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RLLVTGGAGFIGANFVRTTVQQRPDVQVTVLDSLTYAGSRESLRGVDSQIRLVEGDITDAELVGKLVADS DAVVHFAAETHVDNALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHISTDEVYGDLELDDPARFTD ATPYNPSSPYSSTKAAADMLVRAWVRSYRVAATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPELYGTG ANVRDWIHVDDHNSAVWRILHDGTVGRTYLIGADGERDNLSVMRTILRLMGRSPEDFDHVTDRVGHDLRY AIDPTPLRDELGWRPEHTDFESGLRDTIDWYRDNESWWGPLKDAVEATYQRRRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | - | 100% (335) | dTDP-glucose 4,6-dehydratase |
| M. vanbaalenii PYR-1 | Mvan_5389 | - | 3e-14 | 25.71% (319) | UDP-glucose 4-epimerase |
| M. vanbaalenii PYR-1 | Mvan_0338 | - | 3e-11 | 28.99% (238) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3493 | rmlB1 | 1e-156 | 79.28% (333) | dTDP-glucose 4,6-dehydratase RmlB1 |
| M. gilvum PYR-GCK | Mflv_5007 | - | 1e-171 | 84.38% (333) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv3464 | rmlB | 1e-156 | 79.28% (333) | dTDP-glucose 4,6-dehydratase RMLB |
| M. leprae Br4923 | MLBr_01964 | rmlB | 1e-154 | 76.42% (335) | dTDP-glucose 4,6-dehydratase |
| M. abscessus ATCC 19977 | MAB_3779 | - | 1e-153 | 75.68% (333) | dTDP-glucose 4,6-dehydratase RmlB |
| M. marinum M | MMAR_1082 | rmlB | 1e-156 | 79.58% (333) | dTDP-glucose-4,6-dehydratase, RmlB |
| M. avium 104 | MAV_4406 | rfbB | 1e-158 | 79.88% (333) | dTDP-glucose 4,6-dehydratase |
| M. smegmatis MC2 155 | MSMEG_1512 | rfbB | 1e-159 | 80.48% (333) | dTDP-glucose 4,6-dehydratase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 1e-143 | 79.61% (304) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_0840 | rmlB | 1e-156 | 79.58% (333) | dTDP-glucose-4,6-dehydratase, RmlB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1365|M.vanbaalenii_PYR-1 ---------MRLLVTG---GAGFIGANFVRTTVQQRP---DVQVTVLDSL
Mflv_5007|M.gilvum_PYR-GCK ---------MRLLVTG---GAGFIGANFVLATVRDRP---DVRVTVLDSL
MAB_3779|M.abscessus_ATCC_1997 ---------MRILVTG---GAGFIGANFVHATVRERP---DVSVTVLDAL
Mb3493|M.bovis_AF2122/97 ---------MRLLVTG---GAGFIGTNFVHSAVREHP---DDAVTVLDAL
Rv3464|M.tuberculosis_H37Rv ---------MRLLVTG---GAGFIGTNFVHSAVREHP---DDAVTVLDAL
MMAR_1082|M.marinum_M ---------MRLLVTG---GAGFIGANFVHSSVREYP---DDAVTVLDAL
MUL_0840|M.ulcerans_Agy99 ---------MRLLVTG---GAGFIGANFVHSSVREYP---DDAVTVLDAL
MAV_4406|M.avium_104 ---------MRLLVTG---GAGFIGANFVHSTVREHP---EDSVTVLDAL
MLBr_01964|M.leprae_Br4923 -------MTMRLLVTG---GAGFIGANFVHNAVRDHP---DDTVTVLDAM
MSMEG_1512|M.smegmatis_MC2_155 ---------MRLLVTG---GAGFIGANFVHLALREAR---TSSITVLDAL
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
*:. ..* * .. : : .. * **::
Mvan_1365|M.vanbaalenii_PYR-1 TYAGSRESLRGVDSQIRLVEGDITDAELVGKLVADSDAVVHFAAETHVDN
Mflv_5007|M.gilvum_PYR-GCK TYAGSRESLAGVDTQIRLVQGDITDADLVGRLVGESDAVVHFAAETHVDN
MAB_3779|M.abscessus_ATCC_1997 TYAGSSESLAPVAAAVQLVQGDICDPDTVERLVADSDVVVHFAAETHNDN
Mb3493|M.bovis_AF2122/97 TYAGRRESLADVEDAIRLVQGDITDAELVSQLVAESDAVVHFAAESHVDN
Rv3464|M.tuberculosis_H37Rv TYAGRRESLADVEDAIRLVQGDITDAELVSQLVAESDAVVHFAAESHVDN
MMAR_1082|M.marinum_M TYAGRRESLADLEDAIRLVEGDITDAELVSQLVAESDAVVHFAAESHVDN
MUL_0840|M.ulcerans_Agy99 TYAGRRESLADLEDAIRLVEGDITDAELVSQLVAESDAVVHFAAESHVDN
MAV_4406|M.avium_104 TYAGRRESLAGVEDSIRLVVGDITDAELVSRLVAESDAVVHFAAESHVDN
MLBr_01964|M.leprae_Br4923 TYAGRHESLADVDHAVRLVQGNITDTKLVFRLVAESDVVVHFAAETHVDN
MSMEG_1512|M.smegmatis_MC2_155 TYAGSRESLAPVADRIRLVQGDITDAALVGDLVAESDAVVHFAAETHVDN
TH_0330|M.thermoresistible__bu TYAGSRESLAPVADRIRVVEGDVTDSDLVDKLVAESDAVVHFAAESHVDN
**** *** : :::* *:: *. * **.:**.*******:* **
Mvan_1365|M.vanbaalenii_PYR-1 ALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHISTDEVYGDLELDD
Mflv_5007|M.gilvum_PYR-GCK ALADPEPFVRSNIVGTFTILEAVRHAAASRPVRLHHVSTDEVYGDLELGD
MAB_3779|M.abscessus_ATCC_1997 SLADPSPFLRSNIIGTYTLLEAVR----RHQVRLHHISTDEVFGDLELDD
Mb3493|M.bovis_AF2122/97 ALDNPEPFLHTNVIGTFTILEAVR----RHGVRLHHISTDEVYGDLELDD
Rv3464|M.tuberculosis_H37Rv ALDNPEPFLHTNVIGTFTILEAVR----RHGVRLHHISTDEVYGDLELDD
MMAR_1082|M.marinum_M ALDNPEPFVHTNVLGTFTILEAVR----RHGVRLHHISTDEVYGDLELHD
MUL_0840|M.ulcerans_Agy99 ALDNPEPFVHTNVLGTFTILEAVR----RHGVRLHHISTDEVYGDLELHD
MAV_4406|M.avium_104 ALAGPEPFLHTNVVGTFTILEAVR----RHGVRLHHISTDEVYGDLELDD
MLBr_01964|M.leprae_Br4923 ALDDPEPFLRTNVIGTFTILEAVR----HHSVRLHHISTDEVYGDLELDE
MSMEG_1512|M.smegmatis_MC2_155 ALADPEPFLHSNVVGTYTILEAVR----RHNVRLHHVSTDEVYGDLELDN
TH_0330|M.thermoresistible__bu ALAEPEPFLRTNVVGTFTVLEAVR----RHRVRLHHISTDEVYGDLPLHD
:* *.**:::*::**:*:***** : *****:*****:*** * :
Mvan_1365|M.vanbaalenii_PYR-1 PARFTDATPYNPSSPYSSTKAAADMLVRAWVRSYRVAATISNCSNNYGPY
Mflv_5007|M.gilvum_PYR-GCK PAKFTESTPYNPSSPYSSTKAASDMLVRAWVRSYRLTATLSNCSNNYGPF
MAB_3779|M.abscessus_ATCC_1997 PNRFTETTPYNPSSPYSATKASADLLVRAWIRSFGISATISNCSNNYGPY
Mb3493|M.bovis_AF2122/97 RARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGPY
Rv3464|M.tuberculosis_H37Rv RARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGPY
MMAR_1082|M.marinum_M PARFTEATPYNPSSPYSATKAGADMLVRAWVRSYGVAATISNCSNNYGPY
MUL_0840|M.ulcerans_Agy99 PARFTEATPYNPSSPYSATKAGADMLVRAWVRSYGVAATISNCSNNYGPY
MAV_4406|M.avium_104 PNRFTESTPYNPSSPYSATKAAADMLVRAWVRSYGVRATISNCSNNYGPY
MLBr_01964|M.leprae_Br4923 PTRFTESTPYNPSSPYSATKAAGDMLVRAWVRSYGVRATISNCSNNYGPY
MSMEG_1512|M.smegmatis_MC2_155 PARFNETTPYNPSSPYSSTKAAADLLVRAWVRSYGVRATISNCSNNYGPY
TH_0330|M.thermoresistible__bu PRRFTESTPYNPSSPYSSTKAAADMLVRAWVRSYGVAATISNCSNNYGPY
:*.::**********:***..*:*****:**: : **:*********:
Mvan_1365|M.vanbaalenii_PYR-1 QHVEKFIPRQITNVLTGRRPELYGTGANVRDWIHVDDHNSAVWRILHDGT
Mflv_5007|M.gilvum_PYR-GCK QHVEKFIPRQITNILTGRRPKLYGTGANVRDWIHVEDHNSAVWKILTHGA
MAB_3779|M.abscessus_ATCC_1997 QHVEKFIPRQITNILTGRRPRLYGAGANVRDWIHVDDHNSAVWRIIEAGT
Mb3493|M.bovis_AF2122/97 QHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRGR
Rv3464|M.tuberculosis_H37Rv QHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRGR
MMAR_1082|M.marinum_M QHIEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRILEKGQ
MUL_0840|M.ulcerans_Agy99 QHIEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRILEKGQ
MAV_4406|M.avium_104 QHVEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRILESGE
MLBr_01964|M.leprae_Br4923 QHVEKFIPRQITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQILEKGQ
MSMEG_1512|M.smegmatis_MC2_155 QHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVWRILTDGT
TH_0330|M.thermoresistible__bu QHVEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVEDHNDAVWRILTAGQ
**:**********:******.***:*.********:***.** :*: *
Mvan_1365|M.vanbaalenii_PYR-1 VGRTYLIGADGERDNLSVMRTILRLMGRSPEDFDHVTDRVGHDLRYAIDP
Mflv_5007|M.gilvum_PYR-GCK VGRTYLIGADGECDNLTVMRTILRLMDRSPDDFDHVTDRAGHDLRYAIDA
MAB_3779|M.abscessus_ATCC_1997 IGRTYLIGADGERDNLSVLHTILELMGKSSDDFDHVTDRAGHDLRYAIDP
Mb3493|M.bovis_AF2122/97 IGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDP
Rv3464|M.tuberculosis_H37Rv IGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDP
MMAR_1082|M.marinum_M IGKTYLISSEGERDNLSVLRTLLRMMDRDPDDFDHVVDRVGHDLRYAIDP
MUL_0840|M.ulcerans_Agy99 IGKTYLISSEGERDNLSVLRTLLRMMDRDPDDFDHVVDRVGHDLRYAIDP
MAV_4406|M.avium_104 IGRTYLISSEGERDNLTVLRTLLQMMGRDPDDFDHVTDRVGHDLRYAIDP
MLBr_01964|M.leprae_Br4923 IGRTYLIGAENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLRYAIDP
MSMEG_1512|M.smegmatis_MC2_155 IGRTYLIGAECERNNLTVMRTILKLMGRDPDDFDHVTDRAGHDLRYAIDP
TH_0330|M.thermoresistible__bu IGRTYLIGADGERDNRTVLRTILKLMDRDPDDFDHVTDRAGHDLRYAIDP
:*:****.:: :* :*::*:*.:*.:..:*****.**.*********.
Mvan_1365|M.vanbaalenii_PYR-1 TPLRDELGWRPEHTDFESGLRDTIDWYRDNESWWGPLKDAVEATYQRRRR
Mflv_5007|M.gilvum_PYR-GCK TALRDELGWRPAHSDFEAGLRDTIDWYSANESWWGPIKDAVEAGYQSRGQ
MAB_3779|M.abscessus_ATCC_1997 TPLRDELGWKPTHSDFTGGLAATIDWYRRNEEWWRPIKDNVESQYAARGQ
Mb3493|M.bovis_AF2122/97 STLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERGQ
Rv3464|M.tuberculosis_H37Rv STLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERGQ
MMAR_1082|M.marinum_M SLLYNELAWAPKHTDFEEGLRTTIDWYRANESWWRPLKDAAEARYQERGQ
MUL_0840|M.ulcerans_Agy99 SLLYNELAWAPKHTDFEEGLRTTIDWYRANESWWRPLKDAAEARYQERGQ
MAV_4406|M.avium_104 STLYDELCWAPKHTDFEEGLRETIDWYRANESWWRPLKDASEARYEERGQ
MLBr_01964|M.leprae_Br4923 TPLYNELCWAPKHANFDEGLRATIDWYRNNESWWRPLKDAVEARYEERGR
MSMEG_1512|M.smegmatis_MC2_155 STLQDELGWAPKHTDFEAGLTDTIDWYRANESWWRPLKDTVEAKYQERGQ
TH_0330|M.thermoresistible__bu SALIDELGWTPRHTDFEAGLRDTIQWYRDNEDWWRPLKDATEDAYAERGQ
: * :** * * *::* ** **:** **.** *:** * * * :