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SLVIVAPETVAAAALDVARIGSSIGAANAAAAGSTTSVLAAGADEVSAAIATLFGSHAREYQAISTQVAA FHDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGI LWGNGGAGGSGAPGQVGGAGGAAGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATG GAGGNAGLFGVGGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGGAAGLL GVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAGGAGGAGGVGGTGGAGGA GFSRALIVAGDNGGDPGAGGAGGTGGAGSTIGAHGAAGASPTSGGNGGAGGNGAHFSSGGKAGGNGGAGG AGGLVGNGGAGGAGGNGAPGAPPSGGDPNGGGGGAGGAGGKGGDGGAQAGDGGAGGAGGKGGNGGNGATG ATGLNGLGAGADGTDGGKGGNGGAGGGGGAGGQGGKALAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAK GTFDNGGDGVGGNGGNGGSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGANATVAGGAGGAG GKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGGTGGAGGN GANGANATTPGAKGGDGGHGGPGAQGGNGGQGGPGGLAGNLFGQNGIQGVGGSGGKGGAGGLAGDGGNGA NGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGNSQVVGGNGGDG GNGGNGGSAGTGGNGGRGGDGAFGGMSANATNPGENGPNGNPGGNGGAGGAGGAGLNGGNGGAGGNGGLG GFGGNGAAGANGVAVGAPGQPGGAGGHGGAGGNGGAGGNGGQGVVSDGAGGAGGAGGDGGAPGDGANGGN GQGAGAFAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGGHGAASGGNGGPGGH GGNGGNGGTGANGGNGGIGGTGGAGSTGAKGVLGTNEGDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGG TPGNGGNGGNGASGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSGPGGTPGDWGTGGTGGTGGTGGQGAN GGLTGGRGGTGGNGGNGNTGGTGGAGGTGGTGHNGSQPGMGGNGGAGGFGGNGFAGVGGRGGMGGSGGTG GTGDAGPFGTGTGGTGGHGGQGGGGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGLGGGEFV*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1450c | PE_PGRS27 | - | 100% (1329) | PE-PGRS FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv2490c | PE_PGRS43 | 0.0 | 50.98% (1581) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv3345c | PE_PGRS50 | 0.0 | 51.68% (1492) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1485c | PE_PGRS27 | 0.0 | 91.53% (1417) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 48.01% (829) | triple helix repeat-containing collagen |
M. leprae Br4923 | MLBr_01556 | infB | 2e-11 | 33.95% (162) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-50 | 31.50% (581) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_3763 | - | 0.0 | 53.07% (1532) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 4e-25 | 43.02% (172) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-175 | 41.23% (1089) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 7e-48 | 39.87% (316) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 49.95% (1091) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-179 | 46.11% (822) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Rv1450c|M.tuberculosis_H37Rv ------------MSLVIVAPETVAAAALDVARIGSSIGAANAAAAGSTTS Mb1485c|M.bovis_AF2122/97 ------------MSLVIVAPETVAAAALDVARIGSSIGVANSAAAGSTTS MMAR_3763|M.marinum_M ------------MSFVSVAPEAVATAASDLARIGSSIDAVNAAAAGATTT MUL_4367|M.ulcerans_Agy99 ------------MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------MSIIDFILNLFRDPVEAASYVADPEAALANAG-- MAV_4827|M.avium_104 -------------------MNIVLGVSMAPSSIQMVVLEGEYADG----- MLBr_01556|M.leprae_Br4923 ------------MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASST Rv1450c|M.tuberculosis_H37Rv VLA----------AGADEVSAAIATLFG----SHAREYQAIST--QVAAF Mb1485c|M.bovis_AF2122/97 VLA----------AGADEVSAAIATLFG----SHAREYQAIST--QVAAF MMAR_3763|M.marinum_M VLA----------AGADEVSVAIAALFG----THAQEYQAIST--RISAL MUL_4367|M.ulcerans_Agy99 VLP----------AAGDEVSAAIAELFG----GFGREYQAMGA--RVALL Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------MMFL----APPGGPGPISA--AIQLT MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------LSAVSAAQVGAVMPVVAESVASNYGYQSQWVN MAV_4827|M.avium_104 ---------------------------------ATVEEDAIDVTGADDAA MLBr_01556|M.leprae_Br4923 VEAP--------------VARRLRESFGGIKPAADKGAEQVATKAQAKRL Rv1450c|M.tuberculosis_H37Rv HDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLNALNAPTQ-------- Mb1485c|M.bovis_AF2122/97 HDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLNALNAPTQ-------- MMAR_3763|M.marinum_M NERFVALLTAGNNSYAASESASVSWLQAVEQDVLGLVNAPSQ-------- MUL_4367|M.ulcerans_Agy99 HDDFVRALTAGGSAYGQAEALNMWPLQELEQQALGVVNAPSM-------- Mflv_5091|M.gilvum_PYR-GCK -----------MVTFGGGATPTPTSLGAAAVDLSGTSCG----------- Mvan_1264|M.vanbaalenii_PYR-1 STGSEATEPWYVVSFGGSGAPTPNNLAASLVDLSGTSCG----------- MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPR---------------- MAV_4827|M.avium_104 TASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR------- MLBr_01556|M.leprae_Br4923 GESLDQTLDRALDKAVAGNGATTAAPVQVDHSAAVVPIVAGE-------- Rv1450c|M.tuberculosis_H37Rv -------------------------------------------------- Mb1485c|M.bovis_AF2122/97 -------------------------------------------------- MMAR_3763|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv1450c|M.tuberculosis_H37Rv ----------------------------------ALLGRPLIGDGAAGAP Mb1485c|M.bovis_AF2122/97 ----------------------------------ALLGRPLIGDGAAGAP MMAR_3763|M.marinum_M ----------------------------------NWFGRPLIGNGADGVA MUL_4367|M.ulcerans_Agy99 ----------------------------------ALFGRPSIGNGVDGVA Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------LICNGQD--- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------LICNGQD--- MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGING-T TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------DNDFLSHNDTDFA MAV_4827|M.avium_104 --------------------------------------DALAARRIDNVM MLBr_01556|M.leprae_Br4923 --------------------------------------GPSTAHREELAP Rv1450c|M.tuberculosis_H37Rv GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFGTGGAGGAG--- Mb1485c|M.bovis_AF2122/97 GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFGTGGAGGAG--- MMAR_3763|M.marinum_M GTGQAGGAGGILWGNGGAGG-SGAVGQSGGAGGSAGLLGHGGAGGAGGQA MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAG--- Mflv_5091|M.gilvum_PYR-GCK GTGQN---GGILFGNGGSGWNSDVVGMDGGNGGNGGLFG--GNGGNG--- Mvan_1264|M.vanbaalenii_PYR-1 GTGQN---GGILFGNGGSGWNSEIAGVSGGNGGNAGLFG--GNGGNG--- MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFGNGGNGGVG--- TH_3810|M.thermoresistible__bu ------------------------VDGDGGSGGRTGLFSKLSRGGDG--- MAB_4284c|M.abscessus_ATCC_199 SHNPIASGNQVMSPSGNVDSFNRGPLLDLSFG--DLQFGNRDTTAIG--- MAV_4827|M.avium_104 LVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIP--- MLBr_01556|M.leprae_Br4923 PAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPP--- Rv1450c|M.tuberculosis_H37Rv ---GAGAAGGAGGSGGWLLGNGGVG------------------------- Mb1485c|M.bovis_AF2122/97 ---GAGAAGGAGGSGGWLLGNGGVG------------------------- MMAR_3763|M.marinum_M GASGTGGVGGAGGAGGWLYGNGGTGGVGGEGPVNGGVGGAGGRAWLLGAG MUL_4367|M.ulcerans_Agy99 ---GVGAAGMTGGSG----------------------------------- Mflv_5091|M.gilvum_PYR-GCK ---GNGLGGGNGGNG----------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---GNGLGSGDGGNG----------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ---WAGLDGGNGGSG----------------------------------- TH_3810|M.thermoresistible__bu ---GDGGLGGNGGHG----------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----DGAVAVGGSNS----------------------------------- MAV_4827|M.avium_104 --DVYKQQIRAESYG----------------------------------- MLBr_01556|M.leprae_Br4923 ---RVGNNPFSSAQS----------------------------------- . . Rv1450c|M.tuberculosis_H37Rv ---GAGGQSL-LGGATGGAGGNAGLFGVGGTGGPGGP------------- Mb1485c|M.bovis_AF2122/97 ---GAGGQSL-LGGATGGAGGNAGLFGVGGTGGPGGP------------- MMAR_3763|M.marinum_M GSGGAGGQGLGLNGGAGGAGGNGGLFGIGGTGGAGGDSAGSGSAGAGGDG MUL_4367|M.ulcerans_Agy99 ----------------GAGGGGGWLWGAGGSGG----------------- Mflv_5091|M.gilvum_PYR-GCK --------------------GNAGAFALFGNGG----------------- Mvan_1264|M.vanbaalenii_PYR-1 --------------------GDAGLFSLFGRGG----------------- MSMEG_0868|M.smegmatis_MC2_155 ----------------------GLLMGIGGAGG----------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv1450c|M.tuberculosis_H37Rv --------GGPGG---------VGGTGGAGGLGGTLYGAGGHGGAGGPGP Mb1485c|M.bovis_AF2122/97 --------GGPGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGP MMAR_3763|M.marinum_M GHGGLWGRGGAGGIGGVNSDSGDGGAGGGGGAGGRLFGSGGAGGAGGTGA MUL_4367|M.ulcerans_Agy99 ----------------------AAGAGGSGGSGGWLWGNAGQTAGAG--- Mflv_5091|M.gilvum_PYR-GCK -------------------------NGGNGGVG----------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------NGGNGGVG----------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------AGGVGADGTSAHVDGGTGGTGGTG- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv1450c|M.tuberculosis_H37Rv IGGVGGHGGVGGAAG-LLGVGGHGGAGGHGAEGVAGAAG-EDLSPHGTSG Mb1485c|M.bovis_AF2122/97 IGGVGGHGGVGGAAG-LLGVGGHGGAGGHGAAGIAGAAGKGGIFPDGSNG MMAR_3763|M.marinum_M VAGSGGDGGAGGAAVGLWGLGGHGGAGGDGAVGLAGGVG--------EAG MUL_4367|M.ulcerans_Agy99 VGGAGGAGGAGDAGD--QGVSG-VAPGEAGAVGFAGGAG----------- Mflv_5091|M.gilvum_PYR-GCK VVGATGAVGAPGVAG------------ATGATGVTSGVV----------- Mvan_1264|M.vanbaalenii_PYR-1 IAGATGAVGAPGVAG------------ATGATGVTSNVT----------- MSMEG_0868|M.smegmatis_MC2_155 -GGTGGTGGIGGTGG-----GLFGLLGHSGSTGAAGAAG----------- TH_3810|M.thermoresistible__bu -----------------------------GGTGIISLLS----------- MAB_4284c|M.abscessus_ATCC_199 --GPIASGQGSTAVN--------------GDVRDSNIIN----------- MAV_4827|M.avium_104 ----DAAGQLSAMVA--------------GLEKLESLPG---------GL MLBr_01556|M.leprae_Br4923 --VARPIPRPPAPRP------------SASPSSMSPRPG----------- . Rv1450c|M.tuberculosis_H37Rv GVGGDAGDGGTGGRGGWLAGAGGAGGAGGVGGTGGAGGAGFSRALIVAGD Mb1485c|M.bovis_AF2122/97 GAGGDAGDGGTGGRGGWLAGAGGAGGDGGIGGTGGAGGAGFSRALIVAGD MMAR_3763|M.marinum_M GEGGSAGNGGAGGLGGWLIGSGGAGGLGGVGGAGGAGGAG--AAGIAPGS MUL_4367|M.ulcerans_Agy99 GAGGAGGNGVGGG----VNGAGGAGGAGGVGGGGGAGASG-----VGAGV Mflv_5091|M.gilvum_PYR-GCK --GGNGED---------AVGYGATGAAGAAGAAGAAGAAG---------- Mvan_1264|M.vanbaalenii_PYR-1 --GGNGAD---------AVGYGATGAAGAAGAAGAAGKAG---------- MSMEG_0868|M.smegmatis_MC2_155 -NGGDGGNGGFG--YVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPG- TH_3810|M.thermoresistible__bu -LAGNGGNGGNG-------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --ADHGSNVGVD-------------------------------------- MAV_4827|M.avium_104 LLVGSGVDVAP--------------------------------------- MLBr_01556|M.leprae_Br4923 GAVGGGGPRPPR-------------------------------------- . . Rv1450c|M.tuberculosis_H37Rv NGGD---------------------------------------------- Mb1485c|M.bovis_AF2122/97 NGGDGGNGGMGGAGGAGGPGGAGGLISLLGGQGAGGDGGDGGAGGVGGDR MMAR_3763|M.marinum_M NGGNGGNGGVGGAGGVGGSGGQGGFLRFLGGQGDGGAGGAGGAGGVAGDG MUL_4367|M.ulcerans_Agy99 AGGDGGTG------------------------------------------ Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv1450c|M.tuberculosis_H37Rv -----------------------PGAGGAGGTGGAGSTIGAHGAAGASPT Mb1485c|M.bovis_AF2122/97 GAGANGNQAVNAGAGGAGGHGGDPGAGGAGGTGGAGSTIGAHGAAGASPT MMAR_3763|M.marinum_M GKGADAAAFSG-AAGGNGGHGGDNGAGGAGGTGGAGSTVGAHGADGFSPI MUL_4367|M.ulcerans_Agy99 ------------------------GAGGAAGVGGAAGTGGTGGAAGVAGT Mflv_5091|M.gilvum_PYR-GCK -------------------------AVGSAGAAGEAGETGTWGNAGLPGK Mvan_1264|M.vanbaalenii_PYR-1 -------------------------AVGSAGTAGSAGAPGVWGNAGLPGA MSMEG_0868|M.smegmatis_MC2_155 ------------------------KGGGGGGGGGGAILIGANGGTVDGHA TH_3810|M.thermoresistible__bu -----------------------------------------YRTTDNNAL MAB_4284c|M.abscessus_ATCC_199 --------------------------QSQTRVGGDYTNVSGHGSADIDKS MAV_4827|M.avium_104 ----------------------------LKQVLQTTTFLDVSVAEEPETA MLBr_01556|M.leprae_Br4923 --------------------------TGVPRPGGGRPGAPVGGRSDAGGG Rv1450c|M.tuberculosis_H37Rv SGGNGGAGGNGAH--FSSGGKAGGNG-----GAGGAGGLVGNGGAGGAGG Mb1485c|M.bovis_AF2122/97 SGGNGGAGGNGAH--FSSGGKAGGNG-----GAGGAGGLVGNGGAGGAGG MMAR_3763|M.marinum_M TGGNGGDGGNGASGPAASAGVAGGAG-----GAGGDGGLYGNGGAGGDGG MUL_4367|M.ulcerans_Agy99 GGDGGDGGAGGAGSDASLAGQAGFAG-----GSGGAGGVGGSAGAGGVNG Mflv_5091|M.gilvum_PYR-GCK AGDAGGAGAVGAAGAAGTVGTAGATG-----GTG---------------- Mvan_1264|M.vanbaalenii_PYR-1 AGAAGGAGAIGTAGVAGAAGTAGATG-----GTG---------------- MSMEG_0868|M.smegmatis_MC2_155 IGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHST TH_3810|M.thermoresistible__bu DGGHGGNG------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 VTVVDDHSQRNTTNINDSFNTDRSTN------------------------ MAV_4827|M.avium_104 LARGAALAAANAPLFASSTAALAYAQ------------------------ MLBr_01556|M.leprae_Br4923 NYRGGGVGALPGGGSGGFRGRPGGGG------------------------ . Rv1450c|M.tuberculosis_H37Rv NGAPG-----APPSGGD-PNGGGGGAGGAGGKGGDGGAQAGD-GGAGGAG Mb1485c|M.bovis_AF2122/97 NGAPG-----APPSGGD-PNGGGGGAGGAGGKGGDGGAQAGD-GGAGGAG MMAR_3763|M.marinum_M NGVAGGQGADATAAGASGENGGDGGAGGMGGAGGMGGVLGGH-GGAGGIG MUL_4367|M.ulcerans_Agy99 S-------------------GGDGGAGAAGGAGGASATVAGS-GGVGGDG Mflv_5091|M.gilvum_PYR-GCK -------------------TGANGGAGGVGGVGGTG-AAGAA-GGAGGLG Mvan_1264|M.vanbaalenii_PYR-1 -------------------VGGNGGAGQAGGIGGTG-AAGAA-GQAGTAG MSMEG_0868|M.smegmatis_MC2_155 GTG----------------IGGNGGIGSVYAYGNNGAVSGTATGGRGGDG TH_3810|M.thermoresistible__bu ---------------------GNVGFFSLFNLGGAG--------GWGGSG MAB_4284c|M.abscessus_ATCC_199 ---------------------IGSGNTTNTEIGSHNQANIGTSTSAGGSA MAV_4827|M.avium_104 ----------------------DPGTGAVDQYSLPDYLYVPVDPEPGDDE MLBr_01556|M.leprae_Br4923 ----------------------HGGGGRPGQRGGAAGAFGRPGGAPRRGR * . Rv1450c|M.tuberculosis_H37Rv GKGGNGGNGATGATGLNGLGAG-ADGTDGGKGGNGGAGGGGGAGGQGGKA Mb1485c|M.bovis_AF2122/97 GKGGNGGNGATGATGLNGLGAG-ADGTDGGKGGNGGAGGGGGAGGQGGKA MMAR_3763|M.marinum_M GVGATGGSGGLGATGAEGVTGGNLHGGDGGNGGKGGIGGAGGDGGAGGKA MUL_4367|M.ulcerans_Agy99 GAGGAAG-GGVGAASLG------------GDGGHAGAGGAGGEGLSGG-- Mflv_5091|M.gilvum_PYR-GCK ETGTTGGAGGVG-----------------GQGTAGGTGGVGG-------- Mvan_1264|M.vanbaalenii_PYR-1 ETGVTGGVGGIG-----------------GQGTEGGTGGVGG-------- MSMEG_0868|M.smegmatis_MC2_155 IDGGTGGAGGMGEIYSG----------ADGEATGISAGGDGGSATGADSL TH_3810|M.thermoresistible__bu VDG---------------------------------VDVVGG-------- MAB_4284c|M.abscessus_ATCC_199 AVGGNAG-----------------------LAGNAGLAGNAG-------- MAV_4827|M.avium_104 LAYSAVG----------------------EEDAESPTVVIEKLFLP---- MLBr_01556|M.leprae_Br4923 KSKRQKR----------------------QEYDSMQAPVVGGVRLPHGNG Rv1450c|M.tuberculosis_H37Rv LAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGGNG Mb1485c|M.bovis_AF2122/97 LAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGGNG MMAR_3763|M.marinum_M QAAGFADGTEGVGGAGGEGGAGGVAGDGGKGADAAAFSG--AAGGNGGHG MUL_4367|M.ulcerans_Agy99 ----FNTG--AAGGIGGAGGAGGTGGDSG------------GVGGVNGDG Mflv_5091|M.gilvum_PYR-GCK -----------IGGAGSTGAVGGVGGKGIQ-------------GGQGLQG Mvan_1264|M.vanbaalenii_PYR-1 -----------VGGVGATGGAGGVGGKGIQ-------------GGQGLQG MSMEG_0868|M.smegmatis_MC2_155 GGRGGTSWVQAGYGPTTGGKASGTAKAGHG-----------GKASDGGKG TH_3810|M.thermoresistible__bu ---------------NPDGGTPGAHGESHT---------------PGVYT MAB_4284c|M.abscessus_ATCC_199 --------------LAGNAGLAGNAGLAGN-------------AGLAGNA MAV_4827|M.avium_104 --------------EDSEPRRRPVLLVGSG-------------LAVVGIS MLBr_01556|M.leprae_Br4923 ETIRLARGASLSDFAEKIDANPAALVQALFN-----------LGEMVTAT . Rv1450c|M.tuberculosis_H37Rv GSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGAN--ATVAGG Mb1485c|M.bovis_AF2122/97 GSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGAN--ATVAGG MMAR_3763|M.marinum_M GDNGAGGAGGTGGAGSTVGAHGADGFSPITGGNGGDGGNGASGPAASAGV MUL_4367|M.ulcerans_Agy99 GAGGGGGRGGDGGSSTSTSG---------VGGAGGAGGNGGN-------- Mflv_5091|M.gilvum_PYR-GCK GKGGDGGAGGKGGDADSMGS---------AGATGGKGGNGGN-------- Mvan_1264|M.vanbaalenii_PYR-1 GQGGDGGTGGTGGDATSMGE---------AGATGGKGGNGGN-------- MSMEG_0868|M.smegmatis_MC2_155 GNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHG TH_3810|M.thermoresistible__bu DRQGEDGEDGTG------------------TGIGGRGGNGGS-------- MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAG----------------LAGNAGLAGNAGL-------- MAV_4827|M.avium_104 AVLALEIALAIG-----------------IRTTGTVALQPTP-------- MLBr_01556|M.leprae_Br4923 QSVGDETLELLGSEMNYNVQVVSPEDEDRELLEPFDLTYGED-------- . . Rv1450c|M.tuberculosis_H37Rv AGGAGGKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGA Mb1485c|M.bovis_AF2122/97 AGGAGGKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGA MMAR_3763|M.marinum_M AGGAGGAGGDGGLYGNGGAGGDGGNGVAGGQGADATAAGASGENGGDGGA MUL_4367|M.ulcerans_Agy99 AGFGVSAGGTGGSAGDGGAGG-GAGGVDGVGGAS-----------GNGGA Mflv_5091|M.gilvum_PYR-GCK -------GGRGGLFGKGGNAGNGADGGTG----------------GAGGA Mvan_1264|M.vanbaalenii_PYR-1 -------GGRGSLFGRGGNAGNGGNGGTG----------------GNGGN MSMEG_0868|M.smegmatis_MC2_155 SITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGN TH_3810|M.thermoresistible__bu -------SSGTHPMAEDGEHVKALDGRPG----------------LDGGN MAB_4284c|M.abscessus_ATCC_199 -------AGNAGLAGNAGLAGNAGLAGNAG---------------LAGNA MAV_4827|M.avium_104 -------NQHLIVPTEQAPAPPPVQASAPQPKIS-----------VPEPV MLBr_01556|M.leprae_Br4923 ------QGDEDELQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGI Rv1450c|M.tuberculosis_H37Rv GGAGGAGGRGGDFGGDGGTG---------GAGGNGANGANATTPG-AKGG Mb1485c|M.bovis_AF2122/97 GGAGGAGGRGGDFGGDGGTGGAGGNGADGGAGGNGANGANATTPG-AKGG MMAR_3763|M.marinum_M GGMGGAGGMGGVLGGHGGAGGIGGVGATGGSGGLGATGAEGVTGGNLHGG MUL_4367|M.ulcerans_Agy99 AGAGGAGGSGIGAGIDGGAG---------GAGGTG--GAAGFPGG---GG Mflv_5091|M.gilvum_PYR-GCK GGTGGTGG-------AGGTG---------GTGGTGGIGGAGSTGG--TGG Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGG-------NGGTG---------GTGGTGGIGGAGSTGG--TGG MSMEG_0868|M.smegmatis_MC2_155 GGDGGFNGTGGATGGRGGDG---------AGASVWKANGQHSTGQTDTGG TH_3810|M.thermoresistible__bu GSHG---------------------------------------------G MAB_4284c|M.abscessus_ATCC_199 GLAGNAG----------------------------------------LAG MAV_4827|M.avium_104 AAPKPLSP-----------------------PVAAPLPAAPPPAAPPLPE MLBr_01556|M.leprae_Br4923 TQHIGAYQVGVDLD-----------------GSERLITFIDTPGHEAFTA Rv1450c|M.tuberculosis_H37Rv DGGHGGPGA---QGGNGGQGGPGGLAGNLFGQNGIQGVGGSGGKGGAGGL Mb1485c|M.bovis_AF2122/97 DGGHGGPGA---QGGNGGQGGPGGLAGNLFGQNGIQGVGGSGGKGGAGGL MMAR_3763|M.marinum_M DGGNGGKGG---IGGAGGDGGAGGKAQAAGFADGTEGAGGAGGEGGAGGV MUL_4367|M.ulcerans_Agy99 TTGAWGTGG---AGGAGGAGGAGDHGGVGVNPGDSGTAGWAGGAGGAGGA Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGG---TGGTGGTGGTG-------------GTGGTGGKGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGG---TGGTGGTGGTG-------------GTGGTGGKGGTGGT MSMEG_0868|M.smegmatis_MC2_155 NGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRGGDGAL TH_3810|M.thermoresistible__bu NGGHGGRGG-------------------------FLGIGGSGGWGG---- MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAG----------------------------LAGNAGLAGNAGL MAV_4827|M.avium_104 APPIPAAPP---------------------------VVPVPVVVPPVPVP MLBr_01556|M.leprae_Br4923 MRARGAKAT----------------------DIAILVVAADDGVMPQTVE . Rv1450c|M.tuberculosis_H37Rv AGDGGNGANGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAHG Mb1485c|M.bovis_AF2122/97 AGDGGNGANGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAHG MMAR_3763|M.marinum_M AGDGGKGAD-AAAFSGAAGGNGGHGGDNGAGGAGGTGGAGSTVGAHGADG MUL_4367|M.ulcerans_Agy99 GG--------SAAFNGVNG-AGGAGGNGGAGGGGGAGASGIGAGVAGGDG Mflv_5091|M.gilvum_PYR-GCK GG------------------AGGTGGDGGTGGTGGTGGTGGTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 GG------------------DGGTGGTGGTGGTGGTGGTGGTGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 GG--------NGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGG TH_3810|M.thermoresistible__bu --------------------HGGNGGDTDADG------------------ MAB_4284c|M.abscessus_ATCC_199 AG------------------NAAVAGNAAVAGNAAVAGNAAVGGVLNTGV MAV_4827|M.avium_104 VP------------------VRIPVPDPVSPPQLLAPPRLSVPQPVQPPV MLBr_01556|M.leprae_Br4923 AIN-----------------HAQAADVPIVVAVNKIDKEGADPAKIRGQL Rv1450c|M.tuberculosis_H37Rv FTPTSGGDGGDGGNGGN--------------------------------- Mb1485c|M.bovis_AF2122/97 FTPTSGGDGGDGGNGGH--------------------------------- MMAR_3763|M.marinum_M FSPTTGGNGGDGGSGGSGFQGVKGGAGGVGGDGGLYGNGGTGGTGGTGGI MUL_4367|M.ulcerans_Agy99 GTGGTGGAAGTGGAAGT--------------------------------- Mflv_5091|M.gilvum_PYR-GCK AGDGTGGTGGTGGTGGQ--------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 AGDGLGGTGGTGGTGGF--------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGGAGRIRVNNGTATGT--------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SGAIGGSSHVGGAINES--------------------------------- MAV_4827|M.avium_104 RVPQPPSPPQVGGTVPQ--------------------------------- MLBr_01556|M.leprae_Br4923 TEYGLVAEDFGGDTMFIDIS------------------------------ Rv1450c|M.tuberculosis_H37Rv ----SQVVGG---------------------------------------- Mb1485c|M.bovis_AF2122/97 ----SQVVGG---------------------------------------- MMAR_3763|M.marinum_M GFNGSTTIGGGNGGDGHTGLTGGDGGAGGKGGALAGHGGDGGTGGVGGTG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv1450c|M.tuberculosis_H37Rv -----------------NGGDGGNGGNGGSAGT-GGNGGRG--------- Mb1485c|M.bovis_AF2122/97 -----------------NGGDGGNGGNGGSAGT-GGNGGRG--------- MMAR_3763|M.marinum_M GTGGSGGTGTSGIFSSANGGDGGNGGDGGTGGT-GGVGGLGGQAQAAGFA MUL_4367|M.ulcerans_Agy99 ------------------GGTGGAAGAAGSAGD-GGAGGAG--------- Mflv_5091|M.gilvum_PYR-GCK ------------------GGQGGQGGTGGTGGQ-GGLGGGG--------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------GGQGGQGGTGGTGGQ-GGLGGVG--------- MSMEG_0868|M.smegmatis_MC2_155 ----------------ATGGNGGNGGNGDADGHRGGKGGDG--------- TH_3810|M.thermoresistible__bu -------------------GNGGDGGNGGSAGR-GGTGGLR--------- MAB_4284c|M.abscessus_ATCC_199 -----------------LGGSGSVGGSTAVGGG--AHTGVG--------- MAV_4827|M.avium_104 -----------------SPPQHQTPPGEGTPPKPDGPGNYG--------- MLBr_01556|M.leprae_Br4923 ----------------AKVGTNIEALLEAVLLTADAALDLR--------- . . Rv1450c|M.tuberculosis_H37Rv -------GDGAFGGMSANATNPGE-------------------------- Mb1485c|M.bovis_AF2122/97 -------GDGAFGGMSANATNPGE-------------------------- MMAR_3763|M.marinum_M DGTQGVGGAGGVGGTGGNAGNGGHGANADVGSGKAGGNGGDGGDPGVGGI MUL_4367|M.ulcerans_Agy99 -------GAGDDGSAGVVSGDPGT-------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv1450c|M.tuberculosis_H37Rv ------------------------------NGPNGNPGGNGGAGGAGGAG Mb1485c|M.bovis_AF2122/97 ------------------------------NGPNGNPGGNGGAGGAGGAG MMAR_3763|M.marinum_M GGQGGAGSIAGVEGAAGVAPTSGGNGGDGGNGASGATGVNGGAGGSGGDG MUL_4367|M.ulcerans_Agy99 ---------------------------------AGKAGGAGGAGGVGGNG Mflv_5091|M.gilvum_PYR-GCK --------------------------------------GTGGQGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------GTGGTGGTGGTG MSMEG_0868|M.smegmatis_MC2_155 ----------------------------------GEALIRATVIGSNASG TH_3810|M.thermoresistible__bu -----------------------------------------GVFGINGGN MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------GGVSTGVGVG MAV_4827|M.avium_104 ----------------------------------------GGHVPTPGAG MLBr_01556|M.leprae_Br4923 -----------------------------------------ANSGMEAQG . . Rv1450c|M.tuberculosis_H37Rv ---LNGGNGGAGGNGGLG-------------------GFGGNGAAGANGV Mb1485c|M.bovis_AF2122/97 ---LNGGNGGAGGNGGLG-------------------GFGGNGAAGANGV MMAR_3763|M.marinum_M GLYGNGGDGGDGGNGGKGQVGSTGPVAGSAGGTGGTGGTGGQGGAGGSGG MUL_4367|M.ulcerans_Agy99 ---VAGGVNGSGGAGGAG-------------------GAGGTGGAGASGV Mflv_5091|M.gilvum_PYR-GCK ------GQGGTGGTGGTG-------------------GTGGTGGAGG--- Mvan_1264|M.vanbaalenii_PYR-1 ------GQGGTGGTGGTG-------------------GTGGTGGAGG--- MSMEG_0868|M.smegmatis_MC2_155 --TATGGDGGNGGTLGATN------------------GTGGAATIVAYNV TH_3810|M.thermoresistible__bu ------GRAGLGGRGXXX-------------------XGGGVGAAVRSG- MAB_4284c|M.abscessus_ATCC_199 ------SHVGGGISESLG-------------------GSGSVGGSTAVG- MAV_4827|M.avium_104 ------GSGGSGGGHVPTP------------------GAGGSG------- MLBr_01556|M.leprae_Br4923 VAIEAHLDRGRGPVATVLVQR----------------GTLRIGDSVVAGD * * . Rv1450c|M.tuberculosis_H37Rv AVGAPGQPG-GAGGHGGAGGNG---------------------------- Mb1485c|M.bovis_AF2122/97 AVGAPGQPG-GAGGHGGAGGNG---------------------------- MMAR_3763|M.marinum_M ALAGHGGDG-GSGGDGGTGGTGGTGRNGANGITGADIDGGSGGKGGNGGT MUL_4367|M.ulcerans_Agy99 PASVDGGDG-GAGGAGGAAGTG---------------------------- Mflv_5091|M.gilvum_PYR-GCK ----DGGLG-GLGGFGGSGGTG---------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----DGGLG-GLGGFGGVGGTG---------------------------- MSMEG_0868|M.smegmatis_MC2_155 VQANPQASGTATDGHGGSGING---------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------GGAHTGVGGGVSTG---------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 AYGRVRRMVDEHGVDIEAALPS---------------------------- Rv1450c|M.tuberculosis_H37Rv -GAGGNGGQG-------VVSDGAGGAGGAGGDGGAPGDGANGGNGQGAGA Mb1485c|M.bovis_AF2122/97 -GAGGNGGQG-------VVSDGAGGAGGAGGDGGAPGDGANGGNGQGAGA MMAR_3763|M.marinum_M GGAGGAGGQGGQAQ-AAGYSDGTQGVGGAGGDGGTAGIGGDGGDGANAVA MUL_4367|M.ulcerans_Agy99 -GSGGSAGNT-----------GAGGAGGAGGAGGSAASTGVNGDG----- Mflv_5091|M.gilvum_PYR-GCK -GQGGLGGPG----------GSTGGAGGAGGQAGTAGKGGLFGGS----- Mvan_1264|M.vanbaalenii_PYR-1 -GQGGQGGPG----------GSTGGAGGAGGQAGVAGKGGLFGGS----- MSMEG_0868|M.smegmatis_MC2_155 -GHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVN-- TH_3810|M.thermoresistible__bu -----------------------NGVFSGGGGTPSAGFG----------- MAB_4284c|M.abscessus_ATCC_199 -----------------------VGVGSHVGGGISESLGGSGSVG----- MAV_4827|M.avium_104 --------------------------GSGGGHVPTPGTGGPGGTG----- MLBr_01556|M.leprae_Br4923 ------------------------SPVQVIGFTSVPGAGDNFLVVDED-- * . Rv1450c|M.tuberculosis_H37Rv FAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGG Mb1485c|M.bovis_AF2122/97 FAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGG MMAR_3763|M.marinum_M GSGERGGDGGHGGDPGNAGAGGQAGAGPTSGGNGKAGSGVTTGGNGGDGG MUL_4367|M.ulcerans_Agy99 ------------------GAGGAGGVG------GLGGDSAATAGGGGAGG Mflv_5091|M.gilvum_PYR-GCK ---------------------------------GSAGKAGATGAAGASGG Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------GSAGTAGVTGASGASGG MSMEG_0868|M.smegmatis_MC2_155 ----------------TTANAANPGSATGTATGGDGGKATGTASQGGNGG TH_3810|M.thermoresistible__bu ----------------------------------VPTTIQFPAGSCTSRA MAB_4284c|M.abscessus_ATCC_199 ------------------------------GSTAVGGGAHTGVGGGVNTG MAV_4827|M.avium_104 ---------------------------------GSGGGHVPTPGAGTPGG MLBr_01556|M.leprae_Br4923 ---------------------------------RIARQIADRRSARKRNA . . Rv1450c|M.tuberculosis_H37Rv HG-----------AASGGNGGPGGHGGNGGNGGTG--------------- Mb1485c|M.bovis_AF2122/97 HG-----------AASGGNGGPGGHGGNGGNGGTG--------------- MMAR_3763|M.marinum_M DGGSGAIGVKGGAGGAGGDGGLYGNGGNGGDGGTGGKGTVGDSGATLSAD MUL_4367|M.ulcerans_Agy99 DG---------------GKGGAGGAGVNGVGGGDG--------------- Mflv_5091|M.gilvum_PYR-GCK KG---------------AQGATGAQGATGAQGATG--------------- Mvan_1264|M.vanbaalenii_PYR-1 KG---------------AQGATGAQGATGAQGATG--------------- MSMEG_0868|M.smegmatis_MC2_155 PS-----------------WVQSGYGSTLGGNATG--------------- TH_3810|M.thermoresistible__bu VS---------------------REGIMPSSRAAS--------------- MAB_4284c|M.abscessus_ATCC_199 VG----------------VGSHVGGGISESLGGSG--------------- MAV_4827|M.avium_104 SG----------------GGHLPFPGAGSTPGGSG--------------- MLBr_01556|M.leprae_Br4923 LAAR-------------SRKRISLEDLDSALKETSQLN------------ . . . Rv1450c|M.tuberculosis_H37Rv --------------------ANGGNGGIGGTGGAGSTGAKG--------- Mb1485c|M.bovis_AF2122/97 --------------------ANGGNGGIGGTGGAGSTGAKG--------- MMAR_3763|M.marinum_M GDRGGAGATGGVGGAGGDGGAKGGNGGLGGSGGTGGMGGTGGDGAHGADM MUL_4367|M.ulcerans_Agy99 -----------------------GKGGTGGAGGAGGAGSDG--------- Mflv_5091|M.gilvum_PYR-GCK -----------------------ATGAAGKAGATGAAGAAG--------- Mvan_1264|M.vanbaalenii_PYR-1 -----------------------ATGASGAQGSAGSAGSAG--------- MSMEG_0868|M.smegmatis_MC2_155 ----------------------TATAGKGGEASNGGVAGNG--------- TH_3810|M.thermoresistible__bu --------------------------ARAGAACASS-------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------SVGGSTAVGGGAHTS--------- MAV_4827|M.avium_104 ----------------------------GGHLPTPGAGTPG--------- MLBr_01556|M.leprae_Br4923 ---------------------LILKGDNAGTVEALEEALMG--------- . Rv1450c|M.tuberculosis_H37Rv --VLGTNEGDGGDGGRGGNGGRGGNGGQG-----------LTGAGGNGGT Mb1485c|M.bovis_AF2122/97 --VLGTNEGDGGDGGRGGNGGRGGNGGQG-----------LTGAGGNGGT MMAR_3763|M.marinum_M ASGSGANGGYGGYGGFGGVGGAGGTGGVGGQAHAAGFTDGATGAGGDGGQ MUL_4367|M.ulcerans_Agy99 --IIPSNGGLGGNGGNGGNGGQAFGDGVG-------------GAGGIGGK Mflv_5091|M.gilvum_PYR-GCK --AAGSAGTTGAQGSAGTNGANGANGSQG-------------AAGKAGAT Mvan_1264|M.vanbaalenii_PYR-1 --VAGSAGTTGAQGSAGTNGANGANGSQG-------------AAGKAGAT MSMEG_0868|M.smegmatis_MC2_155 --GNALVMAAGTTGVATGNTATGGDGGAAT------------TAGATGGA TH_3810|M.thermoresistible__bu --------TSRSRRSFCCSRA----------------------------- MAB_4284c|M.abscessus_ATCC_199 ----AINDALGGSGSVGGSTAVGG----------------GAHTSAIN-- MAV_4827|M.avium_104 ----------GGLGGFGGGHAPAPGGGLG--------------------- MLBr_01556|M.leprae_Br4923 IQVDDEVALRVIDRGVGGITETNVNLASAS------------DAIIIG-- Rv1450c|M.tuberculosis_H37Rv GGTPGN---GGNGGNGASGDLVTSP------GDGGGGGRGGDAGRGGDAG Mb1485c|M.bovis_AF2122/97 GGTPGN---GGNGGNGASGDLVTSP------GDGGGGGRGGDAGRGGDAG MMAR_3763|M.marinum_M GGTGGLGAWGGNGGDGADGSISGPPQNGGKGGDGGGGGPGGLGGQGGLSG MUL_4367|M.ulcerans_Agy99 G------------GNAAIGTIVING------GVGGAGGSGGLGG------ Mflv_5091|M.gilvum_PYR-GCK G-------------------------------TTGATGAAGEDG------ Mvan_1264|M.vanbaalenii_PYR-1 G-------------------------------TTGATGAAGDAG------ MSMEG_0868|M.smegmatis_MC2_155 G------------GFSNIAAIHGAITDSTAISGHGGAGNGGNGG------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Rv1450c|M.tuberculosis_H37Rv LGGSSGPGGTPGDWGTGGTGGTGGTGG--QGANGGLTGGRGGTGGNGGNG Mb1485c|M.bovis_AF2122/97 LGGSSGPGGTPGDWGTGGTGGTGGTGG--QGANGGLTGGRGGTGGN---- MMAR_3763|M.marinum_M DGSSTGAAGELGTFGNGGSGGNGGIGGNATGFNAPGTGGAGGNGGNGAFG MUL_4367|M.ulcerans_Agy99 -------ATEDGVGGVGCAGGAGGNGG--RGDMLFTVGGSGGTGGD---- Mflv_5091|M.gilvum_PYR-GCK ---------DAGSGGSGINGGAGGAGG---------AGGEGGEGGD---- Mvan_1264|M.vanbaalenii_PYR-1 ---------DPGSEAVDINGGAGGAGG---------AGGEGGEGGA---- MSMEG_0868|M.smegmatis_MC2_155 ---------KGADGWVQAYDPAGPVGS--KIANSSAVAGNGGDGGVN--- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------ESMNSSINASHSSSMNES----------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ---------FNVRAEGKATELASREGVEIRYYLVIYQAIDDIEKALR--- Rv1450c|M.tuberculosis_H37Rv NTGGTGGAGG-----TGGTGHNGSQPGMG--------------------- Mb1485c|M.bovis_AF2122/97 -----GGAGG-----TGGTGHNGSQPGMG--------------------- MMAR_3763|M.marinum_M GSGGTGGRGGSSSVGTGGAGGDGGDGGMGFGGIGGGGGTGGQGGSGVDAQ MUL_4367|M.ulcerans_Agy99 ----------------GGGGGSASGSGTG--------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------GGKGGAGAEGGAG--------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------GGAGGDGSEGGAG--------------------- MSMEG_0868|M.smegmatis_MC2_155 ----------------GTGGASGGDGGNG--------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------FGSSMGSHGAAGTG--------------------- MAV_4827|M.avium_104 -----------------GGGGHAPAPGGG--------------------- MLBr_01556|M.leprae_Br4923 ----------------GMLKPIYEENQLG--------------------- Rv1450c|M.tuberculosis_H37Rv -----GNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAG-----PFGTG Mb1485c|M.bovis_AF2122/97 -----GNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAG-----PFGTG MMAR_3763|M.marinum_M GIGGAGNGGVGGNGGDGGDGWDAPGGQGGKGGQGGNGGDGSPPVPPFGGS MUL_4367|M.ulcerans_Agy99 -----GSGGTGGVG-----GIGGDGKLGGFGGDGGDGGDG---------- Mflv_5091|M.gilvum_PYR-GCK -----GGGGAGGSG---------AGGAGGAGGSGGSGGSG---------- Mvan_1264|M.vanbaalenii_PYR-1 -----GSGGAGGSG---------TGGAGGAGGSGGSGGSG---------- MSMEG_0868|M.smegmatis_MC2_155 -----GNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPG---------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------FEAQGHAQGHASETAHTTLP---------- MAV_4827|M.avium_104 -----------------------LGGFGGGHSGGGLGGLG---------- MLBr_01556|M.leprae_Br4923 -----------RAEIRALFRSSKVGIIAGCIISSGVVRRN----AKVRLL Rv1450c|M.tuberculosis_H37Rv TGGTGGHGGQGGGGG----FSILLGLGGLGGLGSPGSIATGTAGGAGGGG Mb1485c|M.bovis_AF2122/97 TGGTGGHGGQGGGGG----FSILLGLGGLGGLGSPGSIATGTAGGAGGGG MMAR_3763|M.marinum_M SGGTGGTGGTGGAGGDRFVDTELVGIGGAGHGGVTGGGPTGPALVDGGTG MUL_4367|M.ulcerans_Agy99 --GFGVIGGQGGGGG----------FGGLGGTGAGG------APSDKGIN Mflv_5091|M.gilvum_PYR-GCK --GSGGSGGAAGDSDD---------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 --GAGGSGGAAGDSD----------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GNGAGGAGGNGGTGG--------TTAGGSGNGGNGGNGGNGGADGTPGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --GAEHH------------------------------------------- MAV_4827|M.avium_104 ----GGHK------------------------------------------ MLBr_01556|M.leprae_Br4923 RDNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGDVIESYE Rv1450c|M.tuberculosis_H37Rv GFGGLGGGEFV Mb1485c|M.bovis_AF2122/97 GFGGLGGGEFV MMAR_3763|M.marinum_M GAGGSGGTGAH MUL_4367|M.ulcerans_Agy99 GEPGNPG---- Mflv_5091|M.gilvum_PYR-GCK ----------- Mvan_1264|M.vanbaalenii_PYR-1 ----------- MSMEG_0868|M.smegmatis_MC2_155 GTTGANNP--- TH_3810|M.thermoresistible__bu ----------- MAB_4284c|M.abscessus_ATCC_199 ----------- MAV_4827|M.avium_104 ----------- MLBr_01556|M.leprae_Br4923 LVEKQRA----