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LDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQAIHTAEQLAAEVLLAHEVAAAGDHRLR VIGVTWNAEASAQAALLVESLTGAGFDNVVPVRRLRAIETLAQAIAPVIGYEQIAVCVLEHESATVVMVD THDGKTQIAVKHVCRGLSGLTSWLTGMFGRDAWRPAGVVVVGSDSEVSEFSWQLERVLPVPVFAQTMAQV TVARGAALAAAQSTEFTDAQLVADSVSQPTVAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLAPHND TGTAKHGAHKPTPRIAKAVAPAVPPPPTVTPPVPARAPRPAAQHEPPARVTSGEALTEPNPPEEQPNASA PQQDRNDSQPITRVLEHIPGAYGDSAPPAE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1887 | - | - | 100% (380) | hypothetical protein Rv1887 |
| M. tuberculosis H37Rv | Rv0538 | - | 2e-09 | 24.75% (400) | hypothetical protein Rv0538 |
| M. tuberculosis H37Rv | Rv0338c | - | 4e-06 | 32.56% (129) | iron-sulfur-binding reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1919 | - | 0.0 | 100.00% (380) | hypothetical protein Mb1919 |
| M. gilvum PYR-GCK | Mflv_3300 | - | 1e-56 | 37.93% (377) | hypothetical protein Mflv_3300 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4296c | - | 1e-32 | 29.00% (400) | hypothetical protein MAB_4296c |
| M. marinum M | MMAR_2779 | - | 1e-140 | 67.54% (382) | hypothetical protein MMAR_2779 |
| M. avium 104 | MAV_2814 | - | 1e-111 | 58.09% (377) | hypothetical protein MAV_2814 |
| M. smegmatis MC2 155 | MSMEG_3531 | - | 9e-44 | 34.12% (422) | hypothetical protein MSMEG_3531 |
| M. thermoresistible (build 8) | TH_3900 | - | 3e-35 | 34.82% (313) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2968 | - | 1e-140 | 67.28% (382) | hypothetical protein MUL_2968 |
| M. vanbaalenii PYR-1 | Mvan_3021 | - | 3e-58 | 38.86% (386) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3300|M.gilvum_PYR-GCK -----MNAVLGLSVTPSGVGVVLVEGH---DDDRVTLDGERFEVRRRGSA
Mvan_3021|M.vanbaalenii_PYR-1 -----MDAVLGLSVTPSAVGLVLVEGQ---DVDGVTLDGDGFEVGGDGAA
MSMEG_3531|M.smegmatis_MC2_155 -----MDAVIGVSVTPSTVGMVLVEGDSAADFEAVNLDLELFDVAGLDLS
Rv1887|M.tuberculosis_H37Rv -----MDTVLGLSITPTTLGWVLAEGHG---ADGAILDRNELELHSGRNA
Mb1919|M.bovis_AF2122/97 -----MDTVLGLSITPTTLGWVLAEGHG---ADGAILDRNELELHSGRNA
MMAR_2779|M.marinum_M -----MDTVLGLSVTPTTVGWVLAEGHG---ADGAILDHHESQLHGSRGM
MUL_2968|M.ulcerans_Agy99 MRCEVLDTVLGLSVTPTTVGWVLAEGHG---ADGAILDHHESQLHGSRGM
MAV_2814|M.avium_104 -------------MTPTTVGWVLAEGHG---ADGTILDHQELALHSGGAV
MAB_4296c|M.abscessus_ATCC_199 -----MDVVLGVSMTPTTARLVLVEGAG---ADGRIVDTDTIVVSEGEGT
TH_3900|M.thermoresistible__bu -----VDIVLGVSMTPTTVRMVLVEGEK---ADGVTVDHDVFDISAVDGS
:**: **.** : :* . :
Mflv_3300|M.gilvum_PYR-GCK TAAETSAQAAAAVLRTEAVAADLGRRVHSIGVTWSDDAGTEASLLLTSLR
Mvan_3021|M.vanbaalenii_PYR-1 GALCTSEQATAAVRRSEAVAADLGRRVHAIGVTWSDDADTEASLLLKSLS
MSMEG_3531|M.smegmatis_MC2_155 RARAARKEIVATVARAENVAADNGRRLRSIGVTWSDGADMQAAELVGDLN
Rv1887|M.tuberculosis_H37Rv QAIHTAEQLAAEVLLAHEVAAAGDHRLRVIGVTWNAEASAQAALLVESLT
Mb1919|M.bovis_AF2122/97 QAIHTAEQLAAEVLLAHEVAAAGDHRLRVIGVTWNAEASAQAALLVESLT
MMAR_2779|M.marinum_M RIVHTAEQVADEVWHAKEVASGAGHRLRMIGVTWGDEASAQAALLLEALT
MUL_2968|M.ulcerans_Agy99 RIVHTAEQVADEVWHAKEVASGAGHRLRMIGVTWSDEASAQAALLLEALT
MAV_2814|M.avium_104 RAASAAEQVVDEVLRVEAAAAGSDQRLRVIGVTWNDEASVPAALVLEALT
MAB_4296c|M.abscessus_ATCC_199 TS----EQVLSAIVGTRDGMLDGGHNLVSTGVVWSDHA--EAAELRDSLA
TH_3900|M.thermoresistible__bu ATPSAAEQVVAAVLGTQESAAAGGHRLISIGVAWSDHA--EAAALREALA
: : . .:.: **.*. * *: : *
Mflv_3300|M.gilvum_PYR-GCK ESGYDNIVPVRLSEATDALARRIALVLGYRTTAVCVIEPEQLIALVVSVE
Mvan_3021|M.vanbaalenii_PYR-1 EAGFDNIVPVRLSEATDALARRIAKLMGYRTTAVCVIEPEQLIALVATDE
MSMEG_3531|M.smegmatis_MC2_155 EAGFDNVVDVRFRQATDALANSIADMAGFATTVVCVFEPEGALALTVDRR
Rv1887|M.tuberculosis_H37Rv GAGFDNVVPVRRLRAIETLAQAIAPVIGYEQIAVCVLEHESATVVMVDTH
Mb1919|M.bovis_AF2122/97 GAGFDNVVPVRRLRAIETLAQAIAPVIGYEQIAVCVLEHESATVVMVDTH
MMAR_2779|M.marinum_M DAGFDNVVPVRLLDAVETLAEAIAPVIGYDQTAVCILEHDWATVVMVDTQ
MUL_2968|M.ulcerans_Agy99 DAGFDNVVPVRLVDAVETLAEAIAPVIGYDQTAVCILEHDWATVVMVDTQ
MAV_2814|M.avium_104 DAGLHNVVPVRFLQAVETLAQAIAPVIGYEQTAVCVLEHDWTTVVMVDSH
MAB_4296c|M.abscessus_ATCC_199 SRGIDGVEFFSALHAGGALAKAASSVTGYDKSALLVIEPQTATLAVVDSA
TH_3900|M.thermoresistible__bu ARGLDDVMLVSELHAAGALAQAVGRRVGYDTTALFFIERDTATMAVVQTD
* ..: . * :**. . *: .: .:* : .
Mflv_3300|M.gilvum_PYR-GCK DAADGTSEAVQTAVNHSVVTEDDLVGWLSTVFTRADWEPEALVLVGSGED
Mvan_3021|M.vanbaalenii_PYR-1 G-------AVQTAVNHSVVTEEDLIGWLSSVFARADWAPEALVLVGSAED
MSMEG_3531|M.smegmatis_MC2_155 DG------VVDTARSRAIGSVRGLVGWLERLLAASGRVPDALVVVGSAVD
Rv1887|M.tuberculosis_H37Rv DG------KTQIAVKHVCRGLSGLTSWLTGMFGRDAWRPAGVVVVGSDSE
Mb1919|M.bovis_AF2122/97 DG------KTQIAVKHVCRGLSGLTSWLTGMFGRDAWRPAGVVVVGSDSE
MMAR_2779|M.marinum_M DG------KTQTAVKHVRGGFDGLNSWLTGMFDRGAWRPAAVVVVGSDTD
MUL_2968|M.ulcerans_Agy99 DG------KTQTAVKHVRGGFDGLNSWLTGMFDRGAWRPAAVVVVGSDTD
MAV_2814|M.avium_104 DG------QTQTATKQVRGGFDGLTRWLTGMFERDGWQPGGIVVVGAHSD
MAB_4296c|M.abscessus_ATCC_199 DG----SIVGLASEPLITGVTSGVLANLVNPLKGKENAPDGVFLLGLGTD
TH_3900|M.thermoresistible__bu DG----SVVKVLSRDLHNADAMATLTEMALTVDGQDSPPQGMFLIGSGVD
. : : . * .:.::* :
Mflv_3300|M.gilvum_PYR-GCK LED----LLPVLEDALAVPVFSPAEAALALARGAALACAQPGEFAAWEHT
Mvan_3021|M.vanbaalenii_PYR-1 LDG----LSPILEDALAVPVFSPDAAQLALARGAALACASNGDFDVWPGP
MSMEG_3531|M.smegmatis_MC2_155 LDADVDRLMPKLQAALGIPVFTPADGDLALARGAALVSARRGRF-MFPDK
Rv1887|M.tuberculosis_H37Rv VSE----FSWQLERVLPVPVFAQTMAQVTVARGAALAAAQSTEFTDAQLV
Mb1919|M.bovis_AF2122/97 VSE----FSWQLERVLPVPVFAQTMAQVTVARGAALAAAQSTEFTDAQLV
MMAR_2779|M.marinum_M VEE----FSWQLEKALPVPVFAQTMAQVTIARGAALAAAQSTDFTDARLI
MUL_2968|M.ulcerans_Agy99 VEE----FSWQLEKALPVPVFAQTMAQVTIARGAALAAAQSTDFTDARLI
MAV_2814|M.avium_104 IDG----LSWQLEKALPVPVFVQSMAQVTIARGAALSAARSTEFTDEQLV
MAB_4296c|M.abscessus_ATCC_199 VSD----LAESLGDAIALPVNSPDQPELALARGAALASAQEPDFEASTAL
TH_3900|M.thermoresistible__bu ISE----LKAHLDKLLRLPVHAPEESDLALCRGAALAAANAPTFEPSTVG
:. : * : :** :::.***** .* *
Mflv_3300|M.gilvum_PYR-GCK TR--QPVTP-----------------------------------------
Mvan_3021|M.vanbaalenii_PYR-1 AS--ERQTR-----------------------------------------
MSMEG_3531|M.smegmatis_MC2_155 AD--QQRSR-----------------------------------------
Rv1887|M.tuberculosis_H37Rv ADSVSQPTV-----------------------------------------
Mb1919|M.bovis_AF2122/97 ADSVSQPTV-----------------------------------------
MMAR_2779|M.marinum_M AD-VSEPAP-----------------------------------------
MUL_2968|M.ulcerans_Agy99 AD-VSEPAP-----------------------------------------
MAV_2814|M.avium_104 ARRSEPVTP-----------------------------------------
MAB_4296c|M.abscessus_ATCC_199 LGQAYSLEG---------------PTGTGFAHPDAVTESAGEANTELREF
TH_3900|M.thermoresistible__bu LAYSQVPDGGPTVPASVYAAGFGADAATAGGHPYAAYAAFAGAQTQLASI
Mflv_3300|M.gilvum_PYR-GCK ---------------HATRRR--RRRWPQALLAAGAITFVASASAAVALQ
Mvan_3021|M.vanbaalenii_PYR-1 ---------------PATTRF--ARSAPAVLLAAGVVTFVASVSVAVALA
MSMEG_3531|M.smegmatis_MC2_155 ---------------WTSR-----QLAPAAMLLVGVVTFVVSLSLAISQQ
Rv1887|M.tuberculosis_H37Rv ---------------APRRSR--HYAGAAAALAAAAVTFVASLSLAVGIQ
Mb1919|M.bovis_AF2122/97 ---------------APRRSR--HYAGAAAALAAAAVTFVASLSLAVGIQ
MMAR_2779|M.marinum_M ---------------APKRSL--HYAGAATTLAAAAVTFVGSLSLAIGLQ
MUL_2968|M.ulcerans_Agy99 ---------------APKRSL--HYAGAATTLAAAAVTFVGSLSLAIGLQ
MAV_2814|M.avium_104 ---------------APVRHRRLSYAGAMTALTAGAISFVGSVSLAVGIH
MAB_4296c|M.abscessus_ATCC_199 EDFDDQPAE--------RKPFLLVGAPLLLVFGICSIALAVSLTVTVRST
TH_3900|M.thermoresistible__bu GGAAPSPVPGEPPVDEDRKPFLLVGSALTSIFVVGVVALVVSLAVSIRPT
: :::. * : ::
Mflv_3300|M.gilvum_PYR-GCK LTPEPIASP------------PRSAAESPVRQPAAPSP---VPP---APV
Mvan_3021|M.vanbaalenii_PYR-1 LTPGQPAPQ------------PRPAAESAAAPPAAAPPRSQVPPPPVAAV
MSMEG_3531|M.smegmatis_MC2_155 MSPREQAFERPTRPVVNTSGTPAAVRQLPPALPAAPPPPPQAPP--AAEV
Rv1887|M.tuberculosis_H37Rv LAP---------------------HNDTGTAKHGAHKP----TP----RI
Mb1919|M.bovis_AF2122/97 LAP---------------------HNDTGTAKHGAHKP----TP----RI
MMAR_2779|M.marinum_M LTP---------------------ERHHTATGHAGHKP----TP----EI
MUL_2968|M.ulcerans_Agy99 LTP---------------------ERHHTATGHAGHKP----TP----EI
MAV_2814|M.avium_104 VGP---------------------ASATAAAKHATHPP----AP----QV
MAB_4296c|M.abscessus_ATCC_199 VDQGPSSPDRGV---------VQNPLPAEAPKQAAPPPSPVEAPAPAVSP
TH_3900|M.thermoresistible__bu VDQRPSPADS-----------------ALAPGVAAP-----------VQP
: .
Mflv_3300|M.gilvum_PYR-GCK APAPDPAPEP-----VAPAAEDVPVEAPP-------APQELP-----EQV
Mvan_3021|M.vanbaalenii_PYR-1 EPAPVAAVEPAPVAAVEPAPEPVAALVAP-------EPEAPPPVVDEAQS
MSMEG_3531|M.smegmatis_MC2_155 AEAVPPAVDPPLADVAESPVEQALPQLPPQLPLPDAATALPPPVVIPAPP
Rv1887|M.tuberculosis_H37Rv AKAVAPAVPPP-----PTVTPPVPARAPR------------------PAA
Mb1919|M.bovis_AF2122/97 AKAVAPAVPPP-----PTVTPPVPARAPR------------------PAA
MMAR_2779|M.marinum_M VEAVAPVVPMP-----AQPEPSAPHQAPA------------------PGA
MUL_2968|M.ulcerans_Agy99 VEAVAPVVPMP-----AQPEPSAPHQAPA------------------PGA
MAV_2814|M.avium_104 AEAVKAVTPLP-----AAP-QTKPQTKPP------------------SGP
MAB_4296c|M.abscessus_ATCC_199 APVQQVVAPAPQHNPAPAPKQVAPAPVQA-----------APQAPAPAPE
TH_3900|M.thermoresistible__bu ETVPEALXXXPPH-PSPAPN-VKPLRCAG-----------GFSAVVARTT
.
Mflv_3300|M.gilvum_PYR-GCK SPDVL---------------------------------------------
Mvan_3021|M.vanbaalenii_PYR-1 VPAPL---------------------------------------------
MSMEG_3531|M.smegmatis_MC2_155 TKKPLLSRIRDRLR------------------------------------
Rv1887|M.tuberculosis_H37Rv QHEPP---------------------------------------------
Mb1919|M.bovis_AF2122/97 QHEPP---------------------------------------------
MMAR_2779|M.marinum_M GQEP----------------------------------------------
MUL_2968|M.ulcerans_Agy99 GQEP----------------------------------------------
MAV_2814|M.avium_104 APAP----------------------------------------------
MAB_4296c|M.abscessus_ATCC_199 APAPAAPAPVPEEQPAPVAPPPAVVPVPIPLFPPVWEPPRRQENPWWPDR
TH_3900|M.thermoresistible__bu APGP---------------------------FPTGWS-------------
Mflv_3300|M.gilvum_PYR-GCK ------PPATAPVEAVPP------PPPVEP-APAVIPAPVPAERPGILDR
Mvan_3021|M.vanbaalenii_PYR-1 ------PEQAPVVEAASPDAGLPTAPPVIP-APEVVP-PVPQERPGILQR
MSMEG_3531|M.smegmatis_MC2_155 -GEPDVPEQMVIGEPPPPAEITPIPPPGAPPAPPVDDAPAPEAPP---EP
Rv1887|M.tuberculosis_H37Rv ---ARVTSGEALTEPNPPEE-----QPNAS-APQQDRNDSQP-ITRVLEH
Mb1919|M.bovis_AF2122/97 ---ARVTSGEALTEPNPPEE-----QPNAS-APQQDRNDSQP-ITRVLEH
MMAR_2779|M.marinum_M ---IRLTAGEQITDAAPVE------QPGGE-APQSEPADGSPMLTRVLTH
MUL_2968|M.ulcerans_Agy99 ---IRLTAGEQITDAAPVE------QPGGE-APQSEPADGSPMLTRVLTH
MAV_2814|M.avium_104 -------AGEP---AAPDEQ-----PGIGD-DRQMESGNRQPYLTRVLEH
MAB_4296c|M.abscessus_ATCC_199 DRPRYTPPAQTQQPPIISIPGLPPIGGGDSDRGSHGGSRGGSGRGGWGDD
TH_3900|M.thermoresistible__bu ---RRSAAAELVSHATVRCS---------------GDGPGSAGVPGWDPD
.
Mflv_3300|M.gilvum_PYR-GCK IRDRLSRVG--DP-VVEMPPP------PVPGAPV-APVPPPLP-------
Mvan_3021|M.vanbaalenii_PYR-1 IRDRLSNVGPDDPQQAAVPPP------PAP--------APPLP-------
MSMEG_3531|M.smegmatis_MC2_155 PPAPEAPPAADPPPPADVPPPDPPPAEPAPVEPEPAPEAPPAP-------
Rv1887|M.tuberculosis_H37Rv IPGAYG----DSAPPAE---------------------------------
Mb1919|M.bovis_AF2122/97 IPGAYG----DSAPPAE---------------------------------
MMAR_2779|M.marinum_M IPGSYGE--EEGSRPPE---------------------------------
MUL_2968|M.ulcerans_Agy99 IPGSYGE--EEGSRPPE---------------------------------
MAV_2814|M.avium_104 IPGDTGEPAADSAPHPTLDPQP----------------------------
MAB_4296c|M.abscessus_ATCC_199 GDSRGGSDSGSRGGWGDNGGSRGGWGDSGSSRGGSDSGSRGGWGGNSGSH
TH_3900|M.thermoresistible__bu PSIK-----------ADGGRHRFRFAVQMTTRCGLIAHP-----------
Mflv_3300|M.gilvum_PYR-GCK -------------------
Mvan_3021|M.vanbaalenii_PYR-1 -------------------
MSMEG_3531|M.smegmatis_MC2_155 -------------------
Rv1887|M.tuberculosis_H37Rv -------------------
Mb1919|M.bovis_AF2122/97 -------------------
MMAR_2779|M.marinum_M -------------------
MUL_2968|M.ulcerans_Agy99 -------------------
MAV_2814|M.avium_104 -------------------
MAB_4296c|M.abscessus_ATCC_199 GGGSGGGSNSGFPWPFGGR
TH_3900|M.thermoresistible__bu -------------------