For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. tuberculosis H37Rv Rv1450c (PE_PGRS27)

annotation: PE-PGRS FAMILY PROTEIN
coordinates: 1630638 - 1634627
length: 1329

SLVIVAPETVAAAALDVARIGSSIGAANAAAAGSTTSVLAAGADEVSAAIATLFGSHAREYQAISTQVAA
FHDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGI
LWGNGGAGGSGAPGQVGGAGGAAGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATG
GAGGNAGLFGVGGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGGAAGLL
GVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAGGAGGAGGVGGTGGAGGA
GFSRALIVAGDNGGDPGAGGAGGTGGAGSTIGAHGAAGASPTSGGNGGAGGNGAHFSSGGKAGGNGGAGG
AGGLVGNGGAGGAGGNGAPGAPPSGGDPNGGGGGAGGAGGKGGDGGAQAGDGGAGGAGGKGGNGGNGATG
ATGLNGLGAGADGTDGGKGGNGGAGGGGGAGGQGGKALAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAK
GTFDNGGDGVGGNGGNGGSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGANATVAGGAGGAG
GKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGGTGGAGGN
GANGANATTPGAKGGDGGHGGPGAQGGNGGQGGPGGLAGNLFGQNGIQGVGGSGGKGGAGGLAGDGGNGA
NGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGNSQVVGGNGGDG
GNGGNGGSAGTGGNGGRGGDGAFGGMSANATNPGENGPNGNPGGNGGAGGAGGAGLNGGNGGAGGNGGLG
GFGGNGAAGANGVAVGAPGQPGGAGGHGGAGGNGGAGGNGGQGVVSDGAGGAGGAGGDGGAPGDGANGGN
GQGAGAFAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGGHGAASGGNGGPGGH
GGNGGNGGTGANGGNGGIGGTGGAGSTGAKGVLGTNEGDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGG
TPGNGGNGGNGASGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSGPGGTPGDWGTGGTGGTGGTGGQGAN
GGLTGGRGGTGGNGGNGNTGGTGGAGGTGGTGHNGSQPGMGGNGGAGGFGGNGFAGVGGRGGMGGSGGTG
GTGDAGPFGTGTGGTGGHGGQGGGGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGLGGGEFV*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1450cPE_PGRS27-100% (1329)PE-PGRS FAMILY PROTEIN
M. tuberculosis H37RvRv2490cPE_PGRS430.050.98% (1581) PE-PGRS family protein
M. tuberculosis H37RvRv3345cPE_PGRS500.051.68% (1492) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1485cPE_PGRS270.091.53% (1417) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-0.048.01% (829) triple helix repeat-containing collagen
M. leprae Br4923MLBr_01556infB2e-1133.95% (162) translation initiation factor IF-2
M. abscessus ATCC 19977MAB_4284c-1e-5031.50% (581) hypothetical protein MAB_4284c
M. marinum MMMAR_3763-0.053.07% (1532) PE-PGRS family protein
M. avium 104MAV_4827-4e-2543.02% (172) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-17541.23% (1089) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-7e-4839.87% (316) PUTATIVE -
M. ulcerans Agy99MUL_4367-0.049.95% (1091) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-1e-17946.11% (822) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Rv1450c|M.tuberculosis_H37Rv        ------------MSLVIVAPETVAAAALDVARIGSSIGAANAAAAGSTTS
Mb1485c|M.bovis_AF2122/97           ------------MSLVIVAPETVAAAALDVARIGSSIGVANSAAAGSTTS
MMAR_3763|M.marinum_M               ------------MSFVSVAPEAVATAASDLARIGSSIDAVNAAAAGATTT
MUL_4367|M.ulcerans_Agy99           ------------MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVG
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------MSIIDFILNLFRDPVEAASYVADPEAALANAG--
MAV_4827|M.avium_104                -------------------MNIVLGVSMAPSSIQMVVLEGEYADG-----
MLBr_01556|M.leprae_Br4923          ------------MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASST
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        VLA----------AGADEVSAAIATLFG----SHAREYQAIST--QVAAF
Mb1485c|M.bovis_AF2122/97           VLA----------AGADEVSAAIATLFG----SHAREYQAIST--QVAAF
MMAR_3763|M.marinum_M               VLA----------AGADEVSVAIAALFG----THAQEYQAIST--RISAL
MUL_4367|M.ulcerans_Agy99           VLP----------AAGDEVSAAIAELFG----GFGREYQAMGA--RVALL
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------MMFL----APPGGPGPISA--AIQLT
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------LSAVSAAQVGAVMPVVAESVASNYGYQSQWVN
MAV_4827|M.avium_104                ---------------------------------ATVEEDAIDVTGADDAA
MLBr_01556|M.leprae_Br4923          VEAP--------------VARRLRESFGGIKPAADKGAEQVATKAQAKRL
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        HDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLNALNAPTQ--------
Mb1485c|M.bovis_AF2122/97           HDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLNALNAPTQ--------
MMAR_3763|M.marinum_M               NERFVALLTAGNNSYAASESASVSWLQAVEQDVLGLVNAPSQ--------
MUL_4367|M.ulcerans_Agy99           HDDFVRALTAGGSAYGQAEALNMWPLQELEQQALGVVNAPSM--------
Mflv_5091|M.gilvum_PYR-GCK          -----------MVTFGGGATPTPTSLGAAAVDLSGTSCG-----------
Mvan_1264|M.vanbaalenii_PYR-1       STGSEATEPWYVVSFGGSGAPTPNNLAASLVDLSGTSCG-----------
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPR----------------
MAV_4827|M.avium_104                TASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR-------
MLBr_01556|M.leprae_Br4923          GESLDQTLDRALDKAVAGNGATTAAPVQVDHSAAVVPIVAGE--------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1485c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_3763|M.marinum_M               --------------------------------------------------
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        ----------------------------------ALLGRPLIGDGAAGAP
Mb1485c|M.bovis_AF2122/97           ----------------------------------ALLGRPLIGDGAAGAP
MMAR_3763|M.marinum_M               ----------------------------------NWFGRPLIGNGADGVA
MUL_4367|M.ulcerans_Agy99           ----------------------------------ALFGRPSIGNGVDGVA
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------LICNGQD---
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------LICNGQD---
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGING-T
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------------------------DNDFLSHNDTDFA
MAV_4827|M.avium_104                --------------------------------------DALAARRIDNVM
MLBr_01556|M.leprae_Br4923          --------------------------------------GPSTAHREELAP
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFGTGGAGGAG---
Mb1485c|M.bovis_AF2122/97           GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFGTGGAGGAG---
MMAR_3763|M.marinum_M               GTGQAGGAGGILWGNGGAGG-SGAVGQSGGAGGSAGLLGHGGAGGAGGQA
MUL_4367|M.ulcerans_Agy99           GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAG---
Mflv_5091|M.gilvum_PYR-GCK          GTGQN---GGILFGNGGSGWNSDVVGMDGGNGGNGGLFG--GNGGNG---
Mvan_1264|M.vanbaalenii_PYR-1       GTGQN---GGILFGNGGSGWNSEIAGVSGGNGGNAGLFG--GNGGNG---
MSMEG_0868|M.smegmatis_MC2_155      ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFGNGGNGGVG---
TH_3810|M.thermoresistible__bu      ------------------------VDGDGGSGGRTGLFSKLSRGGDG---
MAB_4284c|M.abscessus_ATCC_199      SHNPIASGNQVMSPSGNVDSFNRGPLLDLSFG--DLQFGNRDTTAIG---
MAV_4827|M.avium_104                LVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIP---
MLBr_01556|M.leprae_Br4923          PAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPP---
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        ---GAGAAGGAGGSGGWLLGNGGVG-------------------------
Mb1485c|M.bovis_AF2122/97           ---GAGAAGGAGGSGGWLLGNGGVG-------------------------
MMAR_3763|M.marinum_M               GASGTGGVGGAGGAGGWLYGNGGTGGVGGEGPVNGGVGGAGGRAWLLGAG
MUL_4367|M.ulcerans_Agy99           ---GVGAAGMTGGSG-----------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ---GNGLGGGNGGNG-----------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ---GNGLGSGDGGNG-----------------------------------
MSMEG_0868|M.smegmatis_MC2_155      ---WAGLDGGNGGSG-----------------------------------
TH_3810|M.thermoresistible__bu      ---GDGGLGGNGGHG-----------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----DGAVAVGGSNS-----------------------------------
MAV_4827|M.avium_104                --DVYKQQIRAESYG-----------------------------------
MLBr_01556|M.leprae_Br4923          ---RVGNNPFSSAQS-----------------------------------
                                                . .                                   

Rv1450c|M.tuberculosis_H37Rv        ---GAGGQSL-LGGATGGAGGNAGLFGVGGTGGPGGP-------------
Mb1485c|M.bovis_AF2122/97           ---GAGGQSL-LGGATGGAGGNAGLFGVGGTGGPGGP-------------
MMAR_3763|M.marinum_M               GSGGAGGQGLGLNGGAGGAGGNGGLFGIGGTGGAGGDSAGSGSAGAGGDG
MUL_4367|M.ulcerans_Agy99           ----------------GAGGGGGWLWGAGGSGG-----------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------GNAGAFALFGNGG-----------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------GDAGLFSLFGRGG-----------------
MSMEG_0868|M.smegmatis_MC2_155      ----------------------GLLMGIGGAGG-----------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        --------GGPGG---------VGGTGGAGGLGGTLYGAGGHGGAGGPGP
Mb1485c|M.bovis_AF2122/97           --------GGPGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGP
MMAR_3763|M.marinum_M               GHGGLWGRGGAGGIGGVNSDSGDGGAGGGGGAGGRLFGSGGAGGAGGTGA
MUL_4367|M.ulcerans_Agy99           ----------------------AAGAGGSGGSGGWLWGNAGQTAGAG---
Mflv_5091|M.gilvum_PYR-GCK          -------------------------NGGNGGVG-----------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------NGGNGGVG-----------------
MSMEG_0868|M.smegmatis_MC2_155      -------------------------AGGVGADGTSAHVDGGTGGTGGTG-
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        IGGVGGHGGVGGAAG-LLGVGGHGGAGGHGAEGVAGAAG-EDLSPHGTSG
Mb1485c|M.bovis_AF2122/97           IGGVGGHGGVGGAAG-LLGVGGHGGAGGHGAAGIAGAAGKGGIFPDGSNG
MMAR_3763|M.marinum_M               VAGSGGDGGAGGAAVGLWGLGGHGGAGGDGAVGLAGGVG--------EAG
MUL_4367|M.ulcerans_Agy99           VGGAGGAGGAGDAGD--QGVSG-VAPGEAGAVGFAGGAG-----------
Mflv_5091|M.gilvum_PYR-GCK          VVGATGAVGAPGVAG------------ATGATGVTSGVV-----------
Mvan_1264|M.vanbaalenii_PYR-1       IAGATGAVGAPGVAG------------ATGATGVTSNVT-----------
MSMEG_0868|M.smegmatis_MC2_155      -GGTGGTGGIGGTGG-----GLFGLLGHSGSTGAAGAAG-----------
TH_3810|M.thermoresistible__bu      -----------------------------GGTGIISLLS-----------
MAB_4284c|M.abscessus_ATCC_199      --GPIASGQGSTAVN--------------GDVRDSNIIN-----------
MAV_4827|M.avium_104                ----DAAGQLSAMVA--------------GLEKLESLPG---------GL
MLBr_01556|M.leprae_Br4923          --VARPIPRPPAPRP------------SASPSSMSPRPG-----------
                                                                 .                    

Rv1450c|M.tuberculosis_H37Rv        GVGGDAGDGGTGGRGGWLAGAGGAGGAGGVGGTGGAGGAGFSRALIVAGD
Mb1485c|M.bovis_AF2122/97           GAGGDAGDGGTGGRGGWLAGAGGAGGDGGIGGTGGAGGAGFSRALIVAGD
MMAR_3763|M.marinum_M               GEGGSAGNGGAGGLGGWLIGSGGAGGLGGVGGAGGAGGAG--AAGIAPGS
MUL_4367|M.ulcerans_Agy99           GAGGAGGNGVGGG----VNGAGGAGGAGGVGGGGGAGASG-----VGAGV
Mflv_5091|M.gilvum_PYR-GCK          --GGNGED---------AVGYGATGAAGAAGAAGAAGAAG----------
Mvan_1264|M.vanbaalenii_PYR-1       --GGNGAD---------AVGYGATGAAGAAGAAGAAGKAG----------
MSMEG_0868|M.smegmatis_MC2_155      -NGGDGGNGGFG--YVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPG-
TH_3810|M.thermoresistible__bu      -LAGNGGNGGNG--------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --ADHGSNVGVD--------------------------------------
MAV_4827|M.avium_104                LLVGSGVDVAP---------------------------------------
MLBr_01556|M.leprae_Br4923          GAVGGGGPRPPR--------------------------------------
                                       . .                                            

Rv1450c|M.tuberculosis_H37Rv        NGGD----------------------------------------------
Mb1485c|M.bovis_AF2122/97           NGGDGGNGGMGGAGGAGGPGGAGGLISLLGGQGAGGDGGDGGAGGVGGDR
MMAR_3763|M.marinum_M               NGGNGGNGGVGGAGGVGGSGGQGGFLRFLGGQGDGGAGGAGGAGGVAGDG
MUL_4367|M.ulcerans_Agy99           AGGDGGTG------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        -----------------------PGAGGAGGTGGAGSTIGAHGAAGASPT
Mb1485c|M.bovis_AF2122/97           GAGANGNQAVNAGAGGAGGHGGDPGAGGAGGTGGAGSTIGAHGAAGASPT
MMAR_3763|M.marinum_M               GKGADAAAFSG-AAGGNGGHGGDNGAGGAGGTGGAGSTVGAHGADGFSPI
MUL_4367|M.ulcerans_Agy99           ------------------------GAGGAAGVGGAAGTGGTGGAAGVAGT
Mflv_5091|M.gilvum_PYR-GCK          -------------------------AVGSAGAAGEAGETGTWGNAGLPGK
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------AVGSAGTAGSAGAPGVWGNAGLPGA
MSMEG_0868|M.smegmatis_MC2_155      ------------------------KGGGGGGGGGGAILIGANGGTVDGHA
TH_3810|M.thermoresistible__bu      -----------------------------------------YRTTDNNAL
MAB_4284c|M.abscessus_ATCC_199      --------------------------QSQTRVGGDYTNVSGHGSADIDKS
MAV_4827|M.avium_104                ----------------------------LKQVLQTTTFLDVSVAEEPETA
MLBr_01556|M.leprae_Br4923          --------------------------TGVPRPGGGRPGAPVGGRSDAGGG
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        SGGNGGAGGNGAH--FSSGGKAGGNG-----GAGGAGGLVGNGGAGGAGG
Mb1485c|M.bovis_AF2122/97           SGGNGGAGGNGAH--FSSGGKAGGNG-----GAGGAGGLVGNGGAGGAGG
MMAR_3763|M.marinum_M               TGGNGGDGGNGASGPAASAGVAGGAG-----GAGGDGGLYGNGGAGGDGG
MUL_4367|M.ulcerans_Agy99           GGDGGDGGAGGAGSDASLAGQAGFAG-----GSGGAGGVGGSAGAGGVNG
Mflv_5091|M.gilvum_PYR-GCK          AGDAGGAGAVGAAGAAGTVGTAGATG-----GTG----------------
Mvan_1264|M.vanbaalenii_PYR-1       AGAAGGAGAIGTAGVAGAAGTAGATG-----GTG----------------
MSMEG_0868|M.smegmatis_MC2_155      IGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHST
TH_3810|M.thermoresistible__bu      DGGHGGNG------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VTVVDDHSQRNTTNINDSFNTDRSTN------------------------
MAV_4827|M.avium_104                LARGAALAAANAPLFASSTAALAYAQ------------------------
MLBr_01556|M.leprae_Br4923          NYRGGGVGALPGGGSGGFRGRPGGGG------------------------
                                           .                                          

Rv1450c|M.tuberculosis_H37Rv        NGAPG-----APPSGGD-PNGGGGGAGGAGGKGGDGGAQAGD-GGAGGAG
Mb1485c|M.bovis_AF2122/97           NGAPG-----APPSGGD-PNGGGGGAGGAGGKGGDGGAQAGD-GGAGGAG
MMAR_3763|M.marinum_M               NGVAGGQGADATAAGASGENGGDGGAGGMGGAGGMGGVLGGH-GGAGGIG
MUL_4367|M.ulcerans_Agy99           S-------------------GGDGGAGAAGGAGGASATVAGS-GGVGGDG
Mflv_5091|M.gilvum_PYR-GCK          -------------------TGANGGAGGVGGVGGTG-AAGAA-GGAGGLG
Mvan_1264|M.vanbaalenii_PYR-1       -------------------VGGNGGAGQAGGIGGTG-AAGAA-GQAGTAG
MSMEG_0868|M.smegmatis_MC2_155      GTG----------------IGGNGGIGSVYAYGNNGAVSGTATGGRGGDG
TH_3810|M.thermoresistible__bu      ---------------------GNVGFFSLFNLGGAG--------GWGGSG
MAB_4284c|M.abscessus_ATCC_199      ---------------------IGSGNTTNTEIGSHNQANIGTSTSAGGSA
MAV_4827|M.avium_104                ----------------------DPGTGAVDQYSLPDYLYVPVDPEPGDDE
MLBr_01556|M.leprae_Br4923          ----------------------HGGGGRPGQRGGAAGAFGRPGGAPRRGR
                                                            *       .                 

Rv1450c|M.tuberculosis_H37Rv        GKGGNGGNGATGATGLNGLGAG-ADGTDGGKGGNGGAGGGGGAGGQGGKA
Mb1485c|M.bovis_AF2122/97           GKGGNGGNGATGATGLNGLGAG-ADGTDGGKGGNGGAGGGGGAGGQGGKA
MMAR_3763|M.marinum_M               GVGATGGSGGLGATGAEGVTGGNLHGGDGGNGGKGGIGGAGGDGGAGGKA
MUL_4367|M.ulcerans_Agy99           GAGGAAG-GGVGAASLG------------GDGGHAGAGGAGGEGLSGG--
Mflv_5091|M.gilvum_PYR-GCK          ETGTTGGAGGVG-----------------GQGTAGGTGGVGG--------
Mvan_1264|M.vanbaalenii_PYR-1       ETGVTGGVGGIG-----------------GQGTEGGTGGVGG--------
MSMEG_0868|M.smegmatis_MC2_155      IDGGTGGAGGMGEIYSG----------ADGEATGISAGGDGGSATGADSL
TH_3810|M.thermoresistible__bu      VDG---------------------------------VDVVGG--------
MAB_4284c|M.abscessus_ATCC_199      AVGGNAG-----------------------LAGNAGLAGNAG--------
MAV_4827|M.avium_104                LAYSAVG----------------------EEDAESPTVVIEKLFLP----
MLBr_01556|M.leprae_Br4923          KSKRQKR----------------------QEYDSMQAPVVGGVRLPHGNG
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        LAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGGNG
Mb1485c|M.bovis_AF2122/97           LAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGGNG
MMAR_3763|M.marinum_M               QAAGFADGTEGVGGAGGEGGAGGVAGDGGKGADAAAFSG--AAGGNGGHG
MUL_4367|M.ulcerans_Agy99           ----FNTG--AAGGIGGAGGAGGTGGDSG------------GVGGVNGDG
Mflv_5091|M.gilvum_PYR-GCK          -----------IGGAGSTGAVGGVGGKGIQ-------------GGQGLQG
Mvan_1264|M.vanbaalenii_PYR-1       -----------VGGVGATGGAGGVGGKGIQ-------------GGQGLQG
MSMEG_0868|M.smegmatis_MC2_155      GGRGGTSWVQAGYGPTTGGKASGTAKAGHG-----------GKASDGGKG
TH_3810|M.thermoresistible__bu      ---------------NPDGGTPGAHGESHT---------------PGVYT
MAB_4284c|M.abscessus_ATCC_199      --------------LAGNAGLAGNAGLAGN-------------AGLAGNA
MAV_4827|M.avium_104                --------------EDSEPRRRPVLLVGSG-------------LAVVGIS
MLBr_01556|M.leprae_Br4923          ETIRLARGASLSDFAEKIDANPAALVQALFN-----------LGEMVTAT
                                                               .                      

Rv1450c|M.tuberculosis_H37Rv        GSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGAN--ATVAGG
Mb1485c|M.bovis_AF2122/97           GSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGAN--ATVAGG
MMAR_3763|M.marinum_M               GDNGAGGAGGTGGAGSTVGAHGADGFSPITGGNGGDGGNGASGPAASAGV
MUL_4367|M.ulcerans_Agy99           GAGGGGGRGGDGGSSTSTSG---------VGGAGGAGGNGGN--------
Mflv_5091|M.gilvum_PYR-GCK          GKGGDGGAGGKGGDADSMGS---------AGATGGKGGNGGN--------
Mvan_1264|M.vanbaalenii_PYR-1       GQGGDGGTGGTGGDATSMGE---------AGATGGKGGNGGN--------
MSMEG_0868|M.smegmatis_MC2_155      GNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHG
TH_3810|M.thermoresistible__bu      DRQGEDGEDGTG------------------TGIGGRGGNGGS--------
MAB_4284c|M.abscessus_ATCC_199      GLAGNAGLAGNAG----------------LAGNAGLAGNAGL--------
MAV_4827|M.avium_104                AVLALEIALAIG-----------------IRTTGTVALQPTP--------
MLBr_01556|M.leprae_Br4923          QSVGDETLELLGSEMNYNVQVVSPEDEDRELLEPFDLTYGED--------
                                       .       .                                      

Rv1450c|M.tuberculosis_H37Rv        AGGAGGKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGA
Mb1485c|M.bovis_AF2122/97           AGGAGGKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGA
MMAR_3763|M.marinum_M               AGGAGGAGGDGGLYGNGGAGGDGGNGVAGGQGADATAAGASGENGGDGGA
MUL_4367|M.ulcerans_Agy99           AGFGVSAGGTGGSAGDGGAGG-GAGGVDGVGGAS-----------GNGGA
Mflv_5091|M.gilvum_PYR-GCK          -------GGRGGLFGKGGNAGNGADGGTG----------------GAGGA
Mvan_1264|M.vanbaalenii_PYR-1       -------GGRGSLFGRGGNAGNGGNGGTG----------------GNGGN
MSMEG_0868|M.smegmatis_MC2_155      SITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGN
TH_3810|M.thermoresistible__bu      -------SSGTHPMAEDGEHVKALDGRPG----------------LDGGN
MAB_4284c|M.abscessus_ATCC_199      -------AGNAGLAGNAGLAGNAGLAGNAG---------------LAGNA
MAV_4827|M.avium_104                -------NQHLIVPTEQAPAPPPVQASAPQPKIS-----------VPEPV
MLBr_01556|M.leprae_Br4923          ------QGDEDELQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGI
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        GGAGGAGGRGGDFGGDGGTG---------GAGGNGANGANATTPG-AKGG
Mb1485c|M.bovis_AF2122/97           GGAGGAGGRGGDFGGDGGTGGAGGNGADGGAGGNGANGANATTPG-AKGG
MMAR_3763|M.marinum_M               GGMGGAGGMGGVLGGHGGAGGIGGVGATGGSGGLGATGAEGVTGGNLHGG
MUL_4367|M.ulcerans_Agy99           AGAGGAGGSGIGAGIDGGAG---------GAGGTG--GAAGFPGG---GG
Mflv_5091|M.gilvum_PYR-GCK          GGTGGTGG-------AGGTG---------GTGGTGGIGGAGSTGG--TGG
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGTGG-------NGGTG---------GTGGTGGIGGAGSTGG--TGG
MSMEG_0868|M.smegmatis_MC2_155      GGDGGFNGTGGATGGRGGDG---------AGASVWKANGQHSTGQTDTGG
TH_3810|M.thermoresistible__bu      GSHG---------------------------------------------G
MAB_4284c|M.abscessus_ATCC_199      GLAGNAG----------------------------------------LAG
MAV_4827|M.avium_104                AAPKPLSP-----------------------PVAAPLPAAPPPAAPPLPE
MLBr_01556|M.leprae_Br4923          TQHIGAYQVGVDLD-----------------GSERLITFIDTPGHEAFTA
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        DGGHGGPGA---QGGNGGQGGPGGLAGNLFGQNGIQGVGGSGGKGGAGGL
Mb1485c|M.bovis_AF2122/97           DGGHGGPGA---QGGNGGQGGPGGLAGNLFGQNGIQGVGGSGGKGGAGGL
MMAR_3763|M.marinum_M               DGGNGGKGG---IGGAGGDGGAGGKAQAAGFADGTEGAGGAGGEGGAGGV
MUL_4367|M.ulcerans_Agy99           TTGAWGTGG---AGGAGGAGGAGDHGGVGVNPGDSGTAGWAGGAGGAGGA
Mflv_5091|M.gilvum_PYR-GCK          TGGTGGTGG---TGGTGGTGGTG-------------GTGGTGGKGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       TGGTGGTGG---TGGTGGTGGTG-------------GTGGTGGKGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      NGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRGGDGAL
TH_3810|M.thermoresistible__bu      NGGHGGRGG-------------------------FLGIGGSGGWGG----
MAB_4284c|M.abscessus_ATCC_199      NAGLAGNAG----------------------------LAGNAGLAGNAGL
MAV_4827|M.avium_104                APPIPAAPP---------------------------VVPVPVVVPPVPVP
MLBr_01556|M.leprae_Br4923          MRARGAKAT----------------------DIAILVVAADDGVMPQTVE
                                         .                                            

Rv1450c|M.tuberculosis_H37Rv        AGDGGNGANGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAHG
Mb1485c|M.bovis_AF2122/97           AGDGGNGANGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAHG
MMAR_3763|M.marinum_M               AGDGGKGAD-AAAFSGAAGGNGGHGGDNGAGGAGGTGGAGSTVGAHGADG
MUL_4367|M.ulcerans_Agy99           GG--------SAAFNGVNG-AGGAGGNGGAGGGGGAGASGIGAGVAGGDG
Mflv_5091|M.gilvum_PYR-GCK          GG------------------AGGTGGDGGTGGTGGTGGTGGTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1       GG------------------DGGTGGTGGTGGTGGTGGTGGTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155      GG--------NGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGG
TH_3810|M.thermoresistible__bu      --------------------HGGNGGDTDADG------------------
MAB_4284c|M.abscessus_ATCC_199      AG------------------NAAVAGNAAVAGNAAVAGNAAVGGVLNTGV
MAV_4827|M.avium_104                VP------------------VRIPVPDPVSPPQLLAPPRLSVPQPVQPPV
MLBr_01556|M.leprae_Br4923          AIN-----------------HAQAADVPIVVAVNKIDKEGADPAKIRGQL
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        FTPTSGGDGGDGGNGGN---------------------------------
Mb1485c|M.bovis_AF2122/97           FTPTSGGDGGDGGNGGH---------------------------------
MMAR_3763|M.marinum_M               FSPTTGGNGGDGGSGGSGFQGVKGGAGGVGGDGGLYGNGGTGGTGGTGGI
MUL_4367|M.ulcerans_Agy99           GTGGTGGAAGTGGAAGT---------------------------------
Mflv_5091|M.gilvum_PYR-GCK          AGDGTGGTGGTGGTGGQ---------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       AGDGLGGTGGTGGTGGF---------------------------------
MSMEG_0868|M.smegmatis_MC2_155      NGGAGRIRVNNGTATGT---------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SGAIGGSSHVGGAINES---------------------------------
MAV_4827|M.avium_104                RVPQPPSPPQVGGTVPQ---------------------------------
MLBr_01556|M.leprae_Br4923          TEYGLVAEDFGGDTMFIDIS------------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        ----SQVVGG----------------------------------------
Mb1485c|M.bovis_AF2122/97           ----SQVVGG----------------------------------------
MMAR_3763|M.marinum_M               GFNGSTTIGGGNGGDGHTGLTGGDGGAGGKGGALAGHGGDGGTGGVGGTG
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        -----------------NGGDGGNGGNGGSAGT-GGNGGRG---------
Mb1485c|M.bovis_AF2122/97           -----------------NGGDGGNGGNGGSAGT-GGNGGRG---------
MMAR_3763|M.marinum_M               GTGGSGGTGTSGIFSSANGGDGGNGGDGGTGGT-GGVGGLGGQAQAAGFA
MUL_4367|M.ulcerans_Agy99           ------------------GGTGGAAGAAGSAGD-GGAGGAG---------
Mflv_5091|M.gilvum_PYR-GCK          ------------------GGQGGQGGTGGTGGQ-GGLGGGG---------
Mvan_1264|M.vanbaalenii_PYR-1       ------------------GGQGGQGGTGGTGGQ-GGLGGVG---------
MSMEG_0868|M.smegmatis_MC2_155      ----------------ATGGNGGNGGNGDADGHRGGKGGDG---------
TH_3810|M.thermoresistible__bu      -------------------GNGGDGGNGGSAGR-GGTGGLR---------
MAB_4284c|M.abscessus_ATCC_199      -----------------LGGSGSVGGSTAVGGG--AHTGVG---------
MAV_4827|M.avium_104                -----------------SPPQHQTPPGEGTPPKPDGPGNYG---------
MLBr_01556|M.leprae_Br4923          ----------------AKVGTNIEALLEAVLLTADAALDLR---------
                                                                       .  .           

Rv1450c|M.tuberculosis_H37Rv        -------GDGAFGGMSANATNPGE--------------------------
Mb1485c|M.bovis_AF2122/97           -------GDGAFGGMSANATNPGE--------------------------
MMAR_3763|M.marinum_M               DGTQGVGGAGGVGGTGGNAGNGGHGANADVGSGKAGGNGGDGGDPGVGGI
MUL_4367|M.ulcerans_Agy99           -------GAGDDGSAGVVSGDPGT--------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        ------------------------------NGPNGNPGGNGGAGGAGGAG
Mb1485c|M.bovis_AF2122/97           ------------------------------NGPNGNPGGNGGAGGAGGAG
MMAR_3763|M.marinum_M               GGQGGAGSIAGVEGAAGVAPTSGGNGGDGGNGASGATGVNGGAGGSGGDG
MUL_4367|M.ulcerans_Agy99           ---------------------------------AGKAGGAGGAGGVGGNG
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------GTGGQGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------GTGGTGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155      ----------------------------------GEALIRATVIGSNASG
TH_3810|M.thermoresistible__bu      -----------------------------------------GVFGINGGN
MAB_4284c|M.abscessus_ATCC_199      ----------------------------------------GGVSTGVGVG
MAV_4827|M.avium_104                ----------------------------------------GGHVPTPGAG
MLBr_01556|M.leprae_Br4923          -----------------------------------------ANSGMEAQG
                                                                                   . .

Rv1450c|M.tuberculosis_H37Rv        ---LNGGNGGAGGNGGLG-------------------GFGGNGAAGANGV
Mb1485c|M.bovis_AF2122/97           ---LNGGNGGAGGNGGLG-------------------GFGGNGAAGANGV
MMAR_3763|M.marinum_M               GLYGNGGDGGDGGNGGKGQVGSTGPVAGSAGGTGGTGGTGGQGGAGGSGG
MUL_4367|M.ulcerans_Agy99           ---VAGGVNGSGGAGGAG-------------------GAGGTGGAGASGV
Mflv_5091|M.gilvum_PYR-GCK          ------GQGGTGGTGGTG-------------------GTGGTGGAGG---
Mvan_1264|M.vanbaalenii_PYR-1       ------GQGGTGGTGGTG-------------------GTGGTGGAGG---
MSMEG_0868|M.smegmatis_MC2_155      --TATGGDGGNGGTLGATN------------------GTGGAATIVAYNV
TH_3810|M.thermoresistible__bu      ------GRAGLGGRGXXX-------------------XGGGVGAAVRSG-
MAB_4284c|M.abscessus_ATCC_199      ------SHVGGGISESLG-------------------GSGSVGGSTAVG-
MAV_4827|M.avium_104                ------GSGGSGGGHVPTP------------------GAGGSG-------
MLBr_01556|M.leprae_Br4923          VAIEAHLDRGRGPVATVLVQR----------------GTLRIGDSVVAGD
                                             * *                              .       

Rv1450c|M.tuberculosis_H37Rv        AVGAPGQPG-GAGGHGGAGGNG----------------------------
Mb1485c|M.bovis_AF2122/97           AVGAPGQPG-GAGGHGGAGGNG----------------------------
MMAR_3763|M.marinum_M               ALAGHGGDG-GSGGDGGTGGTGGTGRNGANGITGADIDGGSGGKGGNGGT
MUL_4367|M.ulcerans_Agy99           PASVDGGDG-GAGGAGGAAGTG----------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----DGGLG-GLGGFGGSGGTG----------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----DGGLG-GLGGFGGVGGTG----------------------------
MSMEG_0868|M.smegmatis_MC2_155      VQANPQASGTATDGHGGSGING----------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------GGAHTGVGGGVSTG----------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          AYGRVRRMVDEHGVDIEAALPS----------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        -GAGGNGGQG-------VVSDGAGGAGGAGGDGGAPGDGANGGNGQGAGA
Mb1485c|M.bovis_AF2122/97           -GAGGNGGQG-------VVSDGAGGAGGAGGDGGAPGDGANGGNGQGAGA
MMAR_3763|M.marinum_M               GGAGGAGGQGGQAQ-AAGYSDGTQGVGGAGGDGGTAGIGGDGGDGANAVA
MUL_4367|M.ulcerans_Agy99           -GSGGSAGNT-----------GAGGAGGAGGAGGSAASTGVNGDG-----
Mflv_5091|M.gilvum_PYR-GCK          -GQGGLGGPG----------GSTGGAGGAGGQAGTAGKGGLFGGS-----
Mvan_1264|M.vanbaalenii_PYR-1       -GQGGQGGPG----------GSTGGAGGAGGQAGVAGKGGLFGGS-----
MSMEG_0868|M.smegmatis_MC2_155      -GHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVN--
TH_3810|M.thermoresistible__bu      -----------------------NGVFSGGGGTPSAGFG-----------
MAB_4284c|M.abscessus_ATCC_199      -----------------------VGVGSHVGGGISESLGGSGSVG-----
MAV_4827|M.avium_104                --------------------------GSGGGHVPTPGTGGPGGTG-----
MLBr_01556|M.leprae_Br4923          ------------------------SPVQVIGFTSVPGAGDNFLVVDED--
                                                                  *     .             

Rv1450c|M.tuberculosis_H37Rv        FAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGG
Mb1485c|M.bovis_AF2122/97           FAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGG
MMAR_3763|M.marinum_M               GSGERGGDGGHGGDPGNAGAGGQAGAGPTSGGNGKAGSGVTTGGNGGDGG
MUL_4367|M.ulcerans_Agy99           ------------------GAGGAGGVG------GLGGDSAATAGGGGAGG
Mflv_5091|M.gilvum_PYR-GCK          ---------------------------------GSAGKAGATGAAGASGG
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------------------GSAGTAGVTGASGASGG
MSMEG_0868|M.smegmatis_MC2_155      ----------------TTANAANPGSATGTATGGDGGKATGTASQGGNGG
TH_3810|M.thermoresistible__bu      ----------------------------------VPTTIQFPAGSCTSRA
MAB_4284c|M.abscessus_ATCC_199      ------------------------------GSTAVGGGAHTGVGGGVNTG
MAV_4827|M.avium_104                ---------------------------------GSGGGHVPTPGAGTPGG
MLBr_01556|M.leprae_Br4923          ---------------------------------RIARQIADRRSARKRNA
                                                                               .     .

Rv1450c|M.tuberculosis_H37Rv        HG-----------AASGGNGGPGGHGGNGGNGGTG---------------
Mb1485c|M.bovis_AF2122/97           HG-----------AASGGNGGPGGHGGNGGNGGTG---------------
MMAR_3763|M.marinum_M               DGGSGAIGVKGGAGGAGGDGGLYGNGGNGGDGGTGGKGTVGDSGATLSAD
MUL_4367|M.ulcerans_Agy99           DG---------------GKGGAGGAGVNGVGGGDG---------------
Mflv_5091|M.gilvum_PYR-GCK          KG---------------AQGATGAQGATGAQGATG---------------
Mvan_1264|M.vanbaalenii_PYR-1       KG---------------AQGATGAQGATGAQGATG---------------
MSMEG_0868|M.smegmatis_MC2_155      PS-----------------WVQSGYGSTLGGNATG---------------
TH_3810|M.thermoresistible__bu      VS---------------------REGIMPSSRAAS---------------
MAB_4284c|M.abscessus_ATCC_199      VG----------------VGSHVGGGISESLGGSG---------------
MAV_4827|M.avium_104                SG----------------GGHLPFPGAGSTPGGSG---------------
MLBr_01556|M.leprae_Br4923          LAAR-------------SRKRISLEDLDSALKETSQLN------------
                                     .                       .        .               

Rv1450c|M.tuberculosis_H37Rv        --------------------ANGGNGGIGGTGGAGSTGAKG---------
Mb1485c|M.bovis_AF2122/97           --------------------ANGGNGGIGGTGGAGSTGAKG---------
MMAR_3763|M.marinum_M               GDRGGAGATGGVGGAGGDGGAKGGNGGLGGSGGTGGMGGTGGDGAHGADM
MUL_4367|M.ulcerans_Agy99           -----------------------GKGGTGGAGGAGGAGSDG---------
Mflv_5091|M.gilvum_PYR-GCK          -----------------------ATGAAGKAGATGAAGAAG---------
Mvan_1264|M.vanbaalenii_PYR-1       -----------------------ATGASGAQGSAGSAGSAG---------
MSMEG_0868|M.smegmatis_MC2_155      ----------------------TATAGKGGEASNGGVAGNG---------
TH_3810|M.thermoresistible__bu      --------------------------ARAGAACASS--------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------SVGGSTAVGGGAHTS---------
MAV_4827|M.avium_104                ----------------------------GGHLPTPGAGTPG---------
MLBr_01556|M.leprae_Br4923          ---------------------LILKGDNAGTVEALEEALMG---------
                                                                .                     

Rv1450c|M.tuberculosis_H37Rv        --VLGTNEGDGGDGGRGGNGGRGGNGGQG-----------LTGAGGNGGT
Mb1485c|M.bovis_AF2122/97           --VLGTNEGDGGDGGRGGNGGRGGNGGQG-----------LTGAGGNGGT
MMAR_3763|M.marinum_M               ASGSGANGGYGGYGGFGGVGGAGGTGGVGGQAHAAGFTDGATGAGGDGGQ
MUL_4367|M.ulcerans_Agy99           --IIPSNGGLGGNGGNGGNGGQAFGDGVG-------------GAGGIGGK
Mflv_5091|M.gilvum_PYR-GCK          --AAGSAGTTGAQGSAGTNGANGANGSQG-------------AAGKAGAT
Mvan_1264|M.vanbaalenii_PYR-1       --VAGSAGTTGAQGSAGTNGANGANGSQG-------------AAGKAGAT
MSMEG_0868|M.smegmatis_MC2_155      --GNALVMAAGTTGVATGNTATGGDGGAAT------------TAGATGGA
TH_3810|M.thermoresistible__bu      --------TSRSRRSFCCSRA-----------------------------
MAB_4284c|M.abscessus_ATCC_199      ----AINDALGGSGSVGGSTAVGG----------------GAHTSAIN--
MAV_4827|M.avium_104                ----------GGLGGFGGGHAPAPGGGLG---------------------
MLBr_01556|M.leprae_Br4923          IQVDDEVALRVIDRGVGGITETNVNLASAS------------DAIIIG--
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        GGTPGN---GGNGGNGASGDLVTSP------GDGGGGGRGGDAGRGGDAG
Mb1485c|M.bovis_AF2122/97           GGTPGN---GGNGGNGASGDLVTSP------GDGGGGGRGGDAGRGGDAG
MMAR_3763|M.marinum_M               GGTGGLGAWGGNGGDGADGSISGPPQNGGKGGDGGGGGPGGLGGQGGLSG
MUL_4367|M.ulcerans_Agy99           G------------GNAAIGTIVING------GVGGAGGSGGLGG------
Mflv_5091|M.gilvum_PYR-GCK          G-------------------------------TTGATGAAGEDG------
Mvan_1264|M.vanbaalenii_PYR-1       G-------------------------------TTGATGAAGDAG------
MSMEG_0868|M.smegmatis_MC2_155      G------------GFSNIAAIHGAITDSTAISGHGGAGNGGNGG------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        LGGSSGPGGTPGDWGTGGTGGTGGTGG--QGANGGLTGGRGGTGGNGGNG
Mb1485c|M.bovis_AF2122/97           LGGSSGPGGTPGDWGTGGTGGTGGTGG--QGANGGLTGGRGGTGGN----
MMAR_3763|M.marinum_M               DGSSTGAAGELGTFGNGGSGGNGGIGGNATGFNAPGTGGAGGNGGNGAFG
MUL_4367|M.ulcerans_Agy99           -------ATEDGVGGVGCAGGAGGNGG--RGDMLFTVGGSGGTGGD----
Mflv_5091|M.gilvum_PYR-GCK          ---------DAGSGGSGINGGAGGAGG---------AGGEGGEGGD----
Mvan_1264|M.vanbaalenii_PYR-1       ---------DPGSEAVDINGGAGGAGG---------AGGEGGEGGA----
MSMEG_0868|M.smegmatis_MC2_155      ---------KGADGWVQAYDPAGPVGS--KIANSSAVAGNGGDGGVN---
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------ESMNSSINASHSSSMNES-----------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          ---------FNVRAEGKATELASREGVEIRYYLVIYQAIDDIEKALR---
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        NTGGTGGAGG-----TGGTGHNGSQPGMG---------------------
Mb1485c|M.bovis_AF2122/97           -----GGAGG-----TGGTGHNGSQPGMG---------------------
MMAR_3763|M.marinum_M               GSGGTGGRGGSSSVGTGGAGGDGGDGGMGFGGIGGGGGTGGQGGSGVDAQ
MUL_4367|M.ulcerans_Agy99           ----------------GGGGGSASGSGTG---------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------GGKGGAGAEGGAG---------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----------------GGAGGDGSEGGAG---------------------
MSMEG_0868|M.smegmatis_MC2_155      ----------------GTGGASGGDGGNG---------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------FGSSMGSHGAAGTG---------------------
MAV_4827|M.avium_104                -----------------GGGGHAPAPGGG---------------------
MLBr_01556|M.leprae_Br4923          ----------------GMLKPIYEENQLG---------------------
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        -----GNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAG-----PFGTG
Mb1485c|M.bovis_AF2122/97           -----GNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAG-----PFGTG
MMAR_3763|M.marinum_M               GIGGAGNGGVGGNGGDGGDGWDAPGGQGGKGGQGGNGGDGSPPVPPFGGS
MUL_4367|M.ulcerans_Agy99           -----GSGGTGGVG-----GIGGDGKLGGFGGDGGDGGDG----------
Mflv_5091|M.gilvum_PYR-GCK          -----GGGGAGGSG---------AGGAGGAGGSGGSGGSG----------
Mvan_1264|M.vanbaalenii_PYR-1       -----GSGGAGGSG---------TGGAGGAGGSGGSGGSG----------
MSMEG_0868|M.smegmatis_MC2_155      -----GNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPG----------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------FEAQGHAQGHASETAHTTLP----------
MAV_4827|M.avium_104                -----------------------LGGFGGGHSGGGLGGLG----------
MLBr_01556|M.leprae_Br4923          -----------RAEIRALFRSSKVGIIAGCIISSGVVRRN----AKVRLL
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        TGGTGGHGGQGGGGG----FSILLGLGGLGGLGSPGSIATGTAGGAGGGG
Mb1485c|M.bovis_AF2122/97           TGGTGGHGGQGGGGG----FSILLGLGGLGGLGSPGSIATGTAGGAGGGG
MMAR_3763|M.marinum_M               SGGTGGTGGTGGAGGDRFVDTELVGIGGAGHGGVTGGGPTGPALVDGGTG
MUL_4367|M.ulcerans_Agy99           --GFGVIGGQGGGGG----------FGGLGGTGAGG------APSDKGIN
Mflv_5091|M.gilvum_PYR-GCK          --GSGGSGGAAGDSDD----------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --GAGGSGGAAGDSD-----------------------------------
MSMEG_0868|M.smegmatis_MC2_155      GNGAGGAGGNGGTGG--------TTAGGSGNGGNGGNGGNGGADGTPGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --GAEHH-------------------------------------------
MAV_4827|M.avium_104                ----GGHK------------------------------------------
MLBr_01556|M.leprae_Br4923          RDNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGDVIESYE
                                                                                      

Rv1450c|M.tuberculosis_H37Rv        GFGGLGGGEFV
Mb1485c|M.bovis_AF2122/97           GFGGLGGGEFV
MMAR_3763|M.marinum_M               GAGGSGGTGAH
MUL_4367|M.ulcerans_Agy99           GEPGNPG----
Mflv_5091|M.gilvum_PYR-GCK          -----------
Mvan_1264|M.vanbaalenii_PYR-1       -----------
MSMEG_0868|M.smegmatis_MC2_155      GTTGANNP---
TH_3810|M.thermoresistible__bu      -----------
MAB_4284c|M.abscessus_ATCC_199      -----------
MAV_4827|M.avium_104                -----------
MLBr_01556|M.leprae_Br4923          LVEKQRA----