For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
FSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQQAQHLRRYRDHVARGLDMSRLMIFTWDL PGRCNIRAMNYAINAHLRRHDTYHSWFEFDNAEHIVRHTIADPADIEVVQAEHQNMTSAELRHHIATPQP LQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIVGVLFIEIHMMYSALVGGDPPIELPPAGRYDDHCVRQY ADTAALTLDSARVRRWVEFAANNDGTLPHFPLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVAAGARF SGGVFACAALAERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITVPVASGLFDSAARVAQISFDS GKDLATVPFDRVLELARPETGLRPPRPGNFVMSFLDASIAPLSTVANSDLNFRIYDEGRVSHQVSMWVNR YQHQTTVTVLFPDNPIASESVANYIAAMKSIYIRTADGTLATLKPGT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3820c | papA2 | - | 100% (468) | POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA2 |
| M. tuberculosis H37Rv | Rv1182 | papA3 | e-143 | 53.91% (460) | polyketide synthase associated protein PapA3 |
| M. tuberculosis H37Rv | Rv3824c | papA1 | e-138 | 53.68% (462) | polyketide synthase associated protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3850c | papA2 | 0.0 | 99.79% (468) | polyketide synthase associated protein PapA2 |
| M. gilvum PYR-GCK | Mflv_0404 | - | 1e-115 | 46.32% (462) | condensation domain-containing protein |
| M. leprae Br4923 | MLBr_01230 | papA3 | 1e-140 | 53.63% (455) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_3147c | - | 1e-126 | 50.11% (455) | polyketide synthase associated protein |
| M. marinum M | MMAR_2343 | - | 1e-141 | 54.57% (460) | hypothetical protein MMAR_2343 |
| M. avium 104 | MAV_1762 | - | 1e-130 | 49.78% (462) | condensation domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4728 | - | 1e-141 | 53.56% (463) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-151 | 56.62% (461) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. ulcerans Agy99 | MUL_1531 | papA3 | 1e-126 | 49.24% (459) | polyketide synthase associated protein PapA3 |
| M. vanbaalenii PYR-1 | Mvan_0270 | - | 1e-116 | 46.32% (462) | condensation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3820c|M.tuberculosis_H37Rv -------MFSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQ
Mb3850c|M.bovis_AF2122/97 -------MFSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQ
MSMEG_4728|M.smegmatis_MC2_155 -------MFELTDIQNWDDAPGKHVSWGPSPSTVAKVAEAPVSDVPASYQ
MMAR_2343|M.marinum_M MKLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQAPVSAVPPSHI
TH_2204|M.thermoresistible__bu --MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQAPVSSVPVSYM
MUL_1531|M.ulcerans_Agy99 --MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKAPISPVPPSYM
Mflv_0404|M.gilvum_PYR-GCK ---MRIGKITVGALEEWSLSPGKVISWHPTAASIEKARQAPVSSVPVSYM
Mvan_0270|M.vanbaalenii_PYR-1 ---MRIGKITVGALDEWSLNPGSVTSWHPTAAAVETARRAQVSSVPVSYM
MAV_1762|M.avium_104 ---MRIGKITIGSLGDWTPTPGPVTSWHPTAAAAEKVRQAPASPVPVSYM
MLBr_01230|M.leprae_Br4923 ---MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQAPVSSVPVAYM
MAB_3147c|M.abscessus_ATCC_199 ---MRGGPVTVSLTDKWEPTAGSVITWQPSPASYAKALEAPVSDVPPSFM
. .* .* * .: : .. .* * ** :.
Rv3820c|M.tuberculosis_H37Rv QAQHLRRYRDHVARGLDMSRLMIFTWDLPGRCNIRAMNYAINAHLRRHDT
Mb3850c|M.bovis_AF2122/97 QAQHLRRYRDHVARGLDMSRLMIFTWDLPGRCNIRAMNYAINAHLRRHDT
MSMEG_4728|M.smegmatis_MC2_155 QAQHLRAYREHTARGVPMARLTVPVWNMDSQCDMRAMSHVINAYLRRHDT
MMAR_2343|M.marinum_M QARHLRGFAEQTARGHDMSRLVVAAMDIPGECDIRAMTYVINSHLRRHDT
TH_2204|M.thermoresistible__bu QAQHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYVINAHMRRHDT
MUL_1531|M.ulcerans_Agy99 QAHHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHVVNAHMRRHDT
Mflv_0404|M.gilvum_PYR-GCK QGQHLRNYCDRTTEGLNFSRQIIASCDVAGVCDIEAMDHAVNAYLRRHDT
Mvan_0270|M.vanbaalenii_PYR-1 QGQHLRNYWERTTAGLNFSRQIIASCEVPGQCDIAAMDHAVNAYLRRHDT
MAV_1762|M.avium_104 QGQHLRNYHERTAAGLDFSRQIIATCDVPGRCDISAMNYAVNAYLRRHDT
MLBr_01230|M.leprae_Br4923 QAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYIVNAHLRRHDT
MAB_3147c|M.abscessus_ATCC_199 QVQHLRTYLRQAAKGLDFSRVLVFTLDMPGRCDKRAMGHVINAHLRRHDT
* :*:* : * :* : : . *: :: : :*:::*****
Rv3820c|M.tuberculosis_H37Rv YHSWFEFDNAEHIVRHTIADPADIEVVQAEHQNMTSA-ELRHHIA-TPQP
Mb3850c|M.bovis_AF2122/97 YHSWFEFDNAEHIVRHTIADPADIEVVQAEHQNMTSA-ELRHHIA-TPQP
MSMEG_4728|M.smegmatis_MC2_155 YHSRFEFTVDDRIVRRKLRSPRDLRFVPTDHGVQTCD-QWREHILDTPGP
MMAR_2343|M.marinum_M YRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMSPK-QWQDYILATPGP
TH_2204|M.thermoresistible__bu YRSWFEYHDFHHIVRHTITDPADIELVPTRHGAMTPE-QWQQHLLSTPDP
MUL_1531|M.ulcerans_Agy99 FRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQWRERLLATPSP
Mflv_0404|M.gilvum_PYR-GCK FRSWFEHSGDGEFVRRALVDPEDIEFVPVEHGHMGVDEIHAHVV-AIPSP
Mvan_0270|M.vanbaalenii_PYR-1 FRSWFERTEEGEFLRRAIADPADIEFVPIEHGDMTVDEIFAHVV-DIPSP
MAV_1762|M.avium_104 FRSWFHHSGDGEFVRHTVSNPADIEFAPIHHGEMTAEEIRAHVV-AIPNP
MLBr_01230|M.leprae_Br4923 YRSWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLSLAQIRELAV-STPDP
MAB_3147c|M.abscessus_ATCC_199 YRSWFSLDDEQNIVRRTMADPADVEFVQVKLGEMTSDEVRELVVSETPDP
::* * .: *: : * *:... : * *
Rv3820c|M.tuberculosis_H37Rv LQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIVGVLFIEIHMMYSALVGG
Mb3850c|M.bovis_AF2122/97 LQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIVGVLFIEIHMMYSALVGG
MSMEG_4728|M.smegmatis_MC2_155 LQWDCFRFGIIQRTDHFTCYMSVDHVHVDATFLGLMLIEIHLMYAALVSG
MMAR_2343|M.marinum_M LEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEIEAMYNTLADG
TH_2204|M.thermoresistible__bu LQWNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEIHMQYAALVGG
MUL_1531|M.ulcerans_Agy99 LEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEIHLMYLALVSG
Mflv_0404|M.gilvum_PYR-GCK LEWGCFTFGVIQNDDHFSFFASMDHVHGDATLIGTTMMEANGMYSALSSG
Mvan_0270|M.vanbaalenii_PYR-1 LEWGCFTFGVIQHDGHFTFFASMDHVHGDATLIGTTMMEANGMYSALSGG
MAV_1762|M.avium_104 LEWGCFTFGVVQNEEYFTFFAAMDHVHGDATLIGTTMLEANGMYAAASAG
MLBr_01230|M.leprae_Br4923 LEWGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEFHMMYSALVSG
MAB_3147c|M.abscessus_ATCC_199 FRWDCFRFGIVQSSGHFTFYFSVDHLHLDATFARLLIMEILMGYKALVQG
:.*.*. *.::* :*: .: *: *. : : * * : *
Rv3820c|M.tuberculosis_H37Rv DPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFAANNDGTLPHF
Mb3850c|M.bovis_AF2122/97 DPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFAANNDGTLPHF
MSMEG_4728|M.smegmatis_MC2_155 GAPITLPPAGSYDDYCVRQRKYTSGLTLDSPEIKEWVTFLEGNNGTMPKF
MMAR_2343|M.marinum_M GAPISLPEAGSYGEYCLRERAYTSALTLESPEVRQWIDFFESNDGALPSF
TH_2204|M.thermoresistible__bu GAPIPL-QAGSYDDFCVRQRQYTESLTADSPEVRAWVDFAGQMGGTLPNF
MUL_1531|M.ulcerans_Agy99 GAPLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFFDNNDGSLPKF
Mflv_0404|M.gilvum_PYR-GCK GAALALPDAGSFDDFCVREREYTAELTEDSPGVRAWIEFAENNSDGFPEF
Mvan_0270|M.vanbaalenii_PYR-1 GAALTLPDAGSFDEFCVRERAHTSELTEDSPEVRAWIEFAENSGGGFPEF
MAV_1762|M.avium_104 SEPLELPDAGSFDDFCAREREYTSALTVDSPEVRAWIDFAENNNGSFPEF
MLBr_01230|M.leprae_Br4923 AGPLELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFAEPNEGSFPDF
MAB_3147c|M.abscessus_ATCC_199 GAPIELPPAGSYGDYCIRQHEFLSGLTPDSEPVREWTQFAENNRGSLPDF
.: * .* :.:.* *: ** :* : * * . :* *
Rv3820c|M.tuberculosis_H37Rv PLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVAAGARFSGGVFACAAL
Mb3850c|M.bovis_AF2122/97 PLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVAAGARFSGGVFACAAL
MSMEG_4728|M.smegmatis_MC2_155 PLPLGDLSVPCTGDLMTVQLLDEPQTQGFEKACVAAGSRFIGGVFAAAAL
MMAR_2343|M.marinum_M PLPLGDLSLVDTGELLSLQLMDAGQTARFEAACTSAGARFSGGVFACAAL
TH_2204|M.thermoresistible__bu PLPLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARFVGGVFACAAL
MUL_1531|M.ulcerans_Agy99 PLPLGDTSAQC--EMMGVRLMDERQTLALEAACMSAGARFCGGVFAISAV
Mflv_0404|M.gilvum_PYR-GCK PLPLGNPKDSTRSVMTSAVLMDTAQTERFDAAATAAGARFVGGLFACLAQ
Mvan_0270|M.vanbaalenii_PYR-1 PLPLGNPAESTRSCMTSEILMDTAQTERFESACTAAGARFVGGLFACLAQ
MAV_1762|M.avium_104 PLPLGNPSEATASAMVSELVMDAEQTERFESACTAVGVRFIGGLFACIAL
MLBr_01230|M.leprae_Br4923 PLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARFVGGVLACCGL
MAB_3147c|M.abscessus_ATCC_199 PLPLGDHGVQCGTAIVTEQLLDEQQALKFESLCVDAGARFIGGVMAALGF
*****: : ::* * :: . .* ** **::* .
Rv3820c|M.tuberculosis_H37Rv AERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITVPVASGLFDSA
Mb3850c|M.bovis_AF2122/97 AERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITVPVASGLFDSA
MSMEG_4728|M.smegmatis_MC2_155 AQYQLTDIDTYHVITPTTTRGTEAEVMATGWFTGTVPITVPVGS-SFAET
MMAR_2343|M.marinum_M AEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTVAVA-SSFDET
TH_2204|M.thermoresistible__bu TENELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITVPAAGVSFGEA
MUL_1531|M.ulcerans_Agy99 VQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITVPTVGSSFGEI
Mflv_0404|M.gilvum_PYR-GCK VEHELTGALTYYGLTPRDSRSGSDNFMTQGWFTGLIPITVPIGAASFGEA
Mvan_0270|M.vanbaalenii_PYR-1 VEHELTGALTYYGLTPRDSRSASDNFMTQGWFTGLIPITVPIGATSFADA
MAV_1762|M.avium_104 VEHELTGALTYYGLTPRDTRRTTDNFMTQGWFTGLVPITVPIAAASFADA
MLBr_01230|M.leprae_Br4923 AEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITVPIAGSSFGDA
MAB_3147c|M.abscessus_ATCC_199 AERELTGTDTYYGITPSDAREEAD-MFTTGWFTGLVPITAPVDG-TFAAA
.: :*:. : :.. * . : ***.* :*:*.. *
Rv3820c|M.tuberculosis_H37Rv ARVAQISFDSGKDLATVPFDRVLELARPETGLRPPRPGNFVMSFLDASIA
Mb3850c|M.bovis_AF2122/97 ARVAQISFDSGKDLATVPFDRVLELARPETGLRPPRPGNFVMSFLDASIA
MSMEG_4728|M.smegmatis_MC2_155 ARTAQRSFDSGLYLAHVPFDRVLELGATERGLRAPDPGVPMVSYLDATAA
MMAR_2343|M.marinum_M VRGAQANFDASAHLANVPFERVLELAPWLK-KPPPRGGFPMVSFLDGGVP
TH_2204|M.thermoresistible__bu ARAAQQSFDSGIGLGHVPYDRVLELVPSLR-RAETCS--PMMSFLDAGVP
MUL_1531|M.ulcerans_Agy99 VKAAQGSFDSGRDLAEVPLDCVMELVLWLR---EGQWGAPLLFYLDAGIP
Mflv_0404|M.gilvum_PYR-GCK AWAAQSSFDSGLNMAKVPYYRVLELAPWLG---WPRPNFPVSNFFHGGAA
Mvan_0270|M.vanbaalenii_PYR-1 AWAAQASFDSNLFMAKVPYYRVLELAPWLS---WPRPNFPVSNFFHGGAA
MAV_1762|M.avium_104 AWTAQTSFDSGQQLAKVPYYRVLELAPWLK---WPQPNFPVSNFFHAGAA
MLBr_01230|M.leprae_Br4923 ARAAQNCFDTDVHLAEVPYDRVVELAPTVH---KPRPNFPVINFLDAGTA
MAB_3147c|M.abscessus_ATCC_199 AVAAQESFDRGRQLVNVPFYRVLELVPQLS---WPRPYHPMINFFDGGAP
. ** ** . : ** *:** : ::.. .
Rv3820c|M.tuberculosis_H37Rv PLSTVANSDLN-----FRIYDEGRVSHQVSMWVNRYQHQTTVTVLFPDNP
Mb3850c|M.bovis_AF2122/97 PLSTVANSDLN-----FRIYDEGRVSHQVSMWVNRYQHQTTVTVLFPDNP
MSMEG_4728|M.smegmatis_MC2_155 PLSPAVVAEWNRIN--GRIFSEMGAANQVGMWVNQFGSGTWITVAFPNNP
MMAR_2343|M.marinum_M PLSGVVAMQLDRIN--ARAFSDGRVAARVCIWVNKFQEETTVTASFPNNP
TH_2204|M.thermoresistible__bu PLSALVASQLDGLN--ARVYGDGKVPAQLCMWVNRMDNETSVTVFFPDNP
MUL_1531|M.ulcerans_Agy99 PLSAMANSHVEGLR--ARLCHDGGMMGQIDIRVNRLEKETQLTVLFPNNP
Mflv_0404|M.gilvum_PYR-GCK PLNAILAASEMGLADNIGIYPDGRFSYQLTIYIFRYGQGTEMAIMHPDNP
Mvan_0270|M.vanbaalenii_PYR-1 PLNAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGTVMAIMHPDNP
MAV_1762|M.avium_104 PLNAVLAAADLGYANNIGIYSDGRYSYQLTIYVFRYGEGTAMAMMYPDNP
MLBr_01230|M.leprae_Br4923 PLSVLLTAGLDGLN--IGVYSDGRYSYQMSIYVIRVEQETAVAVMFPDNP
MAB_3147c|M.abscessus_ATCC_199 PLSQLFTN-PLLVSNPIGLYAESKSVYQLTIFISRFPTETTLMIAYPDNP
**. : :: : : : * : .*:**
Rv3820c|M.tuberculosis_H37Rv IASESVANYIAAMKSIYIRTADG---TLATLKPGT---------------
Mb3850c|M.bovis_AF2122/97 IASESVANYIAAMKSIYIRTADG---TLAILKPGT---------------
MSMEG_4728|M.smegmatis_MC2_155 VARASVQEYVDAFRSVCVAVAEGRHDDVPTPRVNELDLRSA---------
MMAR_2343|M.marinum_M IAYDSVARYLDTMKSVYLRIAEG------ARWDAIAQVL-----------
TH_2204|M.thermoresistible__bu VARASVEKYVATLRSIYVAVAEGRADRLGARRSGELQRQPA---------
MUL_1531|M.ulcerans_Agy99 VARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAYSRRTYEPPA
Mflv_0404|M.gilvum_PYR-GCK VAKRSVERYMQTMSSVASLVADT------GHWGRVA--------------
Mvan_0270|M.vanbaalenii_PYR-1 VAKKSVTRYMKVMKSVAGLVADS------GTWGLVA--------------
MAV_1762|M.avium_104 VAHKSVARYTETMRSVCGRVADT------GHWGRVA--------------
MLBr_01230|M.leprae_Br4923 EAQESVARYLETLKSVFECVAES------GHWRNVA--------------
MAB_3147c|M.abscessus_ATCC_199 VARESITRYVDLVKSTFARVCEQ------NDVVPAR--------------
* *: .* . * .:
Rv3820c|M.tuberculosis_H37Rv -----------
Mb3850c|M.bovis_AF2122/97 -----------
MSMEG_4728|M.smegmatis_MC2_155 -----------
MMAR_2343|M.marinum_M -----------
TH_2204|M.thermoresistible__bu -----------
MUL_1531|M.ulcerans_Agy99 TVSPLTSWRTG
Mflv_0404|M.gilvum_PYR-GCK -----------
Mvan_0270|M.vanbaalenii_PYR-1 -----------
MAV_1762|M.avium_104 -----------
MLBr_01230|M.leprae_Br4923 -----------
MAB_3147c|M.abscessus_ATCC_199 -----------