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MVLRPITGAIPPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQVNSVLPDGRRVVGEWVYGPHNNAINAG PGGGAIYYVHGSGYTMCSPRTHRRLTSWLSSLTGLPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGL AAEHMVIAADSAGGHLTVDMLLQPEVAARPPAAVVLFSPLIDLTFRLGASRELQRPDPVVRADRAARSVA LYYTGVDPAHHRLALDVAGGPPLPPTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHVFQALP RMTPEAAKAMTYVAQFIRSTTARGDL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2385 | mbtJ | - | 100% (306) | PUTATIVE ACETYL HYDROLASE MBTJ |
| M. tuberculosis H37Rv | Rv3487c | lipF | 8e-33 | 35.43% (254) | esterase/lipase LipF |
| M. tuberculosis H37Rv | Rv1076 | lipU | 8e-30 | 33.47% (239) | lipase LipU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2406 | mbtJ | 0.0 | 100.00% (306) | putative acetyl hydrolase MBTJ |
| M. gilvum PYR-GCK | Mflv_4606 | - | 1e-50 | 40.07% (302) | alpha/beta hydrolase domain-containing protein |
| M. leprae Br4923 | MLBr_00314 | - | 1e-31 | 35.27% (241) | putative esterase |
| M. abscessus ATCC 19977 | MAB_4052c | - | 1e-69 | 48.84% (303) | putative lipase/esterase |
| M. marinum M | MMAR_3699 | mbtJ | 1e-131 | 75.08% (297) | acetyl hydrolase MbtJ |
| M. avium 104 | MAV_1798 | - | 1e-115 | 69.42% (291) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5271 | - | 5e-29 | 34.03% (238) | esterase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 1e-28 | 29.84% (305) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_3642 | mbtJ | 1e-131 | 74.75% (297) | acetyl hydrolase MbtJ |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 5e-27 | 33.20% (244) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mvan_4675|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5271|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 MTLHTDVAIIGAGFTGLSVAAALKRSGVHNFVVLDRRSAASSEEWRGDTV
Mflv_4606|M.gilvum_PYR-GCK --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mvan_4675|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5271|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 RLFALAKHLHSGHEAAALAYDAADERWTIKVAGGEDLSVRSVVLATGSRT
Mflv_4606|M.gilvum_PYR-GCK --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mvan_4675|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5271|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 AGDPTVPGIEAYTGVVMRGQDFRDVDLAGKRVAVVGNGAAAATLLPEIVR
Mflv_4606|M.gilvum_PYR-GCK --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mvan_4675|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5271|M.smegmatis_MC2_155 ------------------------------------------------MV
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 EAASVKLFQSSPDWVLPRQGGRIVRLLEGVPVVREATRQAWFAGRRPQRR
Mflv_4606|M.gilvum_PYR-GCK --------------------------------------------------
TH_1370|M.thermoresistible__bu -MTAPSKVPRTSPLATRAARGHYSRTFPVSDGTPSEYVEDGPSLAGRLTA
Mvan_4675|M.vanbaalenii_PYR-1 -MTAPSKVPATPHAAIAAARAGKIRRFPVSDGAPVEVVEDGPSIAGRLMG
MSMEG_5271|M.smegmatis_MC2_155 AMTAPSKVTRSPRAGIGPGGAYRTRKFPVSDSAPVEIVEDGTSVAGRLAS
MLBr_00314|M.leprae_Br4923 --------------------------MAISAGAPVEIVESGPSIAARLAS
Rv2385|M.tuberculosis_H37Rv -------------------------------------------MVLRP--
Mb2406|M.bovis_AF2122/97 -------------------------------------------MVLRP--
MMAR_3699|M.marinum_M ----------------------MTDVVPVRGSLRSRTAVAVSSIMMPP--
MUL_3642|M.ulcerans_Agy99 ----------------------MTDVVPVRGSLRSRTAVAVSSIMMPP--
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 GIMELLARIHLRRHVDDPWVRRQLTPLPLTGRPNVVIADEFYTALQAPNC
Mflv_4606|M.gilvum_PYR-GCK ----------------------MSSPARPNPSMASHLVAATARRVLRP--
TH_1370|M.thermoresistible__bu LAAYLTVRPTLAIGSFAPRLP-----------------------------
Mvan_4675|M.vanbaalenii_PYR-1 LAAVATVKPFLTVGSYAPKLP-----------------------------
MSMEG_5271|M.smegmatis_MC2_155 LAAMLTIRPTLAIGSRVPHLP-----------------------------
MLBr_00314|M.leprae_Br4923 LTSRLTIRPILAVGSYVPQLP-----------------------------
Rv2385|M.tuberculosis_H37Rv --ITGAIPPDGPWGIWASR-------------------------------
Mb2406|M.bovis_AF2122/97 --ITGAIPPDGPWGIWASR-------------------------------
MMAR_3699|M.marinum_M --ITAAIPPERAWGIWMTR-------------------------------
MUL_3642|M.ulcerans_Agy99 --IIAAIPPERAWGIWMTR-------------------------------
MAV_1798|M.avium_104 -----MIPPERAWGLWLSR-------------------------------
MAB_4052c|M.abscessus_ATCC_199 KLITWPIARCSARGIRTAEGIEHHCDVIIFASAPDDAGASQIPVTGDGGQ
Mflv_4606|M.gilvum_PYR-GCK ---LTQVIPANDHGFAVMD-------------------------------
: *
TH_1370|M.thermoresistible__bu ------------------------------------WPWGLLDFAARAVR
Mvan_4675|M.vanbaalenii_PYR-1 ------------------------------------WPWGLLDFAARVLK
MSMEG_5271|M.smegmatis_MC2_155 ------------------------------------WPFGALNFAARMLR
MLBr_00314|M.leprae_Br4923 ------------------------------------WPFGLIDHAARVLL
Rv2385|M.tuberculosis_H37Rv ---------------------------------------RIIAGLMGTFG
Mb2406|M.bovis_AF2122/97 ---------------------------------------RIIAGLMGTFG
MMAR_3699|M.marinum_M ---------------------------------------QLIARLMGTLG
MUL_3642|M.ulcerans_Agy99 ---------------------------------------QVIARLMGTLG
MAV_1798|M.avium_104 ---------------------------------------QIVARIMGTFG
MAB_4052c|M.abscessus_ATCC_199 PLPESDEISVAGFPNLFLADPPPWQPGRDAVQRIRGRVHRVAARVQGTVR
Mflv_4606|M.gilvum_PYR-GCK ---------------------------------------RVLRGTLVVSR
TH_1370|M.thermoresistible__bu PV--------PGTVRATIRLPHCT------------------AQLVRAPG
Mvan_4675|M.vanbaalenii_PYR-1 PA--------PGTVRATIGLPHCN------------------AQLVRAAG
MSMEG_5271|M.smegmatis_MC2_155 PS--------PGTIKATIALPNCT------------------AQLIRADG
MLBr_00314|M.leprae_Br4923 PV--------TNAARAEVNLSNTS------------------AQLVRAAG
Rv2385|M.tuberculosis_H37Rv PS-----LAGTRVEQVNSVLPDG--------------------RRVVGEW
Mb2406|M.bovis_AF2122/97 PS-----LAGTRVEQVNSVLPDG--------------------RRVVGEW
MMAR_3699|M.marinum_M PS-----LSGTHVKPVNSVLPDG--------------------RRVVGEW
MUL_3642|M.ulcerans_Agy99 PS-----LSGTHVKPVNSVLPDG--------------------RRVVGEW
MAV_1798|M.avium_104 PS-----LSGTRVQSVDTRLPDG--------------------RRVKGEW
MAB_4052c|M.abscessus_ATCC_199 PETSIGVLPASRLTRATVALAAMGLRPLIERVPMSRLGVAASRRLVATAM
Mflv_4606|M.gilvum_PYR-GCK PR------RAISVEKVDTPFAGE---------------------RVRGDW
* . :. :
TH_1370|M.thermoresistible__bu VLPADGRR--------------------------SVVLYLHGGAFLTCGA
Mvan_4675|M.vanbaalenii_PYR-1 VLPADGHR--------------------------SVILYLHGGAFLTCGV
MSMEG_5271|M.smegmatis_MC2_155 VLPADGTR--------------------------SVILYLHGGAFLACGS
MLBr_00314|M.leprae_Br4923 VRPADGSG--------------------------RIVLYLHGGAFLGCGA
Rv2385|M.tuberculosis_H37Rv VYGPHNNA----------------INAGPGG---GAIYYVHGSGYTMCSP
Mb2406|M.bovis_AF2122/97 VYGPHNNA----------------INAGPGG---GAIYYVHGSGYTMCSP
MMAR_3699|M.marinum_M VHGPHLPT----------------GPAPNRS---GAIYFVHGSGYTMCSP
MUL_3642|M.ulcerans_Agy99 VHGPHLPT----------------GPAPNRS---GAIYFVHGSGYTMCSP
MAV_1798|M.avium_104 VFGPRTPT----------------SEHSRPSSIAEAIYYIHGSGYAVCSP
MAB_4052c|M.abscessus_ATCC_199 TAGSPMPTNVRIDRVREQGLRGEWVHAPDSDRDGPVIFYIHGSGYVVCSS
Mflv_4606|M.gilvum_PYR-GCK VKAANVAS------------------------DAPPILYIHGGAFSMCSP
. . : ::**..: *.
TH_1370|M.thermoresistible__bu HTHGRLVTALSEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAK-G
Mvan_4675|M.vanbaalenii_PYR-1 NTHGRLVTALSKCADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLREL-G
MSMEG_5271|M.smegmatis_MC2_155 NTHGGMATSLSEYADSPVLVVDYRMVPKHSVGTAVDDCYDAYVWLRRA-G
MLBr_00314|M.leprae_Br4923 NSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRL-G
Rv2385|M.tuberculosis_H37Rv RTHRRLTSWLSSLTGLPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCG
Mb2406|M.bovis_AF2122/97 RTHRRLTSWLSSLTGLPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCG
MMAR_3699|M.marinum_M RTHRRLTAWLSSLTGLPVFSVDYRLAPRHRFPTAADDVRAGWDWLPGACG
MUL_3642|M.ulcerans_Agy99 RTHRRLTAWLSSLTGLPVFSVDYRLAPRHRFPTAADDVRAGWDWLPGACG
MAV_1798|M.avium_104 KTHRRLTSWLSSLTGLPVFCVDYRLAPRHRFPTAADDVRAGWDWLINTCG
MAB_4052c|M.abscessus_ATCC_199 RTHRRLVARLSQASGLPAFSLDYRLAPEHPFPAAADDVRAAYQWLLST-G
Mflv_4606|M.gilvum_PYR-GCK ETHRGLISELSAAARRPVFAVRYRLVPRYPFPAAADDALIAYRWLTEGSA
.:* : ** : * : : **: *.: . * * .: ** .
TH_1370|M.thermoresistible__bu YEPDQ--IVLAGDSAGGYLALSLAQRLLDE------GEEPAALVALSPLF
Mvan_4675|M.vanbaalenii_PYR-1 YEPDQ--IVLAGDSAGGYLALSLAERLQAEGINGFVGETPAAIVTMSPLF
MSMEG_5271|M.smegmatis_MC2_155 YEPEQ--IVVAGDSAGGYLGLALAERLLDD------GEVPAALVAMSPLY
MLBr_00314|M.leprae_Br4923 YDPEQ--IVLAGDSAGGYLALALAQRLQDV------GEEPAALVAISPLL
Rv2385|M.tuberculosis_H37Rv LAAEH--MVIAADSAGGHLTVDMLLQ-PEVAAR-----PPAAVVLFSPLI
Mb2406|M.bovis_AF2122/97 LAAEH--MVIAADSAGGHLTVDMLLQ-PEVAAR-----PPAAVVLFSPLI
MMAR_3699|M.marinum_M LSPER--MVVVADSAGGHLSVDLLLQ-PDVAAR-----PPASLVLFSPLI
MUL_3642|M.ulcerans_Agy99 LSPER--MVVVADSAGGHLSVDLLLQ-PDVAAR-----PPASLVLFSPLI
MAV_1798|M.avium_104 VPPEQ--MVIAGDSAGGHLSVDLLLQ-PGVEH-------PAAMVLFSPLY
MAB_4052c|M.abscessus_ATCC_199 HAAKD--IVIAADSAGGHLAVDLIAENHRMGVA-----QPGALVLFSPLA
Mflv_4606|M.gilvum_PYR-GCK ITASSGTVALAGDSAGGQLAAATALGAREHRLP-----TPDAMLLMSPVL
.. :.:..***** * * ::: :**:
TH_1370|M.thermoresistible__bu EIDNESRAQHPNIRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEP
Mvan_4675|M.vanbaalenii_PYR-1 EIDNEARADHPNVRTDAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEP
MSMEG_5271|M.smegmatis_MC2_155 EIDNRARAEHPNARRDAMFPPKAFDALVEIVEAAAAR---NG--EQVYEP
MLBr_00314|M.leprae_Br4923 QLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEP
Rv2385|M.tuberculosis_H37Rv DLTFRLGASRELQRPDPVVRADRAARSVALYYTGVDPA------HHRLAL
Mb2406|M.bovis_AF2122/97 DLTFRLGASRELQRPDPVVRADRAARSVALYYTGVDPA------HHRLAL
MMAR_3699|M.marinum_M DLTFGLSAARERTKPDPAVRAATAARVVGLYHAGIDPT------HHRLSL
MUL_3642|M.ulcerans_Agy99 DLTFGLSAARERTKPDPAVRAATAARVVGLYHAGIDPT------HHRLSL
MAV_1798|M.avium_104 DLTFELAKARERIRPDPATRAANAIRLVGLYHSGVDLT------HERLTL
MAB_4052c|M.abscessus_ATCC_199 DLTLGLSAERERDAPDPIISAAAARRLVDCYTAAQPVD------SPRLRL
Mflv_4606|M.gilvum_PYR-GCK DLTCQLAMDRDLRRRDPFASAISASRTIGLYVAGADPA------DPRISV
:: : *. . .
TH_1370|M.thermoresistible__bu LDNIEPGLPRTLIHVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMHV
Mvan_4675|M.vanbaalenii_PYR-1 LDHIEPGLPRTLIHVSGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHV
MSMEG_5271|M.smegmatis_MC2_155 LDHIEPGLPRTLIHVSGSEVLISDARKAARMLCAAGVPVEVHVWPGQMHV
MLBr_00314|M.leprae_Br4923 LDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHV
Rv2385|M.tuberculosis_H37Rv DVAGGPPLPPTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHV
Mb2406|M.bovis_AF2122/97 DVAGGPPLPPTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHV
MMAR_3699|M.marinum_M DVAGGSPLPSTLIQAGAAEMLEADARQLAADIRTAGGRCELQVWPDQMHV
MUL_3642|M.ulcerans_Agy99 DVAGGSPLPSTLIQAGAAEMLEADARQLAADIRTAGGRCELQVWPDQMHV
MAV_1798|M.avium_104 DVARGPVLPPTLIQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVHV
MAB_4052c|M.abscessus_ATCC_199 ALGPGVMLPPTLIQVGGREMMVADAEHLELMITRAGGACELQVWPGQVHV
Mflv_4606|M.gilvum_PYR-GCK LDADLTDMPPTLIQVGGREMLLDDSRVFAKRLQTAGVSSQLQVFRGQIHV
:* ***:... * : *:. : .* ::::: *:**
TH_1370|M.thermoresistible__bu FQIAAPFVPEAKRSLRQIGEYIREATW-----------
Mvan_4675|M.vanbaalenii_PYR-1 FQLGAPAVSEANRSIKQIGEYIREATW-----------
MSMEG_5271|M.smegmatis_MC2_155 FQIAGNLVPEAKRSLRQIGAYIREATW-----------
MLBr_00314|M.leprae_Br4923 FQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL-
Rv2385|M.tuberculosis_H37Rv FQALPRMTPEAAKAMTYVAQFIR---STTARGDL----
Mb2406|M.bovis_AF2122/97 FQALPRMTPEAAKAMTYVAQFIR---STTARGDL----
MMAR_3699|M.marinum_M FQALPRMTPEAAKAMAYASAFIAGSLQDNATAEAV---
MUL_3642|M.ulcerans_Agy99 FQALPRMTPEAAKAMAYASAFIAGSLQDNATAEAV---
MAV_1798|M.avium_104 FQALPRMTPEAAKAMAYVARFITHALQDARALTQEVH-
MAB_4052c|M.abscessus_ATCC_199 FQALPRFSSEATAAVREAARFITATLAARSELTAEQSA
Mflv_4606|M.gilvum_PYR-GCK FQAMFRLLPEAREALRLGGEFLATSATVR---------
** .** :: . ::