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M. tuberculosis H37Rv Rv2350c (plcB)

annotation: PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB
coordinates: 2628781 - 2630319
length: 512 

TRRQFFAKAAAATTAGAFMSLAGPIIEKAYGAGPCPGHLTDIEHIVLLMQENRSFDHYFGTLSDTRGFDD
TTPPVVFAQSGWNPMTQAVDPAGVTLPYRFDTTRGPLVAGECVNDPDHSWIGMHNSWNGGANDNWLPAQV
PFSPLQGNVPVTMGFYTRRDLPIHYLLADTFTVCDGYFCSLLGGTTPNRLYWMSAWIDPDGTDGGPVLIE
PNIQPLQHYSWRIMPENLEDAGVSWKVYQNKLLGALNNTVVGYNGLVNDFKQAADPRSNLARFGISPTYP
LDFAADVRNNRLPKVSWVLPGFLLSEHPAFPVNVGAVAIVDALRILLSNPAVWEKTALIVNYDENGGFFD
HVVPPTPPPGTPGEFVTVPDIDSVPGSGGIRGPIGLGFRVPCLVISPYSRGPLMVHDTFDHTSTLKLIRA
RFGVPVPNLTAWRDATVGDMTSTFNFAAPPNPSKPNLDHPRLNALPKLPQCVPNAVLGTVTKTAIPYRVP
FPQSMPTQETAPTRGIPSGLC*

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2350cplcB-100% (512)PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB
M. tuberculosis H37RvRv2351cplcA0.075.49% (514) membrane-associated phospholipase C
M. tuberculosis H37RvRv2349cplcC0.067.64% (513) phospholipase C 3 PLCC

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1784cplcD0.071.48% (512) phospholipase C 4 PLCD
M. gilvum PYR-GCK-----
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0555-2e-9339.68% (504) non-hemolytic phospholipase C
M. marinum MMMAR_3823plcB_10.080.08% (512) membrane-associated phospholipase C 2 PlcB_1
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_2799plcB0.073.54% (514) membrane-associated phospholipase C 2 PlcB
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3823|M.marinum_M               MSKSPVDAMSRREFLAKAAAASGAGAFMSLAGPVIEKAYA-AGPCSGHLS
MUL_2799|M.ulcerans_Agy99           --------MSRREFMAKLAAASSAGAMMSLAGPVIEKAYG-AGPCSGHLT
Rv2350c|M.tuberculosis_H37Rv        --------MTRRQFFAKAAAATTAGAFMSLAGPIIEKAYG-AGPCPGHLT
Mb1784c|M.bovis_AF2122/97           MSQSHIGGVSRREFLAKVAAG-GAGALMSFAGPVIEKAYG-AGPCSGHLT
MAB_0555|M.abscessus_ATCC_1997      -----MSPLTRRRLLTSAAGTAAFSAAVSLMPANLQRVLAQPAPRSGSLR
                                            ::**.:::. *.    .* :*:  . :::. . ..* .* * 

MMAR_3823|M.marinum_M               DIEHIVLFMQENRSFDHYFGKLSGTNGFDSGSP--LFAQKGWNPQTQSND
MUL_2799|M.ulcerans_Agy99           DIEHFVFMLQENRSFDHYFGSLSGINGFDTPSS--AFQQKGWNPQTQSID
Rv2350c|M.tuberculosis_H37Rv        DIEHIVLLMQENRSFDHYFGTLSDTRGFDDTTPPVVFAQSGWNPMTQAVD
Mb1784c|M.bovis_AF2122/97           DIEHFVFFMQENRSFDHYFGTLSGTDGFNTVSP--LFQQKGWNPMTQALD
MAB_0555|M.abscessus_ATCC_1997      DVEHVVVLMMENRSFDHYFGTLSGVRGFDDPTAVTLSTGKSVFHQPDPQN
                                    *:**.*.:: **********.**.  **:  :.      ..    .:. :

MMAR_3823|M.marinum_M               PAGTTIPYRFDTTRGPLVAGECVNDPGHDWIAMHNAWNNGGNDNWLPAQA
MUL_2799|M.ulcerans_Agy99           PAGVTIPYRFDTTRGPLLNGACANDPGHQWIDMHRAFNNGANDNWLGAQA
Rv2350c|M.tuberculosis_H37Rv        PAGVTLPYRFDTTRGPLVAGECVNDPDHSWIGMHNSWNGGANDNWLPAQV
Mb1784c|M.bovis_AF2122/97           ATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQA
MAB_0555|M.abscessus_ATCC_1997      PDGYLLPFHLDTAVNSVQK---IPTTSHAWSVQHDSWNHGKMDNWMAAHR
                                    . *  :*:::**: ...        ..* *   * ::* *  ***: *: 

MMAR_3823|M.marinum_M               AVSALQGNTPVTMGYYQREDIPIHYLLADTFTICDGYFCSLIGGTSPNRL
MUL_2799|M.ulcerans_Agy99           QAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPNRL
Rv2350c|M.tuberculosis_H37Rv        PFSPLQGNVPVTMGFYTRRDLPIHYLLADTFTVCDGYFCSLLGGTTPNRL
Mb1784c|M.bovis_AF2122/97           KTRSAA-HTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPNRL
MAB_0555|M.abscessus_ATCC_1997      --KADGEHYPYVMGYYERADIPFHFALAEAFTVCDNFHSSVMGPTWPNRM
                                       .   : * .**:* * * *:*: **::**:** :..*::* * ***:

MMAR_3823|M.marinum_M               YWMSGTIDPDGANGGPLLVDPNIQPQGRFSWRTMPDNLEDAGVSWKIYQN
MUL_2799|M.ulcerans_Agy99           YWMSAWVDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVYQN
Rv2350c|M.tuberculosis_H37Rv        YWMSAWIDPDGTDGGPVLIEPNIQPLQHYSWRIMPENLEDAGVSWKVYQN
Mb1784c|M.bovis_AF2122/97           YWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVYRN
MAB_0555|M.abscessus_ATCC_1997      MWMTGTIDPDAAHGGPIIRNTPVS--GGYGWTTYAERLEAAGVSWRVYAE
                                     *::. :**:. .*** : .. ..    :.*   .:.*. **:**::* :

MMAR_3823|M.marinum_M               -KLLGALNNTVIGYDGMLNDFKQAQNPRTNLARYGIAPTYPRDFVSDVRN
MUL_2799|M.ulcerans_Agy99           -KLLGALNNTVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVADVAS
Rv2350c|M.tuberculosis_H37Rv        -KLLGALNNTVVGYNGLVNDFKQAADPRSNLARFGISPTYPLDFAADVRN
Mb1784c|M.bovis_AF2122/97           -KTLGPIS-SVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLA
MAB_0555|M.abscessus_ATCC_1997      EDDYGGCN-----VLKLFSRFQRSR-PGEPLYDKGIAPVRATQFEDDARA
                                     .  *  .        :.. * ::  *   :   *::*  . .*  *.  

MMAR_3823|M.marinum_M               NRLPKVSWVLPGFLLSEHPAFPVN--VGAVAIVDVLRILLSNPAVWEKTA
MUL_2799|M.ulcerans_Agy99           NRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEKTA
Rv2350c|M.tuberculosis_H37Rv        NRLPKVSWVLPGFLLSEHPAFPVN--VGAVAIVDALRILLSNPAVWEKTA
Mb1784c|M.bovis_AF2122/97           NRLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWEKTA
MAB_0555|M.abscessus_ATCC_1997      GRLPAVSWLIMTSTASEHPDYRPA--DGAAYIASKIDAIAANPEVWAKTV
                                    .*** ***::     ****        *.  *.. :  : :** ** **.

MMAR_3823|M.marinum_M               LIVSYDENGGFFDHVTPTTAPPGTPGEWITVPNIDAVTGSGGIRGPIGLG
MUL_2799|M.ulcerans_Agy99           LIVSFDENGGFFDHVTPTTAPEGTPGEWITVPDINAVTGSGGIRGPIGLG
Rv2350c|M.tuberculosis_H37Rv        LIVNYDENGGFFDHVVPPTPPPGTPGEFVTVPDIDSVPGSGGIRGPIGLG
Mb1784c|M.bovis_AF2122/97           LIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLG
MAB_0555|M.abscessus_ATCC_1997      FILNYDENDGLFDHVVPPTPPPGTPGEWVKG-------------VPIGGG
                                    :*:.:***.*:****.*.*.* *****::.               *** *

MMAR_3823|M.marinum_M               YRVPCFVISPYSRGPLMVHDTFDHTSQLKLIETRFGVPVPNISAWRNGLV
MUL_2799|M.ulcerans_Agy99           YRVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRRGVT
Rv2350c|M.tuberculosis_H37Rv        FRVPCLVISPYSRGPLMVHDTFDHTSTLKLIRARFGVPVPNLTAWRDATV
Mb1784c|M.bovis_AF2122/97           FRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVT
MAB_0555|M.abscessus_ATCC_1997      FRVPAIVISPWSVGGWVAGESFDHTSVLRFLEEFTGVREPNISGWRRKTF
                                    :***.:****:* *  :. : ***** *:::.   **  **:: **    

MMAR_3823|M.marinum_M               GDMTSTFNFAVPPNSSRPNLSHPAINAVQKLPQCVPNYVLGTVTKTAVPY
MUL_2799|M.ulcerans_Agy99           GDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVT-VFTKTVPPY
Rv2350c|M.tuberculosis_H37Rv        GDMTSTFNFAAPPNPSKPNLDHPRLNALPKLPQCVPNAVLGTVTKTAIPY
Mb1784c|M.bovis_AF2122/97           GDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINR-GIPY
MAB_0555|M.abscessus_ATCC_1997      GNLLSAFGFDSPVRPAPELPDTAAVVAAADRTDTRP-----------PPV
                                    *:: *:*.*  * ..:    . . : *     :  *            * 

MMAR_3823|M.marinum_M               RVPFPQVMPTQE-TQPARGIPSGLC
MUL_2799|M.ulcerans_Agy99           RVPFPQVMPSQE-TSPTRGIPSGPC
Rv2350c|M.tuberculosis_H37Rv        RVPFPQSMPTQE-TAPTRGIPSGLC
Mb1784c|M.bovis_AF2122/97           RVPDPQIMPTQE-TTPTRGIPSGPC
MAB_0555|M.abscessus_ATCC_1997      IPPAPQTSPVQEPGSRPRRYPRR--
                                      * **  * **    .*  *