSIQQGGAGGAGGNGGLLFGS AGAGGAGGSGANALGAGTGGTGGDGGHAGVFGNGGDGGCRRVWRRYRRQRWCRRQRRADRQRRQRRQRRQ SRGHARCRRHRRAAARRERTQRLAIAGRPATTRGVEGISCSPQMMP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0278c | PE_PGRS3 | - | 100% (957) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1759c | wag22 | 0.0 | 67.48% (901) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv0279c | PE_PGRS4 | 0.0 | 66.37% (907) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0286c | PE_PGRS3 | 0.0 | 76.20% (916) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-157 | 44.61% (854) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 5e-13 | 39.56% (91) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-46 | 35.10% (453) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_0755 | - | 0.0 | 53.36% (1012) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 3e-24 | 42.60% (169) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-127 | 39.28% (914) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 1e-38 | 39.74% (312) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_3062 | - | 0.0 | 52.63% (931) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-151 | 44.62% (800) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
Rv0278c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0286c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M --------------------------------------------------
MUL_3062|M.ulcerans_Agy99 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
Rv0278c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0286c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M --------------------------------------------------
MUL_3062|M.ulcerans_Agy99 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
Rv0278c|M.tuberculosis_H37Rv -----------------------------------------MS-FVIAAP
Mb0286c|M.bovis_AF2122/97 -----------------------------------------MS-FVIAAP
MLBr_01183|M.leprae_Br4923 -----------------------------------------MPLFLNAEP
MMAR_0755|M.marinum_M -----------------------------------------MS-YLIATP
MUL_3062|M.ulcerans_Agy99 -----------------------------------------MA-FVLAVP
MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------MSIIDFILN--
MAV_4827|M.avium_104 -------------------------------------MNIVLGVSMAPSS
TH_3810|M.thermoresistible__bu ------------------------------------------VDGDGGSG
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
Rv0278c|M.tuberculosis_H37Rv ----------------------------------------EVIAAAATDL
Mb0286c|M.bovis_AF2122/97 ----------------------------------------EVIAAAATDL
MLBr_01183|M.leprae_Br4923 ----------------------------------------QALTAAANTL
MMAR_0755|M.marinum_M ----------------------------------------DLLSAAATDL
MUL_3062|M.ulcerans_Agy99 ----------------------------------------DMVAEAAADL
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------LFRDPVEA
MAV_4827|M.avium_104 ---------------------------------------IQMVVLEGEYA
:
TH_3810|M.thermoresistible__bu GR-----------------------------------------TGLFSKL
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
Rv0278c|M.tuberculosis_H37Rv AS----------------------------------------LGSSISAA
Mb0286c|M.bovis_AF2122/97 AS----------------------------------------LGSSISAA
MLBr_01183|M.leprae_Br4923 EG----------------------------------------LSAATVAS
MMAR_0755|M.marinum_M AG----------------------------------------IGNTIGQA
MUL_3062|M.ulcerans_Agy99 AG----------------------------------------VGSVIDAA
MAB_4284c|M.abscessus_ATCC_199 AS-------------------------------------------YVADP
MAV_4827|M.avium_104 DG------------------------------------------ATVEED
TH_3810|M.thermoresistible__bu SRGGDGGDGGLGGNGGHGGGTGIISLLSLAGNGGNGGNGYRTTDNNALDG
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
Rv0278c|M.tuberculosis_H37Rv NAAAAANTTALMAAGADEVSTAIAALFGAHGQAYQALSAQAQAFHAQFVQ
Mb0286c|M.bovis_AF2122/97 NAAAAANTTALMAAGADEVSTAIAALFGAHGQAYQALSAQAQAFHAQFVQ
MLBr_01183|M.leprae_Br4923 NAAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQ
MMAR_0755|M.marinum_M SYAAAAPTTAVISAAADEISMQIAALFGAHGQSFQAVSSQAALFHDQFVQ
MUL_3062|M.ulcerans_Agy99 NTAAAGSTTGIVAAAEDEVSAAIAALFSGHGQAYQQISTRVAEFHAQFER
MAB_4284c|M.abscessus_ATCC_199 EAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSG
MAV_4827|M.avium_104 AIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA
.
TH_3810|M.thermoresistible__bu GHGGNGGNVGFFSLFNLGGAGGWG--------------------GSGVDG
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
Rv0278c|M.tuberculosis_H37Rv ALTSGGGAYAAAEAAAVSPLLDPINEFFLAN-------TGRPLIGNGANG
Mb0286c|M.bovis_AF2122/97 ALTSGGGAYAAAEAAAVSPLLDPINEFFLAN-------TGRPLIGNGANG
MLBr_01183|M.leprae_Br4923 SLLTSSSAYAGTETANHD-SL-----------------------------
MMAR_0755|M.marinum_M ALTTGASSYASAEAASQN-LLNLVNAPTQAL-------LNRPLIGNGANG
MUL_3062|M.ulcerans_Agy99 VFAAGVQAYSGAEAANASFLQDPLQTALNATNKPVQDLTGRPLVGNGANG
MAB_4284c|M.abscessus_ATCC_199 NLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMS
MAV_4827|M.avium_104 AALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTA
TH_3810|M.thermoresistible__bu VDVVGGNPDGGTPGAHGESHTPGVYTDR----------------------
Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
Rv0278c|M.tuberculosis_H37Rv APG--TGANGGDGGWLIGNGGAGGSGAAGVNGGAG---------------
Mb0286c|M.bovis_AF2122/97 APG--TGANGGDGGWLIGNGGAGGSGAAGVNG------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M AAG--TGASGGDGGILIGNGGAGGSGATGLTG------------------
MUL_3062|M.ulcerans_Agy99 VPG--TGANGAAGGWLLGNGGAGGSGAAGQAG------------------
MAB_4284c|M.abscessus_ATCC_199 PSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIG------------------
MAV_4827|M.avium_104 TLAVVETSDGSIPDVYKQQIRAESYGDAAGQLS-----------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----------------
Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----------------
MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
Rv0278c|M.tuberculosis_H37Rv -GNGGAGGNGGAGGLIG---NGGAGGAGGVASSG----------------
Mb0286c|M.bovis_AF2122/97 ----GAGGNGGAGGLIG---NGGAGGAGGVASSG----------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M ----GAGGNGGAAGLLAG--TAGAGGSGGLGAAG----------------
MUL_3062|M.ulcerans_Agy99 -------GDGGAAGLIGAGGAGGAGGNSPLRNTA----------------
MAB_4284c|M.abscessus_ATCC_199 --------DG----------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AVGAAGAAG------TVGTAGATGGTG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1 AIGTAGVAG------AAGTAGATGGTG-----------------------
MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAE------------------
Rv0278c|M.tuberculosis_H37Rv IGGSGGAGGN-AMLFGAGGAGGAGGGVVALTGGAGGAGGAGGNAGLLFGA
Mb0286c|M.bovis_AF2122/97 IGGSGGAGGN-AMLFGAGGAGGAGGGVVALTG------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M AGGAGGQGGT-GGLFSAGGAGGTGG--VGASGGTGGAGGLG-----LFGA
MUL_3062|M.ulcerans_Agy99 NGGNGGTGGAGGLLFGPGGVGGAGG-------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------QGEDGEDGTGTGIGGRGGNG----------------
Mflv_5091|M.gilvum_PYR-GCK --------------TGANGGAGGVGGVGGTGAAG--------------AA
Mvan_1264|M.vanbaalenii_PYR-1 --------------VGGNGGAGQAGGIGGTGAAG--------------AA
MSMEG_0868|M.smegmatis_MC2_155 ----GTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTAT
Rv0278c|M.tuberculosis_H37Rv AGVGGAGGFTNGSALGGAGGAGGAGGLFATGGVGGSGGAGSSGG--AGGA
Mb0286c|M.bovis_AF2122/97 ----GAGGFTNGSALGGAGGAGGAGGLFATGGVGGSGGAGSSGG--AGGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M GGAGGAGGMAN-ATVGGTGGAGGASLLFGNGGAGGLGGGGATAGGAGGQG
MUL_3062|M.ulcerans_Agy99 ----------ASFLTGGTGGDGGAGGLFGAGGLGGVGGSGNVGG--NGGA
MAB_4284c|M.abscessus_ATCC_199 -----------AVAVGGSNSGPIASGQGSTAVNG----------------
MAV_4827|M.avium_104 --------------AMVAGLEKLESLPGGLLLVG----------------
TH_3810|M.thermoresistible__bu GSSSGTHPMAEDGEHVKALDGRPGLDGGNGSHGG----------------
Mflv_5091|M.gilvum_PYR-GCK GGAGGLGETGTTGGAGGVGGQ--GTAGGTGGVGG-----IGGAGSTGAVG
Mvan_1264|M.vanbaalenii_PYR-1 GQAGTAGETGVTGGVGGIGGQ--GTEGGTGGVGG-----VGGVGATGGAG
MSMEG_0868|M.smegmatis_MC2_155 GGRGGDGIDGGTGGAGGMGEIYSGADGEATGISA-----GGDGGSATGAD
Rv0278c|M.tuberculosis_H37Rv GGAGGLFGAGGTGGHGGFADSSFGGVGGAGGAGG----LFGAGGEGGSGG
Mb0286c|M.bovis_AF2122/97 GGAGGLFGAGGTGGHGGFADSSFGGVGGAGGAGG----LFGAGGEGGSGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M GDAGTFYGDGGVGGAGGAGGNIPGSSGGAGGAGGNAGLFHGDGGAGGTGG
MUL_3062|M.ulcerans_Agy99 GGAGGLLAGLVGAGGGDGGSGGLGAAGGDGGNGGRAGLFGGAGGAGGMGA
MAB_4284c|M.abscessus_ATCC_199 DVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSG-----HGSADIDKSVT
MAV_4827|M.avium_104 -SGVDVAPLKQVLQTTTFLDVSVAEEPETALARG----------------
TH_3810|M.thermoresistible__bu ------------------------------------NGGHGGRGG-----
Mflv_5091|M.gilvum_PYR-GCK GVGGKG----IQGGQG-------------LQGGKGGDGGAGGKGGDADSM
Mvan_1264|M.vanbaalenii_PYR-1 GVGGKG----IQGGQG-------------LQGGQGGDGGTGGTGGDATSM
MSMEG_0868|M.smegmatis_MC2_155 SLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVM
Rv0278c|M.tuberculosis_H37Rv HSLVAGGDGGAGGNAGMLALG-----------AAGGAGGIGGDGGTLTAG
Mb0286c|M.bovis_AF2122/97 HSLVAGGDGGAGGNAGMLALG-----------AAGGAGGIGGDGGTLTAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M VATSAGGAGGAGGNAADLVGTGGVGGAGGTSFDAGGAGGIGGSAGALFGA
MUL_3062|M.ulcerans_Agy99 TGGHSGGDGGAGGDAGLLFGT----------------GGAGGAGGHAFDG
MAB_4284c|M.abscessus_ATCC_199 VVDDHSQRNTTNINDSFNTDR-------------STNIGSGNTTNTEIGS
MAV_4827|M.avium_104 -------------------------------------AALAAANAPLFAS
TH_3810|M.thermoresistible__bu -------------------------FLGIGGSGGWGGHG-----------
Mflv_5091|M.gilvum_PYR-GCK GS--------------------AGATGGKGGNGGNGGRGGLFG-------
Mvan_1264|M.vanbaalenii_PYR-1 GE--------------------AGATGGKGGNGGNGGRGSLFG-------
MSMEG_0868|M.smegmatis_MC2_155 AAG--ATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSA
Rv0278c|M.tuberculosis_H37Rv G-----------IGGAGGAGGNAGLLFGSGGSGGAGGFG-FADGGQGGPG
Mb0286c|M.bovis_AF2122/97 G-----------IGGAGGAGGNAGLLFGSGGSGGAGGFG-FADGGQGGPG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M GGAGGAGGFGQVSGGAGGAGGNSGMVYGDGGAGGAGGIGGAAAGGKGGDG
MUL_3062|M.ulcerans_Agy99 D------------GGAGGAGGNAGLMFSSGGSGGVGGAG-SIDGGAGGAG
MAB_4284c|M.abscessus_ATCC_199 HN-----------------QANIGTSTSAGGSAAVGGNAGLAG-------
MAV_4827|M.avium_104 ST-------------------AALAYAQDPGTGAVDQYSLPDYLYVPVDP
TH_3810|M.thermoresistible__bu ----------GNGGDTDAD-------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------KGGNAGNGAD----------------------GGTGGAGGAG
Mvan_1264|M.vanbaalenii_PYR-1 --------RGGNAGNGGN----------------------GGTGGNGGNG
MSMEG_0868|M.smegmatis_MC2_155 TSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFN
Rv0278c|M.tuberculosis_H37Rv GNAGTVFGSGGAGGNGGVG-----------------QGFAGGIGGAGGTP
Mb0286c|M.bovis_AF2122/97 GNAGTVFGSGGAGGNGGVG-----------------QGFAGGIGGAGGTP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M GDAATLFGSGGTGGHGAAG-----------------AVAGGDGGRGGTGG
MUL_3062|M.ulcerans_Agy99 GDAG-WLGGGGAGGAGGFG-----------------TISDGGAGGRGGGG
MAB_4284c|M.abscessus_ATCC_199 --------NAGLAGNAGLAG-------------------NAGLAGNAGLA
MAV_4827|M.avium_104 EPGDDELAYSAVGEEDAES-------------------------PTVVIE
TH_3810|M.thermoresistible__bu -------------------------------------------------G
Mflv_5091|M.gilvum_PYR-GCK GTGG-TGGAGGTGG-------------------------------TGGTG
Mvan_1264|M.vanbaalenii_PYR-1 GTGG-TGGNGGTGG-------------------------------TGGTG
MSMEG_0868|M.smegmatis_MC2_155 GTGGATGGRGGDGAGASVWKANGQHST--------------GQTDTGGNG
Rv0278c|M.tuberculosis_H37Rv G-LIGNGGNGGNGGASAVT------------------------------G
Mb0286c|M.bovis_AF2122/97 G-LIGNGGNGGNGGASAVT------------------------------G
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M G-LAGSGGTGGNGAVGTVSGVGGDGGNAAGLFGDGGTGGNGGLATAGGAG
MUL_3062|M.ulcerans_Agy99 GQLLGNGGAGGAGGQGGND------------------------------G
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGNAG--------------------------------LA
MAV_4827|M.avium_104 KLFLPEDSEPRRRPVLLVG------------------------------S
TH_3810|M.thermoresistible__bu GNGGDGGNGGSAGRGGTGGLRGVFGINGGNGRAGLGGRGXXXXG------
Mflv_5091|M.gilvum_PYR-GCK GIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKGG------
Mvan_1264|M.vanbaalenii_PYR-1 GIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKGG------
MSMEG_0868|M.smegmatis_MC2_155 GRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRGG------
Rv0278c|M.tuberculosis_H37Rv GNGGIGGTGVLIGNGGNGGSGGIGAG--KAGVGGVSGLLLGLDG------
Mb0286c|M.bovis_AF2122/97 GNGGIGGTGVLIGNGGNGGSGGIGAG--KAGVGGVSGLLLGLDG------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M GDGGAGGKAALIGSGGNGGAGGSGTV--DPGGNGGRGGDAQLFGTGGNGG
MUL_3062|M.ulcerans_Agy99 GAGGLGGNGVLIGNGGNGGVGGVGETPGGDGGGGISGLLLGADG------
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGN------
MAV_4827|M.avium_104 GLAVVGISAVLALEIALAIGIRTTGTVALQPTPNQHLIVPTEQAP-----
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ---------TGGTGGAGGTG----GDGGTGGTGGTGGTG---------GT
Mvan_1264|M.vanbaalenii_PYR-1 ---------TGGTGGDGGTG----GTGGTGGTGGTGGTG---------GT
MSMEG_0868|M.smegmatis_MC2_155 ---------DGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGA
Rv0278c|M.tuberculosis_H37Rv ---------FNAPASTSPLHTLQQNVLNVVNEPFQTLTGRPLIGNGANGT
Mb0286c|M.bovis_AF2122/97 ---------FNAPASTSPLHTLQQNVLNVVNEPFQTLTGRPLIGNGANGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M NPGLGVPAGTAGEAGAPGLATSNQALLDVINAPTQALLDRPLIGNGANGA
MUL_3062|M.ulcerans_Agy99 ---------FNAPAGSSPVHALQQQALAAINAPVQELTGRPLIGNGLPGS
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGAG-----------DGTGGTGGTGG------------------
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGAG-----------DGLGGTGGTGG------------------
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGAGRIRVNNGTATGTATGGNGGNGGN-----------------
Rv0278c|M.tuberculosis_H37Rv PGTGADGGAGGWLFGNGANGTPGTGAAGGAGGWLFGNGGNGGHGATNTAA
Mb0286c|M.bovis_AF2122/97 PGTGADGGAGGWLFGNGGNG--GSGATG-------TNGGDGGD-------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M AGTGANGGDGGILFGNGGAGGSGAVNGLGTG----QAGGNGGAAGLLSGG
MUL_3062|M.ulcerans_Agy99 AGSGAAGAPGGWLLGDGGAG------------------------------
MAB_4284c|M.abscessus_ATCC_199 --AGLAGNAG----------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ---------TGGQGGQGGQGG-----------------TGGTGGQGG---
Mvan_1264|M.vanbaalenii_PYR-1 ---------TGGFGGQGGQGG-----------------TGGTGGQGG---
MSMEG_0868|M.smegmatis_MC2_155 ------GDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGT--
Rv0278c|M.tuberculosis_H37Rv TATGGAGGAGGILFGTGGNGGTG-------GIATGAGGIGGAGGAGGVSL
Mb0286c|M.bovis_AF2122/97 ------GGAGGIFFGTGGTGGAG-------GVGT--TGTGGDGGAGGAAF
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M AGVGGTGGIGAVLGGAGGTGGMAGLFGAGGAGGEGGGGQSGGAGGAGGVG
MUL_3062|M.ulcerans_Agy99 --------------------------------GSAAATPGAAGGAGGAAG
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------LAGNAGLAGN--
MAV_4827|M.avium_104 --------------------------------------------------
TH_3810|M.thermoresistible__bu ----------------------------------GGVGAAVRSGNGVFSG
Mflv_5091|M.gilvum_PYR-GCK ---LGGGGGTG-----------------------GQGGTGGTGGQGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 ---LGGVGGTG-----------------------GTGGTGGTGGQGGTGG
MSMEG_0868|M.smegmatis_MC2_155 ---LGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGG
Rv0278c|M.tuberculosis_H37Rv LIGSGGTGGNGGNSIGVAGIGGAGGRGGDAGLLFGAAGTGGHGAAGGVPA
Mb0286c|M.bovis_AF2122/97 LVGSGGNGGSGGAGLTAG---GDGGDGGNAGSFFGAAGTGGAGAS-TKAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M LFGAGGNGGTGGFSLVTG----GAGGAGGASLLSGNGGAGGAGGIGGTGA
MUL_3062|M.ulcerans_Agy99 LVGAGGAGGAGANTGISN---------------PGFGGAGGAGGAGAGAG
MAB_4284c|M.abscessus_ATCC_199 ---------------------------------AGLAGNAGLAGNAGLAG
MAV_4827|M.avium_104 ----------------------------------APPPVQASAPQPKISV
TH_3810|M.thermoresistible__bu GGGTPSAG------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK TGGTGGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLG----
Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTG--------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQG----
MSMEG_0868|M.smegmatis_MC2_155 QGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAA----
Rv0278c|M.tuberculosis_H37Rv G--VGGAG--------GNGGLFANGGAGGAGGFN---AAGGNGGNG----
Mb0286c|M.bovis_AF2122/97 G--TGGTG--------GNGGLFANGGAGGSGGLGGDAGTGGAGGNG----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M GGAGGDGG--------AAGAFSGNGGAGGAGGIAPAGTEGGAGGAGGNAG
MUL_3062|M.ulcerans_Agy99 GG-VGEAG--------GAGGLLGAGGTGGGGGVAPSLVDGGTGGAG----
MAB_4284c|M.abscessus_ATCC_199 NAAVAGNA--------AVAGNAAVAGNAAVGGVLNTGVSGAIGGSS----
MAV_4827|M.avium_104 PEPVAAPKPLSP----PVAAPLPAAPPPAAPPLPEAPPIPAAPPVVP---
TH_3810|M.thermoresistible__bu -------FGVPTTIQFPAGSCTSRAVSREGIMPSSRAASARAGAACASST
Mflv_5091|M.gilvum_PYR-GCK -----GPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGA
Mvan_1264|M.vanbaalenii_PYR-1 -----GPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGA
MSMEG_0868|M.smegmatis_MC2_155 -----NPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNAT
Rv0278c|M.tuberculosis_H37Rv ---GLFGTGGTGGAGTNFG--AGGNGGNGGLFG-AGGTGGAAGSGG-SGI
Mb0286c|M.bovis_AF2122/97 ---GLFGAGGTGGAGGSLGPGAGGAGGNGGLFG-AGGTGGSGGHGTPAAV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M VFSGTGGAGGAGGAGQTVGGAGGTGGGAATLFG-AGGAGGAGAIGLDTGG
MUL_3062|M.ulcerans_Agy99 ------GAGGAGGLFGGIFGAGGGDGGAGGFTGGIDGAGGVGGAGGNTGL
MAB_4284c|M.abscessus_ATCC_199 -----HVGGAINESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVG
MAV_4827|M.avium_104 ----VPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVP
TH_3810|M.thermoresistible__bu SRSRRSFCCSRA--------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATGAAGAA
Mvan_1264|M.vanbaalenii_PYR-1 SGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAGSAGSA
MSMEG_0868|M.smegmatis_MC2_155 GTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTA
Rv0278c|M.tuberculosis_H37Rv TTGGGGHGGNAGLLSLGASGGAGGS-GGAS-SLAGGAGGTGGNGALLFGF
Mb0286c|M.bovis_AF2122/97 PGGAGGAGGNAGLFSLGASGGAGGS-GGSSLTDSGGIGGVGGAGGLLFGY
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M AGGAGGSAG--ALSGTGGAGGAGGI-GVGGGGGGGGVGGAGGNAGVVYGD
MUL_3062|M.ulcerans_Agy99 LGGPGGSGG----------SGGDGI-AKLGFNVDGGAGGAGVNGGFLFGS
MAB_4284c|M.abscessus_ATCC_199 GGISESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVG-GGISESL
MAV_4827|M.avium_104 QPPSPPQVGGTVPQSPPQHQTPPGE---GTPPKPDGPGNYGGGHVPTPGA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GAAGSAG-----------TTGAQGSAGTNGA-NGANGSQG----------
Mvan_1264|M.vanbaalenii_PYR-1 GVAGSAG-----------TTGAQGSAGTNGA-NGANGSQG----------
MSMEG_0868|M.smegmatis_MC2_155 GATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKG----------
Rv0278c|M.tuberculosis_H37Rv RGAGGAGGHGGAALTSIQQGGAGGAGGNGGLLFGSAGAG-----------
Mb0286c|M.bovis_AF2122/97 GGAGGAGGYS-----NIGAGGAGGAGGNAGMLSGSGGSG-----------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M GGAGGAGGGG-----TVAAGAAGGSGGNAAMLFGNGGAGGTGAVGAAVGG
MUL_3062|M.ulcerans_Agy99 GGTGGFGGVGGVG-TSTGIGGAGGRGGNAGLLFSDAGVGG-------FGG
MAB_4284c|M.abscessus_ATCC_199 GGSGSVGG--------STAVGGGAHTGVGGGVNTGVGVGS----------
MAV_4827|M.avium_104 GGSGGSGGG------HVPTPGAGGSGGSGGGHVPTPGTGG----------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --AAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG
Mvan_1264|M.vanbaalenii_PYR-1 --AAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155 --ADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGG
Rv0278c|M.tuberculosis_H37Rv ------------GAGGSGANALGAGTGGTGGDGGHAG-VFGNGGDGGCRR
Mb0286c|M.bovis_AF2122/97 ------------GTGG----ASGAAKGGVGGNGGTAG-VFGNGGDGGAGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M NGGTGGDGGGLSGSGGAGGNGAGGGTGGTGGDGGRARGLLGDGGTGGDGG
MUL_3062|M.ulcerans_Agy99 FGGTGGNAGWLGSGGSGGAGGGSNGDGGAGGTGGSGGQIVGDGGAGGAGG
MAB_4284c|M.abscessus_ATCC_199 ----------HVGGGISESLGGSGSVGGSTAVGGGAHTSAINDALGGSGS
MAV_4827|M.avium_104 ------------PGGTGGSGGGHVPTPGAGTPGGSGGGHLPFPGAGSTPG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -----------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGS
Mvan_1264|M.vanbaalenii_PYR-1 -----------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGS
MSMEG_0868|M.smegmatis_MC2_155 NTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGT
Rv0278c|M.tuberculosis_H37Rv VWRRYRRQRWCRRQRRADRQRRQRRQRRQSRGHARCR--RHRRAAARRER
Mb0286c|M.bovis_AF2122/97 FG----------AGTGGNGGVGGNAVLIGNGGNGGNG--GKAGGTPGAGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MMAR_0755|M.marinum_M FG----------GITSGDGGNGGTGALIGDGGNGGAGGIGLGAAPGGDGG
MUL_3062|M.ulcerans_Agy99 QG-----DLLAAGGSGGDGGQGGDAVLIGTGGNGGNGASGVLAGIGGDGG
MAB_4284c|M.abscessus_ATCC_199 VG----------GSTAVGGGAHTSAINESMNSSINASHSSSMNESFGSSM
MAV_4827|M.avium_104 ---------------GSGGGHLPTPGAGTPGGGLGGFGGGHAPAPGGGLG
TH_3810|M.thermoresistible__bu --------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD----------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-----------
MSMEG_0868|M.smegmatis_MC2_155 TAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP----------
Rv0278c|M.tuberculosis_H37Rv TQRLAIAGRPATTRGVEGISCSPQMMP-----------------
Mb0286c|M.bovis_AF2122/97 TSGLLIG-----ENGLNGLP------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------
MMAR_0755|M.marinum_M KGGDAQLVGTGGNGGILGLGLPPGTAGTGGTGGTLIGENGHDGA
MUL_3062|M.ulcerans_Agy99 SRGLLLG-----EDGVNGEAAPPMTHIVLLGGDFPAAAS-----
MAB_4284c|M.abscessus_ATCC_199 GSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH----------
MAV_4827|M.avium_104 GGGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK-----------