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M. tuberculosis H37Rv Rv2349c (plcC)

annotation: PROBABLE PHOSPHOLIPASE C 3 PLCC
coordinates: 2627172 - 2628698
length: 508 

SRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSAVDGFDT
PTPLFQQKGWNPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQART
RSVANTPVVMGYYARPDIPIHYLLADTFTICDQYFSSLLGGTMPNRLYWISATVNPDGDQGGPQIVEPAI
QPKLTFTWRIMPQNLSDAGISWKVYNSKLLGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDF
IRDVINNTLPQVSWVVPLTVESEHPSFPVAVGAVTIVNLIRVLLRNPAVWEKTALIIAYDEHGGFFDHVT
PLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSRGGLMVHDRFDHTSQLQLIGKRF
GVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPNVVLGFLNEGLPYRVPYPQT
TPVQESGPARPIPSGIC*

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2349cplcC-100% (508)PROBABLE PHOSPHOLIPASE C 3 PLCC
M. tuberculosis H37RvRv2351cplcA0.068.09% (514) membrane-associated phospholipase C
M. tuberculosis H37RvRv2350cplcB0.067.64% (513) membrane-associated phospholipase C

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1784cplcD0.068.37% (509) phospholipase C 4 PLCD
M. gilvum PYR-GCK-----
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0555-2e-8938.98% (508) non-hemolytic phospholipase C
M. marinum MMMAR_3656plcB_50.087.80% (508) membrane-associated phospholipase C 2 PlcB_5
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_2799plcB0.066.60% (512) membrane-associated phospholipase C 2 PlcB
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


Rv2349c|M.tuberculosis_H37Rv        --------MSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYG-AGPCSGHLT
MMAR_3656|M.marinum_M               MSRDAFAGMSRREFMAKATGVGAGGFLTDWAAPVIEKAYA-AGPCSGHLT
Mb1784c|M.bovis_AF2122/97           MSQSHIGGVSRREFLAKVAAGG-AGALMSFAGPVIEKAYG-AGPCSGHLT
MUL_2799|M.ulcerans_Agy99           --------MSRREFMAKLAAASSAGAMMSLAGPVIEKAYG-AGPCSGHLT
MAB_0555|M.abscessus_ATCC_1997      -----MSPLTRRRLLTSAAGTAAFSAAVSLMPANLQRVLAQPAPRSGSLR
                                            ::** :::. :. .  .   .   . :::. . ..* ** * 

Rv2349c|M.tuberculosis_H37Rv        DIEHIVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKGWNPETQA--LD
MMAR_3656|M.marinum_M               DIEHIVLCLQENRSFDHYFGSLSSVDGFDTPTSLFQQKGWDPRTQS--VD
Mb1784c|M.bovis_AF2122/97           DIEHFVFFMQENRSFDHYFGTLSGTDGFNTVSPLFQQKGWNPMTQA--LD
MUL_2799|M.ulcerans_Agy99           DIEHFVFMLQENRSFDHYFGSLSGINGFDTPSSAFQQKGWNPQTQS--ID
MAB_0555|M.abscessus_ATCC_1997      DVEHVVVLMMENRSFDHYFGTLSGVRGFDDPTAVTLSTGKSVFHQPDPQN
                                    *:**.*. : **********:**.  **:  :.   ..* .   *.   :

Rv2349c|M.tuberculosis_H37Rv        PTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQA
MMAR_3656|M.marinum_M               PAGTTVPYRIDTTRGPNGVGECVNDPDHQWIAAHLSWNGGGNDGWLAAQA
Mb1784c|M.bovis_AF2122/97           ATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQA
MUL_2799|M.ulcerans_Agy99           PAGVTIPYRFDTTRGPLLNGACANDPGHQWIDMHRAFNNGANDNWLGAQA
MAB_0555|M.abscessus_ATCC_1997      PDGYLLPFHLDTAVNSVQK---IPTTSHAWSVQHDSWNHGKMDNWMAAHR
                                    . *  :*::::*: ..         ..* *   * ::* *  *.*: *: 

Rv2349c|M.tuberculosis_H37Rv        RTRSVA-NTPVVMGYYARPDIPIHYLLADTFTICDQYFSSLLGGTMPNRL
MMAR_3656|M.marinum_M               RTRSQA-NTPVVMGYYARPDIPIHYLLADTFTICDQYHSSLLGGTMPNRL
Mb1784c|M.bovis_AF2122/97           KTRSAA-HTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPNRL
MUL_2799|M.ulcerans_Agy99           QAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPNRL
MAB_0555|M.abscessus_ATCC_1997      KADGEH--YPYVMGYYERADIPFHFALAEAFTVCDNFHSSVMGPTWPNRM
                                    ::       * .**** * * *:*: **::**:** :..*::* * ***:

Rv2349c|M.tuberculosis_H37Rv        YWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNS
MMAR_3656|M.marinum_M               YWISGTVNPDGDKGGPQIVEPTIQPKLTFSWRLMPENLSDAGVSWKVYNS
Mb1784c|M.bovis_AF2122/97           YWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVYRN
MUL_2799|M.ulcerans_Agy99           YWMSAWVDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVYQN
MAB_0555|M.abscessus_ATCC_1997      MWMTGTIDPDAAHGGPIIRNTPVS--GGYGWTTYAERLEAAGVSWRVYAE
                                     *::. ::*:. :*** : .. ..    : *   .:.*. **:**:** .

Rv2349c|M.tuberculosis_H37Rv        -KLLGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVIN
MMAR_3656|M.marinum_M               -KLLGGLNDTSLSRNGYVGSFKQAGDPRSDLARYGIAPRYPADFVLDIMN
Mb1784c|M.bovis_AF2122/97           -KTLGPIS-SVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLA
MUL_2799|M.ulcerans_Agy99           -KLLGALNNTVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVADVAS
MAB_0555|M.abscessus_ATCC_1997      EDDYGGCN--VLK---LFSRFQRSR-PGEPLYDKGIAPVRATQFEDDARA
                                     .  *  .   :     .  * ::  * . :   *:**  . .*  *   

Rv2349c|M.tuberculosis_H37Rv        NTLPQVSWVVPLTVESEHPSFPVA--VGAVTIVNLIRVLLRNPAVWEKTA
MMAR_3656|M.marinum_M               NRLPQVSWVVPLTVESEHPSFPVA--VGAVTIVNLIRALLRNPAVWEKTA
Mb1784c|M.bovis_AF2122/97           NRLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWEKTA
MUL_2799|M.ulcerans_Agy99           NRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEKTA
MAB_0555|M.abscessus_ATCC_1997      GRLPAVSWLIMTSTASEHPDYRPA--DGAAYIASKIDAIAANPEVWAKTV
                                    . ** ***::     ****    *   *.  *.. :  :  ** ** **.

Rv2349c|M.tuberculosis_H37Rv        LIIAYDEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGL
MMAR_3656|M.marinum_M               LIIAYDEHGGFFDHVTPPTPPEGTPGEWIPPTVDINTVDGSGGIRGPIGL
Mb1784c|M.bovis_AF2122/97           LIVSYDENGGFFDHVVPATAPAGTPGEYVT-VPDIDQVPGSGGIRGPIGL
MUL_2799|M.ulcerans_Agy99           LIVSFDENGGFFDHVTPTTAPEGTPGEWIT-VPDINAVTGSGGIRGPIGL
MAB_0555|M.abscessus_ATCC_1997      FILNYDENDGLFDHVVPPTPPPGTPGEWVK--------------GVPIGG
                                    :*: :**:.*:****.* *.* *****::                 *** 

Rv2349c|M.tuberculosis_H37Rv        GFRVPCFVISPYSRGGLMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASV
MMAR_3656|M.marinum_M               GYRVPCFVISPYSRGGLLAHERFDHTSQLQLIGKRFGVPVPNLTPWRASV
Mb1784c|M.bovis_AF2122/97           GFRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSV
MUL_2799|M.ulcerans_Agy99           GYRVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRRGV
MAB_0555|M.abscessus_ATCC_1997      GFRVPAIVISPWSVGGWVAGESFDHTSVLRFLEEFTGVREPNISGWRRKT
                                    *:***.:****:* *  :. : ***** *:::    **  **:: **  .

Rv2349c|M.tuberculosis_H37Rv        TGDMTSAFNFAAPPDPSPPNLDHP-VRQLPKVAKCVPNVVLGFLNEGLPY
MMAR_3656|M.marinum_M               TGDMTSAFNFAVPPNPSPPNLDHP-AKQLPKLINCVPNAVLGFLNEGLPY
Mb1784c|M.bovis_AF2122/97           TGDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINRGIPY
MUL_2799|M.ulcerans_Agy99           TGDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVTVFTKTVPPY
MAB_0555|M.abscessus_ATCC_1997      FGNLLSAFGFDSPVRPAPELPDTAAVVAAADRTDTRP----------PPV
                                     *:: *:*.*  *  .:    * .     .   .  *           * 

Rv2349c|M.tuberculosis_H37Rv        RVPYPQTTPVQESGP-ARPIPSGIC
MMAR_3656|M.marinum_M               RVPYPQTTPTQESGP-VRGVPSGIC
Mb1784c|M.bovis_AF2122/97           RVPDPQIMPTQETTP-TRGIPSGPC
MUL_2799|M.ulcerans_Agy99           RVPFPQVMPSQETSP-TRGIPSGPC
MAB_0555|M.abscessus_ATCC_1997      IPPAPQTSPVQEPGSRPRRYPRR--
                                      * **  * **. .  *  *