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TQLPQPTWRWWQQRETEQVQSSHIDGEIVGALIPDLAVLHSEDASRAAVGREKHRCSLDPLGGGFRSRRA SMPAGALLLSAVIAIQLDRMNARVFGDGWIGAQACMWVNKFHEESTVTALSPSSPIAQGSIARHPETMQS AYVRIAEGGSRDVAPAAQLQRRRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1528c | papA4 | - | 100% (165) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA4 |
| M. tuberculosis H37Rv | Rv3820c | papA2 | 1e-10 | 37.88% (66) | polyketide synthase associated protein PapA2 |
| M. tuberculosis H37Rv | Rv1182 | papA3 | 1e-08 | 32.50% (80) | polyketide synthase associated protein PapA3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1555c | papA4 | 2e-93 | 100.00% (165) | polyketide synthase associated protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | MLBr_01230 | papA3 | 2e-09 | 35.71% (84) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_0852 | - | 3e-09 | 33.85% (65) | polyketide synthase associated protein PapA2 |
| M. marinum M | MMAR_2343 | - | 2e-21 | 52.69% (93) | hypothetical protein MMAR_2343 |
| M. avium 104 | MAV_2723 | - | 6e-10 | 37.18% (78) | PapA2 protein |
| M. smegmatis MC2 155 | MSMEG_4728 | - | 6e-09 | 31.71% (82) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-17 | 48.05% (77) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. ulcerans Agy99 | MUL_1531 | papA3 | 4e-11 | 38.82% (85) | polyketide synthase associated protein PapA3 |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
TH_2204|M.thermoresistible__bu --MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQAPVSSVPVSYM
MUL_1531|M.ulcerans_Agy99 --MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKAPISPVPPSYM
MLBr_01230|M.leprae_Br4923 ---MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQAPVSSVPVAYM
MAB_0852|M.abscessus_ATCC_1997 -------MVALGTIHDWRPTPGTVISWSASPRAREVAAQAPASTIPPSYQ
MAV_2723|M.avium_104 --------------------------------------------MPASYQ
MSMEG_4728|M.smegmatis_MC2_155 -------MFELTDIQNWDDAPGKHVSWGPSPSTVAKVAEAPVSDVPASYQ
MMAR_2343|M.marinum_M MKLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQAPVSAVPPSHI
Rv1528c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1555c|M.bovis_AF2122/97 --------------------------------------------------
TH_2204|M.thermoresistible__bu QAQHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYVINAHMRRHDT
MUL_1531|M.ulcerans_Agy99 QAHHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHVVNAHMRRHDT
MLBr_01230|M.leprae_Br4923 QAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYIVNAHLRRHDT
MAB_0852|M.abscessus_ATCC_1997 QAQHLRSYRDLARQDREMARLGIGSWDVPGVCDIDAMTAAINAHLRRHDT
MAV_2723|M.avium_104 QLHHLRRFSEHAARGLDMARLNIGVWDISGVCDVAAMTEAINAHLRRHDT
MSMEG_4728|M.smegmatis_MC2_155 QAQHLRAYREHTARGVPMARLTVPVWNMDSQCDMRAMSHVINAYLRRHDT
MMAR_2343|M.marinum_M QARHLRGFAEQTARGHDMSRLVVAAMDIPGECDIRAMTYVINSHLRRHDT
Rv1528c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1555c|M.bovis_AF2122/97 --------------------------------------------------
TH_2204|M.thermoresistible__bu YRSWFEYHDFHHIVRHTITDPADIELVPTRHGAMT-PEQWQQHLLSTP-D
MUL_1531|M.ulcerans_Agy99 FRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQWRERLLATP-S
MLBr_01230|M.leprae_Br4923 YRSWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLS-LAQIRELAVSTP-D
MAB_0852|M.abscessus_ATCC_1997 YHSWFEFDPVDKIVRHVIDDPASIDFVPQDHGLQG-PDEIRAHLLRTSGT
MAV_2723|M.avium_104 YHSWFEHRTDGRIVRHTFDDPADIEFAALQRGEMT-PTELRAHILATP-N
MSMEG_4728|M.smegmatis_MC2_155 YHSRFEFTVDDRIVRRKLRSPRDLRFVPTDHGVQT-CDQWREHILDTP-G
MMAR_2343|M.marinum_M YRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMS-PKQWQDYILATP-G
Rv1528c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1555c|M.bovis_AF2122/97 --------------------------------------------------
TH_2204|M.thermoresistible__bu PLQWNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEIHMQYAALVG
MUL_1531|M.ulcerans_Agy99 PLEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEIHLMYLALVS
MLBr_01230|M.leprae_Br4923 PLEWGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEFHMMYSALVS
MAB_0852|M.abscessus_ATCC_1997 PLSWDCFTFGVIQRADHFTVYISVDHLHTDGMSTGILYIEIQLMYASLVH
MAV_2723|M.avium_104 PLRWDCFTFGLVQHPDHFTFYMSADHLVIDGMSVGVIFLEIHLTYAALVS
MSMEG_4728|M.smegmatis_MC2_155 PLQWDCFRFGIIQRTDHFTCYMSVDHVHVDATFLGLMLIEIHLMYAALVS
MMAR_2343|M.marinum_M PLEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEIEAMYNTLAD
Rv1528c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1555c|M.bovis_AF2122/97 --------------------------------------------------
TH_2204|M.thermoresistible__bu GGAPIPLQ-AGSYDDFCVRQRQYTESLTADSPEVRAWVDFAGQMGGTLPN
MUL_1531|M.ulcerans_Agy99 GGAPLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFFDNNDGSLPK
MLBr_01230|M.leprae_Br4923 GAGPLELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFAEPNEGSFPD
MAB_0852|M.abscessus_ATCC_1997 G-SALQLPPPAGYLDFSARELAHNQAMTLDSFEVQTWLRYARDNGGTLPD
MAV_2723|M.avium_104 GGRPLPLPEPASYHDYCRRQHQHTEALTLQSPQVRAWIRFAEDNGGTLPS
MSMEG_4728|M.smegmatis_MC2_155 GGAPITLPPAGSYDDYCVRQRKYTSGLTLDSPEIKEWVTFLEGNNGTMPK
MMAR_2343|M.marinum_M GGAPISLPEAGSYGEYCLRERAYTSALTLESPEVRQWIDFFESNDGALPS
Rv1528c|M.tuberculosis_H37Rv -----------------------------------------------MTQ
Mb1555c|M.bovis_AF2122/97 -----------------------------------------------MTQ
:..
TH_2204|M.thermoresistible__bu FPLPLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARFVGGVFACAA
MUL_1531|M.ulcerans_Agy99 FPLPLGDTSAQC--EMMGVRLMDERQTLALEAACMSAGARFCGGVFAISA
MLBr_01230|M.leprae_Br4923 FPLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARFVGGVLACCG
MAB_0852|M.abscessus_ATCC_1997 FALPLGDRTAPNVGAMVAIPLLDAHGTVAFEKACEQAGVRFSGGVFACTA
MAV_2723|M.avium_104 FPLPLGDPSVPCGSGVVVAPLMDESQTERFDATCTKAGARFSGGVFACAA
MSMEG_4728|M.smegmatis_MC2_155 FPLPLGDLSVPCTGDLMTVQLLDEPQTQGFEKACVAAGSRFIGGVFAAAA
MMAR_2343|M.marinum_M FPLPLGDLSLVDTGELLSLQLMDAGQTARFEAACTSAGARFSGGVFACAA
Rv1528c|M.tuberculosis_H37Rv LPQPT-------------WRWWQQRETEQVQSSHIDG--EIVGALIPDLA
Mb1555c|M.bovis_AF2122/97 LPQPT-------------WRWWQQRETEQVQSSHIDG--EIVGALIPDLA
:. * : * .: : . .: *.::. .
TH_2204|M.thermoresistible__bu LTENELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITVPAAGVSFGE
MUL_1531|M.ulcerans_Agy99 VVQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITVPTVGSSFGE
MLBr_01230|M.leprae_Br4923 LAEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITVPIAGSSFGD
MAB_0852|M.abscessus_ATCC_1997 LIDRELTGAGTFYGITPYDTRGTAEEQMSVGWYASFIPFIVDMSDDSFAT
MAV_2723|M.avium_104 FAEYELTGAETYCAITPYDHRSTPAEFVTPGWFASFIPVTFPVAGASFGD
MSMEG_4728|M.smegmatis_MC2_155 LAQYQLTDIDTYHVITPTTTRGTEAEVMATGWFTGTVPITVPVG-SSFAE
MMAR_2343|M.marinum_M LAEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTVAVA-SSFDE
Rv1528c|M.tuberculosis_H37Rv VLHSEDASR----AAVGREKHRCSLDPLGGGFRS----------------
Mb1555c|M.bovis_AF2122/97 VLHSEDASR----AAVGREKHRCSLDPLGGGFRS----------------
. . : :. . : : : *:
TH_2204|M.thermoresistible__bu AARAAQQSFDSGIGLGHVPYDRVLELVPS---LRRAETCSPMMSFLDAGV
MUL_1531|M.ulcerans_Agy99 IVKAAQGSFDSGRDLAEVPLDCVMELVLW---LREGQWGAPLLFYLDAGI
MLBr_01230|M.leprae_Br4923 AARAAQNCFDTDVHLAEVPYDRVVELAPT---VHKPRPNFPVINFLDAGT
MAB_0852|M.abscessus_ATCC_1997 VARSAQKSFDECQPLAKVPFERALELAGPDSGLTAPEYVVPMVSFLDARK
MAV_2723|M.avium_104 AVIAAQASFDSAIGLADVPFDRVLELSSFGGRISKPTGDVHMLSFADARG
MSMEG_4728|M.smegmatis_MC2_155 TARTAQRSFDSGLYLAHVPFDRVLELGATERGLRAPDPGVPMVSYLDATA
MMAR_2343|M.marinum_M TVRGAQANFDASAHLANVPFERVLELAPWLK-KPPPRGGFPMVSFLDGGV
Rv1528c|M.tuberculosis_H37Rv -----------------------------------------RRASMPAGA
Mb1555c|M.bovis_AF2122/97 -----------------------------------------RRASMPAGA
.
TH_2204|M.thermoresistible__bu PPLSALVASQLDGLNARVYGDGKVPAQLCMWVNRMDNETSVTVFFPDNPV
MUL_1531|M.ulcerans_Agy99 PPLSAMANSHVEGLRARLCHDGGMMGQIDIRVNRLEKETQLTVLFPNNPV
MLBr_01230|M.leprae_Br4923 APLSVLLTAGLDGLNIGVYSDGRYSYQMSIYVIRVEQETAVAVMFPDNPE
MAB_0852|M.abscessus_ATCC_1997 IPVS----AEWDRINGGIYGDSRSSDQVCMWVNRFENETNLTISFPDNAV
MAV_2723|M.avium_104 IPFS----GQWDGLNAGIYGDGRSSDQVLMWVNRFDTETTLTVAFPQNPV
MSMEG_4728|M.smegmatis_MC2_155 APLSPAVVAEWNRINGRIFSEMGAANQVGMWVNQFGSGTWITVAFPNNPV
MMAR_2343|M.marinum_M PPLSGVVAMQLDRINARAFSDGRVAARVCIWVNKFQEETTVTASFPNNPI
Rv1528c|M.tuberculosis_H37Rv LLLSAVIAIQLDRMNARVFGDGWIGAQACMWVNKFHEESTVTALSPSSPI
Mb1555c|M.bovis_AF2122/97 LLLSAVIAIQLDRMNARVFGDGWIGAQACMWVNKFHEESTVTALSPSSPI
.* : :. : : : * :. : :: *...
TH_2204|M.thermoresistible__bu ARASVEKYVATLRSIYVAVAEGR-----ADRLG-------ARRSGELQRQ
MUL_1531|M.ulcerans_Agy99 ARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAYSRRTYEPPAT
MLBr_01230|M.leprae_Br4923 AQESVARYLETLKSVFECVAESG-----------------HWRNVA----
MAB_0852|M.abscessus_ATCC_1997 ARESVSRYFEVARVVYQRVAQSQFVS------------------------
MAV_2723|M.avium_104 ARDSVERYIRAVRAMCLRVVEHGAAAVPNRRRVVAAVNASAARSTANAAD
MSMEG_4728|M.smegmatis_MC2_155 ARASVQEYVDAFRSVCVAVAEGRHDDVPTPR-----VNELDLRSA-----
MMAR_2343|M.marinum_M AYDSVARYLDTMKSVYLRIAEGAR-----------------WDAIAQVL-
Rv1528c|M.tuberculosis_H37Rv AQGSIARHPETMQSAYVRIAEGGS------------------RDVAPAAQ
Mb1555c|M.bovis_AF2122/97 AQGSIARHPETMQSAYVRIAEGGS------------------RDVAPAAQ
* *: .: . : :.:
TH_2204|M.thermoresistible__bu PA----------------
MUL_1531|M.ulcerans_Agy99 VSPLTSWRTG--------
MLBr_01230|M.leprae_Br4923 ------------------
MAB_0852|M.abscessus_ATCC_1997 ------------------
MAV_2723|M.avium_104 RTDRRLQGAGFGANPVLR
MSMEG_4728|M.smegmatis_MC2_155 ------------------
MMAR_2343|M.marinum_M ------------------
Rv1528c|M.tuberculosis_H37Rv LQRRRP------------
Mb1555c|M.bovis_AF2122/97 LQRRRP------------