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M. tuberculosis H37Rv Rv1768 (PE_PGRS31)

annotation: PE-PGRS FAMILY PROTEIN
coordinates: 2000614 - 2002470
length: 618

MSYLVVVPELVAAAATDLANIGSSISAANAAAAAPTTALVAAGGDEVSAAIAALFGAHARAYQALSAQAA
MFHEQFVRALAAGGNSYAVAEAATAQSVQQDLLNLINAPTQALLGRPLIGNGANGLPGTGQNGGDGGILY
GNGGNGGSGGVNQAGGNGGNAGLWGNGGSGGAGGNATTAGRNGFNGGAGGSGGLLWGNGGAGGAGGNGGP
APLVGGVGTTGGAGGNGGGAGLFYGFGGAGGNGGMGGVAPSTGPSMGILPAGGVGGPGGSGGASALAFGS
GGVGGAGGLGGPTDGTVQGVGGFGGQGGNGGQSGLLFGNAGAGGAGAAGGAGTGDTESFGGHGGAGGDGG
AVGLIGNGGAGGTGSPGAVVGGNGGVGGLGGAGSPGGLLYGTGGAGGNGGPGGDGGTGATVGFAGSGGFG
GAGGIAQLFGTGGMGGSGGGIGAGTTTVVPPDVAPVGGTGGNGGRAGLLLGVGGMGGNGGATSVGGTLYA
AGGNGGDGGLVWGNGGTGGSGGAGGAGSVGNGGAGGNAALLFGNGGAGGAGGAGGIGAGGAGGFGAVLFG
NGGAGGSGAPGGIGAGGNGGNALLVGNGGNGGAGTGGAAGGAGGSGGLLFGQNGMPGP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1768PE_PGRS31-100% (618)PE-PGRS FAMILY PROTEIN
M. tuberculosis H37RvRv1091PE_PGRS22e-17652.51% (697) PE-PGRS family protein
M. tuberculosis H37RvRv1803cPE_PGRS32e-16652.56% (664) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1797PE_PGRS310.098.88% (624) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-1e-11142.86% (658) triple helix repeat-containing collagen
M. leprae Br4923MLBr_01183-1e-1134.38% (96) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-1e-4634.24% (476) hypothetical protein MAB_4284c
M. marinum MMMAR_2645-0.073.72% (624) PE-PGRS family protein
M. avium 104MAV_4827-2e-2441.29% (201) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-8e-9540.59% (611) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_4332-3e-4137.70% (382) PUTATIVE -
M. ulcerans Agy99MUL_0212-1e-16352.56% (664) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-1e-10841.45% (690) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Rv1768|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1797|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2645|M.marinum_M               --------------------------------------------------
MUL_0212|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1797|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2645|M.marinum_M               --------------------------------------------------
MUL_0212|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1797|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2645|M.marinum_M               --------------------------------------------------
MUL_0212|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1797|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2645|M.marinum_M               --------------------------------------------------
MUL_0212|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1797|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2645|M.marinum_M               --------------------------------------------------
MUL_0212|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         ---------MSYLVVVPELVAAAATDLANIG-------------------
Mb1797|M.bovis_AF2122/97            ---------MSYLVVVPELVAAAATDLANIG-------------------
MMAR_2645|M.marinum_M               ---------MSYLIAAPEMVAAAATDLASVG-------------------
MUL_0212|M.ulcerans_Agy99           ---------MSFVNVTPEAVAAAASDLTGIG-------------------
MLBr_01183|M.leprae_Br4923          --------MPLFLNAEPQALTAAANTLEGLS-------------------
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
TH_4332|M.thermoresistible__bu      ---------MPFITSGAAFVGGAAMLLAGPG-------------------
MAB_4284c|M.abscessus_ATCC_199      ------MSIIDFILNLFRDPVEAASYVADPEAALAN--------------
MAV_4827|M.avium_104                -------MNIVLGVSMAPSSIQMVVLEGEYADG-----------------
                                                           .                          

Rv1768|M.tuberculosis_H37Rv         -----------------------SSISAANAAAAAPTTALVAAGGDEVSA
Mb1797|M.bovis_AF2122/97            -----------------------SSISAANAAAAAPTTALVAAGGDEVSA
MMAR_2645|M.marinum_M               -----------------------SSISAANAAAAAPTMSVLAAGADEVSA
MUL_0212|M.ulcerans_Agy99           -----------------------SVLGEANAVAARATTTVLAAGGDEVSA
MLBr_01183|M.leprae_Br4923          -----------------------AATVASNAAAAQLTTEIAPPAADDVSI
Mflv_5091|M.gilvum_PYR-GCK          GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1       GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155      LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
TH_4332|M.thermoresistible__bu      ------------------------GVSALEAAGSAPR-TVEYEYSLVACD
MAB_4284c|M.abscessus_ATCC_199      -----------------------AGLSAVSAAQVGAVMPVVAESVASNYG
MAV_4827|M.avium_104                -----------------------ATVEEDAIDVTGADDAATASAPDRVIS
                                                                                      

Rv1768|M.tuberculosis_H37Rv         AIAALFGAHARAYQALSAQAAMFHEQFVRALAAGG---------------
Mb1797|M.bovis_AF2122/97            AIAALFGAHARAYQALSAQAAMFHEQFVRALAAGG---------------
MMAR_2645|M.marinum_M               VVAALFDAHAQAYQSLSAQAALFHEQFVQALNAGA---------------
MUL_0212|M.ulcerans_Agy99           AIAALFSFHGQSYQTLGAQAEAFHAQFAQLMANGA---------------
MLBr_01183|M.leprae_Br4923          LLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSS---------------
Mflv_5091|M.gilvum_PYR-GCK          VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1       VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155      GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
TH_4332|M.thermoresistible__bu      STLPLMCEAGDSVGGLGGASHDRSAFSASALGMAS---------------
MAB_4284c|M.abscessus_ATCC_199      YQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSP---------------
MAV_4827|M.avium_104                AILGTREGAADAGLQLSSIGVTWTDQLEAAALRDA---------------
                                                    .                                 

Rv1768|M.tuberculosis_H37Rv         -NSYAVAEAATAQSVQQDLLNLINAPTQALLGRP----------------
Mb1797|M.bovis_AF2122/97            -NSYAVAEAATAQSVQQDLLNLINAPTQALLGRP----------------
MMAR_2645|M.marinum_M               -GSYALAEAASVS-PLQDALNLINAPTQALFGRP----------------
MUL_0212|M.ulcerans_Agy99           -GTYASAEAANAA-PFQGLLGAVNAPVQTLTGRP----------------
MLBr_01183|M.leprae_Br4923          -SAYAGTETANHDSL-----------------------------------
Mflv_5091|M.gilvum_PYR-GCK          VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------
Mvan_1264|M.vanbaalenii_PYR-1       VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------
MSMEG_0868|M.smegmatis_MC2_155      VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
TH_4332|M.thermoresistible__bu      FGPDWNPGGAFLGLIGPGGLLIGDGLNGTDAYID----------------
MAB_4284c|M.abscessus_ATCC_199      -SLLSPRDNDFLSHNDTDFASHNPIASGNQVMSP----------------
MAV_4827|M.avium_104                -LAARRIDNVMLVSAFLAAAALAQNVGGAMGYER----------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         -LIGNGANGLPGTGQNGGDGGILYGNG-----GNGGSGGVNQAGGNGGNA
Mb1797|M.bovis_AF2122/97            -LIGNGANGLPGTGQNGGDGGILYGNG-----GNGGSGGVNQAGGNGGNA
MMAR_2645|M.marinum_M               -LIGNGADGAPGTGQSGGNGGFLYGNG-----GNGGSGANNQGGGNGGSA
MUL_0212|M.ulcerans_Agy99           -LIGNGANGAPGTGANGGAGGWLIGNG-----GAGGSGAPGLNGGAGGAA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG
Mvan_1264|M.vanbaalenii_PYR-1       -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG
MSMEG_0868|M.smegmatis_MC2_155      AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
TH_4332|M.thermoresistible__bu      ------ENGVFHEATRGGNGGLLWGNG--------------GKGGNGLDA
MAB_4284c|M.abscessus_ATCC_199      --SGNVDSFNRGPLLDLSFGDLQFGNR----DTTAIGDGAVAVGGSNSGP
MAV_4827|M.avium_104                ------TAVLLVEPDTATLAVVETSDG-------SIPDVYKQQIRAESYG
                                                                                      

Rv1768|M.tuberculosis_H37Rv         GLWGNGGSGGAG-------------------GNATTAGRNGFNGGAGGSG
Mb1797|M.bovis_AF2122/97            GLWGNGGSGGAG-------------------GNATTAGRNGFNGGAGGSG
MMAR_2645|M.marinum_M               GLWGNGGAGGAG-------------------GDSTVAGVNGFNGGAGGSG
MUL_0212|M.ulcerans_Agy99           GLIGTGGAGGAG-------------------GSSSTV--NGGLGGTGGAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG
Mvan_1264|M.vanbaalenii_PYR-1       ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG
MSMEG_0868|M.smegmatis_MC2_155      TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
TH_4332|M.thermoresistible__bu      GLYTVPDPDNPG--------------------STIQMYFEASDGADGGRG
MAB_4284c|M.abscessus_ATCC_199      IASGQGSTAVNG-------------------DVRDSNIINADHGSNVGVD
MAV_4827|M.avium_104                DAAGQLSAMVAG-----------------------LEKLESLPGGLLLVG
                                                                                      

Rv1768|M.tuberculosis_H37Rv         --------------------------------------------------
Mb1797|M.bovis_AF2122/97            --------------------------------------------------
MMAR_2645|M.marinum_M               --------------------------------------------------
MUL_0212|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------STGAVGG-------VGGKG----IQGGQG-----------
Mvan_1264|M.vanbaalenii_PYR-1       ----------ATGGAGG-------VGGKG----IQGGQG-----------
MSMEG_0868|M.smegmatis_MC2_155      SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         -GLLWGNGGAGGAGGNGGPAPLVGG------------------VGTTGGA
Mb1797|M.bovis_AF2122/97            -GLLWGNGGAGGAGGHGGPAPLVGG------------------VGTTGGA
MMAR_2645|M.marinum_M               -GLLWGNGGAGGAGGNGGGAPLAGF------------------VGTSGGN
MUL_0212|M.ulcerans_Agy99           -GWLLGNGGAGGAGG-ASAIPLGPD------------------LIGKGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK
Mvan_1264|M.vanbaalenii_PYR-1       --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK
MSMEG_0868|M.smegmatis_MC2_155      KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV
TH_4332|M.thermoresistible__bu      -GFLFGNGGDGGNGGNVGGK--------------------------NGAD
MAB_4284c|M.abscessus_ATCC_199      -QSQTRVGGDYTNVSGHGSADIDKS------------------VTVVDDH
MAV_4827|M.avium_104                SGVDVAPLKQVLQTTTFLDVSVAEE-------------------PETALA
                                                                                      

Rv1768|M.tuberculosis_H37Rv         GGNGG--GAGLFYG---------------FGGAGGNGG------------
Mb1797|M.bovis_AF2122/97            GGNGG--GAGLFYG---------------FGGAGGNGG------------
MMAR_2645|M.marinum_M               GGNGG--GAGLLYG---------------YGGAGGAGG------------
MUL_0212|M.ulcerans_Agy99           GGPGGLFGAGGLGG---------------AGGFGGSGGG-----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGNGGNGGRGGLFG---------------KGGNAGNGAD-----------
Mvan_1264|M.vanbaalenii_PYR-1       GGNGGNGGRGSLFG---------------RGGNAGNGGN-----------
MSMEG_0868|M.smegmatis_MC2_155      GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP
TH_4332|M.thermoresistible__bu      PVTATVAADKSVAG-----------------GNGGNGGR-----------
MAB_4284c|M.abscessus_ATCC_199      SQRNTTNINDSFNT--------------DRSTNIGSGNT-----------
MAV_4827|M.avium_104                RGAALAAANAPLFAS-----------STAALAYAQDPGTG----------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         ----------------MGGVAPSTGPSMGILPAGG---------------
Mb1797|M.bovis_AF2122/97            ----------------MGGVAPSTGPSMGILPAGG---------------
MMAR_2645|M.marinum_M               ----------------TGGVAPPTGVGQTILSAGG---------------
MUL_0212|M.ulcerans_Agy99           ----------------AGGQGGAGGLLSGLVGAGGG--------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -----------GGTGGAGGAGGTGG-TGGAGGTGG---------------
Mvan_1264|M.vanbaalenii_PYR-1       -----------GGTGGNGGNGGTGG-TGGNGGTGG---------------
MSMEG_0868|M.smegmatis_MC2_155      AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ
TH_4332|M.thermoresistible__bu      -----------------------GGLLFGLGGNGG---------------
MAB_4284c|M.abscessus_ATCC_199      ---------------TNTEIGSHNQANIGTSTSAGG--------------
MAV_4827|M.avium_104                ---------------AVDQYSLPDYLYVPVDPEPGD--------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         --VGGPGGSGG--ASALAFGSGGVGGAGGLGG-----PTDGTVQGVGGF-
Mb1797|M.bovis_AF2122/97            --VGGPGGSGG--ASALAFGSGGVGGAGGLGG-----PTDGTVQGVGGF-
MMAR_2645|M.marinum_M               --VGGTGGAGG--GGAALIGFGGAGGTGGTGG-----LSDTTTETIGGY-
MUL_0212|M.ulcerans_Agy99           --HGGTGGYGGGAGGAGATGGGNTGGIGGDGGSAGMLFSNSGAGGAGGAS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
Mvan_1264|M.vanbaalenii_PYR-1       --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
MSMEG_0868|M.smegmatis_MC2_155      TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG
TH_4332|M.thermoresistible__bu      --NGGWSTTSYLDARGGNGGNGGLGGVLRPGGLLSLLLPSGAASEPGGLF
MAB_4284c|M.abscessus_ATCC_199      --SAAVGGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG
MAV_4827|M.avium_104                -DELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRPVLLVGSGLAVVGIS
                                                                                      

Rv1768|M.tuberculosis_H37Rv         ----GGQGGNGGQSGLLFGNAGAGGAGAAGGAGTGDTESFGGHGGAGGDG
Mb1797|M.bovis_AF2122/97            ----GGQGGNGGQSGLLFGNAGAGGAGAAGGAGTGDTESFGGHGGAGGDG
MMAR_2645|M.marinum_M               ----GGMGGLGGQSGVLFGTPGAGGAGGAGGAGVGTFASPGGHGGSGGDA
MUL_0212|M.ulcerans_Agy99           ELADGGAGGAGGNGGWLLSNGGVGGAGGAGADAVGPPFGIPAGSGSGGGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --GTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       --GTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      --GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGN
TH_4332|M.thermoresistible__bu      ------TGGNGGNGGLAIANHWVGITDGVPGPD-----------------
MAB_4284c|M.abscessus_ATCC_199      NAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNA
MAV_4827|M.avium_104                -------AVLALEIALAIGIRTTGTVALQPTPNQHLIVPTEQAPAPPPVQ
                                                                                      

Rv1768|M.tuberculosis_H37Rv         GAVG----------LIGNGG------AGGTGSPGAVVGGNGG--------
Mb1797|M.bovis_AF2122/97            GAVG----------LIGNGGGGGNGGAGGTGSPGAVVGGNGG--------
MMAR_2645|M.marinum_M               GAIG----------LFGNGAAGGDGGIGGDGASGGNDGGNGG--------
MUL_0212|M.ulcerans_Agy99           GGAGGV--------FFGNGG------AGGAGGTGGDGGGTGG--------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG--------
Mvan_1264|M.vanbaalenii_PYR-1       GGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG--------
MSMEG_0868|M.smegmatis_MC2_155      GGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATV
TH_4332|M.thermoresistible__bu      ----------------------------DDAVSSSAYGGHGG--------
MAB_4284c|M.abscessus_ATCC_199      GLAG-------------NAGLAGNAGLAGNAGLAGNAGLAGN--------
MAV_4827|M.avium_104                ASAPQP--------KISVPEPVAAPKPLSPPVAAPLPAAPPP--------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         ---------VGGLGGAGSPGGLLYGTG-----------------------
Mb1797|M.bovis_AF2122/97            ---------VGGLGGAGSPGGLLYGTG-----------------------
MMAR_2645|M.marinum_M               ---------VGGLGGVGGPGGWIFGTG-----------------------
MUL_0212|M.ulcerans_Agy99           ---------AGGAAGNG----VLIGNG-----------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ---------TGGTGGQGG-LGGGGGTG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------TGGTGGQGG-LGGVGGTG-----------------------
MSMEG_0868|M.smegmatis_MC2_155      IGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATD
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------AGLAGNAAVAGNAAVAG-----------------------
MAV_4827|M.avium_104                ---------AAPPLPEAPPIPAAPPVVP----------------------
                                                                                      

Rv1768|M.tuberculosis_H37Rv         ---GAGGNGGPGGDGGTG-ATVGFA-------GSGGFGGAGGIAQLFGTG
Mb1797|M.bovis_AF2122/97            ---GAGGNGGPGGDGGTG-ATVGFA-------GSGGFGGAGGIAQLFGTG
MMAR_2645|M.marinum_M               ---GAGGNGGLGGSGGTGVVTNGFA-------GSGGFGGAGGDAQFLGFG
MUL_0212|M.ulcerans_Agy99           ---GNGGIGGAAGLWGTG-GTGGSG-------GSGGTGATGGFSGLLASG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFG
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFG
MSMEG_0868|M.smegmatis_MC2_155      GHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNG
TH_4332|M.thermoresistible__bu      ----HGAGPGSGGNGGSAVANSLGN-------AIAGNGGDAGRFVLIGPG
MAB_4284c|M.abscessus_ATCC_199      -NAAVAGNAAVGGVLNTGVSGAIGGS---SHVGGAINESLGGSGSVGGST
MAV_4827|M.avium_104                -VPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPP
                                                                                      

Rv1768|M.tuberculosis_H37Rv         GMGGSGGGIGAGTTTVVPPDVAPVGG-----TGGNGGRAGLLLGVGGMGG
Mb1797|M.bovis_AF2122/97            GMGGSGGGIGAGTTTVVPPDVAPVGG-----TGGNGGRAGLLLGVGGMGG
MMAR_2645|M.marinum_M               GTGGSGGGIGAGETAAVPLTTQPVGG-----TGGNGGRAGLFFGVGGTGG
MUL_0212|M.ulcerans_Agy99           DGGAGGAGGAGGAGGLLDGLVGAGGG-----DGGAGGNAGTLFGSGGVGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAG
Mvan_1264|M.vanbaalenii_PYR-1       GVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAG
MSMEG_0868|M.smegmatis_MC2_155      GDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGS
TH_4332|M.thermoresistible__bu      GNGGNGGTGLXXX--------------------------------PRPRR
MAB_4284c|M.abscessus_ATCC_199      AVGGGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHT
MAV_4827|M.avium_104                SPPQVGGTVPQSPPQHQTPPGEGTPP----KPDGPGNYGGGHVPTPGAGG
                                                                                      

Rv1768|M.tuberculosis_H37Rv         NGGATSVGGTLYAAGGNGGDGGLVWGN------------------GGTGG
Mb1797|M.bovis_AF2122/97            NGGATSVGGTLYAAGGNGGDGGLVWGN------------------GGTGG
MMAR_2645|M.marinum_M               NGGATSTNGALYATGGNGGDGGLIFGN------------------GGTGG
MUL_0212|M.ulcerans_Agy99           DGGSGHGNG---GDGGGGGNAGLLFSD------------------AGGGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          KAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGA
Mvan_1264|M.vanbaalenii_PYR-1       TAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGS
MSMEG_0868|M.smegmatis_MC2_155      TLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGD
TH_4332|M.thermoresistible__bu      RRNHRRTRRRPNGRRPRPPPGR----------------------------
MAB_4284c|M.abscessus_ATCC_199      GVGGGVSTGVGVGSHVGGGISESLGGS------------------GSVGG
MAV_4827|M.avium_104                SGGSGGGHVPTPGAGGSGGSG--------------------------GGH
                                                                                      

Rv1768|M.tuberculosis_H37Rv         SGGAGGAGSVGNGG------------------AGGNAALLFGNGGAGGAG
Mb1797|M.bovis_AF2122/97            SGGAGGAGSVGNGG------------------AGGNAALLFGNGGAGGAG
MMAR_2645|M.marinum_M               NGGAGGGTSVGAGG------------------QGGAASAFFGNGGAGGDG
MUL_0212|M.ulcerans_Agy99           FGGFGLAGGGGTGG------------------SGGDAG-WLGSGGAGGAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          TGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
Mvan_1264|M.vanbaalenii_PYR-1       AGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
MSMEG_0868|M.smegmatis_MC2_155      GGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADG
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      STAVGGGAHTGVGG---------------GVNTGVGVGSHVGGGISESLG
MAV_4827|M.avium_104                VPTPGTGGPGGTGG------------------SGGGHVPTPGAGTPGGSG
                                                                                      

Rv1768|M.tuberculosis_H37Rv         GA---GGIGAGG--------------AGGFGAVLFGNGGAGGSG------
Mb1797|M.bovis_AF2122/97            GA---GGIGAGG--------------AGGFGAVLFGNGGAGGSG------
MMAR_2645|M.marinum_M               GA---GGQGAGG--------------AGGSGALFFGNGGAGGNG------
MUL_0212|M.ulcerans_Agy99           GISVNGDAGAGG--------------AGGTSGQLLGDGGAGGAGG-----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          KAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-----
Mvan_1264|M.vanbaalenii_PYR-1       KAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-----
MSMEG_0868|M.smegmatis_MC2_155      WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVW
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GSGSVGGSTAVG-------------GGAHTSAINDALGGSGSVGG-----
MAV_4827|M.avium_104                GGHLPFPGAGST--------------PGGSGGGHLPTPGAGTPGG-----
                                                                                      

Rv1768|M.tuberculosis_H37Rv         -----------APGGIG-AGGNGGN--------ALLVGNGGNGGAGTGGA
Mb1797|M.bovis_AF2122/97            -----------APGGIG-AGGNGGN--------ALLVGNGGNGGAGTGGA
MMAR_2645|M.marinum_M               -----------APGGTG-VGGTGGS--------AVLIGNGGDGGDGTGGA
MUL_0212|M.ulcerans_Agy99           -------EAELAAGGAGGSGGVGGD--------AVLIGAGGNGGNGGPGT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGA
Mvan_1264|M.vanbaalenii_PYR-1       ------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGA
MSMEG_0868|M.smegmatis_MC2_155      KSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGS
TH_4332|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------STAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGA
MAV_4827|M.avium_104                --------------GLGGFGGGHAP----------APGGGLGGGGGHAPA
                                                                                      

Rv1768|M.tuberculosis_H37Rv         AG-GAGGSG--GLLFGQNGMPGP------
Mb1797|M.bovis_AF2122/97            AG-GAGGSG--GLLFGQNGMPGP------
MMAR_2645|M.marinum_M               AG-GAGGSG--GFIFGQNGSNGLP-----
MUL_0212|M.ulcerans_Agy99           AK-GDPGSGGAGGLLGVDGLNGLS-----
MLBr_01183|M.leprae_Br4923          -----------------------------
Mflv_5091|M.gilvum_PYR-GCK          G--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1       G--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155      GNGGNGGNGGNGGADGTPGTAGTTGANNP
TH_4332|M.thermoresistible__bu      -----------------------------
MAB_4284c|M.abscessus_ATCC_199      AGTGFEAQGHAQGHASETAHTTLPGAEHH
MAV_4827|M.avium_104                PGGGLGGFGGGHSGGGLGGLGGGHK----