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DAVLGLSVTPSAVGLVLVEGQDVDGVTLDGDGFEVGGDGAAGALCTSEQATAAVRRSEAVAADLGRRVHA IGVTWSDDADTEASLLLKSLSEAGFDNIVPVRLSEATDALARRIAKLMGYRTTAVCVIEPEQLIALVATD EGAVQTAVNHSVVTEEDLIGWLSSVFARADWAPEALVLVGSAEDLDGLSPILEDALAVPVFSPDAAQLAL ARGAALACASNGDFDVWPGPASERQTRPATTRFARSAPAVLLAAGVVTFVASVSVAVALALTPGQPAPQP RPAAESAAAPPAAAPPRSQVPPPPVAAVEPAPVAAVEPAPVAAVEPAPEPVAALVAPEPEAPPPVVDEAQ SVPAPLPEQAPVVEAASPDAGLPTAPPVIPAPEVVPPVPQERPGILQRIRDRLSNVGPDDPQQAAVPPPP APAPPLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3021 | - | - | 100% (428) | FHA domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1015 | - | 2e-47 | 36.78% (416) | hypothetical protein Mvan_1015 |
| M. vanbaalenii PYR-1 | Mvan_0590 | - | 5e-45 | 30.91% (482) | hypothetical protein Mvan_0590 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1919 | - | 3e-58 | 38.86% (386) | hypothetical protein Mb1919 |
| M. gilvum PYR-GCK | Mflv_3300 | - | 1e-131 | 62.56% (438) | hypothetical protein Mflv_3300 |
| M. tuberculosis H37Rv | Rv1887 | - | 3e-58 | 38.86% (386) | hypothetical protein Rv1887 |
| M. leprae Br4923 | MLBr_00048 | - | 3e-08 | 28.27% (191) | hypothetical protein MLBr_00048 |
| M. abscessus ATCC 19977 | MAB_4296c | - | 6e-46 | 34.39% (474) | hypothetical protein MAB_4296c |
| M. marinum M | MMAR_2779 | - | 4e-61 | 41.48% (352) | hypothetical protein MMAR_2779 |
| M. avium 104 | MAV_2814 | - | 1e-54 | 37.82% (386) | hypothetical protein MAV_2814 |
| M. smegmatis MC2 155 | MSMEG_3531 | - | 7e-79 | 43.18% (440) | hypothetical protein MSMEG_3531 |
| M. thermoresistible (build 8) | TH_3900 | - | 2e-38 | 29.89% (435) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2968 | - | 9e-62 | 41.76% (352) | hypothetical protein MUL_2968 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3021|M.vanbaalenii_PYR-1 --------MDAVLGLSVTPSAVGLVLVEGQ-------------DVDGVTL
Mflv_3300|M.gilvum_PYR-GCK --------MNAVLGLSVTPSGVGVVLVEGH-------------DDDRVTL
MSMEG_3531|M.smegmatis_MC2_155 --------MDAVIGVSVTPSTVGMVLVEGDSAA----------DFEAVNL
Mb1919|M.bovis_AF2122/97 --------MDTVLGLSITPTTLGWVLAEGHG-------------ADGAIL
Rv1887|M.tuberculosis_H37Rv --------MDTVLGLSITPTTLGWVLAEGHG-------------ADGAIL
MMAR_2779|M.marinum_M --------MDTVLGLSVTPTTVGWVLAEGHG-------------ADGAIL
MUL_2968|M.ulcerans_Agy99 ---MRCEVLDTVLGLSVTPTTVGWVLAEGHG-------------ADGAIL
MAV_2814|M.avium_104 ----------------MTPTTVGWVLAEGHG-------------ADGTIL
MAB_4296c|M.abscessus_ATCC_199 --------MDVVLGVSMTPTTARLVLVEGAG-------------ADGRIV
TH_3900|M.thermoresistible__bu --------VDIVLGVSMTPTTVRMVLVEGEK-------------ADGVTV
MLBr_00048|M.leprae_Br4923 MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTPNGEVA
:* * :. :
Mvan_3021|M.vanbaalenii_PYR-1 D-----GDGFEVGGDGAAGALCTSEQATAAVRRSEAVAADLGRRVHAIG-
Mflv_3300|M.gilvum_PYR-GCK D-----GERFEVRRRGSATAAETSAQAAAAVLRTEAVAADLGRRVHSIG-
MSMEG_3531|M.smegmatis_MC2_155 D-----LELFDVAGLDLSRARAARKEIVATVARAENVAADNGRRLRSIG-
Mb1919|M.bovis_AF2122/97 D-----RNELELHSGRNAQAIHTAEQLAAEVLLAHEVAAAGDHRLRVIG-
Rv1887|M.tuberculosis_H37Rv D-----RNELELHSGRNAQAIHTAEQLAAEVLLAHEVAAAGDHRLRVIG-
MMAR_2779|M.marinum_M D-----HHESQLHGSRGMRIVHTAEQVADEVWHAKEVASGAGHRLRMIG-
MUL_2968|M.ulcerans_Agy99 D-----HHESQLHGSRGMRIVHTAEQVADEVWHAKEVASGAGHRLRMIG-
MAV_2814|M.avium_104 D-----HQELALHSGGAVRAASAAEQVVDEVLRVEAAAAGSDQRLRVIG-
MAB_4296c|M.abscessus_ATCC_199 D-----TDTIVVSEGEGTTS----EQVLSAIVGTRDGMLDGGHNLVSTG-
TH_3900|M.thermoresistible__bu D-----HDVFDISAVDGSATPSAAEQVVAAVLGTQESAAAGGHRLISIG-
MLBr_00048|M.leprae_Br4923 SPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAP
. . : : .
Mvan_3021|M.vanbaalenii_PYR-1 --------VTWSDDADTEASLLLKSLSEAGFDNIVPVRLSEATDALARRI
Mflv_3300|M.gilvum_PYR-GCK --------VTWSDDAGTEASLLLTSLRESGYDNIVPVRLSEATDALARRI
MSMEG_3531|M.smegmatis_MC2_155 --------VTWSDGADMQAAELVGDLNEAGFDNVVDVRFRQATDALANSI
Mb1919|M.bovis_AF2122/97 --------VTWNAEASAQAALLVESLTGAGFDNVVPVRRLRAIETLAQAI
Rv1887|M.tuberculosis_H37Rv --------VTWNAEASAQAALLVESLTGAGFDNVVPVRRLRAIETLAQAI
MMAR_2779|M.marinum_M --------VTWGDEASAQAALLLEALTDAGFDNVVPVRLLDAVETLAEAI
MUL_2968|M.ulcerans_Agy99 --------VTWSDEASAQAALLLEALTDAGFDNVVPVRLVDAVETLAEAI
MAV_2814|M.avium_104 --------VTWNDEASVPAALVLEALTDAGLHNVVPVRFLQAVETLAQAI
MAB_4296c|M.abscessus_ATCC_199 --------VVWSDHA--EAAELRDSLASRGIDGVEFFSALHAGGALAKAA
TH_3900|M.thermoresistible__bu --------VAWSDHA--EAAALREALAARGLDDVMLVSELHAAGALAQAV
MLBr_00048|M.leprae_Br4923 PRSPAASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATP
: . . .: . . . : .
Mvan_3021|M.vanbaalenii_PYR-1 AKLMGYRTTAVCVIEPEQLIALVATDEG-------AVQTAVNHSVVTEED
Mflv_3300|M.gilvum_PYR-GCK ALVLGYRTTAVCVIEPEQLIALVVSVEDAADGTSEAVQTAVNHSVVTEDD
MSMEG_3531|M.smegmatis_MC2_155 ADMAGFATTVVCVFEPEGALALTVDRRDG------VVDTARSRAIGSVRG
Mb1919|M.bovis_AF2122/97 APVIGYEQIAVCVLEHESATVVMVDTHDG------KTQIAVKHVCRGLSG
Rv1887|M.tuberculosis_H37Rv APVIGYEQIAVCVLEHESATVVMVDTHDG------KTQIAVKHVCRGLSG
MMAR_2779|M.marinum_M APVIGYDQTAVCILEHDWATVVMVDTQDG------KTQTAVKHVRGGFDG
MUL_2968|M.ulcerans_Agy99 APVIGYDQTAVCILEHDWATVVMVDTQDG------KTQTAVKHVRGGFDG
MAV_2814|M.avium_104 APVIGYEQTAVCVLEHDWTTVVMVDSHDG------QTQTATKQVRGGFDG
MAB_4296c|M.abscessus_ATCC_199 SSVTGYDKSALLVIEPQTATLAVVDSADG----SIVGLASEPLITGVTSG
TH_3900|M.thermoresistible__bu GRRVGYDTTALFFIERDTATMAVVQTDDG----SVVKVLSRDLHNADAMA
MLBr_00048|M.leprae_Br4923 MPMTPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRP
. .
Mvan_3021|M.vanbaalenii_PYR-1 LIGWLSSVFARADWAPEALVLVGSAEDLDG----LSPILEDALAVPVFSP
Mflv_3300|M.gilvum_PYR-GCK LVGWLSTVFTRADWEPEALVLVGSGEDLED----LLPVLEDALAVPVFSP
MSMEG_3531|M.smegmatis_MC2_155 LVGWLERLLAASGRVPDALVVVGSAVDLDADVDRLMPKLQAALGIPVFTP
Mb1919|M.bovis_AF2122/97 LTSWLTGMFGRDAWRPAGVVVVGSDSEVSE----FSWQLERVLPVPVFAQ
Rv1887|M.tuberculosis_H37Rv LTSWLTGMFGRDAWRPAGVVVVGSDSEVSE----FSWQLERVLPVPVFAQ
MMAR_2779|M.marinum_M LNSWLTGMFDRGAWRPAAVVVVGSDTDVEE----FSWQLEKALPVPVFAQ
MUL_2968|M.ulcerans_Agy99 LNSWLTGMFDRGAWRPAAVVVVGSDTDVEE----FSWQLEKALPVPVFAQ
MAV_2814|M.avium_104 LTRWLTGMFERDGWQPGGIVVVGAHSDIDG----LSWQLEKALPVPVFVQ
MAB_4296c|M.abscessus_ATCC_199 VLANLVNPLKGKENAPDGVFLLGLGTDVSD----LAESLGDAIALPVNSP
TH_3900|M.thermoresistible__bu TLTEMALTVDGQDSPPQGMFLIGSGVDISE----LKAHLDKLLRLPVHAP
MLBr_00048|M.leprae_Br4923 SANQHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAE
. . .
Mvan_3021|M.vanbaalenii_PYR-1 DAAQLALARGAALACASNGDFDVWPGPAS----ERQTR------------
Mflv_3300|M.gilvum_PYR-GCK AEAALALARGAALACAQPGEFAAWEHTTR----QPVTP------------
MSMEG_3531|M.smegmatis_MC2_155 ADGDLALARGAALVSARRGRF-MFPDKAD----QQRSR------------
Mb1919|M.bovis_AF2122/97 TMAQVTVARGAALAAAQSTEFTDAQLVADSVSQPTVAP------------
Rv1887|M.tuberculosis_H37Rv TMAQVTVARGAALAAAQSTEFTDAQLVADSVSQPTVAP------------
MMAR_2779|M.marinum_M TMAQVTIARGAALAAAQSTDFTDARLIAD-VSEPAPAP------------
MUL_2968|M.ulcerans_Agy99 TMAQVTIARGAALAAAQSTDFTDARLIAD-VSEPAPAP------------
MAV_2814|M.avium_104 SMAQVTIARGAALSAARSTEFTDEQLVARRSEPVTPAP------------
MAB_4296c|M.abscessus_ATCC_199 DQPELALARGAALASAQEPDFEASTALLGQAYSLEG--------------
TH_3900|M.thermoresistible__bu EESDLALCRGAALAAANAPTFEPSTVGLAYSQVPDGGPTVPASVYAAGFG
MLBr_00048|M.leprae_Br4923 PAPTQHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTG------------
: * .* . .
Mvan_3021|M.vanbaalenii_PYR-1 --------------------------------------------PATTRF
Mflv_3300|M.gilvum_PYR-GCK --------------------------------------------HATRRR
MSMEG_3531|M.smegmatis_MC2_155 --------------------------------------------WTSR--
Mb1919|M.bovis_AF2122/97 --------------------------------------------RRSR--
Rv1887|M.tuberculosis_H37Rv --------------------------------------------RRSR--
MMAR_2779|M.marinum_M --------------------------------------------KRSL--
MUL_2968|M.ulcerans_Agy99 --------------------------------------------KRSL--
MAV_2814|M.avium_104 --------------------------------------------VRHRRL
MAB_4296c|M.abscessus_ATCC_199 -PTGTGFAHPDAVTESAGEANTELREFEDFDDQPAE--------RKPFLL
TH_3900|M.thermoresistible__bu ADAATAGGHPYAAYAAFAGAQTQLASIGGAAPSPVPGEPPVDEDRKPFLL
MLBr_00048|M.leprae_Br4923 -----AKKPSKVVAKRGWRHWVHTVTRINLGLSPDERYELDLRTRVRRPP
Mvan_3021|M.vanbaalenii_PYR-1 ARSAPAVLLAAGVVTFVASVSVAVALALTPGQPAPQ------------PR
Mflv_3300|M.gilvum_PYR-GCK RRRWPQALLAAGAITFVASASAAVALQLTPEPIASP------------PR
MSMEG_3531|M.smegmatis_MC2_155 -QLAPAAMLLVGVVTFVVSLSLAISQQMSPREQAFERPTRPVVNTSGTPA
Mb1919|M.bovis_AF2122/97 HYAGAAAALAAAAVTFVASLSLAVGIQLAPHN------------------
Rv1887|M.tuberculosis_H37Rv HYAGAAAALAAAAVTFVASLSLAVGIQLAPHN------------------
MMAR_2779|M.marinum_M HYAGAATTLAAAAVTFVGSLSLAIGLQLTPER------------------
MUL_2968|M.ulcerans_Agy99 HYAGAATTLAAAAVTFVGSLSLAIGLQLTPER------------------
MAV_2814|M.avium_104 SYAGAMTALTAGAISFVGSVSLAVGIHVGPAS------------------
MAB_4296c|M.abscessus_ATCC_199 VGAPLLLVFGICSIALAVSLTVTVRSTVDQGPSSPDRGVVQNPLPAEAPK
TH_3900|M.thermoresistible__bu VGSALTSIFVVGVVALVVSLAVSIRPTVDQRPSPADS--------ALAPG
MLBr_00048|M.leprae_Br4923 RGSYQIGILGLKGGAGKTTVTVTLGSMFARVRNDRILVVDADTSCGNLAD
: : : : :: .
Mvan_3021|M.vanbaalenii_PYR-1 PAAESA---------AAPPAAAPPRSQVPPPPVAAVEPAPVAAVEPAPVA
Mflv_3300|M.gilvum_PYR-GCK SAAESP---------VRQPAAPSP---VPP---APVAPAPDPAPEP----
MSMEG_3531|M.smegmatis_MC2_155 AVRQLP---------PALPAAPPPPPQAPP--AAEVAEAVPPAVDPPLAD
Mb1919|M.bovis_AF2122/97 -----------------DTGTAKHGAHKPTPRIAKAVAPAVPPPPTVTPP
Rv1887|M.tuberculosis_H37Rv -----------------DTGTAKHGAHKPTPRIAKAVAPAVPPPPTVTPP
MMAR_2779|M.marinum_M -----------------HHTATGHAGHKPTPEIVEAVAPVVPMPAQPEPS
MUL_2968|M.ulcerans_Agy99 -----------------HHTATGHAGHKPTPEIVEAVAPVVPMPAQPEPS
MAV_2814|M.avium_104 -----------------ATAAAKHATHPPAPQVAEAVKAVTPLPAAP-QT
MAB_4296c|M.abscessus_ATCC_199 QAAPPPSPVEAPAPAVSPAPVQQVVAPAPQHNPAPAPKQVAPAPVQAAPQ
TH_3900|M.thermoresistible__bu VAAP-----------VQPETVPEALXXXPPH-PSPAPN-VKPLRCAGGFS
MLBr_00048|M.leprae_Br4923 RAGRFSEAN--IADLLADKDVKSYNDIRTHTSVNAVNLEVLPAAEYSTAQ
. . . .
Mvan_3021|M.vanbaalenii_PYR-1 AVEPAPEPVAALVAP-------EPEAPPPVVDEAQSVPAPL---------
Mflv_3300|M.gilvum_PYR-GCK -VAPAAEDVPVEAPP-------APQELP-----EQVSPDVL---------
MSMEG_3531|M.smegmatis_MC2_155 VAESPVEQALPQLPPQLPLPDAATALPPPVVIPAPPTKKPLLSRIRDRLR
Mb1919|M.bovis_AF2122/97 VPARAPRPAAQHEPP-----------------------------------
Rv1887|M.tuberculosis_H37Rv VPARAPRPAAQHEPP-----------------------------------
MMAR_2779|M.marinum_M APHQAPAPGAGQEP------------------------------------
MUL_2968|M.ulcerans_Agy99 APHQAPAPGAGQEP------------------------------------
MAV_2814|M.avium_104 KPQTKPPSGPAPAP------------------------------------
MAB_4296c|M.abscessus_ATCC_199 APAPAPEAPAPAAPAPVPEEQPAPVAPPPAVVPVPIPLFPPVWEPPRRQE
TH_3900|M.thermoresistible__bu AVVARTTAPGP---------------------------FPTGWS------
MLBr_00048|M.leprae_Br4923 HALSGEDWNFAAATVSKYYNVMLADCGVGLFDPVTRG-------------
Mvan_3021|M.vanbaalenii_PYR-1 -----PEQAPVVEAASPDAGLPTAPPVIP-APEVVP-PVPQERPGILQRI
Mflv_3300|M.gilvum_PYR-GCK -----PPATAPVEAVPP------PPPVEP-APAVIPAPVPAERPGILDRI
MSMEG_3531|M.smegmatis_MC2_155 GEPDVPEQMVIGEPPPPAEITPIPPPGAPPAPPVDDAPAPEAPP---EPP
Mb1919|M.bovis_AF2122/97 --------ARVTSGEALTEPNPPEEQPNASAPQQDRNDSQP-ITRVLEHI
Rv1887|M.tuberculosis_H37Rv --------ARVTSGEALTEPNPPEEQPNASAPQQDRNDSQP-ITRVLEHI
MMAR_2779|M.marinum_M --------IRLTAGEQITDAAPVE-QPGGEAPQSEPADGSPMLTRVLTHI
MUL_2968|M.ulcerans_Agy99 --------IRLTAGEQITDAAPVE-QPGGEAPQSEPADGSPMLTRVLTHI
MAV_2814|M.avium_104 ------------AGEP---AAPDEQPGIGDDRQMESGNRQPYLTRVLEHI
MAB_4296c|M.abscessus_ATCC_199 -----NPWWPDRDRPRYTPPAQTQQPPIISIPGLPPIGGGDSDRGSHGGS
TH_3900|M.thermoresistible__bu ---------------RRSAAAELVSHATVRCS---------------GDG
MLBr_00048|M.leprae_Br4923 ---------VLSTASGVVIVTSTSVDAARQAAIALDWLRHNGYQDLLSRA
Mvan_3021|M.vanbaalenii_PYR-1 RDRLSNVGPDDPQQAAVPPP------PAP--------APPLP--------
Mflv_3300|M.gilvum_PYR-GCK RDRLSRVG--DP-VVEMPPP------PVPGAPV-APVPPPLP--------
MSMEG_3531|M.smegmatis_MC2_155 PAPEAPPAADPPPPADVPPPDPPPAEPAPVEPEPAPEAPPAP--------
Mb1919|M.bovis_AF2122/97 PGAYG----DSAPPAE----------------------------------
Rv1887|M.tuberculosis_H37Rv PGAYG----DSAPPAE----------------------------------
MMAR_2779|M.marinum_M PGSYGE--EEGSRPPE----------------------------------
MUL_2968|M.ulcerans_Agy99 PGSYGE--EEGSRPPE----------------------------------
MAV_2814|M.avium_104 PGDTGEPAADSAPHPTLDPQP-----------------------------
MAB_4296c|M.abscessus_ATCC_199 RGGSGRGGWGDDGDSRGGSDSGSRGGWGDNGGSRGGWGDSGSSRGGSDSG
TH_3900|M.thermoresistible__bu PGSAGVPGWDPDPSIK-----------ADGGRHRFRFAVQMTTRCGLIAH
MLBr_00048|M.leprae_Br4923 CVVINHVMPKEPNIASKDLVQQFEQQIQPGRVVVLPWDKHIAAGTEIRLD
Mvan_3021|M.vanbaalenii_PYR-1 -------------------------------
Mflv_3300|M.gilvum_PYR-GCK -------------------------------
MSMEG_3531|M.smegmatis_MC2_155 -------------------------------
Mb1919|M.bovis_AF2122/97 -------------------------------
Rv1887|M.tuberculosis_H37Rv -------------------------------
MMAR_2779|M.marinum_M -------------------------------
MUL_2968|M.ulcerans_Agy99 -------------------------------
MAV_2814|M.avium_104 -------------------------------
MAB_4296c|M.abscessus_ATCC_199 SRGGWGGNSGSHGGGSGGGSNSGFPWPFGGR
TH_3900|M.thermoresistible__bu P------------------------------
MLBr_00048|M.leprae_Br4923 RLDPLYRRRILELAAALSDDFERAGRH----