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TLDVPVNQGHVPPGSVACCLVGVTAVADGIAGHSLSNFGALPPEINSGRMYSGPGSGPLMAAAAAWDGLA AELSSAATGYGAAISELTNMRWWSGPASDSMVAAVLPFVGWLSTTATLAEQAAMQARAAAAAFEAAFAMT VPPPAIAANRTLLMTLVDTNWFGQNTPAIATTESQYAEMWAQDAAAMYGYASAAAPATVLTPFAPPPQTT NATGLVGHATAVAALRGQHSWAAAIPWSDIQKYWMMFLGALATAEGFIYDSGGLTLNALQFVGGMLWSTA LAEAGAAEAAAGAGGAAGWSAWSQLGAGPVAASATLAAKIGPMSVPPGWSAPPATPQAQTVARSIPGIRS AAEAAETSVLLRGAPTPGRSRAAHMGRRYGRRLTVMADRPNVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1706c | PPE23 | - | 100% (394) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1787 | PPE25 | 1e-83 | 48.54% (377) | PPE family protein |
| M. tuberculosis H37Rv | Rv2892c | PPE45 | 9e-80 | 45.39% (412) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1732c | PPE23 | 0.0 | 100.00% (394) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 5e-29 | 38.92% (185) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-39 | 32.38% (386) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 4e-30 | 29.97% (347) | PPE family protein |
| M. marinum M | MMAR_2517 | - | 3e-99 | 49.87% (395) | PPE family protein, PPE23 |
| M. avium 104 | MAV_2928 | - | 7e-73 | 43.13% (422) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 7e-30 | 31.25% (368) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-30 | 42.19% (192) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1702 | - | 1e-98 | 50.52% (384) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-31 | 31.89% (370) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1706c|M.tuberculosis_H37Rv MTLDVPVNQG---------HVPPGSVACCLVG-----------------V
Mb1732c|M.bovis_AF2122/97 MTLDVPVNQG---------HVPPGSVACCLVG-----------------V
MMAR_2517|M.marinum_M MTPDLSIGLNALWGSAALPQIETGADELLLAADRAIEVAELRELATAPAT
MUL_1702|M.ulcerans_Agy99 --------------------------------------------------
MAV_2928|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_0415|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Rv1706c|M.tuberculosis_H37Rv TAVADGIAGHSLSNFGALPPEINSGRMYSGPGSGPLMAAAAAWDGLAAEL
Mb1732c|M.bovis_AF2122/97 TAVADGIAGHSLSNFGALPPEINSGRMYSGPGSGPLMAAAAAWDGLAAEL
MMAR_2517|M.marinum_M AGVVGDIAPPVVLDYGALPPEVNSGRMYAGPGAGSLLAAACAWDSLAAEL
MUL_1702|M.ulcerans_Agy99 -----------MLDYGALPPEVNSGRMYAGPGAGSLLAAACAWDSLAAEL
MAV_2928|M.avium_104 -----------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAEL
MLBr_01182|M.leprae_Br4923 -----------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKEL
Mflv_0325|M.gilvum_PYR-GCK TSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAEY
Mvan_0415|M.vanbaalenii_PYR-1 ---------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAEY
MSMEG_0619|M.smegmatis_MC2_155 ---------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEY
MAB_0809c|M.abscessus_ATCC_199 --------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHY
TH_3113|M.thermoresistible__bu ---------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEY
* .** :* : ***...: :*. * :. .
Rv1706c|M.tuberculosis_H37Rv SSAATGYGAAISELTNMRWWSGPASDSMVAAVLPFVGWLSTTATLAEQAA
Mb1732c|M.bovis_AF2122/97 SSAATGYGAAISELTNMRWWSGPASDSMVAAVLPFVGWLSTTATLAEQAA
MMAR_2517|M.marinum_M HVTAAGYDSAISELTGI-WWFGPAAESMVAAVLPFASWLSATASVAEQAG
MUL_1702|M.ulcerans_Agy99 HVTAAGYDSAISELTGI-WWFGPAAESMVAAVLPFASWLSATASVAEQAG
MAV_2928|M.avium_104 GIAASGYHSVIAELTSG-PWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 TAAAQGLQSAVEALLTT--FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK ASAAAELTSILAGVQSG-AWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAAELSSILADVQAG-AWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 AAAAAELTSVLSAVQAG-SWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 SATAQELRAILAATHAS-AWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu RAAAVELAAVVSQTCAT-AWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : : * .: . *: ** : . .
Rv1706c|M.tuberculosis_H37Rv MQARAAAAAFEAAFAMTVPPPAIAANRTLLMTLVDTNWFGQNTPAIATTE
Mb1732c|M.bovis_AF2122/97 MQARAAAAAFEAAFAMTVPPPAIAANRTLLMTLVDTNWFGQNTPAIATTE
MMAR_2517|M.marinum_M IQARAAAAAYEMAFALTVPPPVIASNRALLAALIATNWFGQNSAAIAATE
MUL_1702|M.ulcerans_Agy99 IQARAAAAAYEMAFALTVPPPVIASNRALLAALIATNWFGQNSAAIAATE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .** *. *:: . : *:. *: :* :* *: .* .*
Rv1706c|M.tuberculosis_H37Rv SQYAEMWAQDAAAMYGYASAAAPAT-VLTPFAPPPQTTNATG--------
Mb1732c|M.bovis_AF2122/97 SQYAEMWAQDAAAMYGYASAAAPAT-VLTPFAPPPQTTNATG--------
MMAR_2517|M.marinum_M LHYAEMWAQDAGAMYEYAGSSAAAS-LLAPFSLPPQTSDPSGLARQAAAT
MUL_1702|M.ulcerans_Agy99 LHYAEMWAQDAGAMYEYAGSAAAAS-LLAPFSLPPQTSDPSGLARQAAAT
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPPNTTAPEGESDQAAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
.* .** * * :* * * .*
Rv1706c|M.tuberculosis_H37Rv --------------LVGHAT--------------------AVAALRG---
Mb1732c|M.bovis_AF2122/97 --------------LVGHAT--------------------AVAALRG---
MMAR_2517|M.marinum_M ANNSGTTVSRSSASLAGRSS--------------------AAARLGQ---
MUL_1702|M.ulcerans_Agy99 ANNSGTTVSRSSASLAGRSS--------------------AAARLGQ---
MAV_2928|M.avium_104 SQAMAQPAGSTAQTAANTSSQLATP--------------QALSAGTS---
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVAT---
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Rv1706c|M.tuberculosis_H37Rv ------------------QHSWAAAIPWSDIQKYWMMFLGALATAEG---
Mb1732c|M.bovis_AF2122/97 ------------------QHSWAAAIPWSDIQKYWMMFLGALATAEG---
MMAR_2517|M.marinum_M ------------------QASSAAATTTPTWQELWIELMSSFTTAEG---
MUL_1702|M.ulcerans_Agy99 ------------------QASSAAATTTPTWQELWIELMSSFTTAEG---
MAV_2928|M.avium_104 ------------------QAATQASSSSASQTGPFTWLTSALQNLQQSGL
MLBr_01182|M.leprae_Br4923 ------------------PQTAVPDSSSAAAPQLWGGFAQHLSPINDTLS
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
.
Rv1706c|M.tuberculosis_H37Rv ------FIYDSGGLTLNALQFVG---GMLWSTA-----------LAEAGA
Mb1732c|M.bovis_AF2122/97 ------FIYDSGGLTLNALQFVG---GMLWSTA-----------LAEAGA
MMAR_2517|M.marinum_M ------FVYDSGGFTLIALSIFG---SLAWKSG-----------EAAAEG
MUL_1702|M.ulcerans_Agy99 ------FVYDSGGFTLIALSIFG---SLAWKSG-----------EAAAEG
MAV_2928|M.avium_104 PTPTNNYLGLSPTFYTVMLKQTS---GLGYFSNGITAFWSQLAQQLVSGP
MLBr_01182|M.leprae_Br4923 ------MINNHAGMANAGLSLVN---GMGSAMKS--------LAPTTTKA
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
: : .
Rv1706c|M.tuberculosis_H37Rv AEAAAGAGGAAGWS-AWSQL---------GAGPVAASATLAAKIGPMSVP
Mb1732c|M.bovis_AF2122/97 AEAAAGAGGAAGWS-AWSQL---------GAGPVAASATLAAKIGPMSVP
MMAR_2517|M.marinum_M VAGAAGMGGFAAFSGGLAQF---------GGAPPIATAALASKVGPMSVP
MUL_1702|M.ulcerans_Agy99 VAGAAGMGGFAAFSGGLAQF---------GGAPPIATAALASKVGPMSVP
MAV_2928|M.avium_104 GGSTAGAGGAWYPTPQFASLGLGNLGSVGGASHVSAISAGAGRAGALSVP
MLBr_01182|M.leprae_Br4923 AESAFKAMGSAVQSTGRGLLG------SSSGGHVTAQLGRAASIGSLRVP
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
. . . *
Rv1706c|M.tuberculosis_H37Rv PGWS--APPATPQAQT--------VARSIPGIRSAAEAAETS--VLLRGA
Mb1732c|M.bovis_AF2122/97 PGWS--APPATPQAQT--------VARSIPGIRSAAEAAETS--VLLRGA
MMAR_2517|M.marinum_M PTWP--GSSAASTAFS--------AAN------SEVDTIGLS--GLITGV
MUL_1702|M.ulcerans_Agy99 PTWP--GSSAASTAFS--------AAN------SEVDTIGLL--GLITGV
MAV_2928|M.avium_104 QQWATLTSAVSPAVSE--------EGSAVQAAAGGAPGGAAN--GLLRGM
MLBr_01182|M.leprae_Br4923 QTWTTASQPVTAATRA--------LSPARVAVATESESAPLLGGGLPMAP
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
.
Rv1706c|M.tuberculosis_H37Rv PTPGRSR------------------------------------AAH-MGR
Mb1732c|M.bovis_AF2122/97 PTPGRSR------------------------------------AAH-MGR
MMAR_2517|M.marinum_M PPRNQGQ------------------------------------AGRNFGR
MUL_1702|M.ulcerans_Agy99 PPRNQGQ------------------------------------AGRNFGR
MAV_2928|M.avium_104 PVGALGRRG----------------------------------AAAGYVN
MLBr_01182|M.leprae_Br4923 MVPGGGSGT----------------------------------GGVNTAL
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
Rv1706c|M.tuberculosis_H37Rv RYGRRLTVMADRPNVG----------------------------------
Mb1732c|M.bovis_AF2122/97 RYGRRLTVMADRPNVG----------------------------------
MMAR_2517|M.marinum_M RYGARLRVMCRPPNAG----------------------------------
MUL_1702|M.ulcerans_Agy99 RYGARLRVMCRPPNAG----------------------------------
MAV_2928|M.avium_104 KYGFRYSVLTRPPSAG----------------------------------
MLBr_01182|M.leprae_Br4923 RLQPRAFVMPRNPAAG----------------------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
: .
Rv1706c|M.tuberculosis_H37Rv ---------------
Mb1732c|M.bovis_AF2122/97 ---------------
MMAR_2517|M.marinum_M ---------------
MUL_1702|M.ulcerans_Agy99 ---------------
MAV_2928|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------