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WTSQMIVAPAFVDAAAKDLATIGSAISRANAEALVPITALLPAGADDVSAAIAALFATHGQAYQELSAHA VAFHEQFVQLMSAGAAQYASAEAANSSPLQIVGQTALDAINSPVQTLTGRPLIGNGANGVAGTGQNGGDG GWLYGNGGNGGSGGTGQNGGNGGSAGLWGSGGNGGQGGAGANGAAGQPGKAGGSGGNGGAGGWIYGHGGH GGAGGNGGNATAPGGASAGFDGGAGGNGGSGGRGGLLFGNGGNGSVGGMGGQGTNDTAGDSAGSGGLGGN GGNGAQGGWLIGNGGQGGDSGAGGGTDSTQTGVMNGASGGSAGIAGNGGDAGLVGNGGAGGNGGNGAAGS ALGTTIFGGSGGVGGSGGDGGNGGWLFGSGASGGNGGQGGDAGTNGFAGFGGSAGGGGWVGAVNFGPISV QGFGLFGHGGDGGNGGDVGAGSLSIQFGASGGDGGQGGVLYGNGGNGGNAGSGGGTGFEGSAGQGGAAIL IGNGGAGGNGATGGTGVGNIIQEAGGDGSDGGAGGSGGLLFGSGGAGGIGGAGGVGGSGNDGGNGGDGGQ GGASGLGIGNGGPGGSGGTGGAGGTGGSAGTGGAGGDGGNAALLIGTGGDGGDGVPPAPGGQGGKGGLIG LPGQNGQP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1803c | PE_PGRS32 | - | 100% (639) | PE-PGRS FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv1768 | PE_PGRS31 | e-168 | 50.66% (683) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | e-167 | 47.12% (798) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1831c | PE_PGRS32b | 0.0 | 100.00% (540) | hypothetical protein Mb1831c |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-117 | 46.65% (553) | triple helix repeat-containing collagen |
M. leprae Br4923 | MLBr_01183 | - | 3e-09 | 32.97% (91) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 3e-48 | 34.10% (478) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_3008 | - | 0.0 | 75.91% (635) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 7e-20 | 41.40% (157) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 5e-95 | 36.60% (746) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 8e-41 | 37.58% (322) | PUTATIVE - |
M. ulcerans Agy99 | MUL_2250 | - | 0.0 | 75.75% (635) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-118 | 46.08% (549) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Rv1803c|M.tuberculosis_H37Rv -------------------------------------------------- Mb1831c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_3008|M.marinum_M -------------------------------------------------- MUL_2250|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1803c|M.tuberculosis_H37Rv -------------------------------------------------- Mb1831c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_3008|M.marinum_M -------------------------------------------------- MUL_2250|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1803c|M.tuberculosis_H37Rv --------------------------------------MWTSQMIVAPAF Mb1831c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_3008|M.marinum_M --------------------------------------MSILQVTVVPAV MUL_2250|M.ulcerans_Agy99 --------------------------------------MSILQVTVVPAV Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1803c|M.tuberculosis_H37Rv ------------------------------------------VDAAAKDL Mb1831c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_3008|M.marinum_M ------------------------------------------VEMAANDL MUL_2250|M.ulcerans_Agy99 ------------------------------------------VEMAANDL Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------------VEAASYVADP-- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1803c|M.tuberculosis_H37Rv AT---------------------------------------IGSAISRAN Mb1831c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_3008|M.marinum_M AT---------------------------------------IGSTISQAN MUL_2250|M.ulcerans_Agy99 AT---------------------------------------IGSTISQAN Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------EAALANAGLS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------------------------------MNIVLGVS Rv1803c|M.tuberculosis_H37Rv AEALVPITALLP-----------AGADDVSAAIAALFATHGQAY------ Mb1831c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_3008|M.marinum_M AAALAPITGLLP-----------AGTDEVSAGIAALFEAHGNAY------ MUL_2250|M.ulcerans_Agy99 AAALAPITGLLP-----------AGTDEVSAGIAALFEAHGNAY------ Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AVSAAQVGAVMPVVAESVASNYGYQSQWVNTGN-PIHDLSGNLQNYYAAQ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 MAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGT Rv1803c|M.tuberculosis_H37Rv ----QELSAHAVAFHEQFVQLMSAGAAQYASAEAANSSPLQIVGQTALDA Mb1831c|M.bovis_AF2122/97 ---------------------------------------MQIVGQTALDA MMAR_3008|M.marinum_M ----QTLGAQTLALHEQFVKLMSGGAAQYAAAEAANASPLQTVEQAVLDL MUL_2250|M.ulcerans_Agy99 ----QTLGAQTLALHEQFVKLMSGGAAQYAAAEAANASPLQTVEQAVLDL Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 PDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 REGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAA Rv1803c|M.tuberculosis_H37Rv INSPVQTLTGRPLIGN---GANGVAGTGQNGGDGG--------------- Mb1831c|M.bovis_AF2122/97 INSPVQTLTGRPLIGN---GANGVAGTGQNGGDGG--------------- MMAR_3008|M.marinum_M INSPAVALTGRPLIGN---GADGAAGTGENGGDGG--------------- MUL_2250|M.ulcerans_Agy99 INSPAVALTGRPLIGN---GADGAAGTGENGGDGG--------------- Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT TH_3810|M.thermoresistible__bu --------------------------VDGDGGSGG--------------- MAB_4284c|M.abscessus_ATCC_199 RGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGP-------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 LAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGS--------------- Rv1803c|M.tuberculosis_H37Rv -------------------------------------------------W Mb1831c|M.bovis_AF2122/97 -------------------------------------------------W MMAR_3008|M.marinum_M -------------------------------------------------W MUL_2250|M.ulcerans_Agy99 -------------------------------------------------W Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------------- Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------------- MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------I MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1803c|M.tuberculosis_H37Rv LYGN-------------GGNGGSGGTGQ--------------NGGNGGSA Mb1831c|M.bovis_AF2122/97 LYGN-------------GGNGGSGGTGQ--------------NGGNGGSA MMAR_3008|M.marinum_M LIGN-------------GGNGGSGGVGQ--------------NGGSGGSA MUL_2250|M.ulcerans_Agy99 LIGN-------------GGNGGSGGVGQ--------------NGGSGGSA Mflv_5091|M.gilvum_PYR-GCK AVGAAGAAG------TVGTAGATGGTG---------------TGANGGAG Mvan_1264|M.vanbaalenii_PYR-1 AIGTAGVAG------AAGTAGATGGTG---------------VGGNGGAG MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS TH_3810|M.thermoresistible__bu ------------------RTGLFSKLSR---------------GGDGGDG MAB_4284c|M.abscessus_ATCC_199 ASGQ-------------GSTAVNGDVRD-----------SNIINADHGSN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------IPDVYKQQIR------------------AESYG Rv1803c|M.tuberculosis_H37Rv GLWGSGGNGGQG-----------------GAGANGAAGQPGKAGGSGGN- Mb1831c|M.bovis_AF2122/97 GLWGSGGNGGQG-----------------GAGANGAAGQPGKAGGSGGN- MMAR_3008|M.marinum_M GLWGRGGNGGLG-----------------GTGADGASGQAGSAGGAGGN- MUL_2250|M.ulcerans_Agy99 GLWGRGGNGGLG-----------------GTGADGASGQAGSAGGAGGN- Mflv_5091|M.gilvum_PYR-GCK GVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGGQ- Mvan_1264|M.vanbaalenii_PYR-1 QAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGGQ- MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY TH_3810|M.thermoresistible__bu ---GLGGNGGHG-------------------GGTGIISLLSLAG------ MAB_4284c|M.abscessus_ATCC_199 VGVDQSQTRVGG-----------DYTNVSGHGSADIDKSVTVVDDHSQR- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 DAAGQLSAMVAG-----------------LEKLESLPGGLLLVGSG---- Rv1803c|M.tuberculosis_H37Rv -------------------------GGAGG-------------------- Mb1831c|M.bovis_AF2122/97 -------------------------GGAGG-------------------- MMAR_3008|M.marinum_M -------------------------GGAGG-------------------- MUL_2250|M.ulcerans_Agy99 -------------------------GGAGG-------------------- Mflv_5091|M.gilvum_PYR-GCK -GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG----------- Mvan_1264|M.vanbaalenii_PYR-1 -GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG----------- MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------NTTNINDS---------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv1803c|M.tuberculosis_H37Rv --WIYGHGGHGGAGGNGGNATAPGG----------------ASAGFDGGA Mb1831c|M.bovis_AF2122/97 --WIYGHGGHGGAGGNGGNATAPGG----------------ASAGFDGGA MMAR_3008|M.marinum_M --WIYGHGGDGGIGGAGGNATASGT----------------VPAGLDGGA MUL_2250|M.ulcerans_Agy99 --WIYGHGGDGGIGGAGGNATASGS----------------VAAGLDGGA Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV TH_3810|M.thermoresistible__bu ---------NGGNGGNGYRTTDNNA--------------------LDGGH MAB_4284c|M.abscessus_ATCC_199 --FNTDRSTNIGSGNTTNTEIGSHN---------------QANIGTSTSA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---VDVAPLKQVLQTTTFLDVSVAE------------------EPETALA Rv1803c|M.tuberculosis_H37Rv GGNGGSGGRGGLLF-----------------GNGGNGSV----------- Mb1831c|M.bovis_AF2122/97 GGNGGSGGRGGLLF-----------------GNGGNGSV----------- MMAR_3008|M.marinum_M GGAGGSGGHAGLLF-----------------GNGGSGGL----------- MUL_2250|M.ulcerans_Agy99 GGAGGSGGHAGLLF-----------------GNGGSGGL----------- Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD----------- Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN----------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP TH_3810|M.thermoresistible__bu GGNGGNVGFFSLFN------------------------------------ MAB_4284c|M.abscessus_ATCC_199 GGSAAVGGNAGLAG------------------NAGLAGN----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 RGAALAAANAPLFAS----------------STAALAYAQ---------- Rv1803c|M.tuberculosis_H37Rv -----------GGMGGQGTNDTAG-DSAGSGGLGG--------------- Mb1831c|M.bovis_AF2122/97 -----------GGMGGQGTNDTAG-DSAGSGGLGG--------------- MMAR_3008|M.marinum_M -----------GGVGGQATGATTSSDLGGVGGAGG--------------- MUL_2250|M.ulcerans_Agy99 -----------GGVGGQATGATTSSDLGGVGGAGG--------------- Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG--------------- MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ TH_3810|M.thermoresistible__bu -------------LGGAGGWGGSG--VDGVDVVGG--------------- MAB_4284c|M.abscessus_ATCC_199 -----------AGLAGNAGLAGNAGLAGNAGLAGN--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------DPGTGAVDQYSLPDYLYVPVDPEPGD-------------- Rv1803c|M.tuberculosis_H37Rv --NGGNGAQGG--------WLIGNGGQGGDSGAGGGTDSTQTG--VMNGA Mb1831c|M.bovis_AF2122/97 --NGGNGAQGG--------WLIGNGGQGGDSGAGGGTDSTQTG--VMNGA MMAR_3008|M.marinum_M --NGGSGAHGG--------WLIGNAGNGGDSGGGGGSDETQSG--VMNGA MUL_2250|M.ulcerans_Agy99 --NGGSGAHGG--------WLIGNAGNGGDSGSGGGSDETQTG--VMNGA Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT--GGTGG Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT--GGTGG MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGH--GGDGG TH_3810|M.thermoresistible__bu ---------------------NPDGGTPGAHGESHTPGVYTDR--QGEDG MAB_4284c|M.abscessus_ATCC_199 ---AGLAGNAG---------LAGNAGLAGNAGLAGNAGLAGNAGLAGNAG MLBr_01183|M.leprae_Br4923 ------------------------------MPLFLNAEPQALT--AAANT MAV_4827|M.avium_104 -DELAYSAVGEE-------DAESPTVVIEKLFLPEDSEPRRRPVLLVGSG Rv1803c|M.tuberculosis_H37Rv SGGSAGIAGNGGDAG-LVGNGGAGGNGGNGAAG--------SALG-TTIF Mb1831c|M.bovis_AF2122/97 SGGSAGIAGNGGDAG-LVGNGGAGGNGGNGAAG--------SALG-TTIF MMAR_3008|M.marinum_M TGGSAGLAGGGGDAG-VIGNGGAGGSGGKGAAG--------STLGGASIF MUL_2250|M.ulcerans_Agy99 TGGSAGLAGGGGDAG-VIGNGGAGGSGGKGAAG--------STLGGASIF Mflv_5091|M.gilvum_PYR-GCK KGGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 KGGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 RGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGN TH_3810|M.thermoresistible__bu EDGTG---------------TGIGGRGGNGGSS-----------SGTHPM MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAG----NAGLAGNAGLAGNAG--------LAGNAGLA MLBr_01183|M.leprae_Br4923 LEGLS--------------AATVASNAAAAQLT-----------TEIAPP MAV_4827|M.avium_104 LAVVGISAVLALEIALAIGIRTTGTVALQPTPN-------QHLIVPTEQA . . . Rv1803c|M.tuberculosis_H37Rv GGSG------------GVGGSGGDGG------NGGWLFGSGA-------- Mb1831c|M.bovis_AF2122/97 GGSG------------GVGGSGGDGG------NGGWLFGSGA-------- MMAR_3008|M.marinum_M GGSG------------GNGGSAGDGG------AGGLVLGNGG-------- MUL_2250|M.ulcerans_Agy99 GGSG------------GNGGSAGDGG------AGGLVLGNGG-------- Mflv_5091|M.gilvum_PYR-GCK GGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG-------- Mvan_1264|M.vanbaalenii_PYR-1 GGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG-------- MSMEG_0868|M.smegmatis_MC2_155 GGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATV TH_3810|M.thermoresistible__bu AEDG-------------EHVKALDGR-------PGLDGGNGS-------- MAB_4284c|M.abscessus_ATCC_199 GNAG-------------LAGNAGLAG-------NAAVAGNAA-------- MLBr_01183|M.leprae_Br4923 AADD-------------VSILLAH-----------FFSGHGR-------- MAV_4827|M.avium_104 PAPP------------PVQASAPQPK----ISVPEPVAAPKP-------- . Rv1803c|M.tuberculosis_H37Rv ---------SGGNGGQGGDAGTNGFAG----------------------- Mb1831c|M.bovis_AF2122/97 ---------SGGNGGQGGDAGTNGFAG----------------------- MMAR_3008|M.marinum_M ---------AGGNGGQGGDAGANGFAG----------------------- MUL_2250|M.ulcerans_Agy99 ---------AGGNGGQGGDAGANGFAG----------------------- Mflv_5091|M.gilvum_PYR-GCK ---------TGGTGGQGG-LGGGGGTG----------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------TGGTGGQGG-LGGVGGTG----------------------- MSMEG_0868|M.smegmatis_MC2_155 IGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATD TH_3810|M.thermoresistible__bu ---------HGGNGGHGG---RGGFLG----------------------- MAB_4284c|M.abscessus_ATCC_199 ---------VAGNAAVAGNAAVGGVLN----------------------T MLBr_01183|M.leprae_Br4923 ---------QYQAHASQGATNHQDLIQ----------------------- MAV_4827|M.avium_104 ------LSPPVAAPLPAAPPPAAPPLP----------------------- . Rv1803c|M.tuberculosis_H37Rv -FGGSAGGGGWVGAVNFGPISVQG-------FGLFGHGGDG---GNGGDV Mb1831c|M.bovis_AF2122/97 -FGGSAGGGGWVGAVNFGPISVQG-------FGLFGHGGDG---GNGGDV MMAR_3008|M.marinum_M -FGGLGGEGGWVGNITLGPIGVDG-------VGLIGHGGDG---GNAGDV MUL_2250|M.ulcerans_Agy99 -FGGLGGEGGWVGNITLGPIGVDG-------VGLIGHGGDG---GNAGDV Mflv_5091|M.gilvum_PYR-GCK GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFG Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFG MSMEG_0868|M.smegmatis_MC2_155 GHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNG TH_3810|M.thermoresistible__bu -IGGSGGWGGHGGNG--GDTDADG-----------GNGGDG---GNGGSA MAB_4284c|M.abscessus_ATCC_199 GVSGAIGGSSHVGGAINESLGGSG------SVGGSTAVGGGAHTGVGGGV MLBr_01183|M.leprae_Br4923 --SLLTSSSAYAGTETANHDSL---------------------------- MAV_4827|M.avium_104 EAPPIPAAPPVVPVPVVVPPVPVP-------VPVRIPVPDPVSPPQLLAP Rv1803c|M.tuberculosis_H37Rv GAGSLSIQFG------ASGGDGGQGG----VLYGNGGNGG----NAGSGG Mb1831c|M.bovis_AF2122/97 GAGSLSIQFG------ASGGDGGQGG----VLYGNGGNGG----NAGSGG MMAR_3008|M.marinum_M GAGSLSVQFG------ETGGSGGQGG----LLYGNGGNGG----NAGSGG MUL_2250|M.ulcerans_Agy99 GAGSLSVQFG------ETGGSGGQGG----LLYGNGGNGG----NAGSGG Mflv_5091|M.gilvum_PYR-GCK GSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAG Mvan_1264|M.vanbaalenii_PYR-1 GVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAG MSMEG_0868|M.smegmatis_MC2_155 GDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGS TH_3810|M.thermoresistible__bu GRG-------------GTGGLRGVFG-------INGGNGR-----AGLGG MAB_4284c|M.abscessus_ATCC_199 STGVGVGSHVGGGISESLGGSGSVGG-----STAVGGGAH-----TGVGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PRLSVPQPVQPPVRVPQPPSPPQVGG-------TVPQSPPQHQTPPGEGT Rv1803c|M.tuberculosis_H37Rv GTGFEGSAGQ-GGAAILIGNGGAGGNG-------------ATGGTGVGNI Mb1831c|M.bovis_AF2122/97 GTGFEGSAGQ-GGAAILIGNGGAGGNG-------------ATGGTGVGNI MMAR_3008|M.marinum_M TSGFEGVAGQ-GGAAMLIGNGGAGGNG-------------ATGGTGFGNV MUL_2250|M.ulcerans_Agy99 TSGFEGVAGQ-GGAAMLIGNGGAGGNG-------------ATGGTGFGNV Mflv_5091|M.gilvum_PYR-GCK KAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGA Mvan_1264|M.vanbaalenii_PYR-1 TAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGS MSMEG_0868|M.smegmatis_MC2_155 TLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGD TH_3810|M.thermoresistible__bu RGXXX--XGGGVGAAVRSGNGVFSGGG-------------GTPSAGFGVP MAB_4284c|M.abscessus_ATCC_199 GVSTGVGVGSHVGGGISESLGGSGSVG-------------GSTAVGGGAH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PPKPDGPGNYGGGHVPTPGAGGSGGSG-----------GGHVPTPGAGGS Rv1803c|M.tuberculosis_H37Rv IQEAGGDGSDGGAGG-----------------SGGLLFGSGGAGGIGGAG Mb1831c|M.bovis_AF2122/97 IQEAGGDGSDGGAGG-----------------SGGLLFGSGGAGGIGGAG MMAR_3008|M.marinum_M LQESGGAGSDGGIGG-----------------SGGLLFGNGGAGGNAGDG MUL_2250|M.ulcerans_Agy99 LQESGGAGSDGGIGG-----------------SGGLLFGNGGAGGNAGDG Mflv_5091|M.gilvum_PYR-GCK TGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG Mvan_1264|M.vanbaalenii_PYR-1 AGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG MSMEG_0868|M.smegmatis_MC2_155 GGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADG TH_3810|M.thermoresistible__bu TTIQFPAG-------------------------------SCTSRAVSREG MAB_4284c|M.abscessus_ATCC_199 TGVGGGVNTGVGVGS---------------HVGGGISESLGGSGSVGGST MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GGSGGGHVPTPGTGG-----------------------PGGTGGSGGGHV Rv1803c|M.tuberculosis_H37Rv GVGGSGNDGGNG----------GDGGQGGASGLGIGNGGPGGSGG----- Mb1831c|M.bovis_AF2122/97 GVGGSGNDGGNG----------GDGGQGGASGLGIGNGGPGGSGG----- MMAR_3008|M.marinum_M GVGGTGFDGGDG----------GVGGQGGSSGLLFGNGGDGGDGG----- MUL_2250|M.ulcerans_Agy99 GVGGTGFDGGDG----------GVGGQGGSSGLLFGNGGDGGDGG----- Mflv_5091|M.gilvum_PYR-GCK KAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG----- Mvan_1264|M.vanbaalenii_PYR-1 KAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG----- MSMEG_0868|M.smegmatis_MC2_155 WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVW TH_3810|M.thermoresistible__bu IMPSSRAASARA-------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AVGGGAHTSAIN---------DALGGSGSVGGSTAVGGGAHTSAIN---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PTPGAGTPGGSG------------GGHLPFPGAGSTPGGSGGGHLP---- Rv1803c|M.tuberculosis_H37Rv ------TGGAGGTGGSAGTGG--------------AGGDGGNAALLIGTG Mb1831c|M.bovis_AF2122/97 ------TGGAGGTGGSAGTGG--------------AGGDGGNAALLIGTG MMAR_3008|M.marinum_M ------AGGAGGTGGSAGTGG--------------AGGNGGNAALLIGTG MUL_2250|M.ulcerans_Agy99 ------AG---GTGGSAGTGG--------------AGGNGGNAALLIGTG Mflv_5091|M.gilvum_PYR-GCK ------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGA Mvan_1264|M.vanbaalenii_PYR-1 ------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGA MSMEG_0868|M.smegmatis_MC2_155 KSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGS TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------ESMNSSINASHSSSMN-------------ESFGSSMGSHGAAGT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----TPGAGTPGGGLGGFGGG-------------HAPAPGGGLGGGGGH Rv1803c|M.tuberculosis_H37Rv GDGGDGVPPAPGGQGGKGGLIGLPGQNGQP Mb1831c|M.bovis_AF2122/97 GDGGDGVPPAPGGQGGKGGLIGLPGQNGQP MMAR_3008|M.marinum_M GNGGAGVPPASGGSGGRGGLIGSAGQNG-- MUL_2250|M.ulcerans_Agy99 GNGGAGVPPASGGSGGRGGLIGSAGQNG-- Mflv_5091|M.gilvum_PYR-GCK G--GAGGSGGSGGSGGSGGSGGAAGDSDD- Mvan_1264|M.vanbaalenii_PYR-1 G--GAGGSGGSGGSGGAGGSGGAAGDSD-- MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGNGGNGGADGTPGTAGTTGANNP- TH_3810|M.thermoresistible__bu -----GAACASSTSRSRRSFCCSRA----- MAB_4284c|M.abscessus_ATCC_199 GFEAQGHAQGHASETAHTTLPGAEHH---- MLBr_01183|M.leprae_Br4923 ------------------------------ MAV_4827|M.avium_104 APAPGGGLGGFGGGHSGGGLGGLGGGHK--