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PASYQQLHHLRRFSEHAARGLDMARLNIGVWDISGVCDVAAMTEAINAHLRRHDTYHSWFEHRTDGRIVR HTFDDPADIEFAALQRGEMTPTELRAHILATPNPLRWDCFTFGLVQHPDHFTFYMSADHLVIDGMSVGVI FLEIHLTYAALVSGGRPLPLPEPASYHDYCRRQHQHTEALTLQSPQVRAWIRFAEDNGGTLPSFPLPLGD PSVPCGSGVVVAPLMDESQTERFDATCTKAGARFSGGVFACAAFAEYELTGAETYCAITPYDHRSTPAEF VTPGWFASFIPVTFPVAGASFGDAVIAAQASFDSAIGLADVPFDRVLELSSFGGRISKPTGDVHMLSFAD ARGIPFSGQWDGLNAGIYGDGRSSDQVLMWVNRFDTETTLTVAFPQNPVARDSVERYIRAVRAMCLRVVE HGAAAVPNRRRVVAAVNASAARSTANAADRTDRRLQGAGFGANPVLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2723 | - | - | 100% (468) | PapA2 protein |
| M. avium 104 | MAV_1762 | - | e-117 | 48.02% (429) | condensation domain-containing protein |
| M. avium 104 | MAV_2005 | - | e-113 | 48.23% (423) | PapA2 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3850c | papA2 | 1e-128 | 54.74% (422) | polyketide synthase associated protein PapA2 |
| M. gilvum PYR-GCK | Mflv_0404 | - | 1e-109 | 46.84% (427) | condensation domain-containing protein |
| M. tuberculosis H37Rv | Rv3820c | papA2 | 1e-128 | 54.74% (422) | polyketide synthase associated protein PapA2 |
| M. leprae Br4923 | MLBr_01230 | papA3 | 1e-127 | 49.65% (427) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_0852 | - | 1e-130 | 53.55% (422) | polyketide synthase associated protein PapA2 |
| M. marinum M | MMAR_2343 | - | 1e-127 | 53.18% (425) | hypothetical protein MMAR_2343 |
| M. smegmatis MC2 155 | MSMEG_4728 | - | 1e-126 | 50.34% (435) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-136 | 54.82% (436) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. ulcerans Agy99 | MUL_1531 | papA3 | 1e-118 | 48.12% (451) | polyketide synthase associated protein PapA3 |
| M. vanbaalenii PYR-1 | Mvan_0270 | - | 1e-108 | 44.99% (429) | condensation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3850c|M.bovis_AF2122/97 -------MFSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQ
Rv3820c|M.tuberculosis_H37Rv -------MFSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQ
MAV_2723|M.avium_104 --------------------------------------------MPASYQ
MAB_0852|M.abscessus_ATCC_1997 -------MVALGTIHDWRPTPGTVISWSASPRAREVAAQAPASTIPPSYQ
MSMEG_4728|M.smegmatis_MC2_155 -------MFELTDIQNWDDAPGKHVSWGPSPSTVAKVAEAPVSDVPASYQ
MMAR_2343|M.marinum_M MKLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQAPVSAVPPSHI
TH_2204|M.thermoresistible__bu --MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQAPVSSVPVSYM
MUL_1531|M.ulcerans_Agy99 --MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKAPISPVPPSYM
Mflv_0404|M.gilvum_PYR-GCK ---MRIGKITVGALEEWSLSPGKVISWHPTAASIEKARQAPVSSVPVSYM
Mvan_0270|M.vanbaalenii_PYR-1 ---MRIGKITVGALDEWSLNPGSVTSWHPTAAAVETARRAQVSSVPVSYM
MLBr_01230|M.leprae_Br4923 ---MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQAPVSSVPVAYM
:* ::
Mb3850c|M.bovis_AF2122/97 QAQHLRRYRDHVARGLDMSRLMIFTWDLPGRCNIRAMNYAINAHLRRHDT
Rv3820c|M.tuberculosis_H37Rv QAQHLRRYRDHVARGLDMSRLMIFTWDLPGRCNIRAMNYAINAHLRRHDT
MAV_2723|M.avium_104 QLHHLRRFSEHAARGLDMARLNIGVWDISGVCDVAAMTEAINAHLRRHDT
MAB_0852|M.abscessus_ATCC_1997 QAQHLRSYRDLARQDREMARLGIGSWDVPGVCDIDAMTAAINAHLRRHDT
MSMEG_4728|M.smegmatis_MC2_155 QAQHLRAYREHTARGVPMARLTVPVWNMDSQCDMRAMSHVINAYLRRHDT
MMAR_2343|M.marinum_M QARHLRGFAEQTARGHDMSRLVVAAMDIPGECDIRAMTYVINSHLRRHDT
TH_2204|M.thermoresistible__bu QAQHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYVINAHMRRHDT
MUL_1531|M.ulcerans_Agy99 QAHHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHVVNAHMRRHDT
Mflv_0404|M.gilvum_PYR-GCK QGQHLRNYCDRTTEGLNFSRQIIASCDVAGVCDIEAMDHAVNAYLRRHDT
Mvan_0270|M.vanbaalenii_PYR-1 QGQHLRNYWERTTAGLNFSRQIIASCEVPGQCDIAAMDHAVNAYLRRHDT
MLBr_01230|M.leprae_Br4923 QAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYIVNAHLRRHDT
* :*:* : . . :* : : . *:: :: :*:::*****
Mb3850c|M.bovis_AF2122/97 YHSWFEFDNAEHIVRHTIADPADIEVVQAEHQNMTSA-ELRHHIATPQ--
Rv3820c|M.tuberculosis_H37Rv YHSWFEFDNAEHIVRHTIADPADIEVVQAEHQNMTSA-ELRHHIATPQ--
MAV_2723|M.avium_104 YHSWFEHRTDGRIVRHTFDDPADIEFAALQRGEMTPT-ELRAHILATP-N
MAB_0852|M.abscessus_ATCC_1997 YHSWFEFDPVDKIVRHVIDDPASIDFVPQDHGLQGPD-EIRAHLLRTSGT
MSMEG_4728|M.smegmatis_MC2_155 YHSRFEFTVDDRIVRRKLRSPRDLRFVPTDHGVQTCD-QWREHILDTP-G
MMAR_2343|M.marinum_M YRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMSPK-QWQDYILATP-G
TH_2204|M.thermoresistible__bu YRSWFEYHDFHHIVRHTITDPADIELVPTRHGAMTPE-QWQQHLLSTP-D
MUL_1531|M.ulcerans_Agy99 FRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQWRERLLATP-S
Mflv_0404|M.gilvum_PYR-GCK FRSWFEHSGDGEFVRRALVDPEDIEFVPVEHGHMGVD-EIHAHVVAIP-S
Mvan_0270|M.vanbaalenii_PYR-1 FRSWFERTEEGEFLRRAIADPADIEFVPIEHGDMTVD-EIFAHVVDIP-S
MLBr_01230|M.leprae_Br4923 YRSWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLSLA-QIRELAVSTP-D
::* ** .: *: : * .: .. : :
Mb3850c|M.bovis_AF2122/97 PLQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIVGVLFIEIHMMYSALVG
Rv3820c|M.tuberculosis_H37Rv PLQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIVGVLFIEIHMMYSALVG
MAV_2723|M.avium_104 PLRWDCFTFGLVQHPDHFTFYMSADHLVIDGMSVGVIFLEIHLTYAALVS
MAB_0852|M.abscessus_ATCC_1997 PLSWDCFTFGVIQRADHFTVYISVDHLHTDGMSTGILYIEIQLMYASLVH
MSMEG_4728|M.smegmatis_MC2_155 PLQWDCFRFGIIQRTDHFTCYMSVDHVHVDATFLGLMLIEIHLMYAALVS
MMAR_2343|M.marinum_M PLEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEIEAMYNTLAD
TH_2204|M.thermoresistible__bu PLQWNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEIHMQYAALVG
MUL_1531|M.ulcerans_Agy99 PLEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEIHLMYLALVS
Mflv_0404|M.gilvum_PYR-GCK PLEWGCFTFGVIQNDDHFSFFASMDHVHGDATLIGTTMMEANGMYSALSS
Mvan_0270|M.vanbaalenii_PYR-1 PLEWGCFTFGVIQHDGHFTFFASMDHVHGDATLIGTTMMEANGMYSALSG
MLBr_01230|M.leprae_Br4923 PLEWGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEFHMMYSALVS
** *.*. *.::* **: . *: * . * . * :*
Mb3850c|M.bovis_AF2122/97 GDPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFAANNDGTLPH
Rv3820c|M.tuberculosis_H37Rv GDPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFAANNDGTLPH
MAV_2723|M.avium_104 GGRPLPLPEPASYHDYCRRQHQHTEALTLQSPQVRAWIRFAEDNGGTLPS
MAB_0852|M.abscessus_ATCC_1997 G-SALQLPPPAGYLDFSARELAHNQAMTLDSFEVQTWLRYARDNGGTLPD
MSMEG_4728|M.smegmatis_MC2_155 GGAPITLPPAGSYDDYCVRQRKYTSGLTLDSPEIKEWVTFLEGNNGTMPK
MMAR_2343|M.marinum_M GGAPISLPEAGSYGEYCLRERAYTSALTLESPEVRQWIDFFESNDGALPS
TH_2204|M.thermoresistible__bu GGAPIPL-QAGSYDDFCVRQRQYTESLTADSPEVRAWVDFAGQMGGTLPN
MUL_1531|M.ulcerans_Agy99 GGAPLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFFDNNDGSLPK
Mflv_0404|M.gilvum_PYR-GCK GGAALALPDAGSFDDFCVREREYTAELTEDSPGVRAWIEFAENNSDGFPE
Mvan_0270|M.vanbaalenii_PYR-1 GGAALTLPDAGSFDEFCVRERAHTSELTEDSPEVRAWIEFAENSGGGFPE
MLBr_01230|M.leprae_Br4923 GAGPLELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFAEPNEGSFPD
* .: * .. : :.. *: :* :* : * : . :*
Mb3850c|M.bovis_AF2122/97 FPLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVAAGARFSGGVFACAA
Rv3820c|M.tuberculosis_H37Rv FPLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVAAGARFSGGVFACAA
MAV_2723|M.avium_104 FPLPLGDPSVPCGSGVVVAPLMDESQTERFDATCTKAGARFSGGVFACAA
MAB_0852|M.abscessus_ATCC_1997 FALPLGDRTAPNVGAMVAIPLLDAHGTVAFEKACEQAGVRFSGGVFACTA
MSMEG_4728|M.smegmatis_MC2_155 FPLPLGDLSVPCTGDLMTVQLLDEPQTQGFEKACVAAGSRFIGGVFAAAA
MMAR_2343|M.marinum_M FPLPLGDLSLVDTGELLSLQLMDAGQTARFEAACTSAGARFSGGVFACAA
TH_2204|M.thermoresistible__bu FPLPLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARFVGGVFACAA
MUL_1531|M.ulcerans_Agy99 FPLPLGDTSAQC--EMMGVRLMDERQTLALEAACMSAGARFCGGVFAISA
Mflv_0404|M.gilvum_PYR-GCK FPLPLGNPKDSTRSVMTSAVLMDTAQTERFDAAATAAGARFVGGLFACLA
Mvan_0270|M.vanbaalenii_PYR-1 FPLPLGNPAESTRSCMTSEILMDTAQTERFESACTAAGARFVGGLFACLA
MLBr_01230|M.leprae_Br4923 FPLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARFVGGVLACCG
*.****: : ::* :: :. ** ** **::* .
Mb3850c|M.bovis_AF2122/97 LAERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITVPVASGLFDS
Rv3820c|M.tuberculosis_H37Rv LAERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITVPVASGLFDS
MAV_2723|M.avium_104 FAEYELTGAETYCAITPYDHRSTPAEFVTPGWFASFIPVTFPVAGASFGD
MAB_0852|M.abscessus_ATCC_1997 LIDRELTGAGTFYGITPYDTRGTAEEQMSVGWYASFIPFIVDMSDDSFAT
MSMEG_4728|M.smegmatis_MC2_155 LAQYQLTDIDTYHVITPTTTRGTEAEVMATGWFTGTVPITVPVG-SSFAE
MMAR_2343|M.marinum_M LAEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTVAVA-SSFDE
TH_2204|M.thermoresistible__bu LTENELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITVPAAGVSFGE
MUL_1531|M.ulcerans_Agy99 VVQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITVPTVGSSFGE
Mflv_0404|M.gilvum_PYR-GCK QVEHELTGALTYYGLTPRDSRSGSDNFMTQGWFTGLIPITVPIGAASFGE
Mvan_0270|M.vanbaalenii_PYR-1 QVEHELTGALTYYGLTPRDSRSASDNFMTQGWFTGLIPITVPIGATSFAD
MLBr_01230|M.leprae_Br4923 LAEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITVPIAGSSFGD
: :*:. : :.. * : : **:.. :*. . *
Mb3850c|M.bovis_AF2122/97 AARVAQISFDSGKDLATVPFDRVLELARPETGLRPPRPGNFVMSFLDASI
Rv3820c|M.tuberculosis_H37Rv AARVAQISFDSGKDLATVPFDRVLELARPETGLRPPRPGNFVMSFLDASI
MAV_2723|M.avium_104 AVIAAQASFDSAIGLADVPFDRVLELSSFGGRISKPTGDVHMLSFADARG
MAB_0852|M.abscessus_ATCC_1997 VARSAQKSFDECQPLAKVPFERALELAGPDSGLTAPEYVVPMVSFLDARK
MSMEG_4728|M.smegmatis_MC2_155 TARTAQRSFDSGLYLAHVPFDRVLELGATERGLRAPDPGVPMVSYLDATA
MMAR_2343|M.marinum_M TVRGAQANFDASAHLANVPFERVLELAPWLKKP-PPRGGFPMVSFLDGGV
TH_2204|M.thermoresistible__bu AARAAQQSFDSGIGLGHVPYDRVLELVPSLRRA-ETCS--PMMSFLDAGV
MUL_1531|M.ulcerans_Agy99 IVKAAQGSFDSGRDLAEVPLDCVMELVLW---LREGQWGAPLLFYLDAGI
Mflv_0404|M.gilvum_PYR-GCK AAWAAQSSFDSGLNMAKVPYYRVLELAPW---LGWPRPNFPVSNFFHGGA
Mvan_0270|M.vanbaalenii_PYR-1 AAWAAQASFDSNLFMAKVPYYRVLELAPW---LSWPRPNFPVSNFFHGGA
MLBr_01230|M.leprae_Br4923 AARAAQNCFDTDVHLAEVPYDRVVELAPT---VHKPRPNFPVINFLDAGT
. ** ** :. ** .:** : : ..
Mb3850c|M.bovis_AF2122/97 APLS---TVANSDLN--FRIYDEGRVSHQVSMWVNRYQHQTTVTVLFPDN
Rv3820c|M.tuberculosis_H37Rv APLS---TVANSDLN--FRIYDEGRVSHQVSMWVNRYQHQTTVTVLFPDN
MAV_2723|M.avium_104 IPFS----GQWDGLN--AGIYGDGRSSDQVLMWVNRFDTETTLTVAFPQN
MAB_0852|M.abscessus_ATCC_1997 IPVS----AEWDRIN--GGIYGDSRSSDQVCMWVNRFENETNLTISFPDN
MSMEG_4728|M.smegmatis_MC2_155 APLSPAVVAEWNRIN--GRIFSEMGAANQVGMWVNQFGSGTWITVAFPNN
MMAR_2343|M.marinum_M PPLSGVVAMQLDRIN--ARAFSDGRVAARVCIWVNKFQEETTVTASFPNN
TH_2204|M.thermoresistible__bu PPLSALVASQLDGLN--ARVYGDGKVPAQLCMWVNRMDNETSVTVFFPDN
MUL_1531|M.ulcerans_Agy99 PPLSAMANSHVEGLR--ARLCHDGGMMGQIDIRVNRLEKETQLTVLFPNN
Mflv_0404|M.gilvum_PYR-GCK APLNAILAASEMGLADNIGIYPDGRFSYQLTIYIFRYGQGTEMAIMHPDN
Mvan_0270|M.vanbaalenii_PYR-1 APLNAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGTVMAIMHPDN
MLBr_01230|M.leprae_Br4923 APLSVLLTAGLDGLN--IGVYSDGRYSYQMSIYVIRVEQETAVAVMFPDN
*.. : : :: : : : * :: .*:*
Mb3850c|M.bovis_AF2122/97 PIASESVANYIAAMKSIYIRTADGTLAILKPGT-----------------
Rv3820c|M.tuberculosis_H37Rv PIASESVANYIAAMKSIYIRTADGTLATLKPGT-----------------
MAV_2723|M.avium_104 PVARDSVERYIRAVRAMCLRVVEHGAAAVPNRRRVVAAVNASAARSTANA
MAB_0852|M.abscessus_ATCC_1997 AVARESVSRYFEVARVVYQRVAQSQFVS----------------------
MSMEG_4728|M.smegmatis_MC2_155 PVARASVQEYVDAFRSVCVAVAEGRHDDVPTPR-----VNELDLRSA---
MMAR_2343|M.marinum_M PIAYDSVARYLDTMKSVYLRIAEG------ARWDAIAQVL----------
TH_2204|M.thermoresistible__bu PVARASVEKYVATLRSIYVAVAEGRADRLGARRSGELQRQPA--------
MUL_1531|M.ulcerans_Agy99 PVARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAYSRRTYEPP
Mflv_0404|M.gilvum_PYR-GCK PVAKRSVERYMQTMSSVASLVADTGHWGRVA-------------------
Mvan_0270|M.vanbaalenii_PYR-1 PVAKKSVTRYMKVMKSVAGLVADSGTWGLVA-------------------
MLBr_01230|M.leprae_Br4923 PEAQESVARYLETLKSVFECVAESGHWRNVA-------------------
. * ** .*. . .:
Mb3850c|M.bovis_AF2122/97 --------------------
Rv3820c|M.tuberculosis_H37Rv --------------------
MAV_2723|M.avium_104 ADRTDRRLQGAGFGANPVLR
MAB_0852|M.abscessus_ATCC_1997 --------------------
MSMEG_4728|M.smegmatis_MC2_155 --------------------
MMAR_2343|M.marinum_M --------------------
TH_2204|M.thermoresistible__bu --------------------
MUL_1531|M.ulcerans_Agy99 ATVSPLTSWRTG--------
Mflv_0404|M.gilvum_PYR-GCK --------------------
Mvan_0270|M.vanbaalenii_PYR-1 --------------------
MLBr_01230|M.leprae_Br4923 --------------------