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M. marinum M MMAR_3656 (plcB_5)

annotation: membrane-associated phospholipase C 2 PlcB_5
coordinates: 4502018 - 4503568
length: 516 

SRDAFAGMSRREFMAKATGVGAGGFLTDWAAPVIEKAYAAGPCSGHLTDIEHIVLCLQENRSFDHYFGSL
SSVDGFDTPTSLFQQKGWDPRTQSVDPAGTTVPYRIDTTRGPNGVGECVNDPDHQWIAAHLSWNGGGNDG
WLAAQARTRSQANTPVVMGYYARPDIPIHYLLADTFTICDQYHSSLLGGTMPNRLYWISGTVNPDGDKGG
PQIVEPTIQPKLTFSWRLMPENLSDAGVSWKVYNSKLLGGLNDTSLSRNGYVGSFKQAGDPRSDLARYGI
APRYPADFVLDIMNNRLPQVSWVVPLTVESEHPSFPVAVGAVTIVNLIRALLRNPAVWEKTALIIAYDEH
GGFFDHVTPPTPPEGTPGEWIPPTVDINTVDGSGGIRGPIGLGYRVPCFVISPYSRGGLLAHERFDHTSQ
LQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAVPPNPSPPNLDHPAKQLPKLINCVPNAVLGFLNEGLP
YRVPYPQTTPTQESGPVRGVPSGIC*

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3656plcB_5-100% (516)membrane-associated phospholipase C 2 PlcB_5
M. marinum MMMAR_3657plcB_40.068.08% (520) membrane-associated phospholipase C 2 PlcB_4
M. marinum MMMAR_3566plcB0.067.31% (520) membrane-associated phospholipase C 2 PlcB

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1784cplcD0.065.57% (517) phospholipase C 4 PLCD
M. gilvum PYR-GCK-----
M. tuberculosis H37RvRv2349cplcC0.087.80% (508) phospholipase C 3 PLCC
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0555-1e-9340.04% (502) non-hemolytic phospholipase C
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_2799plcB0.067.77% (512) membrane-associated phospholipase C 2 PlcB
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3656|M.marinum_M               MSRDAFAGMSRREFMAKATGVGAGGFLTDWAAPVIEKAYA-AGPCSGHLT
Rv2349c|M.tuberculosis_H37Rv        --------MSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYG-AGPCSGHLT
Mb1784c|M.bovis_AF2122/97           MSQSHIGGVSRREFLAKVAAGG-AGALMSFAGPVIEKAYG-AGPCSGHLT
MUL_2799|M.ulcerans_Agy99           --------MSRREFMAKLAAASSAGAMMSLAGPVIEKAYG-AGPCSGHLT
MAB_0555|M.abscessus_ATCC_1997      -----MSPLTRRRLLTSAAGTAAFSAAVSLMPANLQRVLAQPAPRSGSLR
                                            ::** :::. :. .  .   .   . :::. . ..* ** * 

MMAR_3656|M.marinum_M               DIEHIVLCLQENRSFDHYFGSLSSVDGFDTPTSLFQQKGWDPRTQS--VD
Rv2349c|M.tuberculosis_H37Rv        DIEHIVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKGWNPETQA--LD
Mb1784c|M.bovis_AF2122/97           DIEHFVFFMQENRSFDHYFGTLSGTDGFNTVSPLFQQKGWNPMTQA--LD
MUL_2799|M.ulcerans_Agy99           DIEHFVFMLQENRSFDHYFGSLSGINGFDTPSSAFQQKGWNPQTQS--ID
MAB_0555|M.abscessus_ATCC_1997      DVEHVVVLMMENRSFDHYFGTLSGVRGFDDPTAVTLSTGKSVFHQPDPQN
                                    *:**.*. : **********:**.  **:  :.   ..* .   *.   :

MMAR_3656|M.marinum_M               PAGTTVPYRIDTTRGPNGVGECVNDPDHQWIAAHLSWNGGGNDGWLAAQA
Rv2349c|M.tuberculosis_H37Rv        PTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQA
Mb1784c|M.bovis_AF2122/97           ATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQA
MUL_2799|M.ulcerans_Agy99           PAGVTIPYRFDTTRGPLLNGACANDPGHQWIDMHRAFNNGANDNWLGAQA
MAB_0555|M.abscessus_ATCC_1997      PDGYLLPFHLDTAVNSVQK---IPTTSHAWSVQHDSWNHGKMDNWMAAHR
                                    . *  :*::::*: ..         ..* *   * ::* *  *.*: *: 

MMAR_3656|M.marinum_M               RTRSQA-NTPVVMGYYARPDIPIHYLLADTFTICDQYHSSLLGGTMPNRL
Rv2349c|M.tuberculosis_H37Rv        RTRSVA-NTPVVMGYYARPDIPIHYLLADTFTICDQYFSSLLGGTMPNRL
Mb1784c|M.bovis_AF2122/97           KTRSAA-HTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPNRL
MUL_2799|M.ulcerans_Agy99           QAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPNRL
MAB_0555|M.abscessus_ATCC_1997      KADGEH--YPYVMGYYERADIPFHFALAEAFTVCDNFHSSVMGPTWPNRM
                                    ::       * .**** * * *:*: **::**:** :..*::* * ***:

MMAR_3656|M.marinum_M               YWISGTVNPDGDKGGPQIVEPTIQPKLTFSWRLMPENLSDAGVSWKVYNS
Rv2349c|M.tuberculosis_H37Rv        YWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNS
Mb1784c|M.bovis_AF2122/97           YWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVYRN
MUL_2799|M.ulcerans_Agy99           YWMSAWVDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVYQN
MAB_0555|M.abscessus_ATCC_1997      MWMTGTIDPDAAHGGPIIRNTPVS--GGYGWTTYAERLEAAGVSWRVYAE
                                     *::. ::*:. :*** : .. ..    : *   .:.*. **:**:** .

MMAR_3656|M.marinum_M               -KLLGGLNDTSLSRNGYVGSFKQAGDPRSDLARYGIAPRYPADFVLDIMN
Rv2349c|M.tuberculosis_H37Rv        -KLLGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVIN
Mb1784c|M.bovis_AF2122/97           -KTLGPIS-SVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLA
MUL_2799|M.ulcerans_Agy99           -KLLGALNNTVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVADVAS
MAB_0555|M.abscessus_ATCC_1997      EDDYGGCN--VLK---LFSRFQRSR-PGEPLYDKGIAPVRATQFEDDARA
                                     .  *  .   :     .  * ::  * . :   *:**  . .*  *   

MMAR_3656|M.marinum_M               NRLPQVSWVVPLTVESEHPSFPVA--VGAVTIVNLIRALLRNPAVWEKTA
Rv2349c|M.tuberculosis_H37Rv        NTLPQVSWVVPLTVESEHPSFPVA--VGAVTIVNLIRVLLRNPAVWEKTA
Mb1784c|M.bovis_AF2122/97           NRLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWEKTA
MUL_2799|M.ulcerans_Agy99           NRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEKTA
MAB_0555|M.abscessus_ATCC_1997      GRLPAVSWLIMTSTASEHPDYRPA--DGAAYIASKIDAIAANPEVWAKTV
                                    . ** ***::     ****    *   *.  *.. :  :  ** ** **.

MMAR_3656|M.marinum_M               LIIAYDEHGGFFDHVTPPTPPEGTPGEWIPPTVDINTVDGSGGIRGPIGL
Rv2349c|M.tuberculosis_H37Rv        LIIAYDEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGL
Mb1784c|M.bovis_AF2122/97           LIVSYDENGGFFDHVVPATAPAGTPGEYVT-VPDIDQVPGSGGIRGPIGL
MUL_2799|M.ulcerans_Agy99           LIVSFDENGGFFDHVTPTTAPEGTPGEWIT-VPDINAVTGSGGIRGPIGL
MAB_0555|M.abscessus_ATCC_1997      FILNYDENDGLFDHVVPPTPPPGTPGEWVK--------------GVPIGG
                                    :*: :**:.*:****.* *.* *****::                 *** 

MMAR_3656|M.marinum_M               GYRVPCFVISPYSRGGLLAHERFDHTSQLQLIGKRFGVPVPNLTPWRASV
Rv2349c|M.tuberculosis_H37Rv        GFRVPCFVISPYSRGGLMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASV
Mb1784c|M.bovis_AF2122/97           GFRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSV
MUL_2799|M.ulcerans_Agy99           GYRVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRRGV
MAB_0555|M.abscessus_ATCC_1997      GFRVPAIVISPWSVGGWVAGESFDHTSVLRFLEEFTGVREPNISGWRRKT
                                    *:***.:****:* *  :. : ***** *:::    **  **:: **  .

MMAR_3656|M.marinum_M               TGDMTSAFNFAVPPNPSPPNLDHP-AKQLPKLINCVPNAVLGFLNEGLPY
Rv2349c|M.tuberculosis_H37Rv        TGDMTSAFNFAAPPDPSPPNLDHP-VRQLPKVAKCVPNVVLGFLNEGLPY
Mb1784c|M.bovis_AF2122/97           TGDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINRGIPY
MUL_2799|M.ulcerans_Agy99           TGDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVTVFTKTVPPY
MAB_0555|M.abscessus_ATCC_1997      FGNLLSAFGFDSPVRPAPELPDTAAVVAAADRTDTRP----------PPV
                                     *:: *:*.*  *  .:    * .     .   .  *           * 

MMAR_3656|M.marinum_M               RVPYPQTTPTQESGP-VRGVPSGIC
Rv2349c|M.tuberculosis_H37Rv        RVPYPQTTPVQESGP-ARPIPSGIC
Mb1784c|M.bovis_AF2122/97           RVPDPQIMPTQETTP-TRGIPSGPC
MUL_2799|M.ulcerans_Agy99           RVPFPQVMPSQETSP-TRGIPSGPC
MAB_0555|M.abscessus_ATCC_1997      IPPAPQTSPVQEPGSRPRRYPRR--
                                      * **  * **. .  *  *