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SYLLVAPELLTSAATDLEGIASALSTANLAAAVPTTGMLAAGADEVSAAVASLFAGYGQAYQSISLQANA FQAQFIQAINGAGGAYVAAEAASTSPLQAFEDTVLGVINAPTQTLLGRPLIGDGAAGTVANPNGGAGGFL YGNGGNGFSQTTAGVAGGAGGAAGLIGNGGMGGAGGAGAAGGAGGTGGWWFGNGGVGGAGGAGTAGAVGF NGVSGGAGGAGGAAGWWGAGGAGGQGGTGGMAGGYDNVNGVFGITAGNGGDGGAGGRGGWLFGDAGAGGQ GGLGGDGNYAGQGSYGGVGGAGGAGGAAGMFGSGGSGGAGGEGGAFGDGNAGGSGSGGHGGNGGNGGWLY GDAGAGGQGGNAAPGAYSDNLGTFQSSYTSGNGGAGGNGGVAGMIGTGGAGGAGGAGGVNAFDSGGGGGG GGNGGNGGAGGASGALIEAGGVGGSGGGGGAGVVGPPAGNPGNDGLDGVTGASGLLFGG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_4399 | - | - | 100% (480) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_4400 | - | e-151 | 54.79% (511) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_3507 | - | e-137 | 49.91% (575) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1116 | PE_PGRS21 | 1e-149 | 53.89% (553) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-82 | 42.26% (478) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1087 | PE_PGRS21 | 1e-149 | 52.95% (559) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 5e-11 | 35.42% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-41 | 36.59% (369) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_5321 | - | 0.0 | 86.05% (516) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 6e-21 | 42.26% (168) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 9e-73 | 44.13% (392) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 7e-36 | 36.75% (283) | PUTATIVE - |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 2e-81 | 42.50% (480) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5321|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv1087|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5321|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv1087|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5321|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv1087|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5321|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv1087|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4399|M.ulcerans_Agy99 ------------------------------------MSYLLVAPELLTSA MMAR_5321|M.marinum_M ------------------------------------MSYLLVTPELLTSA Mb1116|M.bovis_AF2122/97 ------------------------------------MSFVVVAPEVLAAA Rv1087|M.tuberculosis_H37Rv ------------------------------------MSFVVVAPEVLAAA Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MAV_4827|M.avium_104 ------------------------------------------MNIVLGVS MUL_4399|M.ulcerans_Agy99 ATDLEGIASALSTANLAAAVPTTGMLAAGADEVSAAVASLFAGYGQAYQS MMAR_5321|M.marinum_M ATDLEGIASALSTANLAAAVPTTGVLAAGADEVSAAVASLFAGYGQAYQS Mb1116|M.bovis_AF2122/97 ASDLAGIGSTLAQANAAALAPTTAVLAAGADEVSAAIASLFGAHGQAYQA Rv1087|M.tuberculosis_H37Rv ASDLAGIGSTLAQANAAALAPTTAVLAAGADEVSAAIASLFGAHGQAYQA Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MLBr_01183|M.leprae_Br4923 -------MPLFLNAEPQALTAAANTLEG---LSAATVASNAAAAQLTTEI MAB_4284c|M.abscessus_ATCC_199 VEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVN MAV_4827|M.avium_104 MAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGT MUL_4399|M.ulcerans_Agy99 ISLQANAFQAQFIQAINGAGGAYVAAEAASTSPLQAFEDTVLGVINAPTQ MMAR_5321|M.marinum_M ISLQANAFQAQFIQAINGAGGAYAAAEAASTSPLQAFEDTVLGVINAPTQ Mb1116|M.bovis_AF2122/97 VSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVEQDLLAAINARFE Rv1087|M.tuberculosis_H37Rv VSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVEQDLLAAINARFE Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGGGTG MLBr_01183|M.leprae_Br4923 APPAADDVSILLAHFFSGHGRQYQAHAS--------------QGATNHQD MAB_4284c|M.abscessus_ATCC_199 TGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHN MAV_4827|M.avium_104 REGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAA MUL_4399|M.ulcerans_Agy99 TLLGRPLIGDGAAGTVANPNGGAGGFLYGNGGNGF--------------- MMAR_5321|M.marinum_M TLLGRPLIGDGAAGTAANPNGGAGGFLYGNGGNGF--------------- Mb1116|M.bovis_AF2122/97 RIFGRPLIGDGANGGPGQ-DGGPGGLLYGNGGNGG--------------- Rv1087|M.tuberculosis_H37Rv RIFGRPLIGDGANGGPGQ-DGGPGGLLYGNGGNGG--------------- Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT TH_3810|M.thermoresistible__bu IIS--------------------LLSLAGNGGNGG--------------- MLBr_01183|M.leprae_Br4923 LIQS---------------------LLTSSSAYAG--------------- MAB_4284c|M.abscessus_ATCC_199 PIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGN--------------- MAV_4827|M.avium_104 LAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGS--------------- . MUL_4399|M.ulcerans_Agy99 -SQTTAGVAGGAGGAAG--------------------------------- MMAR_5321|M.marinum_M -SQTTAGVAGGSGGAAG--------------------------------- Mb1116|M.bovis_AF2122/97 -TSTTVGMAGGNGGAAG--------------------------------- Rv1087|M.tuberculosis_H37Rv -TSTTVGMAGGNGGAAG--------------------------------- Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------------- Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------------- MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH TH_3810|M.thermoresistible__bu NGYRTTDNNALDGGHGG--------------------------------- MLBr_01183|M.leprae_Br4923 --TETANHDSL--------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --RDTTAIGDGAVAVGG--------------------------------- MAV_4827|M.avium_104 --IPDVYKQQIRAESYG--------------------------------- MUL_4399|M.ulcerans_Agy99 ------------------------------------------LIGNGGMG MMAR_5321|M.marinum_M ------------------------------------------LIGNGGMG Mb1116|M.bovis_AF2122/97 ------------------------------------------LIGNGGFG Rv1087|M.tuberculosis_H37Rv ------------------------------------------LIGNGGFG Mflv_5091|M.gilvum_PYR-GCK AVGAAGAAG------TVGTAGATGGTG---------------TGANGGAG Mvan_1264|M.vanbaalenii_PYR-1 AIGTAGVAG------AAGTAGATGGTG---------------VGGNGGAG MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS TH_3810|M.thermoresistible__bu ------------------------------------------NGGNVGFF MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------------SNSGP MAV_4827|M.avium_104 --------------------------------------------DAAGQL MUL_4399|M.ulcerans_Agy99 GAGGAGAAGGAG----------------GTGGWWFGNGGVGGAGGAGTA- MMAR_5321|M.marinum_M GAGGAGAAGGAG----------------GTGGWWFGNGGVGGAGGAGTA- Mb1116|M.bovis_AF2122/97 GGGGPGAAGGNG----------------GAGGWLFGNGGAGGAGGLGVAP Rv1087|M.tuberculosis_H37Rv GGGGPGAAGGNG----------------GAGGWLFGNGGAGGAGGLGVAP Mflv_5091|M.gilvum_PYR-GCK GVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGGQ- Mvan_1264|M.vanbaalenii_PYR-1 QAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGGQ- MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY TH_3810|M.thermoresistible__bu SLFNLGG--------------------AGGWGGSGVDG------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 IASGQGSTAVNG----------------DVRDSNIINADHGSNVGVDQSQ MAV_4827|M.avium_104 SAMVAGLEKLES-----------------LPGGLLLVGSGVDVAPLKQVL MUL_4399|M.ulcerans_Agy99 ----------GAVGFNGVSGGAGGAGGAAG-------------------- MMAR_5321|M.marinum_M ----------GAVGFNGVSGGAGGAGGAAG-------------------- Mb1116|M.bovis_AF2122/97 ----------GVPGGAGGAGGAGGVGGPAG-------------------- Rv1087|M.tuberculosis_H37Rv ----------GVPGGAGGAGGAGGVGGPAG-------------------- Mflv_5091|M.gilvum_PYR-GCK -GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG----------- Mvan_1264|M.vanbaalenii_PYR-1 -GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG----------- MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA TH_3810|M.thermoresistible__bu ---------VDVVGGNP--------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TRVGGDYTNVSGHGSADIDKSVTVVDDHSQ-------------------- MAV_4827|M.avium_104 QTTTFLDVSVAEEPETALARGAALAAANAP-------------------- MUL_4399|M.ulcerans_Agy99 ------WWGAGGAGGQG-----------------------------GTG- MMAR_5321|M.marinum_M ------WWGAGGAGGQG-----------------------------GTG- Mb1116|M.bovis_AF2122/97 ------LWGHGGAGGAG-----------------------------GAGV Rv1087|M.tuberculosis_H37Rv ------LWGHGGAGGAG-----------------------------GAGV Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV TH_3810|M.thermoresistible__bu ---------DGGTPG------------------------------AHGES MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------RNTTNINDSFN----------------------------TDRST MAV_4827|M.avium_104 -----LFASSTAALAYAQ----------------------------DPGT MUL_4399|M.ulcerans_Agy99 GMAGGYDNVNGVFGI----------------------------------- MMAR_5321|M.marinum_M GMAGGYDNVNSVYGT----------------------------------- Mb1116|M.bovis_AF2122/97 AGAGGFEGTIGAGGAG---------------------------------- Rv1087|M.tuberculosis_H37Rv AGAGGFEGTIGAGGAG---------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD----------- Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN----------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP TH_3810|M.thermoresistible__bu HTPGVYTDRQ---------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NIGSGNTTNTEIGSHN---------------------------------- MAV_4827|M.avium_104 GAVDQYSLPDYLYVP----------------------------------- MUL_4399|M.ulcerans_Agy99 -------------TAGNGGDGGAGGRGGWLFGDAG--------------- MMAR_5321|M.marinum_M -------------TAGNGGDGGAGGRGGWLFGDAG--------------- Mb1116|M.bovis_AF2122/97 ------------GVGGAGGVGGAGGAGGWLYGDAG--------------- Rv1087|M.tuberculosis_H37Rv ------------GVGGAGGVGGAGGAGGWLYGDAG--------------- Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG--------------- MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ TH_3810|M.thermoresistible__bu ---------------GEDGEDGTGTGIGGRGGNGG--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------QANIGTSTSAGGSAAVGGNAG--------------- MAV_4827|M.avium_104 ----------------VDPEPGDDELAYSAVGEED--------------- MUL_4399|M.ulcerans_Agy99 --AGGQGGLGGDG------NYAGQGSYGGVGGAG---GAGGAAGMFGSGG MMAR_5321|M.marinum_M --AGGQGGLGGDG------NYAGQGSYGGVGGAG---GAGGAAGMFGSGG Mb1116|M.bovis_AF2122/97 --AGGDGGVGGAGGTGGLGNRGGAGGAGGAGGVG---GAGGAAGLWGGGG Rv1087|M.tuberculosis_H37Rv --AGGDGGVGGAGGTGGLGNRGGAGGAGGAGGVG---GAGGAAGLWGGGG Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG---GTGGTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG---GTGGTGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSE--GEGGTGGHGGDGG TH_3810|M.thermoresistible__bu -SSSGTHPMAEDG--------EHVKALDGRPGLD-----GGNGSHGGNGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --LAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG MAV_4827|M.avium_104 ----AESPTVVIEKLFLPEDSEPRRRPVLLVGSG-----LAVVGISAVLA MUL_4399|M.ulcerans_Agy99 SGGAGGEGG----------------AFGDGNAGGSGSGGHGGNGGNGG-- MMAR_5321|M.marinum_M SGGAGGEGG----------------AFGDGNAGGSGSGGHGGNGGNGG-- Mb1116|M.bovis_AF2122/97 AGGVGGTGGGAGLGAQSVTFSSSLSGLSGGDGGAGGAGGAGGAGGTGG-- Rv1087|M.tuberculosis_H37Rv AGGVGGTGGGAGLGAQSVTFSSSLSGLSGGDGGAGGAGGAGGAGGTGG-- Mflv_5091|M.gilvum_PYR-GCK KGGTGGTGG--------------AGGTG----GDGGTGGTGGTGGTG--- Mvan_1264|M.vanbaalenii_PYR-1 KGGTGGTGG--------------DGGTG----GTGGTGGTGGTGGTG--- MSMEG_0868|M.smegmatis_MC2_155 RGGDGALGG--------------NGGTGGVGLGNGGKGGNGGNGGNGGTY TH_3810|M.thermoresistible__bu HGGRGGFLG--------------IGGSG-------GWGGHGGNGGD---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAG------------------------NAGLAGNAGLAGNAG-- MAV_4827|M.avium_104 LEIALAIG--------------------------IRTTGTVALQPTPN-- MUL_4399|M.ulcerans_Agy99 ---WLYGDAGAGGQGGNA------------APGAYSDNLG----TFQSSY MMAR_5321|M.marinum_M ---WLYGDAGAGGQGGNA------------APGAYSDNLG----TIQYGN Mb1116|M.bovis_AF2122/97 ---WLYGGGGAAGSGGDG------------GTGGQGGAGG----AGVFSL Rv1087|M.tuberculosis_H37Rv ---WLYGGGGAAGSGGDG------------GTGGQGGAGG----AGVFSL Mflv_5091|M.gilvum_PYR-GCK ------GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQGG Mvan_1264|M.vanbaalenii_PYR-1 ------GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFGG MSMEG_0868|M.smegmatis_MC2_155 VDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGG TH_3810|M.thermoresistible__bu -------TDADGGNGGDG---------------GNGGSAG---------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----LAGNAGLAGN--AG-------------LAGNAGLAG-------NAG MAV_4827|M.avium_104 -------QHLIVPTEQAP------------APPPVQASAP---------- MUL_4399|M.ulcerans_Agy99 TSGNGG-----------------AGGNGGVAGMIGTGGAG---------- MMAR_5321|M.marinum_M TSGNGG-----------------AGGNGGVAGMIGTGGAG---------- Mb1116|M.bovis_AF2122/97 FGSGGG-----------------PGGNGGVGGVGGVGGAGGRAGLF---- Rv1087|M.tuberculosis_H37Rv FGSGGG-----------------PGGNGGVGGVGGVGGAGGRAGLF---- Mflv_5091|M.gilvum_PYR-GCK QGGQGG-----------------TGGTGGQGG-LGGGGGTG--------- Mvan_1264|M.vanbaalenii_PYR-1 QGGQGG-----------------TGGTGGQGG-LGGVGGTG--------- MSMEG_0868|M.smegmatis_MC2_155 KGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYN TH_3810|M.thermoresistible__bu -----------------------RGGTGGLRGVFGINGGNG--------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAG-----------------LAGNAGLAGNAGLAGNAG--------- MAV_4827|M.avium_104 ------------------------QPKISVPEPVAAPKPLS--------- MUL_4399|M.ulcerans_Agy99 --------------GAGGAGGVN--AFDSGGGGGGG-------------- MMAR_5321|M.marinum_M --------------GAGGAGGVN--VYDSGGGGGGGGTGGNGGWLYGNAG Mb1116|M.bovis_AF2122/97 --------------GVGGLGGAGGDAGDSGEGGFGGP--GLAGGLFGNPG Rv1087|M.tuberculosis_H37Rv --------------GVGGLGGAGGDAGDSGEGGFGGP--GLAGGLFGNPG Mflv_5091|M.gilvum_PYR-GCK --------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGG Mvan_1264|M.vanbaalenii_PYR-1 --------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGG MSMEG_0868|M.smegmatis_MC2_155 VVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGG TH_3810|M.thermoresistible__bu ---------------RAGLGGRGXXXXGGGVGAAVRSG------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------LAGNAAVAGNAAVAGNAAVAGNAAVG--------GVLN MAV_4827|M.avium_104 ----------------PPVAAPLPAAPPPAAPPLPEAP----------PI MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5321|M.marinum_M SGGQGGAGGDGSFLWDS-------PPNTNVYIGDAGGAGGVGGHGGSAGL Mb1116|M.bovis_AF2122/97 NGGVGGIGGDAAAGGAG------GAGGNGGWLFGNGGAGGSGGDGGAAGR Rv1087|M.tuberculosis_H37Rv NGGVGGIGGDAAAGGAGGAGGNGGAGGNGGWLFGNGGAGGSGGDGGAAGR Mflv_5091|M.gilvum_PYR-GCK AGGDGGLGGLGGFGGSG----------------GTGGQGGLGGPGGSTGG Mvan_1264|M.vanbaalenii_PYR-1 AGGDGGLGGLGGFGGVG----------------GTGGQGGQGGPGGSTGG MSMEG_0868|M.smegmatis_MC2_155 NGGDGIDGGLGGNGGDG----------------VVNTTANAANPGSATGT TH_3810|M.thermoresistible__bu ---NGVFSGGGGTPSAG----------------FGVPTTIQFPAGSCTSR MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TGVSGAIGGSSHVGGAIN-----------------ESLGGSGSVGGSTAV MAV_4827|M.avium_104 PAAPPVVPVPVVVPPVP---------------VPVPVRIPVPDPVSPPQL MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5321|M.marinum_M IGSGGAGGAGGVGGTGGYPAGNGGAGGDGGRAGLLFGSAGVGGQGGDGG- Mb1116|M.bovis_AF2122/97 GGAGNLGSAGGINAPAGNPGSGSVGIGGAGGAGGTAGLFGDGGAGGAG-- Rv1087|M.tuberculosis_H37Rv GGAGNLGSAGGINAPAGNPGSGSVGIGGAGGAGGTAGLFGDGGAGGAGGA Mflv_5091|M.gilvum_PYR-GCK AGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGAT Mvan_1264|M.vanbaalenii_PYR-1 AGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGAT MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASN TH_3810|M.thermoresistible__bu AVSREG------------------------IMPSSRAASARAG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGV MAV_4827|M.avium_104 LAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVPQSPPQHQTPPGEGTPPKP MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5321|M.marinum_M GNYIAFTSNGNPNYNDGDAAGSGGAGGNGGAAGLFGAGAAGGAGGAGGLS Mb1116|M.bovis_AF2122/97 -AAGGFGGISAATPSAGSEGAMGGAGGVGGNARLLGTGGAGGVGGGGGAG Rv1087|M.tuberculosis_H37Rv GAAGGFGGISAATPSAGSEGAMGGAGGVGGNARLLGTGGAGGVGGGGGAG Mflv_5091|M.gilvum_PYR-GCK GAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG------ Mvan_1264|M.vanbaalenii_PYR-1 GAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG------ MSMEG_0868|M.smegmatis_MC2_155 GGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIA TH_3810|M.thermoresistible__bu --------------------AACASSTSRSRRSFCCSRA----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGVGGG----- MAV_4827|M.avium_104 DGPGNYG--------GGHVPTPGAGGSGGSGGGHVPTPGAGGSGG----- MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5321|M.marinum_M GYRSAGNGGAGGAGGAGGVLGGDGGAGGDGGAAGNGVNDPVTGAVEGDGG Mb1116|M.bovis_AF2122/97 GDGGRGGVATPGGQGGDAGDGGAGGAGGNGGGGASGAGGWLLG-TGGAGG Rv1087|M.tuberculosis_H37Rv GDGGRGGVATPGGQGGDAGDGGAGGAGGNGGG-ASGAGGWLLG-TGGAGG Mflv_5091|M.gilvum_PYR-GCK -----TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-------- Mvan_1264|M.vanbaalenii_PYR-1 -----TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-------- MSMEG_0868|M.smegmatis_MC2_155 AIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -VNTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTSAINDALGGSGS MAV_4827|M.avium_104 ----SGGGHVPTPGTGGPGGTGGSGGGHVPTPGAGTPGGSGGGHLPFPGA MUL_4399|M.ulcerans_Agy99 --------------------------------------------GNGGNG MMAR_5321|M.marinum_M IGGNGGTGGAALGWFGNGGAGGDGGAGGA-------SQEFGDSGGNGGNG Mb1116|M.bovis_AF2122/97 AGGNGGNGGKAGFSPGPTNFGLNGAGGG---------------GGVGGNG Rv1087|M.tuberculosis_H37Rv AGGNGGNGGKAGFSPGPTNFGLNGAGGG---------------GGVGGNG Mflv_5091|M.gilvum_PYR-GCK AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDGGKG Mvan_1264|M.vanbaalenii_PYR-1 AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAGGAG MSMEG_0868|M.smegmatis_MC2_155 VAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGSTAVGGGAHTSAINESMNSSIN------------------------- MAV_4827|M.avium_104 GSTPGGSGGGHLPTPGAGTPGGGLGGFG---------------------- MUL_4399|M.ulcerans_Agy99 GAG----------------------GASGALIEAGGVGGSGGGG---GAG MMAR_5321|M.marinum_M GAG----------------------GASGALIGAGGVGGSGGGG---GAG Mb1116|M.bovis_AF2122/97 ATGPWLFGDGGAGGGGGAGGIGGDGGPTPGSTGAGAAGGHGGDAQLIGNG Rv1087|M.tuberculosis_H37Rv ATGPWLFGDG---------------GPTPGSTGAGAAGGHGGDAQLIGNG Mflv_5091|M.gilvum_PYR-GCK GAGAE----------------------GGAGGGGGAGGSGAGGAG--GAG Mvan_1264|M.vanbaalenii_PYR-1 GDGSE----------------------GGAGGSGGAGGSGTGGAG--GAG MSMEG_0868|M.smegmatis_MC2_155 GDGSEPGPGGN--------------GAGGAGGNGGTGGTTAGGSGNGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------ASHSSSMNESFGSSMGSHGAAGTG MAV_4827|M.avium_104 ---------------------------GGHAPAPGGGLGGGGGHAPAPGG MUL_4399|M.ulcerans_Agy99 VVGPPAGNPGNDGLDGVTGASGLLFGG----- MMAR_5321|M.marinum_M VVGPPAGNPGNDGLDGVTGASGLLFGG----- Mb1116|M.bovis_AF2122/97 GHGGAGGTGVPNGSGGAGGLSGLLFGEPGANG Rv1087|M.tuberculosis_H37Rv GHGGAGGTGVPNGSGGAGGLSGLLFGEPGANG Mflv_5091|M.gilvum_PYR-GCK GSGGSGGSGGSGGSGGAAGDSDD--------- Mvan_1264|M.vanbaalenii_PYR-1 GSGGSGGSGGAGGSGGAAGDSD---------- MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGADGTPGTAGTTGANNP--------- TH_3810|M.thermoresistible__bu -------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------- MAB_4284c|M.abscessus_ATCC_199 FEAQGHAQGHASETAHTTLPGAEHH------- MAV_4827|M.avium_104 GLGGFGGGHSGGGLGGLGGGHK----------