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MPGRFREDFIDALRSKIGEKSMGVYGVDYPATTDFPTAMAGIYDAGTHVEQTAANCPQSKLVLGGFSQGA AVMGFVTAAAIPDGAPLDAPRPMPPEVADHVAAVTLFGMPSVAFMHSIGAPPIVIGPLYAEKTIQLCAPG DPVCSSGGNWAAHNGYADDGMVEQAAVFAAGRLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1758 | cut1 | - | 100% (174) | PROBABLE CUTINASE CUT1 |
| M. tuberculosis H37Rv | Rv3724B | cut5b | 3e-49 | 56.63% (166) | cutinase |
| M. tuberculosis H37Rv | Rv1984c | cfp21 | 4e-41 | 48.85% (174) | cutinase precursor CFP21 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1788 | cut1 | 6e-97 | 98.26% (172) | cutinase Cut1 |
| M. gilvum PYR-GCK | Mflv_4439 | - | 4e-56 | 59.88% (172) | cutinase |
| M. leprae Br4923 | MLBr_00099 | - | 1e-05 | 30.63% (111) | hypothetical protein MLBr_00099 |
| M. abscessus ATCC 19977 | MAB_3272c | - | 8e-44 | 52.33% (172) | cutinase Cut1 |
| M. marinum M | MMAR_2419 | cut1 | 1e-53 | 58.93% (168) | cutinase Cut1 |
| M. avium 104 | MAV_2961 | - | 2e-59 | 62.21% (172) | cutinase Cut3 |
| M. smegmatis MC2 155 | MSMEG_1184 | - | 3e-53 | 58.08% (167) | serine esterase, cutinase family protein |
| M. thermoresistible (build 8) | TH_0238 | - | 1e-53 | 58.33% (168) | serine esterase, cutinase family protein |
| M. ulcerans Agy99 | MUL_1597 | cut1 | 7e-53 | 57.74% (168) | cutinase Cut1 |
| M. vanbaalenii PYR-1 | Mvan_5804 | - | 4e-44 | 53.49% (172) | cutinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1758|M.tuberculosis_H37Rv --------------------------------------------------
Mb1788|M.bovis_AF2122/97 --------------------------MVTTWALLFAPVP--AASADPPDP
MMAR_2419|M.marinum_M -------------MGNYSGMNASHVVRFLGPAVITACGLSASVFSAVAIP
MUL_1597|M.ulcerans_Agy99 ------------------------------------------MFSAVAIP
TH_0238|M.thermoresistible__bu ----------------LSRIGSAVGAALTTASLITGTVITSTVVAGTAVP
MAV_2961|M.avium_104 -------------------------MLSPFWALLLG-----PALVGTAAP
Mflv_4439|M.gilvum_PYR-GCK -------------MGLSECLSGVTAPGLALAAGLLLAPHAFAQPALTPAP
MSMEG_1184|M.smegmatis_MC2_155 -----------------MRLAGLVAVAAAATSGMQIA----AMPSAMAAP
MAB_3272c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5804|M.vanbaalenii_PYR-1 ------------------------MNIFSRWLAVAASVVAVTGGLPLAAA
MLBr_00099|M.leprae_Br4923 MVEKVPRKRHRVLAWTAALSMAAVVALAIVAVVILLRSAESPRSSLPPGV
Rv1758|M.tuberculosis_H37Rv ----------------------------------MP---GRFRE--DFID
Mb1788|M.bovis_AF2122/97 TVSDGA---------------CPDVEVVFARGTGEPPGVGGIGE--DFID
MMAR_2419|M.marinum_M SASAEP---------------CPDVEVVFARGTGEPPGLGPTGQ--AFVN
MUL_1597|M.ulcerans_Agy99 SASAEP---------------CPDVEVVFARGTGEPPGLGPTGQ--AFVN
TH_0238|M.thermoresistible__bu AAAAQP---------------CPDVQVVFARGTGEPPGVGPTGQ--AFID
MAV_2961|M.avium_104 -AAADS---------------CPDVEVVFARGTSEPPGVGRIGQ--SFVD
Mflv_4439|M.gilvum_PYR-GCK GPAPPPIAAPAPEPLAAPVAGCPDVEIVFARGTTEAPGLGAMGQ--AFVE
MSMEG_1184|M.smegmatis_MC2_155 ---------------------CPDAEVIFARGTTELPGLGPTGD--AFVE
MAB_3272c|M.abscessus_ATCC_199 ---------------------------MFARGTFEPPGVGGTGE--SFVN
Mvan_5804|M.vanbaalenii_PYR-1 PAYAAP---------------CPDVEVVFARGTFEPPGIGATGQ--AFVD
MLBr_00099|M.leprae_Br4923 LPIPSTAPHPRKPRPAFQDVSCPDVQLLVVPGTWESSLQDNPLDPVQFPD
. : * :
Rv1758|M.tuberculosis_H37Rv ALR--------SKIGEKSMGVYGVDYPATTDFPTA-----------MAGI
Mb1788|M.bovis_AF2122/97 ALR--------SKIGEKSMGVYGVDYPATTDFPTA-----------MAGI
MMAR_2419|M.marinum_M SLR--------SHIGGRSLDVYPVNYPASDNWDTG-----------LDGI
MUL_1597|M.ulcerans_Agy99 SLR--------SHIGGRSLDVYPVNYPASDNWDTG-----------LDGI
TH_0238|M.thermoresistible__bu ALR--------PRVGDRSLDVYAVNYPAIDVWNTG-----------IDGI
MAV_2961|M.avium_104 TLR--------SRLGTKSVGVYPVNYPATTDFPTA-----------ADGI
Mflv_4439|M.gilvum_PYR-GCK DLR--------SRLGGKTVGVYAVDYPASPDFPTA-----------VEGI
MSMEG_1184|M.smegmatis_MC2_155 ALR--------PQLGDKTLGVYAVDYPATTAFSTA-----------VQGI
MAB_3272c|M.abscessus_ATCC_199 ALR--------ARTKGKSVEVYPVEYPASLAFATA-----------ADGV
Mvan_5804|M.vanbaalenii_PYR-1 SLR--------SRAGGRTVDVYAVNYPASFDFATA-----------ADGV
MLBr_00099|M.leprae_Br4923 ALLRNSTMTIGQQFPTSRVQTYTIPYTAQFHNPLSGDKQMTYNDSRAEGT
* : : .* : *.* . *
Rv1758|M.tuberculosis_H37Rv YDAGTHVEQTAANCPQSKLVLGGFSQGAAVMGFVTAAA------------
Mb1788|M.bovis_AF2122/97 YDAGTHVEQTAANCPQSKLVLGGFSQGAAVMGFVTAAA------------
MMAR_2419|M.marinum_M RDAGTHVVSMAGQCPQTKMVLGGYSQGAAVMGFVTSAA------------
MUL_1597|M.ulcerans_Agy99 RDAGTHVVSMAGQCPQTKMVLGGYSQGTAVMSFVTSAA------------
TH_0238|M.thermoresistible__bu RDAGAHVVRMAEQCPDTRLVLGGFSQGAAVMGFVTSAE------------
MAV_2961|M.avium_104 SDAGAHVQQMAANCPRTKMVLGGYSQGAAVMGFVTESA------------
Mflv_4439|M.gilvum_PYR-GCK ADASTHVQQIAMNCPDTKLVLGGYSQGAAVMGFVTTEL------------
MSMEG_1184|M.smegmatis_MC2_155 ADARARILANAANCPDTKMVLGGFSQGAAVMGFVTSSA------------
MAB_3272c|M.abscessus_ATCC_199 IDASNRVKDVAARCPNTKIVMGGFSQGAAVVAYTTADA------------
Mvan_5804|M.vanbaalenii_PYR-1 IDASNRVVTMAANCPDTQLVLGGFSQGAAVAAYITEDT------------
MLBr_00099|M.leprae_Br4923 RAMVQEMINVNNKCPLTSYVLVGFSQGAVIAGDITSDIGNGHGPVDDDLV
.: .** : *: *:***:.: . *
Rv1758|M.tuberculosis_H37Rv -----IPDG-APLDAPR-PMPPEVADHVAAVTLFGMPSVAFMHSIG--AP
Mb1788|M.bovis_AF2122/97 -----IPDG-APLDAPR-PMPPEVADHVAAVTLFGMPSVAFMHSIG--AP
MMAR_2419|M.marinum_M -----VPAGVDPATVPK-PLQPDVAEHVAAVVLFGMPNVRAMDFLG--EP
MUL_1597|M.ulcerans_Agy99 -----VPAGVDPATVPK-PLQPDVAEHVAAVVLFGMPNVRAMNFLG--EP
TH_0238|M.thermoresistible__bu -----VPAGVDPATVPK-PLDPDIAEHVAAVVLFGMPNARAMNFLG--TP
MAV_2961|M.avium_104 -----VPDGVQLVQSLQ-PMPAAVANHVAAVALFGKPSAQFMSIIN--EP
Mflv_4439|M.gilvum_PYR-GCK -----IPDGVSLSEVPA-PMPPDIADHVAAVALLGAPSDRFMDMIK--QP
MSMEG_1184|M.smegmatis_MC2_155 -----VPDGVSPTEVPA-PMPPEIADHVAAVALFGKPSPRFMRVLN--DP
MAB_3272c|M.abscessus_ATCC_199 -----VPPGFELPEGITGPMPAEVADHVAAVALFGKPSSGFLQRIDNTAP
Mvan_5804|M.vanbaalenii_PYR-1 -----IPEGYTPPPGMTGPMPPSVADNVAAVALFGKPSSGFLQMIYTGAP
MLBr_00099|M.leprae_Br4923 LGVTLIADGRRQQGVGN-DIGPNPPGEGAEVTLHEVPVLSGLGMTMTGAR
:. * : . . . * *.* * :
Rv1758|M.tuberculosis_H37Rv PIVIGPLYAEKTIQLCAPGDPVCSS-GGNWAAHNGYADDG-MVEQA----
Mb1788|M.bovis_AF2122/97 PIVIGPLYAEKTIQLCAPGDPVCSS-GGNWAAHNGYADDG-MVEQA----
MMAR_2419|M.marinum_M AVEIGPAYQAKTIKVCVPEDPVCSD-GLNFAAHNAYADDGAVVDQG----
MUL_1597|M.ulcerans_Agy99 AVEIGPAYQAKTIKVCVPEDPVCSD-GLNFAAHNAYADDGAVVDQG----
TH_0238|M.thermoresistible__bu PVVIGPLYEDKTVKLCAVDDPVCSN-GMNFAAHNTYATNAAMVDQG----
MAV_2961|M.avium_104 PVTIGPLYAAKTIELCVPGDPICSG-AVNPAAHRQYVEAG-MVDQA----
Mflv_4439|M.gilvum_PYR-GCK PVTIGALYQPKTLELCVPGDFVCSP-GNDLGAHARYISDG-LVVQA----
MSMEG_1184|M.smegmatis_MC2_155 PVVVGPYYASKAIDLCVENDLVCDPKGSSFAVHNQYQEFG-LVTQA----
MAB_3272c|M.abscessus_ATCC_199 PINIGHLYVAKTMDMCVPEDPICSPDGSDNAAHGSYGDNG-MTSQA----
Mvan_5804|M.vanbaalenii_PYR-1 PINVGSRYAAKTLDLCIPEDPVCSPTGRDNAAHGGYALTG-MTDRA----
MLBr_00099|M.leprae_Br4923 PGGFG-VLHSRTNEICAPGDLICAAPAEAFSVANLPATLNTLASGAGQPI
. .* :: .:* * :* . .. :. .
Rv1758|M.tuberculosis_H37Rv -AVFAAGRLG----------------------------------------
Mb1788|M.bovis_AF2122/97 -AVFAAGRLG----------------------------------------
MMAR_2419|M.marinum_M -VAFAASRLGGDPG------------------------------------
MUL_1597|M.ulcerans_Agy99 -VAFAASRLGGDPG------------------------------------
TH_0238|M.thermoresistible__bu -AAFAADRLGVASD------------------------------------
MAV_2961|M.avium_104 -VDFTTDRV-----------------------------------------
Mflv_4439|M.gilvum_PYR-GCK -ADFAVGKL-----------------------------------------
MSMEG_1184|M.smegmatis_MC2_155 -ATFVAQKLQADWAAEEATDEESTDEATPAPRTPPTRTPSPLSAPVGATP
MAB_3272c|M.abscessus_ATCC_199 -ADFAARQIN----------------------------------------
Mvan_5804|M.vanbaalenii_PYR-1 -AEFAVRNMPRHGSE-----------------------------------
MLBr_00099|M.leprae_Br4923 HAMYATAQFWDLDG------------------------------------
. :.. ..
Rv1758|M.tuberculosis_H37Rv -------------------------------
Mb1788|M.bovis_AF2122/97 -------------------------------
MMAR_2419|M.marinum_M -----GPVPAPSSG--FGN------------
MUL_1597|M.ulcerans_Agy99 -----GPVPAPSSG--FGN------------
TH_0238|M.thermoresistible__bu -----KPLPTPSSGQNFGN------------
MAV_2961|M.avium_104 -------------------------------
Mflv_4439|M.gilvum_PYR-GCK -----AETPAESGGAPA--------------
MSMEG_1184|M.smegmatis_MC2_155 PVQQIASTPAPVGTGPLPGPAVPPPPTAPLA
MAB_3272c|M.abscessus_ATCC_199 -----SPTDTVSAAG----------------
Mvan_5804|M.vanbaalenii_PYR-1 -----QPVDLAAGPR----------------
MLBr_00099|M.leprae_Br4923 -----APATVWTLNWVHRLIEGAPHPKHG--