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KLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQAPVSAVPPSHIQARHLRGFAEQTARGHDMSRL VVAAMDIPGECDIRAMTYVINSHLRRHDTYRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMSPKQWQD YILATPGPLEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEIEAMYNTLADGGAPISLPEAGSY GEYCLRERAYTSALTLESPEVRQWIDFFESNDGALPSFPLPLGDLSLVDTGELLSLQLMDAGQTARFEAA CTSAGARFSGGVFACAALAEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTVAVASSFDETVRG AQANFDASAHLANVPFERVLELAPWLKKPPPRGGFPMVSFLDGGVPPLSGVVAMQLDRINARAFSDGRVA ARVCIWVNKFQEETTVTASFPNNPIAYDSVARYLDTMKSVYLRIAEGARWDAIAQVL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2343 | - | - | 100% (478) | hypothetical protein MMAR_2343 |
| M. marinum M | MMAR_2355 | papA3 | e-146 | 51.71% (468) | polyketide synthase associated protein PapA3 |
| M. marinum M | MMAR_0087 | - | 1e-08 | 22.08% (462) | hypothetical protein MMAR_0087 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3850c | papA2 | 1e-141 | 54.57% (460) | polyketide synthase associated protein PapA2 |
| M. gilvum PYR-GCK | Mflv_0404 | - | 1e-125 | 45.03% (473) | condensation domain-containing protein |
| M. tuberculosis H37Rv | Rv3820c | papA2 | 1e-141 | 54.57% (460) | polyketide synthase associated protein PapA2 |
| M. leprae Br4923 | MLBr_01230 | papA3 | 1e-146 | 50.74% (471) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_0938c | - | 1e-127 | 45.24% (473) | polyketide synthase associated protein PapA3 |
| M. avium 104 | MAV_1762 | - | 1e-135 | 47.78% (473) | condensation domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4728 | - | 1e-144 | 53.55% (465) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-169 | 59.74% (467) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. ulcerans Agy99 | MUL_1531 | papA3 | 1e-144 | 51.28% (468) | polyketide synthase associated protein PapA3 |
| M. vanbaalenii PYR-1 | Mvan_0270 | - | 1e-126 | 46.20% (474) | condensation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2343|M.marinum_M ----------MKLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQA
TH_2204|M.thermoresistible__bu ------------MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQA
Mb3850c|M.bovis_AF2122/97 -----------------MFSITTLRDWTPDPGSIICWHASPTAKAKARQA
Rv3820c|M.tuberculosis_H37Rv -----------------MFSITTLRDWTPDPGSIICWHASPTAKAKARQA
MSMEG_4728|M.smegmatis_MC2_155 -----------------MFELTDIQNWDDAPGKHVSWGPSPSTVAKVAEA
MUL_1531|M.ulcerans_Agy99 ------------MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKA
Mflv_0404|M.gilvum_PYR-GCK -------------MRIGKITVGALEEWSLSPGKVISWHPTAASIEKARQA
Mvan_0270|M.vanbaalenii_PYR-1 -------------MRIGKITVGALDEWSLNPGSVTSWHPTAAAVETARRA
MAB_0938c|M.abscessus_ATCC_199 MPERGRPSERDGVLRIGTITVGALDEWTLNAGTVTSWHPTPAATEKARQA
MAV_1762|M.avium_104 -------------MRIGKITIGSLGDWTPTPGPVTSWHPTAAAAEKVRQA
MLBr_01230|M.leprae_Br4923 -------------MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQA
. : :* .* * .: : .. .*
MMAR_2343|M.marinum_M PVSAVPPSHIQARHLRGFAEQTARGHDMSRLVVAAMDIPGECDIRAMTYV
TH_2204|M.thermoresistible__bu PVSSVPVSYMQAQHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYV
Mb3850c|M.bovis_AF2122/97 PISEVPPSYQQAQHLRRYRDHVARGLDMSRLMIFTWDLPGRCNIRAMNYA
Rv3820c|M.tuberculosis_H37Rv PISEVPPSYQQAQHLRRYRDHVARGLDMSRLMIFTWDLPGRCNIRAMNYA
MSMEG_4728|M.smegmatis_MC2_155 PVSDVPASYQQAQHLRAYREHTARGVPMARLTVPVWNMDSQCDMRAMSHV
MUL_1531|M.ulcerans_Agy99 PISPVPPSYMQAHHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHV
Mflv_0404|M.gilvum_PYR-GCK PVSSVPVSYMQGQHLRNYCDRTTEGLNFSRQIIASCDVAGVCDIEAMDHA
Mvan_0270|M.vanbaalenii_PYR-1 QVSSVPVSYMQGQHLRNYWERTTAGLNFSRQIIASCEVPGQCDIAAMDHA
MAB_0938c|M.abscessus_ATCC_199 PVSSVPVSYMQTQHLRNYYERNNAGLNFSRQIIASCDVPGNCDIAAMNHA
MAV_1762|M.avium_104 PASPVPVSYMQGQHLRNYHERTAAGLDFSRQIIATCDVPGRCDISAMNYA
MLBr_01230|M.leprae_Br4923 PVSSVPVAYMQAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYI
* ** :: * :*:* : . * :* : : . *:: :: :
MMAR_2343|M.marinum_M INSHLRRHDTYRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMSPK-QW
TH_2204|M.thermoresistible__bu INAHMRRHDTYRSWFEYHDFHHIVRHTITDPADIELVPTRHGAMTPE-QW
Mb3850c|M.bovis_AF2122/97 INAHLRRHDTYHSWFEFDNAEHIVRHTIADPADIEVVQAEHQNMTSA-EL
Rv3820c|M.tuberculosis_H37Rv INAHLRRHDTYHSWFEFDNAEHIVRHTIADPADIEVVQAEHQNMTSA-EL
MSMEG_4728|M.smegmatis_MC2_155 INAYLRRHDTYHSRFEFTVDDRIVRRKLRSPRDLRFVPTDHGVQTCD-QW
MUL_1531|M.ulcerans_Agy99 VNAHMRRHDTFRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQW
Mflv_0404|M.gilvum_PYR-GCK VNAYLRRHDTFRSWFEHSGDGEFVRRALVDPEDIEFVPVEHGHMGVD-EI
Mvan_0270|M.vanbaalenii_PYR-1 VNAYLRRHDTFRSWFERTEEGEFLRRAIADPADIEFVPIEHGDMTVD-EI
MAB_0938c|M.abscessus_ATCC_199 LNAYLRRHDTFRSWFERTDDGEFIRHSISDPADIEFAPVTQGHMSVD-EI
MAV_1762|M.avium_104 VNAYLRRHDTFRSWFHHSGDGEFVRHTVSNPADIEFAPIHHGEMTAE-EI
MLBr_01230|M.leprae_Br4923 VNAHLRRHDTYRSWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLSLA-QI
:*:::*****::* *. .: *: : * *:... : :
MMAR_2343|M.marinum_M QDYILATPGPLEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEI
TH_2204|M.thermoresistible__bu QQHLLSTPDPLQWNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEI
Mb3850c|M.bovis_AF2122/97 RHHIA-TPQPLQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIVGVLFIEI
Rv3820c|M.tuberculosis_H37Rv RHHIA-TPQPLQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIVGVLFIEI
MSMEG_4728|M.smegmatis_MC2_155 REHILDTPGPLQWDCFRFGIIQRTDHFTCYMSVDHVHVDATFLGLMLIEI
MUL_1531|M.ulcerans_Agy99 RERLLATPSPLEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEI
Mflv_0404|M.gilvum_PYR-GCK HAHVVAIPSPLEWGCFTFGVIQNDDHFSFFASMDHVHGDATLIGTTMMEA
Mvan_0270|M.vanbaalenii_PYR-1 FAHVVDIPSPLEWGCFTFGVIQHDGHFTFFASMDHVHGDATLIGTTMMEA
MAB_0938c|M.abscessus_ATCC_199 RSHVIDIPSPLEWGCFTFGIIQSENHFTFFAAMDHVHGDATLIGTTMMEA
MAV_1762|M.avium_104 RAHVVAIPNPLEWGCFTFGVVQNEEYFTFFAAMDHVHGDATLIGTTMLEA
MLBr_01230|M.leprae_Br4923 RELAVSTPDPLEWGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEF
* **:*.*. *.::* :*: .: *: *. ::. : *
MMAR_2343|M.marinum_M EAMYNTLADGGAPISLPEAGSYGEYCLRERAYTSALTLESPEVRQWIDFF
TH_2204|M.thermoresistible__bu HMQYAALVGGGAPIPL-QAGSYDDFCVRQRQYTESLTADSPEVRAWVDFA
Mb3850c|M.bovis_AF2122/97 HMMYSALVGGDPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFA
Rv3820c|M.tuberculosis_H37Rv HMMYSALVGGDPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFA
MSMEG_4728|M.smegmatis_MC2_155 HLMYAALVSGGAPITLPPAGSYDDYCVRQRKYTSGLTLDSPEIKEWVTFL
MUL_1531|M.ulcerans_Agy99 HLMYLALVSGGAPLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFF
Mflv_0404|M.gilvum_PYR-GCK NGMYSALSSGGAALALPDAGSFDDFCVREREYTAELTEDSPGVRAWIEFA
Mvan_0270|M.vanbaalenii_PYR-1 NGMYSALSGGGAALTLPDAGSFDEFCVRERAHTSELTEDSPEVRAWIEFA
MAB_0938c|M.abscessus_ATCC_199 NGMYSALSSGGAALTLPDAGSFDDFCTREREFTSALTLDSPGVQAWIDFA
MAV_1762|M.avium_104 NGMYAAASAGSEPLELPDAGSFDDFCAREREYTSALTVDSPEVRAWIDFA
MLBr_01230|M.leprae_Br4923 HMMYSALVSGAGPLELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFA
. * : * .: * .* :.:.* *: ** :*. : * *
MMAR_2343|M.marinum_M ESNDGALPSFPLPLGDLSLVDTGELLSLQLMDAGQTARFEAACTSAGARF
TH_2204|M.thermoresistible__bu GQMGGTLPNFPLPLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARF
Mb3850c|M.bovis_AF2122/97 ANNDGTLPHFPLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVAAGARF
Rv3820c|M.tuberculosis_H37Rv ANNDGTLPHFPLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVAAGARF
MSMEG_4728|M.smegmatis_MC2_155 EGNNGTMPKFPLPLGDLSVPCTGDLMTVQLLDEPQTQGFEKACVAAGSRF
MUL_1531|M.ulcerans_Agy99 DNNDGSLPKFPLPLGDTSAQC--EMMGVRLMDERQTLALEAACMSAGARF
Mflv_0404|M.gilvum_PYR-GCK ENNSDGFPEFPLPLGNPKDSTRSVMTSAVLMDTAQTERFDAAATAAGARF
Mvan_0270|M.vanbaalenii_PYR-1 ENSGGGFPEFPLPLGNPAESTRSCMTSEILMDTAQTERFESACTAAGARF
MAB_0938c|M.abscessus_ATCC_199 ENNNGTFPEFPLPLGNPAEATNSTMTSLLLLNPEQTDRFDAACGTAGARF
MAV_1762|M.avium_104 ENNNGSFPEFPLPLGNPSEATASAMVSELVMDAEQTERFESACTAVGVRF
MLBr_01230|M.leprae_Br4923 EPNEGSFPDFPLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARF
. :* ******: : ::: * :: *. .* **
MMAR_2343|M.marinum_M SGGVFACAALAEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTV
TH_2204|M.thermoresistible__bu VGGVFACAALTENELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITV
Mb3850c|M.bovis_AF2122/97 SGGVFACAALAERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITV
Rv3820c|M.tuberculosis_H37Rv SGGVFACAALAERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITV
MSMEG_4728|M.smegmatis_MC2_155 IGGVFAAAALAQYQLTDIDTYHVITPTTTRGTEAEVMATGWFTGTVPITV
MUL_1531|M.ulcerans_Agy99 CGGVFAISAVVQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITV
Mflv_0404|M.gilvum_PYR-GCK VGGLFACLAQVEHELTGALTYYGLTPRDSRSGSDNFMTQGWFTGLIPITV
Mvan_0270|M.vanbaalenii_PYR-1 VGGLFACLAQVEHELTGALTYYGLTPRDSRSASDNFMTQGWFTGLIPITV
MAB_0938c|M.abscessus_ATCC_199 VGGLFACLGLVEHEFTGAVTYYGLTPRDSRTASDNFMTQGWFTGLIPITV
MAV_1762|M.avium_104 IGGLFACIALVEHELTGALTYYGLTPRDTRRTTDNFMTQGWFTGLVPITV
MLBr_01230|M.leprae_Br4923 VGGVLACCGLAEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITV
**::* . .: :::. : :.. * :. : ***.* :*:**
MMAR_2343|M.marinum_M AVA-SSFDETVRGAQANFDASAHLANVPFERVLELAPWLK-KPPPRGGFP
TH_2204|M.thermoresistible__bu PAAGVSFGEAARAAQQSFDSGIGLGHVPYDRVLELVPSLR-RAETCS--P
Mb3850c|M.bovis_AF2122/97 PVASGLFDSAARVAQISFDSGKDLATVPFDRVLELARPETGLRPPRPGNF
Rv3820c|M.tuberculosis_H37Rv PVASGLFDSAARVAQISFDSGKDLATVPFDRVLELARPETGLRPPRPGNF
MSMEG_4728|M.smegmatis_MC2_155 PVGS-SFAETARTAQRSFDSGLYLAHVPFDRVLELGATERGLRAPDPGVP
MUL_1531|M.ulcerans_Agy99 PTVGSSFGEIVKAAQGSFDSGRDLAEVPLDCVMELVLWLR---EGQWGAP
Mflv_0404|M.gilvum_PYR-GCK PIGAASFGEAAWAAQSSFDSGLNMAKVPYYRVLELAPWLG---WPRPNFP
Mvan_0270|M.vanbaalenii_PYR-1 PIGATSFADAAWAAQASFDSNLFMAKVPYYRVLELAPWLS---WPRPNFP
MAB_0938c|M.abscessus_ATCC_199 PIAATSFNDAAYAAQTAFDSSLDMARVPYYRVLELAPWLK---WPEPNFP
MAV_1762|M.avium_104 PIAAASFADAAWTAQTSFDSGQQLAKVPYYRVLELAPWLK---WPQPNFP
MLBr_01230|M.leprae_Br4923 PIAGSSFGDAARAAQNCFDTDVHLAEVPYDRVVELAPTVH---KPRPNFP
. * . . ** **:. :. ** *:**
MMAR_2343|M.marinum_M MVSFLDGGVPPLSGVVAMQLDRIN--ARAFSDGRVAARVCIWVNKFQEET
TH_2204|M.thermoresistible__bu MMSFLDAGVPPLSALVASQLDGLN--ARVYGDGKVPAQLCMWVNRMDNET
Mb3850c|M.bovis_AF2122/97 VMSFLDASIAPLSTVANSDLN-----FRIYDEGRVSHQVSMWVNRYQHQT
Rv3820c|M.tuberculosis_H37Rv VMSFLDASIAPLSTVANSDLN-----FRIYDEGRVSHQVSMWVNRYQHQT
MSMEG_4728|M.smegmatis_MC2_155 MVSYLDATAAPLSPAVVAEWNRIN--GRIFSEMGAANQVGMWVNQFGSGT
MUL_1531|M.ulcerans_Agy99 LLFYLDAGIPPLSAMANSHVEGLR--ARLCHDGGMMGQIDIRVNRLEKET
Mflv_0404|M.gilvum_PYR-GCK VSNFFHGGAAPLNAILAASEMGLADNIGIYPDGRFSYQLTIYIFRYGQGT
Mvan_0270|M.vanbaalenii_PYR-1 VSNFFHGGAAPLNAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGT
MAB_0938c|M.abscessus_ATCC_199 VSNFFHGGAAPLNAILAAGELGLADNIGIYPDGRFSYQLTIYIFRYGEGT
MAV_1762|M.avium_104 VSNFFHAGAAPLNAVLAAADLGYANNIGIYSDGRYSYQLTIYVFRYGEGT
MLBr_01230|M.leprae_Br4923 VINFLDAGTAPLSVLLTAGLDGLN--IGVYSDGRYSYQMSIYVIRVEQET
: ::.. .**. : :: : : : *
MMAR_2343|M.marinum_M TVTASFPNNPIAYDSVARYLDTMKSVYLRIAEG------ARWDAIAQVL-
TH_2204|M.thermoresistible__bu SVTVFFPDNPVARASVEKYVATLRSIYVAVAEGRADRLGARRSGELQRQP
Mb3850c|M.bovis_AF2122/97 TVTVLFPDNPIASESVANYIAAMKSIYIRTADG---TLAILKPGT-----
Rv3820c|M.tuberculosis_H37Rv TVTVLFPDNPIASESVANYIAAMKSIYIRTADG---TLATLKPGT-----
MSMEG_4728|M.smegmatis_MC2_155 WITVAFPNNPVARASVQEYVDAFRSVCVAVAEGRHDDVPTPRVNELDLRS
MUL_1531|M.ulcerans_Agy99 QLTVLFPNNPVARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLA
Mflv_0404|M.gilvum_PYR-GCK EMAIMHPDNPVAKRSVERYMQTMSSVASLVADT------GHWGRVA----
Mvan_0270|M.vanbaalenii_PYR-1 VMAIMHPDNPVAKKSVTRYMKVMKSVAGLVADS------GTWGLVA----
MAB_0938c|M.abscessus_ATCC_199 AMAIMHPDNPIAEKSALRYMEAMKSVCARVADT------GHWGRVA----
MAV_1762|M.avium_104 AMAMMYPDNPVAHKSVARYTETMRSVCGRVADT------GHWGRVA----
MLBr_01230|M.leprae_Br4923 AVAVMFPDNPEAQESVARYLETLKSVFECVAES------GHWRNVA----
:: .*:** * *. .* .: * *:
MMAR_2343|M.marinum_M ---------------------
TH_2204|M.thermoresistible__bu A--------------------
Mb3850c|M.bovis_AF2122/97 ---------------------
Rv3820c|M.tuberculosis_H37Rv ---------------------
MSMEG_4728|M.smegmatis_MC2_155 A--------------------
MUL_1531|M.ulcerans_Agy99 YSRRTYEPPATVSPLTSWRTG
Mflv_0404|M.gilvum_PYR-GCK ---------------------
Mvan_0270|M.vanbaalenii_PYR-1 ---------------------
MAB_0938c|M.abscessus_ATCC_199 ---------------------
MAV_1762|M.avium_104 ---------------------
MLBr_01230|M.leprae_Br4923 ---------------------