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VRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKAPISPVPPSYMQAHHLRNFRSYRERGLEMSRLLI SSWDIPGICDIRTMTHVVNAHMRRHDTFRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQWRER LLATPSPLEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEIHLMYLALVSGGAPLRLAEPGSYD NYCNRQREHISGLTLDSPVMSKWTEFFDNNDGSLPKFPLPLGDTSAQCEMMGVRLMDERQTLALEAACMS AGARFCGGVFAISAVVQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITVPTVGSSFGEIVKAAQ GSFDSGRDLAEVPLDCVMELVLWLREGQWGAPLLFYLDAGIPPLSAMANSHVEGLRARLCHDGGMMGQID IRVNRLEKETQLTVLFPNNPVARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAYSRRTYEPPA TVSPLTSWRTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1531 | papA3 | - | 100% (502) | polyketide synthase associated protein PapA3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1214 | papA3 | 1e-135 | 50.75% (465) | polyketide synthase associated protein PapA3 |
| M. gilvum PYR-GCK | Mflv_0404 | - | 1e-119 | 45.92% (466) | condensation domain-containing protein |
| M. tuberculosis H37Rv | Rv1182 | papA3 | 1e-135 | 50.75% (465) | polyketide synthase associated protein PapA3 |
| M. leprae Br4923 | MLBr_01230 | papA3 | 1e-134 | 49.78% (464) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_3147c | - | 1e-122 | 47.25% (472) | polyketide synthase associated protein |
| M. marinum M | MMAR_2355 | papA3 | 0.0 | 99.40% (502) | polyketide synthase associated protein PapA3 |
| M. avium 104 | MAV_1762 | - | 1e-122 | 45.49% (466) | condensation domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4728 | - | 1e-134 | 51.49% (470) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-153 | 55.14% (477) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. vanbaalenii PYR-1 | Mvan_0270 | - | 1e-114 | 44.85% (466) | condensation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1531|M.ulcerans_Agy99 MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKAPISPVPPSYMQA
MMAR_2355|M.marinum_M MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKAPISPVPPSYMQA
MSMEG_4728|M.smegmatis_MC2_155 MFELT-----DIQNWDDAPGKHVSWGPSPSTVAKVAEAPVSDVPASYQQA
TH_2204|M.thermoresistible__bu MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQAPVSSVPVSYMQA
Mb1214|M.bovis_AF2122/97 MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYMQA
Rv1182|M.tuberculosis_H37Rv MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYMQA
MLBr_01230|M.leprae_Br4923 -MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQAPVSSVPVAYMQA
Mflv_0404|M.gilvum_PYR-GCK -MRIGKITVGALEEWSLSPGKVISWHPTAASIEKARQAPVSSVPVSYMQG
Mvan_0270|M.vanbaalenii_PYR-1 -MRIGKITVGALDEWSLNPGSVTSWHPTAAAVETARRAQVSSVPVSYMQG
MAV_1762|M.avium_104 -MRIGKITIGSLGDWTPTPGPVTSWHPTAAAAEKVRQAPASPVPVSYMQG
MAB_3147c|M.abscessus_ATCC_199 -MRGGPVTVSLTDKWEPTAGSVITWQPSPASYAKALEAPVSDVPPSFMQV
. .* .* :* *: : .. .* * ** :: *
MUL_1531|M.ulcerans_Agy99 HHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHVVNAHMRRHDTFR
MMAR_2355|M.marinum_M HHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHVVNAHMRRHDTFR
MSMEG_4728|M.smegmatis_MC2_155 QHLRAYREHTARGVPMARLTVPVWNMDSQCDMRAMSHVINAYLRRHDTYH
TH_2204|M.thermoresistible__bu QHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYVINAHMRRHDTYR
Mb1214|M.bovis_AF2122/97 QHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDTYR
Rv1182|M.tuberculosis_H37Rv QHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDTYR
MLBr_01230|M.leprae_Br4923 QHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYIVNAHLRRHDTYR
Mflv_0404|M.gilvum_PYR-GCK QHLRNYCDRTTEGLNFSRQIIASCDVAGVCDIEAMDHAVNAYLRRHDTFR
Mvan_0270|M.vanbaalenii_PYR-1 QHLRNYWERTTAGLNFSRQIIASCEVPGQCDIAAMDHAVNAYLRRHDTFR
MAV_1762|M.avium_104 QHLRNYHERTAAGLDFSRQIIATCDVPGRCDISAMNYAVNAYLRRHDTFR
MAB_3147c|M.abscessus_ATCC_199 QHLRTYLRQAAKGLDFSRVLVFTLDMPGRCDKRAMGHVINAHLRRHDTYR
:*:* : * :* : : . ** : : :**::*****::
MUL_1531|M.ulcerans_Agy99 SWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQWRERLLATPSPLE
MMAR_2355|M.marinum_M SWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQWREHLLATPSPLE
MSMEG_4728|M.smegmatis_MC2_155 SRFEFTVDDRIVRRKLRSPRDLRFVPTDHGVQTCD-QWREHILDTPGPLQ
TH_2204|M.thermoresistible__bu SWFEYHDFHHIVRHTITDPADIELVPTRHGAMTPE-QWQQHLLSTPDPLQ
Mb1214|M.bovis_AF2122/97 SWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLPQIREIVQ-NTPDPLQ
Rv1182|M.tuberculosis_H37Rv SWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLPQIREIVQ-NTPDPLQ
MLBr_01230|M.leprae_Br4923 SWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLSLAQIRELAV-STPDPLE
Mflv_0404|M.gilvum_PYR-GCK SWFEHSGDGEFVRRALVDPEDIEFVPVEHGHMGVDEIHAHVV-AIPSPLE
Mvan_0270|M.vanbaalenii_PYR-1 SWFERTEEGEFLRRAIADPADIEFVPIEHGDMTVDEIFAHVV-DIPSPLE
MAV_1762|M.avium_104 SWFHHSGDGEFVRHTVSNPADIEFAPIHHGEMTAEEIRAHVV-AIPNPLE
MAB_3147c|M.abscessus_ATCC_199 SWFSLDDEQNIVRRTMADPADVEFVQVKLGEMTSDEVRELVVSETPDPFR
* * .::*: : * *:.:. * *.*:.
MUL_1531|M.ulcerans_Agy99 WGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEIHLMYLALVSGGA
MMAR_2355|M.marinum_M WGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEIHLMYLALVSGGA
MSMEG_4728|M.smegmatis_MC2_155 WDCFRFGIIQRTDHFTCYMSVDHVHVDATFLGLMLIEIHLMYAALVSGGA
TH_2204|M.thermoresistible__bu WNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEIHMQYAALVGGGA
Mb1214|M.bovis_AF2122/97 WGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVGGHA
Rv1182|M.tuberculosis_H37Rv WGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVGGHA
MLBr_01230|M.leprae_Br4923 WGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEFHMMYSALVSGAG
Mflv_0404|M.gilvum_PYR-GCK WGCFTFGVIQNDDHFSFFASMDHVHGDATLIGTTMMEANGMYSALSSGGA
Mvan_0270|M.vanbaalenii_PYR-1 WGCFTFGVIQHDGHFTFFASMDHVHGDATLIGTTMMEANGMYSALSGGGA
MAV_1762|M.avium_104 WGCFTFGVVQNEEYFTFFAAMDHVHGDATLIGTTMLEANGMYAAASAGSE
MAB_3147c|M.abscessus_ATCC_199 WDCFRFGIVQSSGHFTFYFSVDHLHLDATFARLLIMEILMGYKALVQGGA
*.*. *.::* :*: .:**:* ** : : * * * *
MUL_1531|M.ulcerans_Agy99 PLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFFDNNDGSLPKFPL
MMAR_2355|M.marinum_M PLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFFDNNDGSLPKFPL
MSMEG_4728|M.smegmatis_MC2_155 PITLPPAGSYDDYCVRQRKYTSGLTLDSPEIKEWVTFLEGNNGTMPKFPL
TH_2204|M.thermoresistible__bu PIPLQ-AGSYDDFCVRQRQYTESLTADSPEVRAWVDFAGQMGGTLPNFPL
Mb1214|M.bovis_AF2122/97 PLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFPDFPL
Rv1182|M.tuberculosis_H37Rv PLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFPDFPL
MLBr_01230|M.leprae_Br4923 PLELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFAEPNEGSFPDFPL
Mflv_0404|M.gilvum_PYR-GCK ALALPDAGSFDDFCVREREYTAELTEDSPGVRAWIEFAENNSDGFPEFPL
Mvan_0270|M.vanbaalenii_PYR-1 ALTLPDAGSFDEFCVRERAHTSELTEDSPEVRAWIEFAENSGGGFPEFPL
MAV_1762|M.avium_104 PLELPDAGSFDDFCAREREYTSALTVDSPEVRAWIDFAENNNGSFPEFPL
MAB_3147c|M.abscessus_ATCC_199 PIELPPAGSYGDYCIRQHEFLSGLTPDSEPVREWTQFAENNRGSLPDFPL
.: * .**:.::* *:: . ** :* : * * . :*.***
MUL_1531|M.ulcerans_Agy99 PLGDTSAQC--EMMGVRLMDERQTLALEAACMSAGARFCGGVFAISAVVQ
MMAR_2355|M.marinum_M PLGDTSAQC--EMMGVRLMDERQTLAFEAACMSAGARFCGGVFAISAVVQ
MSMEG_4728|M.smegmatis_MC2_155 PLGDLSVPCTGDLMTVQLLDEPQTQGFEKACVAAGSRFIGGVFAAAALAQ
TH_2204|M.thermoresistible__bu PLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARFVGGVFACAALTE
Mb1214|M.bovis_AF2122/97 PLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACCGLAE
Rv1182|M.tuberculosis_H37Rv PLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACCGLAE
MLBr_01230|M.leprae_Br4923 PLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARFVGGVLACCGLAE
Mflv_0404|M.gilvum_PYR-GCK PLGNPKDSTRSVMTSAVLMDTAQTERFDAAATAAGARFVGGLFACLAQVE
Mvan_0270|M.vanbaalenii_PYR-1 PLGNPAESTRSCMTSEILMDTAQTERFESACTAAGARFVGGLFACLAQVE
MAV_1762|M.avium_104 PLGNPSEATASAMVSELVMDAEQTERFESACTAVGVRFIGGLFACIALVE
MAB_3147c|M.abscessus_ATCC_199 PLGDHGVQCGTAIVTEQLLDEQQALKFESLCVDAGARFIGGVMAALGFAE
***: : ::* *: :: . .* ** **::* . .:
MUL_1531|M.ulcerans_Agy99 HELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITVPTVGSSFGEIVK
MMAR_2355|M.marinum_M HELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITVPTVGSSFGEIVK
MSMEG_4728|M.smegmatis_MC2_155 YQLTDIDTYHVITPTTTRGTEAEVMATGWFTGTVPITVPVG-SSFAETAR
TH_2204|M.thermoresistible__bu NELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITVPAAGVSFGEAAR
Mb1214|M.bovis_AF2122/97 HELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFGDAAR
Rv1182|M.tuberculosis_H37Rv HELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFGDAAR
MLBr_01230|M.leprae_Br4923 YELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITVPIAGSSFGDAAR
Mflv_0404|M.gilvum_PYR-GCK HELTGALTYYGLTPRDSRSGSDNFMTQGWFTGLIPITVPIGAASFGEAAW
Mvan_0270|M.vanbaalenii_PYR-1 HELTGALTYYGLTPRDSRSASDNFMTQGWFTGLIPITVPIGATSFADAAW
MAV_1762|M.avium_104 HELTGALTYYGLTPRDTRRTTDNFMTQGWFTGLVPITVPIAAASFADAAW
MAB_3147c|M.abscessus_ATCC_199 RELTGTDTYYGITPSDAR-EEADMFTTGWFTGLVPITAPVDG-TFAAAAV
:*:. :: :.* * : :: ***** :***.* :*. .
MUL_1531|M.ulcerans_Agy99 AAQGSFDSGRDLAEVPLDCVMELVL---WLREGQWGAPLLFYLDAGIPPL
MMAR_2355|M.marinum_M AAQGSFDSGRDLAEVPLDCVMELVP---WLREGQWGAPLLFYLDAGIPPL
MSMEG_4728|M.smegmatis_MC2_155 TAQRSFDSGLYLAHVPFDRVLELGATERGLRAPDPGVPMVSYLDATAAPL
TH_2204|M.thermoresistible__bu AAQQSFDSGIGLGHVPYDRVLELVP---SLRRAETCSPMMSFLDAGVPPL
Mb1214|M.bovis_AF2122/97 AAQTSFDSGVKLAEVPYDRVVELSS---TLTMPRPNFPVVNFLDAGAAPL
Rv1182|M.tuberculosis_H37Rv AAQTSFDSGVKLAEVPYDRVVELSS---TLTMPRPNFPVVNFLDAGAAPL
MLBr_01230|M.leprae_Br4923 AAQNCFDTDVHLAEVPYDRVVELAP---TVHKPRPNFPVINFLDAGTAPL
Mflv_0404|M.gilvum_PYR-GCK AAQSSFDSGLNMAKVPYYRVLELAP---WLGWPRPNFPVSNFFHGGAAPL
Mvan_0270|M.vanbaalenii_PYR-1 AAQASFDSNLFMAKVPYYRVLELAP---WLSWPRPNFPVSNFFHGGAAPL
MAV_1762|M.avium_104 TAQTSFDSGQQLAKVPYYRVLELAP---WLKWPQPNFPVSNFFHAGAAPL
MAB_3147c|M.abscessus_ATCC_199 AAQESFDRGRQLVNVPFYRVLELVP---QLSWPRPYHPMINFFDGGAPPL
:** .** . : .** *:** : *: ::.. .**
MUL_1531|M.ulcerans_Agy99 SAMANSHVEG--LRARLCHDGGMMGQIDIRVNRLEKETQLTVLFPNNPVA
MMAR_2355|M.marinum_M SAMANSHVEG--LRARLCHDGGMMGQIDIRVNRLEKETQLTVLFPNNPVA
MSMEG_4728|M.smegmatis_MC2_155 SPAVVAEWNR--INGRIFSEMGAANQVGMWVNQFGSGTWITVAFPNNPVA
TH_2204|M.thermoresistible__bu SALVASQLDG--LNARVYGDGKVPAQLCMWVNRMDNETSVTVFFPDNPVA
Mb1214|M.bovis_AF2122/97 SVLLTAELTG--TNIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFPDNPIA
Rv1182|M.tuberculosis_H37Rv SVLLTAELTG--TNIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFPDNPIA
MLBr_01230|M.leprae_Br4923 SVLLTAGLDG--LNIGVYSDGRYSYQMSIYVIRVEQETAVAVMFPDNPEA
Mflv_0404|M.gilvum_PYR-GCK NAILAASEMGLADNIGIYPDGRFSYQLTIYIFRYGQGTEMAIMHPDNPVA
Mvan_0270|M.vanbaalenii_PYR-1 NAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGTVMAIMHPDNPVA
MAV_1762|M.avium_104 NAVLAAADLGYANNIGIYSDGRYSYQLTIYVFRYGEGTAMAMMYPDNPVA
MAB_3147c|M.abscessus_ATCC_199 SQLFTNPLLVS-NPIGLYAESKSVYQLTIFISRFPTETTLMIAYPDNPVA
. : : *: : : : * : : .*:** *
MUL_1531|M.ulcerans_Agy99 RESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAYSRRTYEPPATV
MMAR_2355|M.marinum_M RESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAYSRRTYEPPATV
MSMEG_4728|M.smegmatis_MC2_155 RASVQEYVDAFRSVCVAVAEGRHDDVPTPRVN-ELDLRSA----------
TH_2204|M.thermoresistible__bu RASVEKYVATLRSIYVAVAEGRADRLGARRSG-ELQRQPA----------
Mb1214|M.bovis_AF2122/97 RESVARYLATLKSVFQRVAESGQQQNVA----------------------
Rv1182|M.tuberculosis_H37Rv RESVARYLATLKSVFQRVAESGQQQNVA----------------------
MLBr_01230|M.leprae_Br4923 QESVARYLETLKSVFECVAESGHWRNVA----------------------
Mflv_0404|M.gilvum_PYR-GCK KRSVERYMQTMSSVASLVADTGHWGRVA----------------------
Mvan_0270|M.vanbaalenii_PYR-1 KKSVTRYMKVMKSVAGLVADSGTWGLVA----------------------
MAV_1762|M.avium_104 HKSVARYTETMRSVCGRVADTGHWGRVA----------------------
MAB_3147c|M.abscessus_ATCC_199 RESITRYVDLVKSTFARVCEQNDVVPAR----------------------
: *: .* . * *.:
MUL_1531|M.ulcerans_Agy99 SPLTSWRTG
MMAR_2355|M.marinum_M SPLTSWRTG
MSMEG_4728|M.smegmatis_MC2_155 ---------
TH_2204|M.thermoresistible__bu ---------
Mb1214|M.bovis_AF2122/97 ---------
Rv1182|M.tuberculosis_H37Rv ---------
MLBr_01230|M.leprae_Br4923 ---------
Mflv_0404|M.gilvum_PYR-GCK ---------
Mvan_0270|M.vanbaalenii_PYR-1 ---------
MAV_1762|M.avium_104 ---------
MAB_3147c|M.abscessus_ATCC_199 ---------