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MTTCPFTPGFDFTDPDLIQHRIPAEEFAYLRKTEPIWWNAQPRGVAGFDDDGYWVVTKHADVKEVSRLNE VFSNSVNTTVVRYNEDITAEQLEIQRENLLIDMDEPKHRILRRIVSPLFTPKAVNGLHARLVERAHGIVE EAAEKSSGNFVSDIASVLPMHAIADLVGIPESDRQQVLDWTNQMFAYDDPAIGRDTATTATVSMLGYAYA MAEERQLNPQDDILTGLVRGAYDDRPLTPLEFAYFVIQLMVAGNETSRNAITHGVLAFADNPAQWRLYRE RRPSTAADEIIRWASPIIAFQRTALQDVELGGVQIRKDQRVGMFYASANFDEDVFDDPFAFNIERDPNPH LAFGGHGIHYCLGANLARLEIGIMFDALADRLPDLMPTGAPTRFRSGWINGVVALPANYHGSGPRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0101 | - | - | 100% (416) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_0613 | - | e-126 | 52.10% (405) | putative cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_0611 | - | e-120 | 53.05% (394) | putative cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3575c | cyp125 | 1e-126 | 52.04% (417) | cytochrome P450 125 |
| M. gilvum PYR-GCK | Mflv_1607 | - | 1e-135 | 55.64% (408) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | 1e-126 | 52.04% (417) | cytochrome P450 125 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-30 | 28.03% (314) | putative cytochrome p450 |
| M. marinum M | MMAR_5032 | cyp125A7 | 1e-131 | 53.27% (413) | cytochrome P450 125A7 Cyp125A7 |
| M. avium 104 | MAV_2811 | - | 1e-131 | 54.43% (406) | putative cytochrome P450 124 |
| M. smegmatis MC2 155 | MSMEG_5853 | - | 1e-133 | 55.34% (412) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_1956 | - | 1e-133 | 54.28% (409) | PROBABLE CYTOCHROME P450 125 CYP125 |
| M. ulcerans Agy99 | MUL_4106 | cyp125A7 | 1e-131 | 53.27% (413) | cytochrome P450 125A7 Cyp125A7 |
| M. vanbaalenii PYR-1 | Mvan_5151 | - | 1e-133 | 56.13% (408) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3575c|M.bovis_AF2122/97 MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAA
Rv3545c|M.tuberculosis_H37Rv MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAA
MMAR_5032|M.marinum_M ----------------MPCPNLPPGFDFTDPDIYAERLPVEEFAELRSSE
MUL_4106|M.ulcerans_Agy99 ----------------MPCPNLPPGFDFTDPDIYAERLPVEEFAELRSSE
MAV_2811|M.avium_104 --------MATVEPTTKPVPNLPPGFDFTDPDIYAERLPVEELAEMRRVA
TH_1956|M.thermoresistible__bu ----------------MPTPNIPPGFDFTDPDIYAVRLPVEELAELRRSA
Mflv_1607|M.gilvum_PYR-GCK --------MTAEDARVQSCPFLPDGYDFTDPDVLLEGVPVAEFAQLRRTA
Mvan_5151|M.vanbaalenii_PYR-1 --------MTAT----QSCPFLPHGYDFTDPDVLLKGIPVTEFAELRRTA
MSMEG_5853|M.smegmatis_MC2_155 --------MATMN----TCPFG-NGYDFTDPDVLFRGIPVEEFAVLRKTA
MAB_0101|M.abscessus_ATCC_1997 ----------------MTTCPFTPGFDFTDPDLIQHRIPAEEFAYLRKTE
MLBr_02088|M.leprae_Br4923 --MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRA
. . * : : .:
Mb3575c|M.bovis_AF2122/97 ---PIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHS-DVFSSYENGV
Rv3545c|M.tuberculosis_H37Rv ---PIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHS-DVFSSYENGV
MMAR_5032|M.marinum_M ---PIWWDEQLPGQGGGFHDGGFWAITKLKDVKEVSRRS-DVFSSYENGV
MUL_4106|M.ulcerans_Agy99 ---PIWWDEQFPGQGGGFHDGGFWAITKLKDVKEVSRRS-DVFSSYENGV
MAV_2811|M.avium_104 ---PIWWNEQPIG-AGGFDDGGFWVVTKHKDVKEVSLRS-DVFSSLQKTA
TH_1956|M.thermoresistible__bu ---PIWWNEQPMG-AGGFDDGGFWLVTRHSDVKEVSRRS-DVFSSQRKTA
Mflv_1607|M.gilvum_PYR-GCK ---PVWWNAQQES---IFDDGGYWVVSRHEDIKSISRNS-ALWSTNAKGA
Mvan_5151|M.vanbaalenii_PYR-1 ---PVWWNEQADS---IFDDGGYWVISRHEDVKAISRNS-TQWSTNTKGA
MSMEG_5853|M.smegmatis_MC2_155 ---PVWWNQQGES---IFDDGGYWVISRHEDIKTISRDGGEVWSTNAKGA
MAB_0101|M.abscessus_ATCC_1997 ---PIWWNAQPRG-VAGFDDDGYWVVTKHADVKEVSRLN-EVFSNSVNTT
MLBr_02088|M.leprae_Br4923 DPFPVYRALIDYG-PMQLPGMPLTVFSSFSDCDEALRHP-LSASDRLKAT
*:: . : . .: * . * : .
Mb3575c|M.bovis_AF2122/97 IPRFKNDIAREDIEVQR-FVMLNMDAPHHTRLRKIISRGFTPRAVGRLHD
Rv3545c|M.tuberculosis_H37Rv IPRFKNDIAREDIEVQR-FVMLNMDAPHHTRLRKIISRGFTPRAVGRLHD
MMAR_5032|M.marinum_M IPRFKNDIAREDIDVQR-FVMLNMDAPHHTRLRKIISRGFTPRAIGRLHD
MUL_4106|M.ulcerans_Agy99 IPRFKNDIAREDIDVQR-FVMLNMDAPHHTRLRKIISRGFTPRAIGRLHD
MAV_2811|M.avium_104 LPRYKDGTVAEQVERGK-FVLLNMDAPQHTRLRKIISRAFTPRAVERLRD
TH_1956|M.thermoresistible__bu LPRYRDGTVAEQIDRGK-YVLLNMDAPHHTRLRKIISRAFTPRAVERLRD
Mflv_1607|M.gilvum_PYR-GCK VMRLPDGVTAEQLDLTK-ALLINHDAPEHTRLRKIVSRLFTPRAIAGMEA
Mvan_5151|M.vanbaalenii_PYR-1 VMRLPDGVTAEQLDLTK-ALLINHDAPEHTRLRKIVSRLFTPRAIAGMED
MSMEG_5853|M.smegmatis_MC2_155 VMRLPDGVTAEQLDLTK-ALLINHDAPEHTRLRKLVSRLFTPRSVAALEE
MAB_0101|M.abscessus_ATCC_1997 VVRYNEDITAEQLEIQRENLLIDMDEPKHRILRRIVSPLFTPKAVNGLHA
MLBr_02088|M.leprae_Br4923 LAQQAIAAGAEPRPFYA-SSFMFLDPPDHTRLRKLVSKAFAPKVVQALEG
: : * :: * *.* **:::* *:*: : :.
Mb3575c|M.bovis_AF2122/97 ELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFH
Rv3545c|M.tuberculosis_H37Rv ELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFH
MMAR_5032|M.marinum_M ELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIPQEDRGKLFD
MUL_4106|M.ulcerans_Agy99 ELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIPQEDRGKLFD
MAV_2811|M.avium_104 DLRERARRIVEAAAAEGSGDFVEQVSCELPLQAIASLMGVPQEDRKKLFH
TH_1956|M.thermoresistible__bu ELNERAHRIVMEAAAAGSGDFVEQVACELPLQAIAGLMGVPQEDRKKLFD
Mflv_1607|M.gilvum_PYR-GCK KLADSARQIVGEAADKAGGNFVDDVATLLPLQAIADLIGVPEEDREKLFH
Mvan_5151|M.vanbaalenii_PYR-1 RLADAAREIVRSAAEKDSGDFVDDVAMMLPLQAIADLIGVPEEDREKLFH
MSMEG_5853|M.smegmatis_MC2_155 KLAVAAHDIVAEAKAEGSGNFVEDIAMKLPLLAIADLIGVPEADREKIFA
MAB_0101|M.abscessus_ATCC_1997 RLVERAHGIVEEAAEKSSGNFVSDIASVLPMHAIADLVGIPESDRQQVLD
MLBr_02088|M.leprae_Br4923 DIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
: . : . :.: ::: *.: .*. *:*:* * :.
Mb3575c|M.bovis_AF2122/97 WSNEMTGNED--------PEYAHIDPKASSAELIGYAMKMAEEKAKNPAD
Rv3545c|M.tuberculosis_H37Rv WSNEMTGNED--------PEYAHIDPKASSAELIGYAMKMAEEKAKNPAD
MMAR_5032|M.marinum_M WSNEMTGTED--------PEFAHIDAKASSVELIGYAMKMAEEKAKNPGD
MUL_4106|M.ulcerans_Agy99 WSNEMTGTED--------PEFAHIDAKASSVELIGYAMKMAEEKAKNPGD
MAV_2811|M.avium_104 WSNEMVGDQD--------PEFASNDAITASVELIMYGMQMAADRAKNPGE
TH_1956|M.thermoresistible__bu WSNQMVGDQD--------PEFADNDAIGASIELIGYGMQLAADRQRNPRD
Mflv_1607|M.gilvum_PYR-GCK WSNAIMNTDD--------PDFDS-DPTIANAELMGYAYTMAEQRRRCPAD
Mvan_5151|M.vanbaalenii_PYR-1 WTNAIMNTDD--------PEFDA-DPTMANAELMGYAYSMAEERRRCPAD
MSMEG_5853|M.smegmatis_MC2_155 WSNAIINTDD--------PDFDS-DPTVANAELMGYAYTMAEERRRCPAD
MAB_0101|M.abscessus_ATCC_1997 WTNQMFAYDD--------PAIGRDTATTATVSMLGYAYAMAEERQLNPQD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
: : * * : : * :. : * :
Mb3575c|M.bovis_AF2122/97 DIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEH
Rv3545c|M.tuberculosis_H37Rv DIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEH
MMAR_5032|M.marinum_M DIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFADN
MUL_4106|M.ulcerans_Agy99 DIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFADN
MAV_2811|M.avium_104 DLVTKLVQADIDGHKLSDDEFGFFVILLAVAGNETTRNSITQGMMAFTDF
TH_1956|M.thermoresistible__bu DLVTTLVQADVDGHKLSDDEFGFFVILLAVAGNETTRNSITQGMMAFTEH
Mflv_1607|M.gilvum_PYR-GCK DIVTRLVEADLDGDALGEVEFAFFVILLAVAGNETTRNAMTHGMNAFLDH
Mvan_5151|M.vanbaalenii_PYR-1 DIVTRLVQADIDGESLGEVEFAFFVILLAVAGNETTRNAMTHGMNAFFDN
MSMEG_5853|M.smegmatis_MC2_155 DIVTRLVQADVSGESLGEVEFAFFVILLAVAGNETTRNAITHGMNAFFEN
MAB_0101|M.abscessus_ATCC_1997 DILTGLVRGAYDDRPLTPLEFAYFVIQLMVAGNETSRNAITHGVLAFADN
MLBr_02088|M.leprae_Br4923 DLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRN
*::: *:. .. * *: * ***:**: * :::.: *:
Mb3575c|M.bovis_AF2122/97 PDQWELYKK--VRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQ
Rv3545c|M.tuberculosis_H37Rv PDQWELYKK--VRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQ
MMAR_5032|M.marinum_M PEQWELYKR--ERPETAADEIVRWATPVTSFQRTALEDYELSGVQIKKGQ
MUL_4106|M.ulcerans_Agy99 PEQWELYKR--ERPGTAADEIVRWATPVTSFQRTALEDYELSGVQIKKGQ
MAV_2811|M.avium_104 PDQWELFKR--ERPATAADEIVRWATPVTSFQRTALQDYELSGVKIKKGQ
TH_1956|M.thermoresistible__bu PDQWELFKE--QRPPTTADEIVRWATPVTSFQRTALADVELSGVQIKAGQ
Mflv_1607|M.gilvum_PYR-GCK PDQWELFKR--ERPETAIDEIIRWATPVHCFQRTALDDVEIGGVTVARGQ
Mvan_5151|M.vanbaalenii_PYR-1 PAQWELFKR--ERPETAIDEIIRWATPVHCFQRTALEDVEVGGVTIAEGQ
MSMEG_5853|M.smegmatis_MC2_155 PDQWELFKR--ERPITAVDEIVRWATPVHCFQRTAVVDTEIGGVPIKAGQ
MAB_0101|M.abscessus_ATCC_1997 PAQWRLYRE--RRPSTAADEIIRWASPIIAFQRTALQDVELGGVQIRKDQ
MLBr_02088|M.leprae_Br4923 PSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGD
* **. *. . :* :*: ..: : *.* * :. . : .:
Mb3575c|M.bovis_AF2122/97 RVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARM
Rv3545c|M.tuberculosis_H37Rv RVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARM
MMAR_5032|M.marinum_M RVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGTGAHYCIGANLARM
MUL_4106|M.ulcerans_Agy99 RVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGTGAHYCIGANLARM
MAV_2811|M.avium_104 RVVMFYRSANFDEDVFDDPFTFNILRDPNPHVGFGGTGAHYCIGANLARM
TH_1956|M.thermoresistible__bu RVVMCYRSANFDDTVFDDPYTFNILRDPNPHLGFGGTGAHYCIGANLARL
Mflv_1607|M.gilvum_PYR-GCK RVGLFYSSANFDEDVFDNPFNFDILRNPNPHLAFGGNGAHYCIGANLARM
Mvan_5151|M.vanbaalenii_PYR-1 RVGLFYSSANFDEDVFDRPFDFDILRDPNPHLAFGGNGAHFCIGANLARM
MSMEG_5853|M.smegmatis_MC2_155 RAGLFYSSANYDEDVFDDPFRFDILRDPNPHLGFGGNGAHYCIGANLARM
MAB_0101|M.abscessus_ATCC_1997 RVGMFYASANFDEDVFDDPFAFNIERDPNPHLAFGGHGIHYCLGANLARL
MLBr_02088|M.leprae_Br4923 TMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFA-VGSHFCLGAALARL
: :** * *:. * *: * .. *:.*. * *:*:** ***:
Mb3575c|M.bovis_AF2122/97 TINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTG----RCPV
Rv3545c|M.tuberculosis_H37Rv TINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTG----RCPV
MMAR_5032|M.marinum_M TINLIFNAVADHMPDLTPIAAPERLRSGWLNGIKHWQVDYTG----KCPV
MUL_4106|M.ulcerans_Agy99 TINLIFNAVADHMPDLKPIAAPERLRSGWLNGIKHWQVDYTG----KCPV
MAV_2811|M.avium_104 TIDLMFNAIADAMPDLESIGKPERLRSGWLNGIKHWQVDYHTNGSSKCPV
TH_1956|M.thermoresistible__bu TIDLIFAAIAEHLPDLRPLGPPERLRSGWLNGIKHWPVDYGAPRVPTGAA
Mflv_1607|M.gilvum_PYR-GCK EIKLMFEAIADRLPDISKRAEPQRLRSGWINGVKDLQVAYR---------
Mvan_5151|M.vanbaalenii_PYR-1 EIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQVAYR---------
MSMEG_5853|M.smegmatis_MC2_155 EIRLMFDEIADQIPDITKVGEPQRLRSGWINGVKDLQVSYRG--------
MAB_0101|M.abscessus_ATCC_1997 EIGIMFDALADRLPDLMPTGAPTRFRSGWINGVVALPANYHG----SGPR
MLBr_02088|M.leprae_Br4923 EATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV----------
: : :: :*:: . . :.*: .
Mb3575c|M.bovis_AF2122/97 AH----
Rv3545c|M.tuberculosis_H37Rv AH----
MMAR_5032|M.marinum_M SH----
MUL_4106|M.ulcerans_Agy99 SH----
MAV_2811|M.avium_104 AH----
TH_1956|M.thermoresistible__bu GPQRCG
Mflv_1607|M.gilvum_PYR-GCK ------
Mvan_5151|M.vanbaalenii_PYR-1 ------
MSMEG_5853|M.smegmatis_MC2_155 ------
MAB_0101|M.abscessus_ATCC_1997 G-----
MLBr_02088|M.leprae_Br4923 ------