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M. tuberculosis H37Rv Rv2351c (plcA)

annotation: PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA (MTP40 ANTIGEN)
coordinates: 2630537 - 2632075
length: 512 

SRREFLTKLTGAGAAAFLMDWAAPVIEKAYGAGPCPGHLTDIEHIVLLMQENRSFDHYFGTLSSTNGFNA
ASPAFQQMGWNPMTQALDPAGVTIPFRLDTTRGPFLDGECVNDPEHQWVGMHLAWNGGANDNWLPAQATT
RAGPYVPLTMGYYTRQDIPIHYLLADTFTICDGYHCSLLTGTLPNRLYWLSANIDPAGTDGGPQLVEPGF
LPLQQFSWRIMPENLEDAGVSWKVYQNKGLGRFINTPISNNGLVQAFRQAADPRSNLARYGIAPTYPGDF
AADVRANRLPKVSWLVPNILQSEHPALPVALGAVSMVTALRILLSNPAVWEKTALIVSYDENGGFFDHVT
PPTAPPGTPGEFVTVPNIDAVPGSGGIRGPLGLGFRVPCIVISPYSRGPLMVSDTFDHTSQLKLIRARFG
VPVPNMTAWRDGVVGDMTSAFNFATPPNSTRPNLSHPLLGALPKLPQCIPNVVLGTTDGALPSIPYRVPY
PQVMPTQETTPVRGTPSGLCS*

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2351cplcA-100% (512)PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA (MTP40 ANTIGEN)
M. tuberculosis H37RvRv2350cplcB0.075.49% (514) membrane-associated phospholipase C
M. tuberculosis H37RvRv2349cplcC0.068.09% (514) phospholipase C 3 PLCC

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1784cplcD0.071.62% (511) phospholipase C 4 PLCD
M. gilvum PYR-GCK-----
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0555-4e-8738.14% (506) non-hemolytic phospholipase C
M. marinum MMMAR_3657plcB_40.087.08% (511) membrane-associated phospholipase C 2 PlcB_4
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_2799plcB0.068.87% (514) membrane-associated phospholipase C 2 PlcB
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


Rv2351c|M.tuberculosis_H37Rv        --------MSRREFLTKLTGAGAAAFLMDWAAPVIEKAYG-AGPCPGHLT
MMAR_3657|M.marinum_M               MSGNPFRGMSRREFIAKMTGAGAAALLMDYAGPVIEKAYG-AGPCSGQLT
MUL_2799|M.ulcerans_Agy99           --------MSRREFMAKLAAASSAGAMMSLAGPVIEKAYG-AGPCSGHLT
Mb1784c|M.bovis_AF2122/97           MSQSHIGGVSRREFLAKVAAGG-AGALMSFAGPVIEKAYG-AGPCSGHLT
MAB_0555|M.abscessus_ATCC_1997      -----MSPLTRRRLLTSAAGTAAFSAAVSLMPANLQRVLAQPAPRSGSLR
                                            ::**.:::. :. .  .  :.   . :::. . ..* .* * 

Rv2351c|M.tuberculosis_H37Rv        DIEHIVLLMQENRSFDHYFGTLSSTNGFNAASPAFQQMGWNPMTQA--LD
MMAR_3657|M.marinum_M               DIEHIVLLMQENRSFDHYFGTLSSIRGFSDPSPAFQQKGWNPRTQA--LD
MUL_2799|M.ulcerans_Agy99           DIEHFVFMLQENRSFDHYFGSLSGINGFDTPSSAFQQKGWNPQTQS--ID
Mb1784c|M.bovis_AF2122/97           DIEHFVFFMQENRSFDHYFGTLSGTDGFNTVSPLFQQKGWNPMTQA--LD
MAB_0555|M.abscessus_ATCC_1997      DVEHVVVLMMENRSFDHYFGTLSGVRGFDDPTAVTLSTGKSVFHQPDPQN
                                    *:**.*.:: **********:**.  **.  :.   . * .   *.   :

Rv2351c|M.tuberculosis_H37Rv        PAGVTIPFRLDTTRGPFLDGECVNDPEHQWVGMHLAWNGGANDNWLPAQA
MMAR_3657|M.marinum_M               PAGTTIPFRLDTTRGPFLDGECVNDPEHQWTAMHLSWNGGANDNWLPAQA
MUL_2799|M.ulcerans_Agy99           PAGVTIPYRFDTTRGPLLNGACANDPGHQWIDMHRAFNNGANDNWLGAQA
Mb1784c|M.bovis_AF2122/97           ATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQA
MAB_0555|M.abscessus_ATCC_1997      PDGYLLPFHLDTAVNSVQK---IPTTSHAWSVQHDSWNHGKMDNWMAAHR
                                    . *  :*:::**: ... .      . * *   * ::* *  ***: *: 

Rv2351c|M.tuberculosis_H37Rv        TTRAGP-YVPLTMGYYTRQDIPIHYLLADTFTICDGYHCSLLTGTLPNRL
MMAR_3657|M.marinum_M               NTRTGP-YVPMTMGYYTRQDIPIHHLLADTFTICDGYHCSLLTGTLPNRL
MUL_2799|M.ulcerans_Agy99           QAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPNRL
Mb1784c|M.bovis_AF2122/97           KTRSAA-HTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPNRL
MAB_0555|M.abscessus_ATCC_1997      KADGEH--YPYVMGYYERADIPFHFALAEAFTVCDNFHSSVMGPTWPNRM
                                     :       * .**** * * *:*. **::**:** :..*::  * ***:

Rv2351c|M.tuberculosis_H37Rv        YWLSANIDPAGTDGGPQLVEPGFLPLQQFSWRIMPENLEDAGVSWKVYQN
MMAR_3657|M.marinum_M               YWMSAWNDPAGTNGGPQLVEPGFLPLHQYSWRIMPENLEDAGVSWKVYQN
MUL_2799|M.ulcerans_Agy99           YWMSAWVDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVYQN
Mb1784c|M.bovis_AF2122/97           YWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVYRN
MAB_0555|M.abscessus_ATCC_1997      MWMTGTIDPDAAHGGPIIRNTPVS--GGYGWTTYAERLEAAGVSWRVYAE
                                     *::.  ** . .*** : .. .     :.*   .:.*. **:**:** :

Rv2351c|M.tuberculosis_H37Rv        KGLGRFINTPISNNGLVQAFRQAADPRSNLARYGIAPTYPGDFAADVRAN
MMAR_3657|M.marinum_M               KDAGRFINTPISNNGLVQAFKQSGDPRSNLARYGIAPGYPVDFAADVKAN
MUL_2799|M.ulcerans_Agy99           KLLGALNNTVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVADVASN
Mb1784c|M.bovis_AF2122/97           KTLG-PISSVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLAN
MAB_0555|M.abscessus_ATCC_1997      EDDYGGCNVLK----LFSRFQRSR-PGEPLYDKGIAPVRATQFEDDARAG
                                    :      .       :.  * ::  * . :   *:**  . .*  *. :.

Rv2351c|M.tuberculosis_H37Rv        RLPKVSWLVPNILQSEHPALPVA--LGAVSMVTALRILLSNPAVWEKTAL
MMAR_3657|M.marinum_M               RLPKVSWLVPNFLQSEHPALPVA--LGAVAMVTALRILLSNPAVWEKTAL
MUL_2799|M.ulcerans_Agy99           RLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEKTAL
Mb1784c|M.bovis_AF2122/97           RLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWEKTAL
MAB_0555|M.abscessus_ATCC_1997      RLPAVSWLIMTSTASEHPDYRPA--DGAAYIASKIDAIAANPEVWAKTVF
                                    *** ***::     ****    *   *.  :.. :  : :** ** **.:

Rv2351c|M.tuberculosis_H37Rv        IVSYDENGGFFDHVTPPTAPPGTPGEFVTVPNIDAVPGSGGIRGPLGLGF
MMAR_3657|M.marinum_M               IISYDENGGFFDHVTPPTAPPGTPGEWVTVPDINSVPGSGGIRGPLGLGF
MUL_2799|M.ulcerans_Agy99           IVSFDENGGFFDHVTPTTAPEGTPGEWITVPDINAVTGSGGIRGPIGLGY
Mb1784c|M.bovis_AF2122/97           IVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLGF
MAB_0555|M.abscessus_ATCC_1997      ILNYDENDGLFDHVVPPTPPPGTPGEWVKG-------------VPIGGGF
                                    *:.:***.*:****.*.*.* *****::.               *:* *:

Rv2351c|M.tuberculosis_H37Rv        RVPCIVISPYSRGPLMVSDTFDHTSQLKLIRARFGVPVPNMTAWRDGVVG
MMAR_3657|M.marinum_M               RVPCIVVSPFSRGGLMVHDIFDHTSQLKLISKRFDVPVPNLTAWRDGVVG
MUL_2799|M.ulcerans_Agy99           RVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRRGVTG
Mb1784c|M.bovis_AF2122/97           RVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVTG
MAB_0555|M.abscessus_ATCC_1997      RVPAIVISPWSVGGWVAGESFDHTSVLRFLEEFTGVREPNISGWRRKTFG
                                    ***.:*:**:* *  :. : ***** *:::    .*  **:: **  . *

Rv2351c|M.tuberculosis_H37Rv        DMTSAFNFATPPNSTRPNLSHPLLGALPKLPQCIPNVVLGTTDGALPSIP
MMAR_3657|M.marinum_M               DMTSTFNFATPPNPSRPNLSHPLLAAVPKLPQCIPNVVLGTSDGTFPAIP
MUL_2799|M.ulcerans_Agy99           DMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVTVFTK-TVP--P
Mb1784c|M.bovis_AF2122/97           DMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINRGIP---
MAB_0555|M.abscessus_ATCC_1997      NLLSAFGFDSPVRPAPELPDTAAVVAAADRTDTRP-------PPVIP---
                                    :: *:*.*  * ..:    . . : * .   :  *          .*   

Rv2351c|M.tuberculosis_H37Rv        YRVPYPQVMPTQET-TPVRGTPSGLCS
MMAR_3657|M.marinum_M               YRVPYPQSMPGQES-TPVRGVPSGLCV
MUL_2799|M.ulcerans_Agy99           YRVPFPQVMPSQET-SPTRGIPSGPC-
Mb1784c|M.bovis_AF2122/97           YRVPDPQIMPTQET-TPTRGIPSGPC-
MAB_0555|M.abscessus_ATCC_1997      ---PAPQTSPVQEPGSRPRRYPRR---
                                       * **  * **. :  *  *