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M. bovis AF2122 / 97 Mb1784c (plcD)

annotation: phospholipase C 4 PLCD
coordinates: 1972246 - 1973790
length: 514

VSQSHIGGVSRREFLAKVAAGGAGALMSFAGPVIEKAYGAGPCSGHLTDIEHFVFFMQENRSFDHYFGTL
SGTDGFNTVSPLFQQKGWNPMTQALDATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDN
WLPAQAKTRSAAHTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPNRLYWLSATIDPDGQNGG
PELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVYRNKTLGPISSVLTYGSLVTSFKQSADPRSDLVRFGVA
PSYPASFAADVLANRLPRVSWVIPNVLESEHPAVPAAAGAFAIVNILRILLANPAVWEKTALIVSYDENG
GFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLGFRVPCFVISPYSRGPQMVHDTFDHTSQLR
LLETRFGVPVPNLTAWRRSVTGDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINRGIPY
RVPDPQIMPTQETTPTRGIPSGPC

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1784c plcD - 100% (514) phospholipase C 4 PLCD

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK - - - - -
M. tuberculosis H37Rv Rv2351c plcA 0.0 71.62% (511) membrane-associated phospholipase C
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_0555 - 8e-91 41.08% (499) non-hemolytic phospholipase C
M. marinum M MMAR_1485 plcB_2 0.0 71.24% (525) membrane-associated phospholipase C 2 PlcB_2
M. avium 104 - - - - -
M. smegmatis MC2 155 - - - - -
M. thermoresistible (build 8) - - - - -
M. ulcerans Agy99 MUL_2799 plcB 0.0 69.47% (511) membrane-associated phospholipase C 2 PlcB
M. vanbaalenii PYR-1 - - - - -

CLUSTAL 2.0.9 multiple sequence alignment


Mb1784c|M.bovis_AF2122/97           MSQSHIGGVSRREFLAKVAAG-GAGALMSFAGPVIEKAYG-AGPCSGHLT
MMAR_1485|M.marinum_M               --MNKLGGMSRRKFLAKAAAG-GAGALMSFAGPVIEKAYG-AGPCSGHLS
Rv2351c|M.tuberculosis_H37Rv        --------MSRREFLTKLTGAGAAAFLMDWAAPVIEKAYG-AGPCPGHLT
MUL_2799|M.ulcerans_Agy99           --------MSRREFMAKLAAASSAGAMMSLAGPVIEKAYG-AGPCSGHLT
MAB_0555|M.abscessus_ATCC_1997      -----MSPLTRRRLLTSAAGTAAFSAAVSLMPANLQRVLAQPAPRSGSLR
                                            ::**.:::. :.  . .  :.   . :::. . ..* .* * 

Mb1784c|M.bovis_AF2122/97           DIEHFVFFMQENRSFDHYFGTLSGTDGFNTVSPLFQQKGWNPMTQA--LD
MMAR_1485|M.marinum_M               DIEHFVFFLMENRSFDHYFGTLSATDGFDSGSPLFQQKGWNPQTQT--ID
Rv2351c|M.tuberculosis_H37Rv        DIEHIVLLMQENRSFDHYFGTLSSTNGFNAASPAFQQMGWNPMTQA--LD
MUL_2799|M.ulcerans_Agy99           DIEHFVFMLQENRSFDHYFGSLSGINGFDTPSSAFQQKGWNPQTQS--ID
MAB_0555|M.abscessus_ATCC_1997      DVEHVVVLMMENRSFDHYFGTLSGVRGFDDPTAVTLSTGKSVFHQPDPQN
                                    *:**.*.:: **********:**.  **:  :.   . * .   *.   :

Mb1784c|M.bovis_AF2122/97           ATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQA
MMAR_1485|M.marinum_M               PAGITMPYRFDTTRGPFVDGECLSDPDHSWEAMHKSWNGGANDNWLPAQV
Rv2351c|M.tuberculosis_H37Rv        PAGVTIPFRLDTTRGPFLDGECVNDPEHQWVGMHLAWNGGANDNWLPAQA
MUL_2799|M.ulcerans_Agy99           PAGVTIPYRFDTTRGPLLNGACANDPGHQWIDMHRAFNNGANDNWLGAQA
MAB_0555|M.abscessus_ATCC_1997      PDGYLLPFHLDTAVNSVQK---IPTTSHAWSVQHDSWNHGKMDNWMAAHR
                                    . *  :*:::**: ... .      . * *   * ::* *  ***: *: 

Mb1784c|M.bovis_AF2122/97           KTR---SAAHTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPN
MMAR_1485|M.marinum_M               GHSPVPNGGNVPVTMGYLTRKDIPIHYLLADTFTVCDRYFSSVLGPTLPN
Rv2351c|M.tuberculosis_H37Rv        TTR--AGP-YVPLTMGYYTRQDIPIHYLLADTFTICDGYHCSLLTGTLPN
MUL_2799|M.ulcerans_Agy99           QAQ--TLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPN
MAB_0555|M.abscessus_ATCC_1997      KAD----GEHYPYVMGYYERADIPFHFALAEAFTVCDNFHSSVMGPTWPN
                                               * .***  * * *:*: **::**:** :..*::  * **

Mb1784c|M.bovis_AF2122/97           RLYWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVY
MMAR_1485|M.marinum_M               RLYWLSASLGADGTQGGPQLTSPPTDPIGRFSWTTMPENLSAAGISWKLY
Rv2351c|M.tuberculosis_H37Rv        RLYWLSANIDPAGTDGGPQLVEPGFLPLQQFSWRIMPENLEDAGVSWKVY
MUL_2799|M.ulcerans_Agy99           RLYWMSAWVDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVY
MAB_0555|M.abscessus_ATCC_1997      RMMWMTGTIDPDAAHGGPIIRNTPVS--GGYGWTTYAERLEAAGVSWRVY
                                    *: *::. :.. . .*** : ..       :.*   .:.*. **:**::*

Mb1784c|M.bovis_AF2122/97           RNKTLGPISS---VLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAAD
MMAR_1485|M.marinum_M               RNKTLGPVLNQYFNYTYDDIVMFFKQAQDPRSELARFGMAPTYPFEFMAD
Rv2351c|M.tuberculosis_H37Rv        QNKGLGRFIN--TPISNNGLVQAFRQAADPRSNLARYGIAPTYPGDFAAD
MUL_2799|M.ulcerans_Agy99           QNKLLGALNN--TVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVAD
MAB_0555|M.abscessus_ATCC_1997      AEEDDYGGCN------VLKLFSRFQRSR-PGEPLYDKGIAPVRATQFEDD
                                     ::      .         :.  * ::  * . :   *:**  . .*  *

Mb1784c|M.bovis_AF2122/97           VLANRLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWE
MMAR_1485|M.marinum_M               VKANRLPQVSWVVPNTPQSEHPAFPPA--VGAVAIVNLLRILLSNPAVWE
Rv2351c|M.tuberculosis_H37Rv        VRANRLPKVSWLVPNILQSEHPALPVA--LGAVSMVTALRILLSNPAVWE
MUL_2799|M.ulcerans_Agy99           VASNRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWE
MAB_0555|M.abscessus_ATCC_1997      ARAGRLPAVSWLIMTSTASEHPDYRPA--DGAAYIASKIDAIAANPEVWA
                                    . :.*** ***::     ****    *   *.  :.. :  : :** ** 

Mb1784c|M.bovis_AF2122/97           KTALIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPI
MMAR_1485|M.marinum_M               KTALIVGYDENGGFFDHVVPPTAPEGTPGEYLTVPDINSVSGAGGIRGPI
Rv2351c|M.tuberculosis_H37Rv        KTALIVSYDENGGFFDHVTPPTAPPGTPGEFVTVPNIDAVPGSGGIRGPL
MUL_2799|M.ulcerans_Agy99           KTALIVSFDENGGFFDHVTPTTAPEGTPGEWITVPDINAVTGSGGIRGPI
MAB_0555|M.abscessus_ATCC_1997      KTVFILNYDENDGLFDHVVPPTPPPGTPGEWVKG-------------VPI
                                    **.:*:.:***.*:****.*.*.* *****::.               *:

Mb1784c|M.bovis_AF2122/97           GLGFRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRR
MMAR_1485|M.marinum_M               GLGYRVPGIVISPFSRGGLMVHDVFDHTSQLKLISKRFSVPVPNLTPWRD
Rv2351c|M.tuberculosis_H37Rv        GLGFRVPCIVISPYSRGPLMVSDTFDHTSQLKLIRARFGVPVPNMTAWRD
MUL_2799|M.ulcerans_Agy99           GLGYRVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRR
MAB_0555|M.abscessus_ATCC_1997      GGGFRVPAIVISPWSVGGWVAGESFDHTSVLRFLEEFTGVREPNISGWRR
                                    * *:*** :****:* *  :. : ***** *:::    .*  **:: ** 

Mb1784c|M.bovis_AF2122/97           SVTGDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINR--
MMAR_1485|M.marinum_M               STVGDMTSAFNFAVPPNPSRPSLSHPGLAALPKLPQCIPNVWLGTVGVNP
Rv2351c|M.tuberculosis_H37Rv        GVVGDMTSAFNFATPPNSTRPNLSHPLLGALPKLPQCIPNVVLGTTDG--
MUL_2799|M.ulcerans_Agy99           GVTGDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVTVFTK---
MAB_0555|M.abscessus_ATCC_1997      KTFGNLLSAFGFDSPVRPAPELPDTAAVVAAADRTDTRP-----------
                                     . *:: *:*.*  * ..:    . . : * .   :  *           

Mb1784c|M.bovis_AF2122/97           --------GIPYRVPDPQIMPTQE-TTPTRGIPSGPC-
MMAR_1485|M.marinum_M               NPYTGSPQGIPYRVPFPQSLPSQE-TTPARGIPSGPC-
Rv2351c|M.tuberculosis_H37Rv        -----ALPSIPYRVPYPQVMPTQE-TTPVRGTPSGLCS
MUL_2799|M.ulcerans_Agy99           -----TVP--PYRVPFPQVMPSQE-TSPTRGIPSGPC-
MAB_0555|M.abscessus_ATCC_1997      ---------PPVIPPAPQTSPVQEPGSRPRRYPRR---
                                              *   * **  * **  :  *  *

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	Mb1784c	plcD	-	100% (514)	phospholipase C 4 PLCD