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M. tuberculosis H37Rv Rv1983 (PE_PGRS35)

annotation: PE-PGRS FAMILY PROTEIN
coordinates: 2226244 - 2227920
length: 558

VSFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGADEVSAAVAALFARFGQEYQAVSAQAS
AFHQQFVQTLNSASGSYAAAEATIASQLQTAQHDLLGAVNAPTETLLGRPLIGDGAPGTATSPNGGAGGL
LYGNGGNGYSATASGVGGGAGGSAGLIGNGGAGGAGGPNAPGGAGGNGGWLLGNGGIGGPGGASSIPGMS
GGAGGTGGAAGLLGWGANGGAGGLGDGVGVDRGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIHVTEP
TVHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMGLPTGLSISGYSGGLYYIFATYTTTVDFGNG
IVTAPTAVNVVLLSIPTSPFAISTYFSALLADPTTTPFEAYFGAVGVDGVLGVGPNAVGPGPSIPTMALP
GDLNQGVLIDAPAGELVFGPNPLPAPNVEVVGSPITTLYVKIDGGTPIPVPSIIDSGGVTGTIPSYVIGS
GTLPANTNIEVYTSPGGDRLYAFNTNDYRPTVISSGLMNTGFLPFRFQPVYIDYSPSGIGTTVFDHPA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1983PE_PGRS35-100% (558)PE-PGRS FAMILY PROTEIN
M. tuberculosis H37RvRv2591PE_PGRS447e-9161.42% (267) PE-PGRS family protein
M. tuberculosis H37RvRv1067cPE_PGRS194e-8759.51% (284) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2005PE_PGRS350.099.82% (558) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-3e-2950.67% (150) triple helix repeat-containing collagen
M. leprae Br4923MLBr_01183-7e-1439.42% (104) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_0321c-4e-1631.58% (228) hypothetical protein MAB_0321c
M. marinum MMMAR_2933-0.069.71% (558) PE-PGRS family protein
M. avium 104MAV_1346-5e-2535.51% (276) PE family protein
M. smegmatis MC2 155MSMEG_0868-7e-3740.24% (251) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-1e-1635.24% (227) PUTATIVE -
M. ulcerans Agy99MUL_4399-5e-9260.00% (285) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_0928-8e-3840.78% (255) carboxymuconolactone decarboxylase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------MSGTQSAESDDDADDSEGDASADDAEDAEE
MUL_4399|M.ulcerans_Agy99           --------------------------------------------------
Rv1983|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2005|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2933|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       FVGDSGNGGSDDDAADDSEKDVDSSTDDGVGDFEGVVLDDAESEADSQLS
MUL_4399|M.ulcerans_Agy99           --------MSYLLVAPELLTSAATDLEGIASALSTANLAAAVPTTGMLAA
Rv1983|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2005|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2933|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       VPQPASTESTEQSADVANDADGNADPIADAGPEAVTAPVALSGASAPAIP
MUL_4399|M.ulcerans_Agy99           GADEVSAAVASLFAGYGQAYQSISLQANAFQAQFIQAINGAGGAYVAAEA
Rv1983|M.tuberculosis_H37Rv         -----------------------MS-FLVVVPEFLTSAAADVENIGSTLR
Mb2005|M.bovis_AF2122/97            -----------------------MS-FLVVVPEFLTSAAADVENIGSTLR
MMAR_2933|M.marinum_M               -----------------------MS-LLVVAPEWLTSAAAELQSIESALS
MLBr_01183|M.leprae_Br4923          -----------------------MPLFLNAEPQALTAAANTLEGLSAATV
MAV_1346|M.avium_104                -----------------------MS-FVTTRPEALLAVASMLEGLGSSMD
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       DGP-----------------------------------APVEPMGPLINS
MUL_4399|M.ulcerans_Agy99           AS--------------------------------------TSPLQAFEDT
Rv1983|M.tuberculosis_H37Rv         AAN-----------------------------------------------
Mb2005|M.bovis_AF2122/97            AAN-----------------------------------------------
MMAR_2933|M.marinum_M               AAN-----------------------------------------------
MLBr_01183|M.leprae_Br4923          ASN-----------------------------------------------
MAV_1346|M.avium_104                AQN-----------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       LWWAVPKSGGRSTNDASLTLAGTGIYPSVTSLFAFGGRCGLICDGADGTE
MUL_4399|M.ulcerans_Agy99           VLG------------------------VINAPTQTLLGRPLIGDGAAGTV
Rv1983|M.tuberculosis_H37Rv         ------------------------------------AAAAASTTALAAAG
Mb2005|M.bovis_AF2122/97            ------------------------------------AAAAASTTALAAAG
MMAR_2933|M.marinum_M               ------------------------------------AAAAVPTTGLAAAA
MLBr_01183|M.leprae_Br4923          ------------------------------------AAAAQLTTEIAPPA
MAV_1346|M.avium_104                ------------------------------------AAAAAPTTSIAPAA
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
TH_3810|M.thermoresistible__bu      -----------------------VDGDGGSGGRTGLFS------------
MAB_0321c|M.abscessus_ATCC_199      ------------------------------MAN-----------------
Mvan_0928|M.vanbaalenii_PYR-1       QNPNGVGGGWLFGDGGDGWSSTLAGIAGGKGGAAG---------------
MUL_4399|M.ulcerans_Agy99           ANPNGGAGGFLYGNGGNGFSQTTAGVAGGAGGAAG---------------
Rv1983|M.tuberculosis_H37Rv         ADEVSAAVAALFARFGQEYQAVSAQASAFHQQFVQT--------------
Mb2005|M.bovis_AF2122/97            ADEVSAAVAALFARFGQEYQAVSAQASAFHQQFVQT--------------
MMAR_2933|M.marinum_M               ADEVSTAVATLFAGFGQEYQAISTQLSAFQQQFALT--------------
MLBr_01183|M.leprae_Br4923          ADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQS--------------
MAV_1346|M.avium_104                ADEVSALQAAQFSAYGTWYQQVSAQAKAIHQTLVQN--------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155      LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
TH_3810|M.thermoresistible__bu      -------------KLSRGGDGGDGGLG-------------GNGGHGGGTG
MAB_0321c|M.abscessus_ATCC_199      -------------IISNGPDGDAGATG--------------AQGSQGAT-
Mvan_0928|M.vanbaalenii_PYR-1       ------------LLWGSGGDGGAGGAG-------------AAGGTGGNAG
MUL_4399|M.ulcerans_Agy99           -------------LIGNGGMGGAGGAG-------------AAGGAGGTGG
Rv1983|M.tuberculosis_H37Rv         -------------LNSASGSYAAAEATIASQLQTAQHDLLGAVNAPTETL
Mb2005|M.bovis_AF2122/97            -------------LNSASGSYAAAEATIASQLQTAQHDLLGAVNAPTETL
MMAR_2933|M.marinum_M               -------------LNSSAGSYSAAEAQSVSILDTLGQDVFGAINAPTEAL
MLBr_01183|M.leprae_Br4923          -------------LLTSSSAYAGTETAN----------------------
MAV_1346|M.avium_104                -------------LDTNADSYGATEAANRVNTSAAALQGLAPNVIPNAAP
                                                     .                                

Mflv_5091|M.gilvum_PYR-GCK          VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
MSMEG_0868|M.smegmatis_MC2_155      GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
TH_3810|M.thermoresistible__bu      IIS--------------------LLSLAGNGGNGG---------------
MAB_0321c|M.abscessus_ATCC_199      -------------------------GAAGAMANCN---------------
Mvan_0928|M.vanbaalenii_PYR-1       LLWG-----------------NGGHGGAGGAGVNG---------------
MUL_4399|M.ulcerans_Agy99           WWFG-----------------NGGVGGAGGAGTAG---------------
Rv1983|M.tuberculosis_H37Rv         LGRP----------------------LIGDGAPG----------------
Mb2005|M.bovis_AF2122/97            LGRP----------------------LIGDGAPG----------------
MMAR_2933|M.marinum_M               LGRP----------------------LIGNGANG----------------
MLBr_01183|M.leprae_Br4923          ------------------------------HDSL----------------
MAV_1346|M.avium_104                AADP----------------------PPAGTTSLG---------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          VG--SAGAAGEAGETGTWGNAGLPGKAGDAGGAG----AVGAAG---AAG
MSMEG_0868|M.smegmatis_MC2_155      VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
TH_3810|M.thermoresistible__bu      ------------------------------------------NG----YR
MAB_0321c|M.abscessus_ATCC_199      -------------------------------------------------W
Mvan_0928|M.vanbaalenii_PYR-1       -----------------------------------------------AVG
MUL_4399|M.ulcerans_Agy99           -----------------------------------------------AVG
Rv1983|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2005|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2933|M.marinum_M               --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                -------------------------------------------------T
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          TVGTAGATGGTG----TGANGGAGGVG-----GVGGTGAAGAAGGAG---
MSMEG_0868|M.smegmatis_MC2_155      AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
TH_3810|M.thermoresistible__bu      TTDNNALDGGHG------GNGGN---------------------------
MAB_0321c|M.abscessus_ATCC_199      IDDDCATRGGTG--------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       TSGVNNGRGGDGTAGGSGGAGGNAGLLS----------------------
MUL_4399|M.ulcerans_Agy99           FNGVSGGAGGAG--------------------------------------
Rv1983|M.tuberculosis_H37Rv         -TATSPNGGAGG--------------------------------------
Mb2005|M.bovis_AF2122/97            -TATSPNGGAGG--------------------------------------
MMAR_2933|M.marinum_M               -TATSPNGGAGG--------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                SIGWAQNVGAAA--------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ---GLGETGTTG--------------GAGGVGGQGTAGGTGGVGGIG---
MSMEG_0868|M.smegmatis_MC2_155      TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
TH_3810|M.thermoresistible__bu      --VGFFSLFNLG--------------GAGGWGGSGVDG------------
MAB_0321c|M.abscessus_ATCC_199      --------------------------GTGGNGGP----------------
Mvan_0928|M.vanbaalenii_PYR-1       ---GRGGDGGVG--------------GAGGKGGAGAHG------------
MUL_4399|M.ulcerans_Agy99           ---GAAGWWGAG--------------GAGGQGGTG---------------
Rv1983|M.tuberculosis_H37Rv         -----------------------LLYGNGGNGYSATASG-----------
Mb2005|M.bovis_AF2122/97            -----------------------LLYGNGGNGYSATASG-----------
MMAR_2933|M.marinum_M               -----------------------LLFGNGGIGYSQTGAG-----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                -----------------------SDFITLGEGQFAPVPG-----------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------GAGSTGAVGG-----------VGGKGIQGG
MSMEG_0868|M.smegmatis_MC2_155      SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
TH_3810|M.thermoresistible__bu      ------------------------VDVVGG--------------------
MAB_0321c|M.abscessus_ATCC_199      ----------------------------GG--------------------
Mvan_0928|M.vanbaalenii_PYR-1       ------------------------SDAVAAE-------------------
MUL_4399|M.ulcerans_Agy99           -------------------------GMAGG--------------------
Rv1983|M.tuberculosis_H37Rv         ------------------------VGG-----------------------
Mb2005|M.bovis_AF2122/97            ------------------------VGG-----------------------
MMAR_2933|M.marinum_M               ------------------------IVG-----------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                ------------------------AAG-----------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          QGLQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK
MSMEG_0868|M.smegmatis_MC2_155      KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV
TH_3810|M.thermoresistible__bu      -------NPDGGTPG------------------------------AHGES
MAB_0321c|M.abscessus_ATCC_199      ---------AGGPGG-------------------------------HGGV
Mvan_0928|M.vanbaalenii_PYR-1       --------EDGGPGG-------------------------------SGGA
MUL_4399|M.ulcerans_Agy99           ---------YDNVNG------------------------------VFGIT
Rv1983|M.tuberculosis_H37Rv         --------GAGGSAG----------------------------LIGNGGA
Mb2005|M.bovis_AF2122/97            --------GAGGSAG----------------------------LIGNGGA
MMAR_2933|M.marinum_M               --------GAGGSAG----------------------------LIGNGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------IPNFNPG----------------------------LTAATTA
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GGNGGNGGRGGLFG---------------KGGNAGNG-------------
MSMEG_0868|M.smegmatis_MC2_155      GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP
TH_3810|M.thermoresistible__bu      HTPGVYTDRQ----------------------------------------
MAB_0321c|M.abscessus_ATCC_199      IDFEVETFMD----------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       GGNAG---------------------------------------------
MUL_4399|M.ulcerans_Agy99           AGNGG---------------------------------------------
Rv1983|M.tuberculosis_H37Rv         GGAGGPNAPG----------------------------------------
Mb2005|M.bovis_AF2122/97            GGAGGPNAPG----------------------------------------
MMAR_2933|M.marinum_M               GGTGGAGATG----------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                GPPAPAAPAA----------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ---------ADGGTGGAGGAGGTGG-TGGAGGTGG---------------
MSMEG_0868|M.smegmatis_MC2_155      AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ
TH_3810|M.thermoresistible__bu      ---------------GEDGEDGTGTGIGGRGGNGG---------------
MAB_0321c|M.abscessus_ATCC_199      --------------------GVTLQAKGGRGGNGG---------------
Mvan_0928|M.vanbaalenii_PYR-1       ----------------AGGVGGRGALLFGRGGDGG---------------
MUL_4399|M.ulcerans_Agy99           ----------------DGGAGGRGGWLFGDAGAGG---------------
Rv1983|M.tuberculosis_H37Rv         ------------------GAGGNGGWLLGNGGIGG---------------
Mb2005|M.bovis_AF2122/97            ------------------GAGGNGGWLLGNGGIGG---------------
MMAR_2933|M.marinum_M               ------------------GAGGNGGWLFGSGGIGG---------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                ------------------AAG--APVLASMGRGPS---------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
MSMEG_0868|M.smegmatis_MC2_155      TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG
TH_3810|M.thermoresistible__bu      -SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSHGGNGGHG
MAB_0321c|M.abscessus_ATCC_199      ------------------------------------HGGAGGTGGTGGKG
Mvan_0928|M.vanbaalenii_PYR-1       --DGGSAGTGGAGGFGGTGGAIVVTLPGGKLSDSDGAGGAGGVGGAAGLG
MUL_4399|M.ulcerans_Agy99           -----QGGLGGDGNYAGQGSYGGVGGAGGAGG----AAGMFGSGGSGGAG
Rv1983|M.tuberculosis_H37Rv         --------------------------PGGASSIPGMSGGAGGTGGAAGLL
Mb2005|M.bovis_AF2122/97            --------------------------PGGASSIPGMSGGAGGTGGATGLL
MMAR_2933|M.marinum_M               --------------------------TGGANALG--TGGTGGLGGSAGLF
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------IGGLSVPPSWAPGGVAPAANATPA
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155      GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGG
TH_3810|M.thermoresistible__bu      GRGGFLGIGGSG-------GWGGHGGNGGD-----------TDADGGNGG
MAB_0321c|M.abscessus_ATCC_199      GDGDDCEFGRTG-------GNGGTGGRGGD------------GNFAGTGG
Mvan_0928|M.vanbaalenii_PYR-1       GDGGGGGLGGLLG------QAGVNGDSGAT---------AAAGNAGGVGG
MUL_4399|M.ulcerans_Agy99           GEGGAFGDGNAGG-----SGSGGHGGNGGNG-----------GWLYGDAG
Rv1983|M.tuberculosis_H37Rv         GWGANGGAGGLGDGVGVDRGTGGAGGRGGLL-----------YGGYGVSG
Mb2005|M.bovis_AF2122/97            GWGANGGAGGLGDGVGVDRGTGGAGGRGGLL-----------YGGYGVSG
MMAR_2933|M.marinum_M               GGGGNGGAGGLG--ISGDLGTGGAGGTGGFL-----------LGDYGVSG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                QLVGAGFTSAAPDTAPVTAVPGGVPSMATAG-----------RGGYGLGA
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          AG-----------DGTGGTGGTGG----TGGQGGQGGQGG----------
MSMEG_0868|M.smegmatis_MC2_155      AGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIG
TH_3810|M.thermoresistible__bu      DG---------------GNGGSAG--------------------------
MAB_0321c|M.abscessus_ATCC_199      NG------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       AG---------------GLGGRLPIVDLNNASPAQATLAALIKKLGLPIQ
MUL_4399|M.ulcerans_Agy99           AG---------------GQGGNAAP-------------------------
Rv1983|M.tuberculosis_H37Rv         PG------------------------------------------------
Mb2005|M.bovis_AF2122/97            PG------------------------------------------------
MMAR_2933|M.marinum_M               AG------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                PR------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -------TGGTGGQGG-LGGGGGTG-----------------------GQ
MSMEG_0868|M.smegmatis_MC2_155      SNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGH
TH_3810|M.thermoresistible__bu      -------RGGTGGLRGVFGINGGNG------------------------R
MAB_0321c|M.abscessus_ATCC_199      -----------GAILVKCQHDLSLG------------------------T
Mvan_0928|M.vanbaalenii_PYR-1       AATGIQLEDVDGRLVGPLNAYLYNTIIGKAIFDVGNTFSSASLSARVKEI
MUL_4399|M.ulcerans_Agy99           --------GAYSDNLGTFQSSYTSG------------------------N
Rv1983|M.tuberculosis_H37Rv         ----------GDGRTVPLEIIHVTEP-----------------------T
Mb2005|M.bovis_AF2122/97            ----------GDGRTVPLEIIHVTEP-----------------------T
MMAR_2933|M.marinum_M               ----------GDGRTVPLEVVNVTEP-----------------------V
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                ----------YGVKPTVMPKPAI---------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGS
MSMEG_0868|M.smegmatis_MC2_155      GGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGD
TH_3810|M.thermoresistible__bu      AGLGGRGXXXXGGGVG---------------AAVRSGNGVFSGGGGTPSA
MAB_0321c|M.abscessus_ATCC_199      HPMDVSAGTGGNGGIG----------------GGGGGGGSVGANG--ATT
Mvan_0928|M.vanbaalenii_PYR-1       VILSVGGQWGSEYELYAHKLAAQLFG-----IPADAIAALANGQAPVGLS
MUL_4399|M.ulcerans_Agy99           GGAGGNGGVAGMIGTGG--------------AGGAGGAGGVNAFDSGGGG
Rv1983|M.tuberculosis_H37Rv         VHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMGLPTGLSISGYS
Mb2005|M.bovis_AF2122/97            VHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMGLPTGLSISGYS
MMAR_2933|M.marinum_M               VNVNVNGGHSTPVLIDTGSAGLVMQVKDVGGPLGLLRMGLPSGISMSAYS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKA
MSMEG_0868|M.smegmatis_MC2_155      GVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTL
TH_3810|M.thermoresistible__bu      GFGVPTTIQFPAGSCTSRAVSREG------------------------IM
MAB_0321c|M.abscessus_ATCC_199      GVFSSSSDCSGPGPQPNPGSPGDP--------------------------
Mvan_0928|M.vanbaalenii_PYR-1       GNELLAAQFVQELVSTRRVSDALFEAAEAAFGQTGVVDMVNLAGTYLGVS
MUL_4399|M.ulcerans_Agy99           G-GGGNGGNGGAGGASGALIEAGG----------------------VGGS
Rv1983|M.tuberculosis_H37Rv         GGLYYIFATYTTTVDFGNGIVTAP------------------TAVNVVLL
Mb2005|M.bovis_AF2122/97            GGLYYIFATYTTTVDFGNGIVTAP------------------TAVNVVLL
MMAR_2933|M.marinum_M               GGLTYLFATYPTTVDFGNGIVTST------------------TGVDVVLF
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATG
MSMEG_0868|M.smegmatis_MC2_155      GGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGG
TH_3810|M.thermoresistible__bu      PSSRAASARAG---------------------------AACASSTSRSRR
MAB_0321c|M.abscessus_ATCC_199      ---GTSVAVSG------------------------------AQGNPGQAQ
Mvan_0928|M.vanbaalenii_PYR-1       ATLNAFKVRGPESFSAPVLPAAPSPVPASDEYGLGGRLPLIDLDTATPAQ
MUL_4399|M.ulcerans_Agy99           GGGGGAGVVGP------------------------------PAGNPGNDG
Rv1983|M.tuberculosis_H37Rv         SIPTSPFAISTYFS-----------------------ALLADPTTTPFEA
Mb2005|M.bovis_AF2122/97            SIPTSPFAISTYFS-----------------------ALLADPTTTPFEA
MMAR_2933|M.marinum_M               SIPTSPYALTTWLN-----------------------ALWSNPLTTPFDA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          AAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA
MSMEG_0868|M.smegmatis_MC2_155      AATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWV
TH_3810|M.thermoresistible__bu      SFCCSRA-------------------------------------------
MAB_0321c|M.abscessus_ATCC_199      FLIVP---------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       LDLAAKIKALAVPTQQATGIELVSPDGRLIGPLNGYLYNPVIGQALFEVG
MUL_4399|M.ulcerans_Agy99           LDGVTGASGLLFGG------------------------------------
Rv1983|M.tuberculosis_H37Rv         YFGAVGVDGVLGVGPNAVGPGPSIPTMALPGDLNQGVLIDAPAGELVFGP
Mb2005|M.bovis_AF2122/97            YFGAVGVDGVLGVGPNAVGPGPSIPTMALPGDLNQGVLIDAPAGELVFGP
MMAR_2933|M.marinum_M               YFQSAGVDGVLGVGPNAVGPGPSIPTQALGGGLGQGLLIDMKGGELVFGP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GATG-TTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG------
MSMEG_0868|M.smegmatis_MC2_155      QAYD-PAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWK
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       NAFASSSLSSRIKEIVILSVGGQWGSGYEVYAHEKVARLVGIPEEAIVSL
MUL_4399|M.ulcerans_Agy99           --------------------------------------------------
Rv1983|M.tuberculosis_H37Rv         NPLPAPNVEVVGSPITTLYVKIDGGTPIPVPSIIDSGGVTGTIPSYVIGS
Mb2005|M.bovis_AF2122/97            NPLPAPNVEVVGSPITTLYVKIDGGTPIPVPSIIDSGGVTGTIPSYVIGS
MMAR_2933|M.marinum_M               NPL-TPEFSISGAPIATLWVSVNGGAPVAVPSIIDSGGVMGTIPSSVIGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----------AGGEGGEGGDGGKGGAG--AEGGAGGGGGAGGSGAGGAG
MSMEG_0868|M.smegmatis_MC2_155      SGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       ASGHAPVGLSGSELVAARFVQELVSTYEVSSELYHSAEAAFGQAGLVDLV
MUL_4399|M.ulcerans_Agy99           --------------------------------------------------
Rv1983|M.tuberculosis_H37Rv         GTLPANTNIEVYTS-PGGDRLYAFNTNDYRPTVISSGLMNTGFLPFRFQP
Mb2005|M.bovis_AF2122/97            GTLPANTNIEVYTS-PGGDRLYAFNTNDYRPTVISSGLMNTGFLPFRFQP
MMAR_2933|M.marinum_M               STLPANTNITVYTDNTMTTEVYHYSTNDYQPTVISSGLMNTGFLPFWNQP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --GAGGSGGSGGSGGSGGSGGAAGDSDD-
MSMEG_0868|M.smegmatis_MC2_155      NGGNGGNGGNGGADGTPGTAGTTGANNP-
TH_3810|M.thermoresistible__bu      -----------------------------
MAB_0321c|M.abscessus_ATCC_199      -----------------------------
Mvan_0928|M.vanbaalenii_PYR-1       NLASTYLGASALLNVFEVPVPTAALITTS
MUL_4399|M.ulcerans_Agy99           -----------------------------
Rv1983|M.tuberculosis_H37Rv         VYIDYSPSGIGTTVFDHPA----------
Mb2005|M.bovis_AF2122/97            VYIDYSPSGIGTTVFDHPA----------
MMAR_2933|M.marinum_M               VYIDYSPAGTGTTVFDMP-----------
MLBr_01183|M.leprae_Br4923          -----------------------------
MAV_1346|M.avium_104                -----------------------------