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HASRPGAPPHAGLPSRRTAGDQDHRADPKVTRIMSASTLEQPAAAHVDELVARMRGRLLDPLAIAVLAAV ISGAWASRPSLWFDEGATISASASRTLPELWSLLGHIDAVHGLYYLLMHGWFAIFPPTELWSRLPSCLAI GAAAAGVVVFAKQFSGRTTAVCAGAVFAILPRVTWAGIEARSSALSVAAAVWLTVLLVAAVRCNTQRRWL LYALVLMLSILVSINLALLVPAYATMVPLLASGKSRKSPVIWWTVVTAAALGAMTPFILFAHGQVWQVGW IAGLNRNIILDVIHRQYFDHSVPFAILAGLIVAAGIAAHLAGARGPGGDTHRLVLVSAAWIVVPTAVVLI YSATVEPIYYPRYLILTAPAAAVILAVCVVTIARKPWLIAGVVFLLAAAAFPNYFFTQRGPYAKEGWDYS QVADVISAHAKPGDCLLVDNTAGWRPGPIRALLATRPAAFRSLIDVERGTYGPKVGTLWDGHVAVWLTTA KIDKCPTLWTIANRDKSLPDHQVGEMLSPGTGFGRTPVYRFPSYLGFRIVERWQFHYSQVVKSTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1635c | - | - | 100% (556) | Probable conserved transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1661c | - | 0.0 | 100.00% (556) | hypothetical protein Mb1661c |
| M. gilvum PYR-GCK | Mflv_0468 | - | 8e-87 | 38.94% (529) | hypothetical protein Mflv_0468 |
| M. leprae Br4923 | MLBr_01389 | - | 0.0 | 71.59% (528) | hypothetical protein MLBr_01389 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2439 | - | 0.0 | 75.99% (558) | transmembrane protein |
| M. avium 104 | MAV_3138 | - | 0.0 | 70.28% (498) | hypothetical protein MAV_3138 |
| M. smegmatis MC2 155 | MSMEG_0999 | - | 2e-06 | 24.41% (254) | integral membrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1618 | - | 0.0 | 78.35% (522) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_4425 | - | 3e-06 | 22.43% (419) | glycosyl transferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1635c|M.tuberculosis_H37Rv -----------MHASRPGAPPHAG----LPSRRTAGDQDHRADPKVTRIM
Mb1661c|M.bovis_AF2122/97 -----------MHASRPGAPPHAG----LPSRRTAGDQDHRADPKVTRIM
MMAR_2439|M.marinum_M MEFQAAQHFSRLWAAQPGGPPKPRGQRPPNPRKMTRDQDHRWALTVTSIM
MUL_1618|M.ulcerans_Agy99 -------------------------------------------------M
MLBr_01389|M.leprae_Br4923 ---------------------------------------------MTSIM
MAV_3138|M.avium_104 --------------------------------------------------
Mflv_0468|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4425|M.vanbaalenii_PYR-1 -------------------------------------------------M
MSMEG_0999|M.smegmatis_MC2_155 --------------------------------------------------
Rv1635c|M.tuberculosis_H37Rv SASTLEQPAAAH-VDELVARMRGRLLDPLAIAVLAAVISGAWASRPSLWF
Mb1661c|M.bovis_AF2122/97 SASTLEQPAAAH-VDELVARMRGRLLDPLAIAVLAAVISGAWASRPSLWF
MMAR_2439|M.marinum_M STPTLEQGATAT-DKAERVRPRGRRLDPWLMALLATLISVAWAGKPSLWF
MUL_1618|M.ulcerans_Agy99 STPTLEQGATAT-DKAERVRPRGRRLDPWLMALLATLISVAWAGRPSLWF
MLBr_01389|M.leprae_Br4923 SVSALEQSAADVGDNSARQHAHGALPDSLAIAMLATVISGAWASRPSLWF
MAV_3138|M.avium_104 ------------------------MLDPWAIAVLATALSAAWACRPSLWF
Mflv_0468|M.gilvum_PYR-GCK ---MLRGDGPGP--------ARQWSADAVVVGVLAFALGVAAAGRPSLWV
Mvan_4425|M.vanbaalenii_PYR-1 TATADLAPRTTADAEPVATERPRWMWPALLALLGATAVLYLWGLGSAGWA
MSMEG_0999|M.smegmatis_MC2_155 -------------------------MQIGRRELVAVIIAILLVTAAFVVP
: * : .
Rv1635c|M.tuberculosis_H37Rv DEGATISASASRTLPELWSLLGHIDAVHGLYY-------LLMHGWFAIFP
Mb1661c|M.bovis_AF2122/97 DEGATISASASRTLPELWSLLGHIDAVHGLYY-------LLMHGWFAIFP
MMAR_2439|M.marinum_M DEGATISAAANRTLPELWKLLGHIDAVHGFYY-------LLMHGWYAIFP
MUL_1618|M.ulcerans_Agy99 DEGATISAAANRTLPELWKLLGHIDAVHGFYY-------LLMHGWYAIFP
MLBr_01389|M.leprae_Br4923 DEAATISASASRTVPELWRLLSHIDAVHGLYY-------LLMHGWFAIFP
MAV_3138|M.avium_104 DEGATISAAASRTLPELWRLLGHIDAVHGAYY-------LLMHGWFALFP
Mflv_0468|M.gilvum_PYR-GCK DEAGTLSAAT-RPVDALWTLVHHVDAVHGFYY-------LLLRGWFEIVP
Mvan_4425|M.vanbaalenii_PYR-1 NQYYAAAAQAGTQDWKAW-LFGSLDAGNAITVDKPPAALWVMALSGRLFG
MSMEG_0999|M.smegmatis_MC2_155 HLDLGIVTPLINSTPAQIYSFADTAPIFGWWN------------------
. : . . .
Rv1635c|M.tuberculosis_H37Rv PTELWSRLPSCLAIGAAAAGVVVFAKQFSGRTTAVCAGAVFAILPRVTWA
Mb1661c|M.bovis_AF2122/97 PTELWSRLPSCLAIGAAAAGVVVFAKQFSGRTTAVCAGAVFAILPRVTWA
MMAR_2439|M.marinum_M PTEFWSRVPSSLAIGGAAAGVVVFTKQFSGRSTALCAGAVFAILPRVTWA
MUL_1618|M.ulcerans_Agy99 PTEFWSRVPSSLAIGGAAAGVVVFTKQFSGRSTALCAGAVFAILPRVTWA
MLBr_01389|M.leprae_Br4923 STEFWSRVPSCLAIGAAAAGVTVFTRQFATRTTAVYAGIVFAILPRITWA
MAV_3138|M.avium_104 PTEFFSRLPSALAVGAAAAGVTVFTRQFAPRRTAVCAGAVFALLPRMTWA
Mflv_0468|M.gilvum_PYR-GCK VTEFWARVPSALMVGVAAAGTCVLGSRLSGRKVGIAAGVVFAVLPRTTWA
Mvan_4425|M.vanbaalenii_PYR-1 FSPFTMLLPQALMGVASVAVLFAAVRRVSGPGAGLIAGAALAVTPVAALM
MSMEG_0999|M.smegmatis_MC2_155 AHVGWGTVPAVLIGAATVWWGPAVAQRLPWRALPLVAWVTSALWAFSLAM
:* * :. . :.. : * . *: .
Rv1635c|M.tuberculosis_H37Rv GIEARSSALSVAAAVWLTVLLVAAVRCNTQRRWLLYALVLMLSILVSINL
Mb1661c|M.bovis_AF2122/97 GIEARSSALSVAAAVWLTVLLVAAVRCNTQRRWLLYALVLMLSILVSINL
MMAR_2439|M.marinum_M GIEARSSALSVAAAVWLTVLLVAAVRRNRPWLWLLYALVLMVSILININL
MUL_1618|M.ulcerans_Agy99 GIEARSSALSVAAAVWLTVLLVAAVRRDRPWLWLLYALVLMVSILININL
MLBr_01389|M.leprae_Br4923 GIEARSSALSVAAAMWLTVLLVASVQRNRPRLWLCYALTLMLSILLNLTL
MAV_3138|M.avium_104 GMEARPYAFVAAAAVWLTVLFVAAVRRGAPRGWVGYALALMLAILLNLNM
Mflv_0468|M.gilvum_PYR-GCK AVEARPYALSMACAVWLTVLFVAAVRRGGRRWWLGYGAALVGAVTVNVMV
Mvan_4425|M.vanbaalenii_PYR-1 FRYNNPDALLVLLLVVAAYLTVRAIQTGGTRWMVLVGIVLGFAFLTKMLQ
MSMEG_0999|M.smegmatis_MC2_155 IDGWQRGFAGRLTARHEYLRQVPSVTDIGEALRTFSSRILDFQPDSWITH
. * :: . * :
Rv1635c|M.tuberculosis_H37Rv ALLVP-AYATMVPLLASGKSRKSPVIWWTVVTAAALGAMTPFILFAHGQV
Mb1661c|M.bovis_AF2122/97 ALLVP-AYATMVPLLASGKSRKSPVIWWTVVTAAALGAMTPFILFAHGQV
MMAR_2439|M.marinum_M GLLVP-VYGALLPLLAPKKSRKSPGIWWAVTSVVAIGAMTPFVLFAHGQV
MUL_1618|M.ulcerans_Agy99 GLLVP-VYGALLPLLAPKKSRKSPGIWWAVTSVVAIGAMTPFVLFAHGQV
MLBr_01389|M.leprae_Br4923 ATLVL-VYAVILPWLAPNKFRNSPFIWWAVTSVVALGTITPFILFAHGQV
MAV_3138|M.avium_104 VLMVP-VYGVMLPLLTARGARRSAALWWAGSSAVAVGAMTPFLLFAHNQV
Mflv_0468|M.gilvum_PYR-GCK VLILA-GHAAML---AATRPDRRTVRAWLVTVVVASVALIPLFVVLLSQQ
Mvan_4425|M.vanbaalenii_PYR-1 AFLVMPGLALAFLVAAPVGLWRRIGTLLTGALAMVATAGSFLAMVSLWPA
MSMEG_0999|M.smegmatis_MC2_155 VSGHPPGALLTFVWLDRIGLGGG---AWAGLLCLLVGSSAAAAIVVALRA
. : :.
Rv1635c|M.tuberculosis_H37Rv WQVGWIAGLNRNIILDVIHRQYFDHS------------------------
Mb1661c|M.bovis_AF2122/97 WQVGWIAGLNRNIILDVIHRQYFDHS------------------------
MMAR_2439|M.marinum_M WQVGWISGLNRNLFLDVVHRQYFDHS------------------------
MUL_1618|M.ulcerans_Agy99 WQVGWISGLNRNLFLDVVHRQYFDHS------------------------
MLBr_01389|M.leprae_Br4923 WQVDWIFRVSWHYVFDITQRQYFDHS------------------------
MAV_3138|M.avium_104 WQVNWIYPVSWHYAFDIILRQYFDHS------------------------
Mflv_0468|M.gilvum_PYR-GCK AQIAWIWPVGPVTLGQIAGEQYFPSVYSDSVRAVGPDQ------------
Mvan_4425|M.vanbaalenii_PYR-1 DSRPYIGGSTDNSLLQLALGYNGIQRVMGGEGGPGGGAGAPPGGPGGPGG
MSMEG_0999|M.smegmatis_MC2_155 VSGEATARLAAPFVAVAPTAIWIAVS------------------------
.
Rv1635c|M.tuberculosis_H37Rv -----------------VPFAILAGLIVAAGIAAHLAGARGP--------
Mb1661c|M.bovis_AF2122/97 -----------------VPFAILAGLIVAAGIAAHLAGARGP--------
MMAR_2439|M.marinum_M -----------------VAFAILAGVLVVAAIAVRLTGIARP--------
MUL_1618|M.ulcerans_Agy99 -----------------VAFAILAGVLVVAAIAVRLTGIARP--------
MLBr_01389|M.leprae_Br4923 -----------------VSFAIATAVIIVPAIATRLAGLRAP--------
MAV_3138|M.avium_104 -----------------VALAVLSAVLIVAAAVARLAGVPAP--------
Mflv_0468|M.gilvum_PYR-GCK -----QQFSAEQLRVAMSAWARVAPLIVVIVIVAALAVRARRRHGALIEN
Mvan_4425|M.vanbaalenii_PYR-1 GANLFFGGDPGLGRLFGASMGAEASWLLPAALIGLVAGLWFTRRAPR---
MSMEG_0999|M.smegmatis_MC2_155 ---------------ADGYFAGVAAWGLALLALAVRDSVHRR--------
. : :
Rv1635c|M.tuberculosis_H37Rv GGDTHRLVLVSAAWIVVPTAVVLIYSATVEPIYYPRYLILTAPAAAVILA
Mb1661c|M.bovis_AF2122/97 GGDTHRLVLVSAAWIVVPTAVVLIYSATVEPIYYPRYLILTAPAAAVILA
MMAR_2439|M.marinum_M GEGTRPLLLASIAWVVIPTGIVLLYSAIVEPIYYPRYLILTAPAAAVILA
MUL_1618|M.ulcerans_Agy99 GEGTRPLLLASIAWVVIPTGIVLLYSAIVEPIYYPRYLILTAPAAAVILA
MLBr_01389|M.leprae_Br4923 AGDLRSLVIICTAWIVIPTTLMVGYSAVIEPVYYPRYLILTAPAAAIVIA
MAV_3138|M.avium_104 PGDLRRLLILCAAWMVIPTALVVVYSAVAEPIYYPRYLIFTAPAMAIVLA
Mflv_0468|M.gilvum_PYR-GCK PSGTRVLVLGAVAWIVVPTVVLLGYSVLVRPLYQPHYLTFTTPALALLIG
Mvan_4425|M.vanbaalenii_PYR-1 TCAVRASLLLWGGWVLVTGVVFS----FMDGIIHPYYTVALAPGIAALIG
MSMEG_0999|M.smegmatis_MC2_155 ----RVALPTAVGSGLLLGWGIFLNYGLALAALIALAVLITAPDWRAALR
: : . :: . . :* :
Rv1635c|M.tuberculosis_H37Rv VCVVTIAR---KPWLIAGVVFLLAAAAFPNYFFTQRGPYAKEGWDYSQVA
Mb1661c|M.bovis_AF2122/97 VCVVTIAR---KPWLIAGVVFLLAAAAFPNYFFTQRGPYAKEGWDYSQVA
MMAR_2439|M.marinum_M VCIVTLAR---KPWLITGVVVLLAVAAFPNYFFTQRGPYAKEGWDYSQVA
MUL_1618|M.ulcerans_Agy99 VCIVTLAR---KPWLITGVVVLLAVAAFPNYFFTQRGPYAKEGWDYSQVA
MLBr_01389|M.leprae_Br4923 VCIVTVAR---KPWPIAGVLVLFAVAAFPNYLFTQRGRYAKEGWDYSQVA
MAV_3138|M.avium_104 VCIVTLAR---RPWPIAGAVLLCAVAALPNYLFVQRWPYAKEGWDYSQVA
Mflv_0468|M.gilvum_PYR-GCK LCVVTLCRD--DTRRLTATLAVLAVAAAPNY-LAQRGPYAKYGSDYSQVA
Mvan_4425|M.vanbaalenii_PYR-1 ICVVELWRGRRHFAPRTTLAVMSAGTGVWAFILLDRTPDWQPWLRWVVLI
MSMEG_0999|M.smegmatis_MC2_155 VAVPAVIA----------VLAVVAVFLVAGFWWFDG---------YTLVQ
:.: : : * : : : :
Rv1635c|M.tuberculosis_H37Rv DVISAHAKPGD---------------CLLVDN-TAGWRPGPIRALLATRP
Mb1661c|M.bovis_AF2122/97 DVISAHAKPGD---------------CLLVDN-TAGWRPGPIRALLATRP
MMAR_2439|M.marinum_M DVISAHAAPGD---------------CLLVDN-TVPWKPGPVRALLATRP
MUL_1618|M.ulcerans_Agy99 DVISTHAAPGD---------------CLLVDN-TVPWKPGPVRALLATRP
MLBr_01389|M.leprae_Br4923 DVISSQAAPGD---------------CLIVDN-TVPWRPGPIRALLAARP
MAV_3138|M.avium_104 DLIGSHAAPGD---------------CLLVDN-TVPWRPGPIRALLATRP
Mflv_0468|M.gilvum_PYR-GCK ELLARESGPRD---------------CVVVDDRTAPSVPHAIEGARRAHP
Mvan_4425|M.vanbaalenii_PYR-1 GSIVAAAVIAVGAHRLGRATAAVAAAAILFGAAAPAAYAIETAGNAHDGP
MSMEG_0999|M.smegmatis_MC2_155 ERYWQGIANNR-----------------PFQYWSWANLASVVCAIGLGSV
. : . .
Rv1635c|M.tuberculosis_H37Rv AAFRSLIDVERGTYGPKV-----GTLWDGHVAVWLTTAKIDKCPTLWTIA
Mb1661c|M.bovis_AF2122/97 AAFRSLIDVERGTYGPKV-----GTLWDGHVAVWLTTAKIDKCPTLWTIA
MMAR_2439|M.marinum_M AAFRSLIDVERGAYGPKV-----GTLWDGHVAVWLTTEKINKCSTLWTIS
MUL_1618|M.ulcerans_Agy99 AAFRSLIDVERGAYGPKV-----GTLWDGHVAVWLTTEKINKCSTLWTIS
MLBr_01389|M.leprae_Br4923 AAFRSLIDIERGFYGPTV-----GTLWDGHVPVWLVTAKINKCSTVWTVS
MAV_3138|M.avium_104 AAFRSLIDVERGAYGPKV-----GTLWDGHVAIWLTTAKINKCSTIWTIT
Mflv_0468|M.gilvum_PYR-GCK VAAR-----DLGLAPPER-----TALFSARDPLGVRADDLRTCAVLWTIG
Mvan_4425|M.vanbaalenii_PYR-1 VAMSGPARTDVDLGGPPGPGGPGASVADNTELQHLVQATDSRWAAASVGS
MSMEG_0999|M.smegmatis_MC2_155 AGIGRVFDIKAARRNPGLP------MLVIGALLAITFADLSMLSKAETER
.. . * : : . .
Rv1635c|M.tuberculosis_H37Rv NRDKSLPDHQVGEMLSPGTGFGRTPVYRFPSYLGFRIVERWQFHYSQVVK
Mb1661c|M.bovis_AF2122/97 NRDKSLPDHQVGEMLSPGTGFGRTPVYRFPSYLGFRIVERWQFHYSQVVK
MMAR_2439|M.marinum_M NRDNALPDHEVGPALSPGTAFGKTPVYLFPHYLGFHIVERWQFHYSQVIK
MUL_1618|M.ulcerans_Agy99 NRDNALPDHEVGPALSPGTAFGKTPVYLFPHYLGFHIVERWQFHYSQVIK
MLBr_01389|M.leprae_Br4923 DRDTSLPDHQAGQLLSPGLILGRAPAYQFPSYLGFRIVERWQFHYSQVIK
MAV_3138|M.avium_104 NKDNSLPDHQSGQSLPPGSAFGQAPAYRFPGYLGFHIVERWQFHYSQVVK
Mflv_0468|M.gilvum_PYR-GCK -------DAAPG---SP----ADAPVDRVARAQGFVPAERWRFNQTEVVR
Mvan_4425|M.vanbaalenii_PYR-1 MVAGELELQTGTSVMAIGGFTGGDNSPTLQQFQDYVADRQVRYFIAGGHG
MSMEG_0999|M.smegmatis_MC2_155 IWLPFTVWLTAAGALLP--------PRSHRWWLGLNVAGALALNHLILTN
.
Rv1635c|M.tuberculosis_H37Rv STR--------------------------------
Mb1661c|M.bovis_AF2122/97 STR--------------------------------
MMAR_2439|M.marinum_M STR--------------------------------
MUL_1618|M.ulcerans_Agy99 STR--------------------------------
MLBr_01389|M.leprae_Br4923 STR--------------------------------
MAV_3138|M.avium_104 STR--------------------------------
Mflv_0468|M.gilvum_PYR-GCK SVPAGARS---------------------------
Mvan_4425|M.vanbaalenii_PYR-1 GPGRNSGSAGDITAWVEQNFAPMDVGGTTVYDLQR
MSMEG_0999|M.smegmatis_MC2_155 W----------------------------------