For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYMQAQHIRGYCEQKAKGLDYSRLM VVSCQQPGQCDIRAANYVINAHLRRHDTYRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLPQIREI VQNTPDPLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVGGHAPLELPPAGSYD DFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVC TAAGARFIGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFGDAARA AQTSFDSGVKLAEVPYDRVVELSSTLTMPRPNFPVVNFLDAGAAPLSVLLTAELTGTNIGVYSDGRYSYQ LSIYVIRVEQGTAVAVMFPDNPIARESVARYLATLKSVFQRVAESGQQQNVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1182 | papA3 | - | 100% (472) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3 |
| M. tuberculosis H37Rv | Rv3824c | papA1 | e-157 | 55.96% (470) | polyketide synthase associated protein |
| M. tuberculosis H37Rv | Rv3820c | papA2 | e-143 | 53.91% (460) | polyketide synthase associated protein PapA2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1214 | papA3 | 0.0 | 100.00% (472) | polyketide synthase associated protein PapA3 |
| M. gilvum PYR-GCK | Mflv_0404 | - | 1e-159 | 54.12% (473) | condensation domain-containing protein |
| M. leprae Br4923 | MLBr_01230 | papA3 | 0.0 | 75.80% (471) | PKS-associated protein, unknown function |
| M. abscessus ATCC 19977 | MAB_0938c | - | 1e-162 | 55.27% (474) | polyketide synthase associated protein PapA3 |
| M. marinum M | MMAR_2343 | - | 1e-137 | 48.83% (471) | hypothetical protein MMAR_2343 |
| M. avium 104 | MAV_1762 | - | 1e-174 | 59.83% (473) | condensation domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0409 | - | 1e-161 | 54.97% (473) | condensation domain-containing protein |
| M. thermoresistible (build 8) | TH_2204 | papA1 | 1e-155 | 55.17% (464) | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN |
| M. ulcerans Agy99 | MUL_1531 | papA3 | 1e-135 | 50.75% (465) | polyketide synthase associated protein PapA3 |
| M. vanbaalenii PYR-1 | Mvan_0270 | - | 1e-160 | 55.67% (467) | condensation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1182|M.tuberculosis_H37Rv ------------MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQA
Mb1214|M.bovis_AF2122/97 ------------MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQA
MLBr_01230|M.leprae_Br4923 -------------MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQA
Mflv_0404|M.gilvum_PYR-GCK -------------MRIGKITVGALEEWSLSPGKVISWHPTAASIEKARQA
Mvan_0270|M.vanbaalenii_PYR-1 -------------MRIGKITVGALDEWSLNPGSVTSWHPTAAAVETARRA
MSMEG_0409|M.smegmatis_MC2_155 -------------MRIGKITVGPLDEWSLKPGTVTSWQPTAAAREVARQA
MAB_0938c|M.abscessus_ATCC_199 MPERGRPSERDGVLRIGTITVGALDEWTLNAGTVTSWHPTPAATEKARQA
MAV_1762|M.avium_104 -------------MRIGKITIGSLGDWTPTPGPVTSWHPTAAAAEKVRQA
MMAR_2343|M.marinum_M ----------MKLVVLGNVGLETVSNWVPAPGLVWRWQPSSATLEKVRQA
TH_2204|M.thermoresistible__bu ------------MVALGNVAVETVREWRPDPGRVVSWDPSPAALEKARQA
MUL_1531|M.ulcerans_Agy99 ------------MVRVGKVEAGTISDWHPEPGTLVSWQPSRGSLAKAAKA
: :* : .: :* .* * *: : . :*
Rv1182|M.tuberculosis_H37Rv PISDVPVSYMQAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYV
Mb1214|M.bovis_AF2122/97 PISDVPVSYMQAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYV
MLBr_01230|M.leprae_Br4923 PVSSVPVAYMQAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYI
Mflv_0404|M.gilvum_PYR-GCK PVSSVPVSYMQGQHLRNYCDRTTEGLNFSRQIIASCDVAGVCDIEAMDHA
Mvan_0270|M.vanbaalenii_PYR-1 QVSSVPVSYMQGQHLRNYWERTTAGLNFSRQIIASCEVPGQCDIAAMDHA
MSMEG_0409|M.smegmatis_MC2_155 PVSSVPVSYMQEQHLRNFCERTAAGLNFSRQIIASCEVPGQCDISAMDHA
MAB_0938c|M.abscessus_ATCC_199 PVSSVPVSYMQTQHLRNYYERNNAGLNFSRQIIASCDVPGNCDIAAMNHA
MAV_1762|M.avium_104 PASPVPVSYMQGQHLRNYHERTAAGLDFSRQIIATCDVPGRCDISAMNYA
MMAR_2343|M.marinum_M PVSAVPPSHIQARHLRGFAEQTARGHDMSRLVVAAMDIPGECDIRAMTYV
TH_2204|M.thermoresistible__bu PVSSVPVSYMQAQHLRGFVEHAARGQEMSRLCIAAFDIPGRCDLRAMTYV
MUL_1531|M.ulcerans_Agy99 PISPVPPSYMQAHHLRNFRSYRERGLEMSRLLISSWDIPGICDIRTMTHV
* ** :::* :*:*.: . * : ** : : : * **: : :
Rv1182|M.tuberculosis_H37Rv INAHLRRHDTYRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLP-QI
Mb1214|M.bovis_AF2122/97 INAHLRRHDTYRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLP-QI
MLBr_01230|M.leprae_Br4923 VNAHLRRHDTYRSWFEYTDEGEIIRHTLCDPADIEFVPIEHGQLSLA-QI
Mflv_0404|M.gilvum_PYR-GCK VNAYLRRHDTFRSWFEHSGDGEFVRRALVDPEDIEFVPVEHGHMGVD-EI
Mvan_0270|M.vanbaalenii_PYR-1 VNAYLRRHDTFRSWFERTEEGEFLRRAIADPADIEFVPIEHGDMTVD-EI
MSMEG_0409|M.smegmatis_MC2_155 VNSYLRRHDTFRSWFEDAGDGKFIRHSIENPDDIEFVPVEHGAMSID-EI
MAB_0938c|M.abscessus_ATCC_199 LNAYLRRHDTFRSWFERTDDGEFIRHSISDPADIEFAPVTQGHMSVD-EI
MAV_1762|M.avium_104 VNAYLRRHDTFRSWFHHSGDGEFVRHTVSNPADIEFAPIHHGEMTAE-EI
MMAR_2343|M.marinum_M INSHLRRHDTYRSWFEFTESNRIARHTLTDPNDIELTPIEHGEMSPK-QW
TH_2204|M.thermoresistible__bu INAHMRRHDTYRSWFEYHDFHHIVRHTITDPADIELVPTRHGAMTPE-QW
MUL_1531|M.ulcerans_Agy99 VNAHMRRHDTFRSWFEHTEGDHFVRRTLERPNDIQFVAVEHGELTTQSQW
:*:::*****:****. .: *::: * **::.. :* : :
Rv1182|M.tuberculosis_H37Rv REIVQNTPDPLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEF
Mb1214|M.bovis_AF2122/97 REIVQNTPDPLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEF
MLBr_01230|M.leprae_Br4923 RELAVSTPDPLEWGCFQFGVIQAEEHFTFYASIDHVHVDAMIVGVTLMEF
Mflv_0404|M.gilvum_PYR-GCK HAHVVAIPSPLEWGCFTFGVIQNDDHFSFFASMDHVHGDATLIGTTMMEA
Mvan_0270|M.vanbaalenii_PYR-1 FAHVVDIPSPLEWGCFTFGVIQHDGHFTFFASMDHVHGDATLIGTTMMEA
MSMEG_0409|M.smegmatis_MC2_155 HAHVTDIPTPLEWACFTFGVIQSEDHFTFFAAMDHVHGDATLIGTTMLEA
MAB_0938c|M.abscessus_ATCC_199 RSHVIDIPSPLEWGCFTFGIIQSENHFTFFAAMDHVHGDATLIGTTMMEA
MAV_1762|M.avium_104 RAHVVAIPNPLEWGCFTFGVVQNEEYFTFFAAMDHVHGDATLIGTTMLEA
MMAR_2343|M.marinum_M QDYILATPGPLEWDCFRFAIIQRDDHFTFCVSVDHLNVDAMFISAVFWEI
TH_2204|M.thermoresistible__bu QQHLLSTPDPLQWNCFRFSIIQRSDHFTFCVCMDHVHIDAMFMGAVFMEI
MUL_1531|M.ulcerans_Agy99 RERLLATPSPLEWGCVRFSIIQRADHFTFCVAIDHLHCDAMFVGVVFAEI
* **:* *. *.::* :*:* ..:**:: ** ::...: *
Rv1182|M.tuberculosis_H37Rv HLMYAALVGGHAPLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFA
Mb1214|M.bovis_AF2122/97 HLMYAALVGGHAPLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFA
MLBr_01230|M.leprae_Br4923 HMMYSALVSGAGPLELPEAGSYDDFCRRQHRFTSMLTAESPQIRSWTQFA
Mflv_0404|M.gilvum_PYR-GCK NGMYSALSSGGAALALPDAGSFDDFCVREREYTAELTEDSPGVRAWIEFA
Mvan_0270|M.vanbaalenii_PYR-1 NGMYSALSGGGAALTLPDAGSFDEFCVRERAHTSELTEDSPEVRAWIEFA
MSMEG_0409|M.smegmatis_MC2_155 NGMYSALSGGGEALVLPEAGSFDDFCIRERERTADLTVDSPEVRAWIEFA
MAB_0938c|M.abscessus_ATCC_199 NGMYSALSSGGAALTLPDAGSFDDFCTREREFTSALTLDSPGVQAWIDFA
MAV_1762|M.avium_104 NGMYAAASAGSEPLELPDAGSFDDFCAREREYTSALTVDSPEVRAWIDFA
MMAR_2343|M.marinum_M EAMYNTLADGGAPISLPEAGSYGEYCLRERAYTSALTLESPEVRQWIDFF
TH_2204|M.thermoresistible__bu HMQYAALVGGGAPIPL-QAGSYDDFCVRQRQYTESLTADSPEVRAWVDFA
MUL_1531|M.ulcerans_Agy99 HLMYLALVSGGAPLRLAEPGSYDNYCNRQREHISGLTLDSPVMSKWTEFF
. * : * .: * .**:.::* *:: ** :** : * .*
Rv1182|M.tuberculosis_H37Rv EGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARF
Mb1214|M.bovis_AF2122/97 EGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARF
MLBr_01230|M.leprae_Br4923 EPNEGSFPDFPLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTVAGARF
Mflv_0404|M.gilvum_PYR-GCK ENNSDGFPEFPLPLGNPKDSTRSVMTSAVLMDTAQTERFDAAATAAGARF
Mvan_0270|M.vanbaalenii_PYR-1 ENSGGGFPEFPLPLGNPAESTRSCMTSEILMDTAQTERFESACTAAGARF
MSMEG_0409|M.smegmatis_MC2_155 EDNNGGFPEFPLPLGNPKKSTSSDMTSEILLDPAQTERFESACNAAGARF
MAB_0938c|M.abscessus_ATCC_199 ENNNGTFPEFPLPLGNPAEATNSTMTSLLLLNPEQTDRFDAACGTAGARF
MAV_1762|M.avium_104 ENNNGSFPEFPLPLGNPSEATASAMVSELVMDAEQTERFESACTAVGVRF
MMAR_2343|M.marinum_M ESNDGALPSFPLPLGDLSLVDTGELLSLQLMDAGQTARFEAACTSAGARF
TH_2204|M.thermoresistible__bu GQMGGTLPNFPLPLGDRTKPWPGELMVVKLLDGRQTDRFEAACVSAGARF
MUL_1531|M.ulcerans_Agy99 DNNDGSLPKFPLPLGDTS--AQCEMMGVRLMDERQTLALEAACMSAGARF
. :*.******: : ::: ** :::.. .*.**
Rv1182|M.tuberculosis_H37Rv IGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITV
Mb1214|M.bovis_AF2122/97 IGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITV
MLBr_01230|M.leprae_Br4923 VGGVLACCGLAEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITV
Mflv_0404|M.gilvum_PYR-GCK VGGLFACLAQVEHELTGALTYYGLTPRDSRSGSDNFMTQGWFTGLIPITV
Mvan_0270|M.vanbaalenii_PYR-1 VGGLFACLAQVEHELTGALTYYGLTPRDSRSASDNFMTQGWFTGLIPITV
MSMEG_0409|M.smegmatis_MC2_155 VGGLFACLAQVEHELTGALTYYGLTPRDSRNATDNFMTQGWFTGLIPITV
MAB_0938c|M.abscessus_ATCC_199 VGGLFACLGLVEHEFTGAVTYYGLTPRDSRTASDNFMTQGWFTGLIPITV
MAV_1762|M.avium_104 IGGLFACIALVEHELTGALTYYGLTPRDTRRTTDNFMTQGWFTGLVPITV
MMAR_2343|M.marinum_M SGGVFACAALAEYELTGSRTYYAVTPTSTRSTPAEFMTTGWFVGHIPFTV
TH_2204|M.thermoresistible__bu VGGVFACAALTENELAGVETFHAITPTDTRSTPADFMTTGWFTGMVPITV
MUL_1531|M.ulcerans_Agy99 CGGVFAISAVVQHELTGADEYYAIVPIDIRRTEEDFMTTGWFTGFVPITV
**::* . .: *::* ::.:.* . * : :* ***.* :*:**
Rv1182|M.tuberculosis_H37Rv PIAGSAFGDAARAAQTSFDSGVKLAEVPYDRVVELSSTLTMP--RPNFPV
Mb1214|M.bovis_AF2122/97 PIAGSAFGDAARAAQTSFDSGVKLAEVPYDRVVELSSTLTMP--RPNFPV
MLBr_01230|M.leprae_Br4923 PIAGSSFGDAARAAQNCFDTDVHLAEVPYDRVVELAPTVHKP--RPNFPV
Mflv_0404|M.gilvum_PYR-GCK PIGAASFGEAAWAAQSSFDSGLNMAKVPYYRVLELAPWLGWP--RPNFPV
Mvan_0270|M.vanbaalenii_PYR-1 PIGATSFADAAWAAQASFDSNLFMAKVPYYRVLELAPWLSWP--RPNFPV
MSMEG_0409|M.smegmatis_MC2_155 PIGAASFTEAAGSAQRSFDANLNMAKVPYYRVLELAPSLRWP--QPNFPV
MAB_0938c|M.abscessus_ATCC_199 PIAATSFNDAAYAAQTAFDSSLDMARVPYYRVLELAPWLKWP--EPNFPV
MAV_1762|M.avium_104 PIAAASFADAAWTAQTSFDSGQQLAKVPYYRVLELAPWLKWP--QPNFPV
MMAR_2343|M.marinum_M AVA-SSFDETVRGAQANFDASAHLANVPFERVLELAPWLKKPPPRGGFPM
TH_2204|M.thermoresistible__bu PAAGVSFGEAARAAQQSFDSGIGLGHVPYDRVLELVPSLRRAETCS--PM
MUL_1531|M.ulcerans_Agy99 PTVGSSFGEIVKAAQGSFDSGRDLAEVPLDCVMELVLWLREGQWGA--PL
. :* : . ** **:. :..** *:** : *:
Rv1182|M.tuberculosis_H37Rv VNFLDAGAAPLSVLLTAELTG--TNIGVYSDGRYSYQLSIYVIRVEQGTA
Mb1214|M.bovis_AF2122/97 VNFLDAGAAPLSVLLTAELTG--TNIGVYSDGRYSYQLSIYVIRVEQGTA
MLBr_01230|M.leprae_Br4923 INFLDAGTAPLSVLLTAGLDG--LNIGVYSDGRYSYQMSIYVIRVEQETA
Mflv_0404|M.gilvum_PYR-GCK SNFFHGGAAPLNAILAASEMGLADNIGIYPDGRFSYQLTIYIFRYGQGTE
Mvan_0270|M.vanbaalenii_PYR-1 SNFFHGGAAPLNAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGTV
MSMEG_0409|M.smegmatis_MC2_155 SNFFHGGAAPLNAVLAAADMGLANNIGIYPDGRYSYQLTIYIFRYGEGTA
MAB_0938c|M.abscessus_ATCC_199 SNFFHGGAAPLNAILAAGELGLADNIGIYPDGRFSYQLTIYIFRYGEGTA
MAV_1762|M.avium_104 SNFFHAGAAPLNAVLAAADLGYANNIGIYSDGRYSYQLTIYVFRYGEGTA
MMAR_2343|M.marinum_M VSFLDGGVPPLSGVVAMQLDR--INARAFSDGRVAARVCIWVNKFQEETT
TH_2204|M.thermoresistible__bu MSFLDAGVPPLSALVASQLDG--LNARVYGDGKVPAQLCMWVNRMDNETS
MUL_1531|M.ulcerans_Agy99 LFYLDAGIPPLSAMANSHVEG--LRARLCHDGGMMGQIDIRVNRLEKETQ
::..* .**. : . ** :: : : : : *
Rv1182|M.tuberculosis_H37Rv VAVMFPDNPIARESVARYLATLKSVFQRVAES------GQQQNVA-----
Mb1214|M.bovis_AF2122/97 VAVMFPDNPIARESVARYLATLKSVFQRVAES------GQQQNVA-----
MLBr_01230|M.leprae_Br4923 VAVMFPDNPEAQESVARYLETLKSVFECVAES------GHWRNVA-----
Mflv_0404|M.gilvum_PYR-GCK MAIMHPDNPVAKRSVERYMQTMSSVASLVADT------GHWGRVA-----
Mvan_0270|M.vanbaalenii_PYR-1 MAIMHPDNPVAKKSVTRYMKVMKSVAGLVADS------GTWGLVA-----
MSMEG_0409|M.smegmatis_MC2_155 MAIMHPDNSVARKSATRYMETMRSVAGQVADS------GNWGRVA-----
MAB_0938c|M.abscessus_ATCC_199 MAIMHPDNPIAEKSALRYMEAMKSVCARVADT------GHWGRVA-----
MAV_1762|M.avium_104 MAMMYPDNPVAHKSVARYTETMRSVCGRVADT------GHWGRVA-----
MMAR_2343|M.marinum_M VTASFPNNPIAYDSVARYLDTMKSVYLRIAEG------ARWDAIAQVL--
TH_2204|M.thermoresistible__bu VTVFFPDNPVARASVEKYVATLRSIYVAVAEGRADRLGARRSGELQRQPA
MUL_1531|M.ulcerans_Agy99 LTVLFPNNPVARESVTRYVEALKSAFVRVAEGRDVMPAPSRTGSQLHLAY
:: .*:*. * *. :* .: * :*:
Rv1182|M.tuberculosis_H37Rv --------------------
Mb1214|M.bovis_AF2122/97 --------------------
MLBr_01230|M.leprae_Br4923 --------------------
Mflv_0404|M.gilvum_PYR-GCK --------------------
Mvan_0270|M.vanbaalenii_PYR-1 --------------------
MSMEG_0409|M.smegmatis_MC2_155 --------------------
MAB_0938c|M.abscessus_ATCC_199 --------------------
MAV_1762|M.avium_104 --------------------
MMAR_2343|M.marinum_M --------------------
TH_2204|M.thermoresistible__bu --------------------
MUL_1531|M.ulcerans_Agy99 SRRTYEPPATVSPLTSWRTG