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MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALLAAGADEVSAAIAALFGAHGQAYQTVSAQAS AFHAQFVQALTGGGGAYAAAEAANVSAAQSTDQRLLDLINGPTQALLGRPLIGDGANGGPGQDGGPGGLL YGNGGNGGTSTTAGVAGGNGGAAGLIGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIPGVAG GNGGAGGSAGLWGTGGAGGDGGNGRSGPVNVAGSAGGNGGAGGAAGLFGDAGAGGNGGKGGAGGAAFSIN FTAGDGGAGGAGGSGGHALLWGAGGAGGNGGSGGTGGAGGSTAGAGGNGGAGGGGGTGGLLFGNGGAGGH GAAAGNGLAAGNGVSSSGGGGAGGTGGAGGDGGAGGAGGNARLWGVGGAGGAGGDGGAGGAGGKGGSGLS GNANGGAGGDSGRGGTGGAGGEGGAAGLLVGTGGHGGDGGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGG SGGSGGDGGGGAAGPAGWLFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGNGGNGGNGGNGGNGATGGWLY GNGGAGGQGATAGAGGAGANGVSSTNGGGTGGNGGIGGTGGSGGAGGNAGLLGVGGAGGHGASGGAGDRG GAGGTGFISSDGGAGGDGGDGGNGGAGGTGGLLFGAGGNGGPGGSGGAADIGGNGGAGNGGGTDGNGGNG GSGGGAGSGGDGGGAGGNGAWLFGNGGAGGGGGKGGNGAGGGLGGGSFGLPGLNGSGGDGGDGGNGAPGG VLYGNGGAGGQGSSGGIGGPGATGGAGGKGGDGGDAQLIGDGGNGGNGGAGGTGGTPGPGGPGGSGGLGG LLFGQTGTAGVSP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | - | 100% (853) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0578c | PE_PGRS7 | 0.0 | 49.77% (1075) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv1087 | PE_PGRS21 | 0.0 | 60.05% (786) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1121 | PE_PGRS22 | 0.0 | 99.65% (853) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-173 | 47.71% (765) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 2e-13 | 39.13% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-51 | 36.89% (431) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_3316 | - | 0.0 | 52.66% (978) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 3e-25 | 44.02% (184) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-152 | 38.73% (1051) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 2e-46 | 42.36% (314) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 51.82% (936) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-177 | 45.68% (821) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1091|M.tuberculosis_H37Rv --------------------------------------------------
Mb1121|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3316|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv ----------MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALL
Mb1121|M.bovis_AF2122/97 ----------MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALL
MMAR_3316|M.marinum_M ----------MAFVLVAPEMVTAAASDLANIGSAINTANTAVAAPTAELL
MUL_4367|M.ulcerans_Agy99 ----------MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVL
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAAT
Rv1091|M.tuberculosis_H37Rv AAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAA
Mb1121|M.bovis_AF2122/97 AAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAA
MMAR_3316|M.marinum_M AAGTDEVSEAIASLFSGHALDYQNLGARMTAFHDQFVAALTAGGGLYSSA
MUL_4367|M.ulcerans_Agy99 PAAGDEVSAAIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRI
Rv1091|M.tuberculosis_H37Rv EAANV--------------------------------SAAQSTDQRLLDL
Mb1121|M.bovis_AF2122/97 EAANV--------------------------------SAAQSTDQRLLDL
MMAR_3316|M.marinum_M EAA------------------------------------AATPLQDLLNV
MUL_4367|M.ulcerans_Agy99 EALNM--------------------------------WPLQELEQQALGV
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 P---------------------------------------SILSPSLLSP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 DNVMLVS----------------------------AFLAAAALAQNVGGA
Rv1091|M.tuberculosis_H37Rv IN--------------------GPTQALLG--------RPLIGDGANG--
Mb1121|M.bovis_AF2122/97 IN--------------------GPTQALLG--------RPLIGDGANG--
MMAR_3316|M.marinum_M VN--------------------APTQALLG--------RPLIGDGADGT-
MUL_4367|M.ulcerans_Agy99 VN--------------------APSMALFG--------RPSIGNGVDGVA
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGT-
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGT-
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGT-
TH_3810|M.thermoresistible__bu -----------------------------------VDGD-----------
MAB_4284c|M.abscessus_ATCC_199 RD-----------------------NDFLS--------------HNDTDF
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 MG----------------------YERTAVLLVEPDTATLAVVETSDGSI
Rv1091|M.tuberculosis_H37Rv GPGQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAAGLIG-NGGAGGGGGA
Mb1121|M.bovis_AF2122/97 GPGQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAAGLIG-NGGAGGGGGA
MMAR_3316|M.marinum_M APGQAGGAGGLLYGNGGNGAAGTNPGVAGGAGGAAGLIG-NGGAGGIGGA
MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGGLG-AAGANGGAGGSAGLIG-TGGVGGAGGV
Mflv_5091|M.gilvum_PYR-GCK GQN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG
Mvan_1264|M.vanbaalenii_PYR-1 GQN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG
MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA
TH_3810|M.thermoresistible__bu ----------------------------GGSGGRTGLFS----------K
MAB_4284c|M.abscessus_ATCC_199 ASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 PDVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAPLK
Rv1091|M.tuberculosis_H37Rv GAA------GGNGGAGG--WLYGNGGAGGAG-----GTSVIPG-----VA
Mb1121|M.bovis_AF2122/97 GAA------GGNGGAGG--WLYGNGGAGGAG-----GTSVIPG-----VA
MMAR_3316|M.marinum_M GGS------GGAGGTGG--WLYGNGGAGGAGGAGAPGLVSFNG-----SN
MUL_4367|M.ulcerans_Agy99 GAAGMTGGSGGAGGGGG--WLWGAGGSGGAAGAG--GSGGSGG-----WL
Mflv_5091|M.gilvum_PYR-GCK GGN------GGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVA
Mvan_1264|M.vanbaalenii_PYR-1 SGD------GGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVA
MSMEG_0868|M.smegmatis_MC2_155 GLD------GGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTG
TH_3810|M.thermoresistible__bu LSR------GGDGGDGG------LGGNGGHG-------------------
MAB_4284c|M.abscessus_ATCC_199 AVG------GSNSGPIAS----GQGSTAVNGDVRDSNIIN---------A
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 QVLQTTTFLDVSVAEEPETALARGAALAAANAPLFASSTAALA------Y
Rv1091|M.tuberculosis_H37Rv GGNGGAGGSAGLWGTGG--AGGDGGNG---RSGPVNVA------------
Mb1121|M.bovis_AF2122/97 GGNGGAGGSAGLWGTGG--AGGDGGNG---RSGPVNVA------------
MMAR_3316|M.marinum_M GGNGGNGGAAGWWGTGG--AGGAGGEGGAAGGGPAGIAYGQT--------
MUL_4367|M.ulcerans_Agy99 WGNAGQTAGAGVGGAGG--AGGAGDAG---DQGVSGVAPGEAG-------
Mflv_5091|M.gilvum_PYR-GCK GATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------
Mvan_1264|M.vanbaalenii_PYR-1 GATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------
MSMEG_0868|M.smegmatis_MC2_155 GTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVL
TH_3810|M.thermoresistible__bu ---GGTGIISLLS-------------------------------------
MAB_4284c|M.abscessus_ATCC_199 DHGSNVGVDQSQTRVGG---------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 AQDPGTGAVDQYSLPDYLYVPVDPEPG-----------------------
Rv1091|M.tuberculosis_H37Rv -------------GSAGGNGGAGGA--AGLFG-DAGAGGNG---------
Mb1121|M.bovis_AF2122/97 -------------GSAGGNGGAGGA--AGLFG-DAGAGGNG---------
MMAR_3316|M.marinum_M -------------GGVGGNGGNGGN--GGWFAGNAGAGGNG---------
MUL_4367|M.ulcerans_Agy99 --------AVGFAGGAGGAGGAGGNGVGGGVNGAGGAGGAG---------
Mflv_5091|M.gilvum_PYR-GCK ------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------
Mvan_1264|M.vanbaalenii_PYR-1 ------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------
MSMEG_0868|M.smegmatis_MC2_155 IAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGAN
TH_3810|M.thermoresistible__bu ---------------LAGNGGNGGN--------GYRTTDNN---------
MAB_4284c|M.abscessus_ATCC_199 -----------DYTNVSGHGSADIDKSVTVVDDHSQRNTTN---------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ----------DDELAYSAVGEEDAESPTVVIEKLFLPEDSE---------
Rv1091|M.tuberculosis_H37Rv -------GKGGAGGAAFSIN--FTAGDGGAGGAG----------------
Mb1121|M.bovis_AF2122/97 -------GKGGAGGAAFSIN--FTAGDGGAGGAG----------------
MMAR_3316|M.marinum_M -------GVGGDGNAADNG---LVGGTGGVGGAG----------------
MUL_4367|M.ulcerans_Agy99 -------GVGGGGGAGASGV--GAGVAGGDGGTG----------------
Mflv_5091|M.gilvum_PYR-GCK -------AVGAAGAAG------TVGTAGATGGTG---------------T
Mvan_1264|M.vanbaalenii_PYR-1 -------AIGTAGVAG------AAGTAGATGGTG---------------V
MSMEG_0868|M.smegmatis_MC2_155 GGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTAT
TH_3810|M.thermoresistible__bu ------------------------ALDGGHGGNG----------------
MAB_4284c|M.abscessus_ATCC_199 --------INDSFNTDR-------STNIGSGNTTN---------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ----------------------PRRRPVLLVGSG----------------
Rv1091|M.tuberculosis_H37Rv -GSGGHALLWGAGGAGGNG----------GSGGTGGAGGSTAGAGGNGGA
Mb1121|M.bovis_AF2122/97 -GSGGHALLWGAGGAGGNG----------GSGGTGGAGGSTAGAGGNGGA
MMAR_3316|M.marinum_M -GSAG---LFGDGGAGGQG----------GDG--GGVTG-LVGAG-HGGA
MUL_4367|M.ulcerans_Agy99 -GAGG---AAGVGGAAGTG----------GTGGAAGVAG-TGGDGGDGGA
Mflv_5091|M.gilvum_PYR-GCK GANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGA
Mvan_1264|M.vanbaalenii_PYR-1 GGNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGV
MSMEG_0868|M.smegmatis_MC2_155 GGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGA
TH_3810|M.thermoresistible__bu -GNVGFFSLFNLGGAGGWG-------------------------------
MAB_4284c|M.abscessus_ATCC_199 -TEIGSHNQANIGTSTSAG-------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 LAVVGISAVLALEIALAIG-------------------------------
Rv1091|M.tuberculosis_H37Rv GGGG------GTGGLLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGT
Mb1121|M.bovis_AF2122/97 GGGG------GTGGLLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGT
MMAR_3316|M.marinum_M GGDG------GRAGWLSGNAGAGGGGGAGGAVDNHGSGGDYAGGGGAGGS
MUL_4367|M.ulcerans_Agy99 GGAGSDASLAGQAGFAGGSGGAGGVGGSAGAGGVNGSGGD-GGAGAAGGA
Mflv_5091|M.gilvum_PYR-GCK GGVGGQ----GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG--
Mvan_1264|M.vanbaalenii_PYR-1 GGIGGQ----GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG--
MSMEG_0868|M.smegmatis_MC2_155 GGMGEIYS--GADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv G-------GAG---GDGGAGGAGGN----ARLWG----------------
Mb1121|M.bovis_AF2122/97 G-------GAG---GDGGAGGAGGN----ARLWG----------------
MMAR_3316|M.marinum_M G-------GAAGLFGNGAAGGAGGAGGASQTFTG----------------
MUL_4367|M.ulcerans_Agy99 GGASATVAGSGGVGGDGGAGGAAGGGVGAASLGGD------------GGH
Mflv_5091|M.gilvum_PYR-GCK -----------LQGGKGGDGGAGGKGGDADSMGS----------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------LQGGQGGDGGTGGTGGDATSMGE----------------
MSMEG_0868|M.smegmatis_MC2_155 TGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNG
TH_3810|M.thermoresistible__bu --------------GSGVDG------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------GSAAVGGNAGLAGNAGLAGN----------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ---------------IRTTGTVALQPTPNQHLIVP---------------
Rv1091|M.tuberculosis_H37Rv --VGGAGGAG-----------GDGGAGGAGGKGG--------SGLSG-NA
Mb1121|M.bovis_AF2122/97 --VGGAGGAG-----------GDGGAGGAGGKGG--------SGLSG-NA
MMAR_3316|M.marinum_M --AGGAGGTGGAGGWLY----GNGGAGGAGGASG--------AGIGG-DS
MUL_4367|M.ulcerans_Agy99 AGAGGAGGEGLSGGFNTGAAGGIGGAGGAGGTGGD------SGGVGGVNG
Mflv_5091|M.gilvum_PYR-GCK --AGATGGKG-----------GNGGNGGRGGLFG----------------
Mvan_1264|M.vanbaalenii_PYR-1 --AGATGGKG-----------GNGGNGGRGSLFG----------------
MSMEG_0868|M.smegmatis_MC2_155 GAASANGAVG-----------GNGGFTNIAAIHGSITDSSATSGHGG-AA
TH_3810|M.thermoresistible__bu --VDVVGGNP----------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --AGLAGNAG----------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --TEQAPAPP--------------------------------------PV
Rv1091|M.tuberculosis_H37Rv NGGAGGDSGRG-------------------GTGGAGGEGGAAGL---LVG
Mb1121|M.bovis_AF2122/97 NGGAGGDSGRG-------------------GTGGAGGEGGAAGL---LVG
MMAR_3316|M.marinum_M LGGSGGNGGNGGISG----------LIGNGGAGGAGGNGSAAGYNG-YSG
MUL_4367|M.ulcerans_Agy99 DGGAGGGGGRGGDGGSS------TSTSGVGGAGGAGGNGGNAGFGVSAGG
Mflv_5091|M.gilvum_PYR-GCK KGGNAGNGAD----------------------GGTGGAGGAGGTGG-TGG
Mvan_1264|M.vanbaalenii_PYR-1 RGGNAGNGGN----------------------GGTGGNGGNGGTGG-TGG
MSMEG_0868|M.smegmatis_MC2_155 QGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGG
TH_3810|M.thermoresistible__bu DGGTPG----------------------------AHGESHTPGVYTDRQG
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGN----------------------AGLAGNAGLAGNAGLAGN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 QASAPQPKISVP-------------------EPVAAPKPLSPPVAAPLPA
Rv1091|M.tuberculosis_H37Rv TGGHGGDG----------------GAGGAAVKGGDGGAAAGTGIAG-AGG
Mb1121|M.bovis_AF2122/97 TGGHGGDG----------------GAGGAAVKGGDGGAAAGTGIAG-AGG
MMAR_3316|M.marinum_M NGGNGGNGGAAQ-------LIGAGGGGGVAGIGGAGGTGAAAGVTG-SAG
MUL_4367|M.ulcerans_Agy99 TGGSAGDGGAGGGAGGVDGVGGASGNGGAAGAGGAGGSGIGAGIDGGAGG
Mflv_5091|M.gilvum_PYR-GCK AGGTGG-------------------TGGTGGIGGAGSTGGTGGTGG-TGG
Mvan_1264|M.vanbaalenii_PYR-1 NGGTGG-------------------TGGTGGIGGAGSTGGTGGTGG-TGG
MSMEG_0868|M.smegmatis_MC2_155 RGGDGAGASVWKANG--QHSTGQTDTGGNGGRGGDGGTFVNAGANG-NGG
TH_3810|M.thermoresistible__bu EDGEDGTG------------------TGIGGRGGNGGS------------
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAG-----------------LAGNAGLAGNAGLAGNAGLAG----
MLBr_01183|M.leprae_Br4923 -------------------------MPLFLNAEPQALTAAANTLEG----
MAV_4827|M.avium_104 APPPAAPP-----------------LPEAPPIPAAPPVVPVPVVVPPVPV
Rv1091|M.tuberculosis_H37Rv RGGAG------------------GSGGSGGDGGGGAAGPAGWLFGD-GGA
Mb1121|M.bovis_AF2122/97 RGGAG------------------GSGGSGGDGGGGAAGPAGWLFGD-GGA
MMAR_3316|M.marinum_M ASGVGGRLYSGNGIPDIFGRPLIGDGADGAPGTGQAGGDGGWLYGN-GGA
MUL_4367|M.ulcerans_Agy99 AGGTGGAAGFPGGGGTTGAWGTGGAGGAGGAGGAGDHGGVGVNPGDSGTA
Mflv_5091|M.gilvum_PYR-GCK TGGTGGTG---------------GTGGTGGTGGTGGKGGTGGTGGA-GGT
Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTG---------------GTGGTGGTGGTGGKGGTGGTGGD-GGT
MSMEG_0868|M.smegmatis_MC2_155 AGGAGGVSE--------------GEGGTGGHGGDGGRGGDGALGGN-GGT
TH_3810|M.thermoresistible__bu --------------------------SSGTHPMAEDGEHVKALDGRPGLD
MAB_4284c|M.abscessus_ATCC_199 ---------------------------NAGLAGNAGLAGNAGLAGNAGLA
MLBr_01183|M.leprae_Br4923 -------------------------LSAATVASNAAAAQLTTEIAPPAAD
MAV_4827|M.avium_104 PVPVR-------------------IPVPDPVSPPQLLAPPRLSVPQPVQP
Rv1091|M.tuberculosis_H37Rv G----GNGGAAAAGGAGGQA-----------GGGGGNGGNG---------
Mb1121|M.bovis_AF2122/97 G----GNGGAAAAGGAGGQA-----------GGGGGNGGNG---------
MMAR_3316|M.marinum_M G----GSGAAGQAGGAGGAAG------LIGNGGAGGTGGSG---------
MUL_4367|M.ulcerans_Agy99 G----WAGGAGGAGGAGGSAA------FNGVNGAGGAGGNG---------
Mflv_5091|M.gilvum_PYR-GCK G----GDGGTGGTGGTGGTG---------GTGGTGGTGGAG---------
Mvan_1264|M.vanbaalenii_PYR-1 G----GTGGTGGTGGTGGTG---------GTGGTGGTGGAG---------
MSMEG_0868|M.smegmatis_MC2_155 GGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTA
TH_3810|M.thermoresistible__bu G----GNGSHGGNGGHGGRG------------GFLGIGGSG---------
MAB_4284c|M.abscessus_ATCC_199 G-----NAGLAGNAGLAGNAG---------LAGNAGLAGNA---------
MLBr_01183|M.leprae_Br4923 D------VSILLAHFFSGHG-----------RQYQAHASQG---------
MAV_4827|M.avium_104 PVRVPQPPSPPQVGGTVPQSP----------PQHQTPPGEG---------
. . . .
Rv1091|M.tuberculosis_H37Rv ---GNGGNGGNGGNGATGGWLYGNGGAGG-----------------QGAT
Mb1121|M.bovis_AF2122/97 ---GNGGNGGNGGNGATGGWLYGNGGAGG-----------------QGAT
MMAR_3316|M.marinum_M ---AAGGSGAAGGNGGAGGWLFGNGGTGG-----------------TGGD
MUL_4367|M.ulcerans_Agy99 ---GAGGGGGAGASGIGAGVAGGDGGTGG-----------------TGGA
Mflv_5091|M.gilvum_PYR-GCK --DGTGGTGGTGG----TGGQGGQGGQGG-----------------TGGT
Mvan_1264|M.vanbaalenii_PYR-1 --DGLGGTGGTGG----TGGFGGQGGQGG-----------------TGGT
MSMEG_0868|M.smegmatis_MC2_155 TGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGD
TH_3810|M.thermoresistible__bu ---GWGGHGGNGGDTDADGGNGGDGGNGG-----------------SAGR
MAB_4284c|M.abscessus_ATCC_199 ---AVAGNAAVAG----NAAVAGNAAVGG-----------------VLNT
MLBr_01183|M.leprae_Br4923 ---ATNHQDLIQS------LLTSSSAYAG-----------------TETA
MAV_4827|M.avium_104 TPPKPDGPGNYGGGHVPTPGAGGSGGSGG-------------GHVPTPGA
. .... .*
Rv1091|M.tuberculosis_H37Rv AGAGG-AGANGVSS-----------------------TNGGGT-----GG
Mb1121|M.bovis_AF2122/97 AGAGG-AGANGVSS-----------------------TNGG--------G
MMAR_3316|M.marinum_M AVAGL-PGLNGGNG-----------------------GNGGAGGAAGWWG
MUL_4367|M.ulcerans_Agy99 AGTGG-AAGTGGTG-----------------------GAAGAAGSAGDGG
Mflv_5091|M.gilvum_PYR-GCK GGQGG-LGGGGGTG-----------------------GQGGTG------G
Mvan_1264|M.vanbaalenii_PYR-1 GGQGG-LGGVGGTG-----------------------GTGGTG------G
MSMEG_0868|M.smegmatis_MC2_155 GGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSG------I
TH_3810|M.thermoresistible__bu GGTGGLRGVFG--------------------------------------I
MAB_4284c|M.abscessus_ATCC_199 GVSGAIGGSSHVGG----------------------------------AI
MLBr_01183|M.leprae_Br4923 NHDSL---------------------------------------------
MAV_4827|M.avium_104 GGSGGSGGGHVPTP-----------------------------------G
.
Rv1091|M.tuberculosis_H37Rv NGGIGGTG--GSGGAGGN-----AGLLGVGGAGGHG------------AS
Mb1121|M.bovis_AF2122/97 NGGIGGTG--GSGGAGGN-----AGLLGVGGAGGHG------------AS
MMAR_3316|M.marinum_M HGGIGGQG--GTGGAAGGNPGIYAGNAGTGGDGGAGG--------WLFGD
MUL_4367|M.ulcerans_Agy99 AGGAGGAGDDGSAGVVSGDPGTAGKAGGAGGAGGVGGNGVAGGVNGSGGA
Mflv_5091|M.gilvum_PYR-GCK TGGQGGTG--GTGGTGGTG--------GTGGAGGDGG---------LGGL
Mvan_1264|M.vanbaalenii_PYR-1 TGGQGGTG--GTGGTGGTG--------GTGGAGGDGG---------LGGL
MSMEG_0868|M.smegmatis_MC2_155 NGGHGGNG--GQGTIEANGPSAVASGIGAGGNGGDGI---------DGGL
TH_3810|M.thermoresistible__bu NGGNGRAG--------------------LGGRGXXXX-------------
MAB_4284c|M.abscessus_ATCC_199 NESLGGSG-------------------SVGGSTAVGG-------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 TGGPGGTG---------------------GSGGGHVP-------------
Rv1091|M.tuberculosis_H37Rv GGAGDRGGAGGTG----FISSDGGAGGDGGDG------------------
Mb1121|M.bovis_AF2122/97 GGAGDRGGAGGTG----FISSDGGAGGDGGDG------------------
MMAR_3316|M.marinum_M AGAGGQGGTGGAANDPLVTSSTGGSGGAGGNGGAA------------GLF
MUL_4367|M.ulcerans_Agy99 GGAGGAGGTGGAGASGVPASVDGGDGGAGGAGGAAGTGGSGGSAGNTGAG
Mflv_5091|M.gilvum_PYR-GCK GGFGGSGGTGGQGGLGGPGGSTGGAGGAGG------------------QA
Mvan_1264|M.vanbaalenii_PYR-1 GGFGGVGGTGGQGGQGGPGGSTGGAGGAGG------------------QA
MSMEG_0868|M.smegmatis_MC2_155 GGNGGDGVVNTTANAANPGSATGTATGGDGGK----------------AT
TH_3810|M.thermoresistible__bu --GGGVGAAVRSG--------NGVFSGGGG--------------------
MAB_4284c|M.abscessus_ATCC_199 GAHTGVGGGVSTGVGVGSHVGGGISESLGGSG------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --TPGAGTPGGSGGGHLPFPGAGSTPGGSGGG----------------HL
Rv1091|M.tuberculosis_H37Rv GNGGAGGTGG--------LLFGAGGNGGPGGSGG-AADIGGNGG-AGNGG
Mb1121|M.bovis_AF2122/97 GNGGAGGTGG--------LLFGAGGNGGPGGSGG-AADIGGNGG-AGNGG
MMAR_3316|M.marinum_M GAGGAGGTGGTAGDG--YLIGGDGGNGGQGGYGGWLAGSGGAGGTAGDGG
MUL_4367|M.ulcerans_Agy99 GAGGAGGAGGSAASTGVNGDGGAGGAGGVGGLGGDSAATAGGGGAGGDGG
Mflv_5091|M.gilvum_PYR-GCK GTAGKGGLFG---------GSGSAGKAGATGAAGASGGKGAQGATGAQGA
Mvan_1264|M.vanbaalenii_PYR-1 GVAGKGGLFG---------GSGSAGTAGVTGASGASGGKGAQGATGAQGA
MSMEG_0868|M.smegmatis_MC2_155 GTASQGGNGGPS-----WVQSGYGSTLGGNATGTATAGKGGEASNGGVAG
TH_3810|M.thermoresistible__bu -TPSAG--------------------FGVPTTIQFPAGSCTSRAVSREGI
MAB_4284c|M.abscessus_ATCC_199 SVGGSTAVGG----------GAHTGVGGGVSTGVGVGSHVGGGISESLGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 PTPGAGTPGG-----------------GLGGFGGGHAPAPGGGLGGGGGH
Rv1091|M.tuberculosis_H37Rv G-----TDGNGGNGGSGGGAGSGGDGGGAGGNGAWLFGN-----------
Mb1121|M.bovis_AF2122/97 G-----TDGNGGNGGSGGGAGSGGDGGGAGGNGAWLFGN-----------
MMAR_3316|M.marinum_M AGI--YPGGAGGTGGSGGAARFFGDGGAAGTGGVGGFGSK---------Y
MUL_4367|M.ulcerans_Agy99 KG---GAGGAGVNGVGGGDGGKGGTGGAGGAGGAGSDGIIP--------S
Mflv_5091|M.gilvum_PYR-GCK TG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG-----------
Mvan_1264|M.vanbaalenii_PYR-1 TG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG-----------
MSMEG_0868|M.smegmatis_MC2_155 NGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGA
TH_3810|M.thermoresistible__bu MP------SSRAASARAGAACASSTSRSRRSFCCSRA-------------
MAB_4284c|M.abscessus_ATCC_199 SG------SVGGSTAVGGGAHTGVGGGVNTGVGVGSHVG-----------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 AP---------APGGGLGGFGGGHSGGGLGGLGGGHK-------------
Rv1091|M.tuberculosis_H37Rv -GGAGGGGGKG---------GNGAGGGLGG-GSFGLPGLN-GSGGD----
Mb1121|M.bovis_AF2122/97 -GGAGGGGGKG---------GNGAGGGLGG-GSFGLPGLN-GSGGD----
MMAR_3316|M.marinum_M VAGSGGSGGTGGAAGWLI--GNGGAGGQGG-VAGTPDGVNRVFGGT----
MUL_4367|M.ulcerans_Agy99 NGGLGGNGGNGGNGGQAFGDGVGGAGGIGGKGGNAAIGTIVINGGV----
Mflv_5091|M.gilvum_PYR-GCK TTGAQGSAGTNGA--------NGANGSQGAAGKAGATGTTGATG------
Mvan_1264|M.vanbaalenii_PYR-1 TTGAQGSAGTNGA--------NGANGSQGAAGKAGATGTTGATG------
MSMEG_0868|M.smegmatis_MC2_155 ITDSTAISGHGGAG-------NGGNGGKGADGWVQAYDPAGPVGSKIANS
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -GGISESLGGSGS----------VGGSTAVGGGAHTSAINDALGGS----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv GGDGGNGAPGGVLYG-------NGGAGGQGSSGGIGG-----PGATGGAG
Mb1121|M.bovis_AF2122/97 GGDGGNGAPGGVLYG-------NGGAGGQGSSGGIGG-----PGATGGAG
MMAR_3316|M.marinum_M GGAGGTGGTAGWLYG-------SGGSGGAGGAGTASIY----PGSTGGNG
MUL_4367|M.ulcerans_Agy99 GGAGGSGGLGGATEDGVGGVGCAGGAGGNGGRGDMLFT----VGGSGGTG
Mflv_5091|M.gilvum_PYR-GCK --AAGEDGDAGSGGSG-----INGGAGGAGG-----------AGGEGGEG
Mvan_1264|M.vanbaalenii_PYR-1 --AAGDAGDPGSEAVD-----INGGAGGAGG-----------AGGEGGEG
MSMEG_0868|M.smegmatis_MC2_155 SAVAGNGGDGGVNGTGG----ASGGDGGNGGNTSVWKSGGQTADGEHNTG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GSVGGSTAVGG-------------------------------GAHTSAIN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv GKGGDGGDAQLIGDGGN--GGNGGAGGTGG-----------TPGPGG---
Mb1121|M.bovis_AF2122/97 GKGGDGGDAQLIGDGGN--GGNGGAGGTGG-----------TPGPGG---
MMAR_3316|M.marinum_M GNGGNGGAAQVIGTGGT--GGTAGTGGAGGPDDPPNNIPAGNDGQDG---
MUL_4367|M.ulcerans_Agy99 GDGGGGGSASGSGTGGS--GGTGGVGGIGGDGKLGGFGGDGGDGGDGGFG
Mflv_5091|M.gilvum_PYR-GCK GDGGKGGAGAE--------GGAGGGGGAGGS----------GAGGAG---
Mvan_1264|M.vanbaalenii_PYR-1 GAGGAGGDGSE--------GGAGGSGGAGGS----------GTGGAG---
MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGDGSEPGPGGNGAGGAGGNGGTGGT----------TAGGSGN--
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ESMNSSINASHSSSMNESFGSSMGSHGAAGTG------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv ----PGGSGGLGGLLFGQTGTAGVSP----------
Mb1121|M.bovis_AF2122/97 ----PGGSGGLGGLLFGQTGTAGVSP----------
MMAR_3316|M.marinum_M ----VGGAGGSGGLVFGNSGG---------------
MUL_4367|M.ulcerans_Agy99 VIGGQGGGGGFGGLGGTGAGGAPSDKGINGEPGNPG
Mflv_5091|M.gilvum_PYR-GCK ---GAGGSGGSGGSGGSGGSGGAAGDSDD-------
Mvan_1264|M.vanbaalenii_PYR-1 ---GAGGSGGSGGSGGAGGSGGAAGDSD--------
MSMEG_0868|M.smegmatis_MC2_155 --GGNGGNGGNGGADGTPGTAGTTGANNP-------
TH_3810|M.thermoresistible__bu ------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----FEAQGHAQGHASETAHTTLPGAEHH-------
MLBr_01183|M.leprae_Br4923 ------------------------------------
MAV_4827|M.avium_104 ------------------------------------