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MVTTWALLFAPVPAASADPPDPTVSDGACPDVEVVFARGTGEPPGVGGIGEDFIDALRSKIGEKSMGVYG VDYPATTDFPTAMAGIYDAGTHVEQTAANCPQSKLVLGGFSQGAAVMGFVTAAAIPDGAPLDAPRPMPPE VADHVAAVTLFGMPSVAFMHSIGAPPIVIGPLYAEKTIQLCAPGDPVCSSGGNWAAHNGYADDGMVEQAA VFAAGRLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1788 | cut1 | - | 100% (218) | cutinase Cut1 |
| M. bovis AF2122 / 97 | Mb3751 | cut5 | 8e-68 | 57.85% (223) | cutinase precursor CUT5 |
| M. bovis AF2122 / 97 | Mb2006c | cfp21 | 1e-50 | 48.20% (222) | cutinase precursor CFP21 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4439 | - | 3e-68 | 58.85% (209) | cutinase |
| M. tuberculosis H37Rv | Rv1758 | cut1 | 8e-97 | 98.26% (172) | cutinase Cut1 |
| M. leprae Br4923 | MLBr_00099 | - | 1e-08 | 27.35% (223) | hypothetical protein MLBr_00099 |
| M. abscessus ATCC 19977 | MAB_3272c | - | 4e-52 | 55.32% (188) | cutinase Cut1 |
| M. marinum M | MMAR_2419 | cut1 | 3e-67 | 58.85% (209) | cutinase Cut1 |
| M. avium 104 | MAV_2961 | - | 4e-73 | 61.68% (214) | cutinase Cut3 |
| M. smegmatis MC2 155 | MSMEG_1184 | - | 2e-63 | 54.63% (216) | serine esterase, cutinase family protein |
| M. thermoresistible (build 8) | TH_0238 | - | 2e-67 | 56.36% (220) | serine esterase, cutinase family protein |
| M. ulcerans Agy99 | MUL_1597 | cut1 | 2e-66 | 57.89% (209) | cutinase Cut1 |
| M. vanbaalenii PYR-1 | Mvan_5793 | - | 1e-57 | 51.69% (207) | cutinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1788|M.bovis_AF2122/97 ---------------------------MVTTWALLFA-------------
Rv1758|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2961|M.avium_104 --------------------------MLSPFWALLLG-------------
Mflv_4439|M.gilvum_PYR-GCK -------------MGLSECLSGVTAPGLALAAGLLLAPHAFAQPALTPAP
MSMEG_1184|M.smegmatis_MC2_155 ---------------------------MRLAGLVAVA-------------
MAB_3272c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2419|M.marinum_M ---------------MGNYSGMNASHVVRFLGPAVITAC-----------
MUL_1597|M.ulcerans_Agy99 --------------------------------------------------
TH_0238|M.thermoresistible__bu ------------------LSRIGSAVGAALTTASLITGT-----------
Mvan_5793|M.vanbaalenii_PYR-1 ---------------------MKMSRVAGIAGAVALG-------------
MLBr_00099|M.leprae_Br4923 MVEKVPRKRHRVLAWTAALSMAAVVALAIVAVVILLRSAESPRSSLPPGV
Mb1788|M.bovis_AF2122/97 ---PVPAASADPPDPTVSDGACPDVEVVFARGTGEPPGVGGIGE--DFID
Rv1758|M.tuberculosis_H37Rv ----------------------------------MP---GRFRE--DFID
MAV_2961|M.avium_104 ---PALVGTAAP----AAADSCPDVEVVFARGTSEPPGVGRIGQ--SFVD
Mflv_4439|M.gilvum_PYR-GCK GPAPPPIAAPAPEPLAAPVAGCPDVEIVFARGTTEAPGLGAMGQ--AFVE
MSMEG_1184|M.smegmatis_MC2_155 --AAATSGMQIAAMPSAMAAPCPDAEVIFARGTTELPGLGPTGD--AFVE
MAB_3272c|M.abscessus_ATCC_199 ---------------------------MFARGTFEPPGVGGTGE--SFVN
MMAR_2419|M.marinum_M --GLSASVFSAVAIPSASAEPCPDVEVVFARGTGEPPGLGPTGQ--AFVN
MUL_1597|M.ulcerans_Agy99 -------MFSAVAIPSASAEPCPDVEVVFARGTGEPPGLGPTGQ--AFVN
TH_0238|M.thermoresistible__bu --VITSTVVAGTAVPAAAAQPCPDVQVVFARGTGEPPGVGPTGQ--AFID
Mvan_5793|M.vanbaalenii_PYR-1 ----ACSAVTGLGAPSAAAQPCPDVEVVFARGTSEPPGVGGVGQ--AFVD
MLBr_00099|M.leprae_Br4923 LPIPSTAPHPRKPRPAFQDVSCPDVQLLVVPGTWESSLQDNPLDPVQFPD
. : * :
Mb1788|M.bovis_AF2122/97 ALR--------SKIGEKSMGVYGVDYPATTDFP-----------TAMAGI
Rv1758|M.tuberculosis_H37Rv ALR--------SKIGEKSMGVYGVDYPATTDFP-----------TAMAGI
MAV_2961|M.avium_104 TLR--------SRLGTKSVGVYPVNYPATTDFP-----------TAADGI
Mflv_4439|M.gilvum_PYR-GCK DLR--------SRLGGKTVGVYAVDYPASPDFP-----------TAVEGI
MSMEG_1184|M.smegmatis_MC2_155 ALR--------PQLGDKTLGVYAVDYPATTAFS-----------TAVQGI
MAB_3272c|M.abscessus_ATCC_199 ALR--------ARTKGKSVEVYPVEYPASLAFA-----------TAADGV
MMAR_2419|M.marinum_M SLR--------SHIGGRSLDVYPVNYPASDNWD-----------TGLDGI
MUL_1597|M.ulcerans_Agy99 SLR--------SHIGGRSLDVYPVNYPASDNWD-----------TGLDGI
TH_0238|M.thermoresistible__bu ALR--------PRVGDRSLDVYAVNYPAIDVWN-----------TGIDGI
Mvan_5793|M.vanbaalenii_PYR-1 ALR--------AQAAPRTVGVYAVNYPAANNFTD----RAAFAGTVIDGI
MLBr_00099|M.leprae_Br4923 ALLRNSTMTIGQQFPTSRVQTYTIPYTAQFHNPLSGDKQMTYNDSRAEGT
* : : .* : *.* : *
Mb1788|M.bovis_AF2122/97 YDAGTHVEQTAANCPQSKLVLGGFSQGAAVMGFVTAAA------------
Rv1758|M.tuberculosis_H37Rv YDAGTHVEQTAANCPQSKLVLGGFSQGAAVMGFVTAAA------------
MAV_2961|M.avium_104 SDAGAHVQQMAANCPRTKMVLGGYSQGAAVMGFVTESA------------
Mflv_4439|M.gilvum_PYR-GCK ADASTHVQQIAMNCPDTKLVLGGYSQGAAVMGFVTTEL------------
MSMEG_1184|M.smegmatis_MC2_155 ADARARILANAANCPDTKMVLGGFSQGAAVMGFVTSSA------------
MAB_3272c|M.abscessus_ATCC_199 IDASNRVKDVAARCPNTKIVMGGFSQGAAVVAYTTADA------------
MMAR_2419|M.marinum_M RDAGTHVVSMAGQCPQTKMVLGGYSQGAAVMGFVTSAA------------
MUL_1597|M.ulcerans_Agy99 RDAGTHVVSMAGQCPQTKMVLGGYSQGTAVMSFVTSAA------------
TH_0238|M.thermoresistible__bu RDAGAHVVRMAEQCPDTRLVLGGFSQGAAVMGFVTSAE------------
Mvan_5793|M.vanbaalenii_PYR-1 RDASNRLQAMSVNCPNTRLVLGGFSQGAVVSGFTTSDT------------
MLBr_00099|M.leprae_Br4923 RAMVQEMINVNNKCPLTSYVLVGFSQGAVIAGDITSDIGNGHGPVDDDLV
.: .** : *: *:***:.: . *
Mb1788|M.bovis_AF2122/97 -----IPDGAPLDAP--RPMPPEVADHVAAVTLFGMPSVAFMHSIG--AP
Rv1758|M.tuberculosis_H37Rv -----IPDGAPLDAP--RPMPPEVADHVAAVTLFGMPSVAFMHSIG--AP
MAV_2961|M.avium_104 -----VPDGVQLVQSL-QPMPAAVANHVAAVALFGKPSAQFMSIIN--EP
Mflv_4439|M.gilvum_PYR-GCK -----IPDGVSLSEVP-APMPPDIADHVAAVALLGAPSDRFMDMIK--QP
MSMEG_1184|M.smegmatis_MC2_155 -----VPDGVSPTEVP-APMPPEIADHVAAVALFGKPSPRFMRVLN--DP
MAB_3272c|M.abscessus_ATCC_199 -----VPPGFELPEGITGPMPAEVADHVAAVALFGKPSSGFLQRIDNTAP
MMAR_2419|M.marinum_M -----VPAGVDPATVP-KPLQPDVAEHVAAVVLFGMPNVRAMDFLG--EP
MUL_1597|M.ulcerans_Agy99 -----VPAGVDPATVP-KPLQPDVAEHVAAVVLFGMPNVRAMNFLG--EP
TH_0238|M.thermoresistible__bu -----VPAGVDPATVP-KPLDPDIAEHVAAVVLFGMPNARAMNFLG--TP
Mvan_5793|M.vanbaalenii_PYR-1 -----VPSSVPAAAAP-TPLPPKVAEHVAAVVLFGAPSGSFMEKYG--AP
MLBr_00099|M.leprae_Br4923 LGVTLIADGRRQQGVG-NDIGPNPPGEGAEVTLHEVPVLSGLGMTMTGAR
:. . : . . . * *.* * :
Mb1788|M.bovis_AF2122/97 PIVIGPLYAEKTIQLCAPGDPVCSS---GGNWAAHNGYADDG-MVEQA--
Rv1758|M.tuberculosis_H37Rv PIVIGPLYAEKTIQLCAPGDPVCSS---GGNWAAHNGYADDG-MVEQA--
MAV_2961|M.avium_104 PVTIGPLYAAKTIELCVPGDPICSG---AVNPAAHRQYVEAG-MVDQA--
Mflv_4439|M.gilvum_PYR-GCK PVTIGALYQPKTLELCVPGDFVCSP---GNDLGAHARYISDG-LVVQA--
MSMEG_1184|M.smegmatis_MC2_155 PVVVGPYYASKAIDLCVENDLVCDPK--GSSFAVHNQYQEFG-LVTQA--
MAB_3272c|M.abscessus_ATCC_199 PINIGHLYVAKTMDMCVPEDPICSPD--GSDNAAHGSYGDNG-MTSQA--
MMAR_2419|M.marinum_M AVEIGPAYQAKTIKVCVPEDPVCS---DGLNFAAHNAYADDGAVVDQG--
MUL_1597|M.ulcerans_Agy99 AVEIGPAYQAKTIKVCVPEDPVCS---DGLNFAAHNAYADDGAVVDQG--
TH_0238|M.thermoresistible__bu PVVIGPLYEDKTVKLCAVDDPVCS---NGMNFAAHNTYATNAAMVDQG--
Mvan_5793|M.vanbaalenii_PYR-1 AVTVGPLYADRTVELCAAGDSICDGAPNGGPNLAHALYPVNG-MVGQG--
MLBr_00099|M.leprae_Br4923 PGGFG-VLHSRTNEICAPGDLICAAP--AEAFSVANLPATLNTLASGAGQ
. .* :: .:*. * :* . . :. .
Mb1788|M.bovis_AF2122/97 ---AVFAAGRLG--------------------------------------
Rv1758|M.tuberculosis_H37Rv ---AVFAAGRLG--------------------------------------
MAV_2961|M.avium_104 ---VDFTTDRV---------------------------------------
Mflv_4439|M.gilvum_PYR-GCK ---ADFAVGKLAETPAESGGAPA---------------------------
MSMEG_1184|M.smegmatis_MC2_155 ---ATFVAQKLQADWAAEEATDEESTDEATPAPRTPPTRTPSPLSAPVGA
MAB_3272c|M.abscessus_ATCC_199 ---ADFAARQINSPTDTVSAAG----------------------------
MMAR_2419|M.marinum_M ---VAFAASRLGGDPGGPVPAPSSG--FGN--------------------
MUL_1597|M.ulcerans_Agy99 ---VAFAASRLGGDPGGPVPAPSSG--FGN--------------------
TH_0238|M.thermoresistible__bu ---AAFAADRLGVASDKPLPTPSSGQNFGN--------------------
Mvan_5793|M.vanbaalenii_PYR-1 ---ASYAAGRL---------------------------------------
MLBr_00099|M.leprae_Br4923 PIHAMYATAQFWDLDGAPATVWTLNWVHRLIEGAPHPKHG----------
. :.. :.
Mb1788|M.bovis_AF2122/97 ---------------------------------
Rv1758|M.tuberculosis_H37Rv ---------------------------------
MAV_2961|M.avium_104 ---------------------------------
Mflv_4439|M.gilvum_PYR-GCK ---------------------------------
MSMEG_1184|M.smegmatis_MC2_155 TPPVQQIASTPAPVGTGPLPGPAVPPPPTAPLA
MAB_3272c|M.abscessus_ATCC_199 ---------------------------------
MMAR_2419|M.marinum_M ---------------------------------
MUL_1597|M.ulcerans_Agy99 ---------------------------------
TH_0238|M.thermoresistible__bu ---------------------------------
Mvan_5793|M.vanbaalenii_PYR-1 ---------------------------------
MLBr_00099|M.leprae_Br4923 ---------------------------------