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M. marinum M MMAR_3763 (-)

annotation: PE-PGRS family protein
coordinates: 4636475 - 4641919
length: 1814

SFVSVAPEAVATAASDLARIGSSIDAVNAAAAGATTTVLAAGADEVSVAIAALFGTHAQEYQAISTRISA
LNERFVALLTAGNNSYAASESASVSWLQAVEQDVLGLVNAPSQNWFGRPLIGNGADGVAGTGQAGGAGGI
LWGNGGAGGSGAVGQSGGAGGSAGLLGHGGAGGAGGQAGASGTGGVGGAGGAGGWLYGNGGTGGVGGEGP
VNGGVGGAGGRAWLLGAGGSGGAGGQGLGLNGGAGGAGGNGGLFGIGGTGGAGGDSAGSGSAGAGGDGGH
GGLWGRGGAGGIGGVNSDSGDGGAGGGGGAGGRLFGSGGAGGAGGTGAVAGSGGDGGAGGAAVGLWGLGG
HGGAGGDGAVGLAGGVGEAGGEGGSAGNGGAGGLGGWLIGSGGAGGLGGVGGAGGAGGAGAAGIAPGSNG
GNGGNGGVGGAGGVGGSGGQGGFLRFLGGQGDGGAGGAGGAGGVAGDGGKGADAAAFSGAAGGNGGHGGD
NGAGGAGGTGGAGSTVGAHGADGFSPITGGNGGDGGNGASGPAASAGVAGGAGGAGGDGGLYGNGGAGGD
GGNGVAGGQGADATAAGASGENGGDGGAGGMGGAGGMGGVLGGHGGAGGIGGVGATGGSGGLGATGAEGV
TGGNLHGGDGGNGGKGGIGGAGGDGGAGGKAQAAGFADGTEGVGGAGGEGGAGGVAGDGGKGADAAAFSG
AAGGNGGHGGDNGAGGAGGTGGAGSTVGAHGADGFSPITGGNGGDGGNGASGPAASAGVAGGAGGAGGDG
GLYGNGGAGGDGGNGVAGGQGADATAAGASGENGGDGGAGGMGGAGGMGGVLGGHGGAGGIGGVGATGGS
GGLGATGAEGVTGGNLHGGDGGNGGKGGIGGAGGDGGAGGKAQAAGFADGTEGAGGAGGEGGAGGVAGDG
GKGADAAAFSGAAGGNGGHGGDNGAGGAGGTGGAGSTVGAHGADGFSPTTGGNGGDGGSGGSGFQGVKGG
AGGVGGDGGLYGNGGTGGTGGTGGIGFNGSTTIGGGNGGDGHTGLTGGDGGAGGKGGALAGHGGDGGTGG
VGGTGGTGGSGGTGTSGIFSSANGGDGGNGGDGGTGGTGGVGGLGGQAQAAGFADGTQGVGGAGGVGGTG
GNAGNGGHGANADVGSGKAGGNGGDGGDPGVGGIGGQGGAGSIAGVEGAAGVAPTSGGNGGDGGNGASGA
TGVNGGAGGSGGDGGLYGNGGDGGDGGNGGKGQVGSTGPVAGSAGGTGGTGGTGGQGGAGGSGGALAGHG
GDGGSGGDGGTGGTGGTGRNGANGITGADIDGGSGGKGGNGGTGGAGGAGGQGGQAQAAGYSDGTQGVGG
AGGDGGTAGIGGDGGDGANAVAGSGERGGDGGHGGDPGNAGAGGQAGAGPTSGGNGKAGSGVTTGGNGGD
GGDGGSGAIGVKGGAGGAGGDGGLYGNGGNGGDGGTGGKGTVGDSGATLSADGDRGGAGATGGVGGAGGD
GGAKGGNGGLGGSGGTGGMGGTGGDGAHGADMASGSGANGGYGGYGGFGGVGGAGGTGGVGGQAHAAGFT
DGATGAGGDGGQGGTGGLGAWGGNGGDGADGSISGPPQNGGKGGDGGGGGPGGLGGQGGLSGDGSSTGAA
GELGTFGNGGSGGNGGIGGNATGFNAPGTGGAGGNGGNGAFGGSGGTGGRGGSSSVGTGGAGGDGGDGGM
GFGGIGGGGGTGGQGGSGVDAQGIGGAGNGGVGGNGGDGGDGWDAPGGQGGKGGQGGNGGDGSPPVPPFG
GSSGGTGGTGGTGGAGGDRFVDTELVGIGGAGHGGVTGGGPTGPALVDGGTGGAGGSGGTGAH*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3763--100% (1814)PE-PGRS family protein
M. marinum MMMAR_2656-0.063.32% (1843) PE-PGRS family protein, PE_PGRS50
M. marinum MMMAR_1829-0.056.48% (1914) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3541PE_PGRS550.049.17% (1991) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-0.048.92% (789) triple helix repeat-containing collagen
M. tuberculosis H37RvRv3508PE_PGRS540.048.64% (2017) PE-PGRS family protein
M. leprae Br4923MLBr_01183-1e-0931.52% (92) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-5e-5233.72% (430) hypothetical protein MAB_4284c
M. avium 104MAV_4827-9e-2642.35% (196) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-16840.26% (1083) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-2e-4742.23% (296) PUTATIVE -
M. ulcerans Agy99MUL_4367-0.050.18% (1118) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-0.048.51% (804) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3763|M.marinum_M               ---MSFVSVAPEAVATAASDLARIGSSIDAVNAAAAGATTTVLAAGADE-
Rv3508|M.tuberculosis_H37Rv         ---MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGADE-
MUL_4367|M.ulcerans_Agy99           ---MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDE-
Mb3541|M.bovis_AF2122/97            ---MSFVLISPEVVSAAAGDLANVGSTISAANKAAAAATTQVLAAGADE-
MSMEG_0868|M.smegmatis_MC2_155      --------MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPK-
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQ-
MLBr_01183|M.leprae_Br4923          --MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTEIAPPAADD-
MAV_4827|M.avium_104                MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDR
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       -------MMFLAPPGGPGPISAAIQLTSTGSEATEPWYVVSFGGSGAPTP
MMAR_3763|M.marinum_M               -VSVAIAALFGTHAQEYQAISTRISALNERFVALLTAGNNSYAASESASV
Rv3508|M.tuberculosis_H37Rv         -VSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAA--
MUL_4367|M.ulcerans_Agy99           -VSAAIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALNM
Mb3541|M.bovis_AF2122/97            -VSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYMLAEATN-
MSMEG_0868|M.smegmatis_MC2_155      -FPAALAPESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -VGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSI
MLBr_01183|M.leprae_Br4923          -VSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAYAGTETAN-
MAV_4827|M.avium_104                VISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLV
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          TSLGAAAVDLSGTSCG---------LICNGQD---GTGQNG---GILFGN
Mvan_1264|M.vanbaalenii_PYR-1       NNLAASLVDLSGTSCG---------LICNGQD---GTGQNG---GILFGN
MMAR_3763|M.marinum_M               SWLQAVEQDVLGLVNAPSQNWFGRPLIGNGADGVAGTGQAGGAGGILWGN
Rv3508|M.tuberculosis_H37Rv         ----AAEQIVLGVINAPTQALLGRPLIGDGAN-ATTPGGAGGAGGLLFGN
MUL_4367|M.ulcerans_Agy99           WPLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILWGN
Mb3541|M.bovis_AF2122/97            -----VEQNLLNLINAPTQTLLGRPLIGDGAN-ATTPGGAGGDGGLLFGS
MSMEG_0868|M.smegmatis_MC2_155      TSTNTTDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVV
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLD
MLBr_01183|M.leprae_Br4923          -------HDSL---------------------------------------
MAV_4827|M.avium_104                SAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQ
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -GGSGWNSDVVGMDGGNGGNGGLFG-------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -GGSGWNSEIAGVSGGNGGNAGLFG-------------------------
MMAR_3763|M.marinum_M               -GGAGG-SGAVGQSGGAGGSAGLLGHGGAGGAGGQA--------------
Rv3508|M.tuberculosis_H37Rv         -GGAGA-AGAPGQAGGPGGPAGLWGNGGPGGAGGSGGGTGGAGGAGGWLF
MUL_4367|M.ulcerans_Agy99           -GGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGG----------------
Mb3541|M.bovis_AF2122/97            -GGNGA-PGAPGQAGGAGGSAGLLGNGGSGGAGGTG-APGGNGGNAGWLY
MSMEG_0868|M.smegmatis_MC2_155      TLGTTLIPNAPTEPADMPGVWAVMAWARRQPMYSDP---AMRTTVNPQAQ
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LSFGDLQFGNRDTTAIGDGAVAVGGSN-----------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                QIRAESYGDAAGQLSAMVAGLEKLESLPGG--------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------GNGGNG------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------GNGGNG------------------
MMAR_3763|M.marinum_M               -------GASGTGGVGGAGGAGGWLYGNGGTGGVGGEGPVNGGVGGAGGR
Rv3508|M.tuberculosis_H37Rv         GVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVGGAGGGTGGAGGRAEL
MUL_4367|M.ulcerans_Agy99           -VGAAG----MTGGSGGAGGGGGWLWGAGGSGGAAGAGG-----------
Mb3541|M.bovis_AF2122/97            GRGGVGGAGGIGGGTGGAGG-HAWLFGHGGTGGIGGGPGGNGG-------
MSMEG_0868|M.smegmatis_MC2_155      LPVPTVASAVLDPTQIVNWLIYQPLHAAGQQFWVVSPIGSTLG-------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----------------GNGLGGGNGGNGGNAGAF---------------
Mvan_1264|M.vanbaalenii_PYR-1       -----------------GNGLGSGDGGNGGDAGLF---------------
MMAR_3763|M.marinum_M               AWLLG--AGGSGGAGGQGLGLNGGAGGAGGNGGLFGIGGTGGAGGDSAGS
Rv3508|M.tuberculosis_H37Rv         LFGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGAGGAGGQ----
MUL_4367|M.ulcerans_Agy99           ---------------------------SGGSGGWLWG-------------
Mb3541|M.bovis_AF2122/97            -------WLLGNGGHGGAGGIGGGSGGAGGNGGWLLGNGGIGGAG-----
MSMEG_0868|M.smegmatis_MC2_155      ----GVINTISGQYLIGNGINGTADNPNGGTGGLLFGDGGHGYDGS----
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -----------------SGPIASGQGSTAVNGDVRDSN------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -------------------------------------------ALFGNGG
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------------------------SLFGRGG
MMAR_3763|M.marinum_M               GSAGAGGDGGHGGLWGRGGAGGIGGVNSDSGDGGAGGGGGAGGRLFGSGG
Rv3508|M.tuberculosis_H37Rv         -GGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGG
MUL_4367|M.ulcerans_Agy99           ------------------NAGQTAGAG-----------------VGGAGG
Mb3541|M.bovis_AF2122/97            -GTGGGAGGTGGNAAWLLGGGGTGGAGGIGGGNGGHGGNGG--WLLGNGG
MSMEG_0868|M.smegmatis_MC2_155      ------------------AAGLAGGNGGNAG-------------LFGNGG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------IINADH
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ------------------------------------------LLLVGSG-
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          NGGNGGVGVVGATG------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       NGGNGGVGIAGATG------------------------------------
MMAR_3763|M.marinum_M               AGGAGGTGAVAGSGGDGGAGGAAVGLWGLGGHGGAGGDGAVGLAGGVGEA
Rv3508|M.tuberculosis_H37Rv         QGGTGGAGGDGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSAGGAAGA
MUL_4367|M.ulcerans_Agy99           AGGAGDAGDQGVSG------------------------------------
Mb3541|M.bovis_AF2122/97            NGGLGGDGDGGTGGGHGGNGGNPGWLLGTAGGGGNGGAGSTGTAGGGSGG
MSMEG_0868|M.smegmatis_MC2_155      NGGVGWAGLDGGNGGSGGLLMG----------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GSNVGVDQSQTRVGG-----------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                VDVAPLKQVLQTTT------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----------------------------AVGAPGVAGATGATGVTSGVV
Mvan_1264|M.vanbaalenii_PYR-1       -----------------------------AVGAPGVAGATGATGVTSNVT
MMAR_3763|M.marinum_M               GGEGGSAGNGGAGGLGGWLIGSGGAGGLGGVGGAGGAGGAGAAGIAPGSN
Rv3508|M.tuberculosis_H37Rv         VGV--------GGTGGQGGAGGAGAAGADAPASTGLTGGTGFAGG-AGGV
MUL_4367|M.ulcerans_Agy99           -------------------------------VAPGEAGAVGFAGG-AGGA
Mb3541|M.bovis_AF2122/97            TG---------GDGGTGGRGGLLMGAGAGGHGGTGGAGGAGVDGGGAGGA
MSMEG_0868|M.smegmatis_MC2_155      ------------------------------IGGAGGAGGVGADGTSAHVD
TH_3810|M.thermoresistible__bu      ------------------------------------------------VD
MAB_4284c|M.abscessus_ATCC_199      -----------------------------DYTNVSGHGSADIDKSVTVVD
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----------------------FLDVSVAEEPETALARGAALAAANAPLF
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GGNGED-AVG-----------------------YGATGAAGAAGAAG---
Mvan_1264|M.vanbaalenii_PYR-1       GGNGAD-AVG-----------------------YGATGAAGAAGAAG---
MMAR_3763|M.marinum_M               GGNGGNGGVGGAGGVGGSGGQGGFLRFLGGQGDGGAGGAGGAGGVAGDGG
Rv3508|M.tuberculosis_H37Rv         GGQGGNAIAGG---------------------INGSGGAGGTGGQGGAGG
MUL_4367|M.ulcerans_Agy99           GGAGGNGVGGG---------------------VNGAGGAGGAGGVGGGGG
Mb3541|M.bovis_AF2122/97            GGAGGNGGAGGQAAL-----------------LFGRGGTGGAGGYGGDGG
MSMEG_0868|M.smegmatis_MC2_155      GGTGGTGGTGG-----------------------GTGGTGGIGGTGG---
TH_3810|M.thermoresistible__bu      ----GDGGSGG-----------------------RTG-------------
MAB_4284c|M.abscessus_ATCC_199      DHSQRNTTNIN---------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ASSTAALAYAQ---------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ----------------------AAGAAGAVG-------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------AAGKAGAVG-------------------
MMAR_3763|M.marinum_M               KGADAAAFSGAAGGNGGHGGDNGAGGAGGTGGAGSTVGAHGADGFSPITG
Rv3508|M.tuberculosis_H37Rv         MGGSGADNASG---------IGADGGAGGTGGNAGAGGAGGAAG------
MUL_4367|M.ulcerans_Agy99           AGASGVG-------------AGVAGGDGGTGGAGGAAGVGGAAG------
Mb3541|M.bovis_AF2122/97            GGGDGFDGTMAG--------LGGTGGSGGTGGDGGAPGNGGAGG------
MSMEG_0868|M.smegmatis_MC2_155      ---------------------GLFGLLGHSG-------------------
TH_3810|M.thermoresistible__bu      ----------------------LFSKLSR---------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------------DSFNTDRSTN-------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ---------------SAGAAGEAG----ETGTWGN---------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------------SAGTAGSAG----APGVWGN---------------
MMAR_3763|M.marinum_M               GNGGDGGNGASGPAASAGVAGGAGGAGGDGGLYGNGGAGGDGGNGVAGGQ
Rv3508|M.tuberculosis_H37Rv         ---TGGTGGVVGAAGKAGIGGTGG----QGGAGGAGSAGTDATA------
MUL_4367|M.ulcerans_Agy99           ---TGGTG------GAAGVAGTGG----DGGDGGAGGAGSDASL------
Mb3541|M.bovis_AF2122/97            ---AGQLLSHSGVAGASGKGGAGG----TGGNGGAGSAGADAPAG-----
MSMEG_0868|M.smegmatis_MC2_155      ---------------STGAAGAAG----NGGDGGNGGFGYVLIAG-----
TH_3810|M.thermoresistible__bu      -----------------------------GGDGGDGGLG-----------
MAB_4284c|M.abscessus_ATCC_199      -----------------------------IGSGNTTN-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ------AGLPGKAGDAGGAGAVGAAG----------AAGTVGTAGATGGT
Mvan_1264|M.vanbaalenii_PYR-1       ------AGLPGAAGAAGGAGAIGTAG----------VAGAAGTAGATGGT
MMAR_3763|M.marinum_M               GADATAAGASGENGGDGGAGGMGGAGGMGGVLGGHGGAGGIGGVGATGGS
Rv3508|M.tuberculosis_H37Rv         ------TGATGGTGFSGGAGGAGGAGGNTGVG-GTNGSGGQGGTGGAGGA
MUL_4367|M.ulcerans_Agy99           ------AGQAG---FAGGSGGAGGVGGSAGAG-GVNGSGGDGGAGAAGGA
Mb3541|M.bovis_AF2122/97            ------SGAMGSTGFAGGAGGDGGNGGGSGASQGNGGNGGNGGTGGKGGT
MSMEG_0868|M.smegmatis_MC2_155      ------PNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILI
TH_3810|M.thermoresistible__bu      ------------------------------------GNGGHGGGTGIISL
MAB_4284c|M.abscessus_ATCC_199      ---------------------------------TEIGSHNQANIGTSTSA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----------------------------------DPGTGAVDQYSLPDYL
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          G------------------------------TGANGGAG-----------
Mvan_1264|M.vanbaalenii_PYR-1       G------------------------------VGGNGGAG-----------
MMAR_3763|M.marinum_M               GGLGATGAEGVTGGNLHGGDGGNGGKGGIGGAGGDGGAGGKAQAAGFADG
Rv3508|M.tuberculosis_H37Rv         GGAGGVGAD---------NPTGIGGTGGTGGKGGAGGAGGQGGSSGAGGT
MUL_4367|M.ulcerans_Agy99           GGASAT----------------VAGSGGVGGDGGAGGAAG----------
Mb3541|M.bovis_AF2122/97            GGAGMNSLDPL-------LAAQDGGQGGTGGTGGNAGAGGTGFTQGADGN
MSMEG_0868|M.smegmatis_MC2_155      GANGGTVDGHA-----------------IGGNGGNGGNGS----------
TH_3810|M.thermoresistible__bu      LS--------------------------LAGNGGNGGNGY----------
MAB_4284c|M.abscessus_ATCC_199      GG--------------------------SAAVGGNAGLAG----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                YVP----------------------------VDPEPGDDE----------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3763|M.marinum_M               TEGVGGAGGEGGAGGVAGD-----------------------------GG
Rv3508|M.tuberculosis_H37Rv         NGSGGAGGTGGQGGAGGAGGAGADNPTGIGGAGGTGGTGGAAGAGGAGGA
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mb3541|M.bovis_AF2122/97            AGNGGDGGVGGNGGNGADN-------TTTAAAGTTGGAGGAGGAGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ----------------------GVGGVGGTG-------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------QAGGIGGTG-------------------
MMAR_3763|M.marinum_M               KGADAAAFSGAAGGNGGHGGDNGAGGAGGTGGAGSTVGAHGADGFSPITG
Rv3508|M.tuberculosis_H37Rv         IGTGGTGGAVGSVGNAGIGGTGGTGGVGGAGGAGAA--------------
MUL_4367|M.ulcerans_Agy99           ----------GGVGAASLGGDGGHAGAGGAGGEGLS--------------
Mb3541|M.bovis_AF2122/97            GGAAGTG-TGGQQGNGGNGGNGGTGGKGGTGGAGMNSL------------
MSMEG_0868|M.smegmatis_MC2_155      -----------------TTAAGGNGGTGGTGRVIAE--------------
TH_3810|M.thermoresistible__bu      -----------------RTTDNN---------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ---------------AAGAAGGAGGLG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------------AAGAAGQAGTAG-----------------------
MMAR_3763|M.marinum_M               GNGGDGGNGASGPAASAGVAGGAGGAGGDGGLYGNGGAGGDGGNGVAGGQ
Rv3508|M.tuberculosis_H37Rv         ---------AAAGSSATGGAGFAGGAGGEGGAGGNSGVGGTNGSG-----
MUL_4367|M.ulcerans_Agy99           ---------GGFNTGAAGGIGGAGGAGGTGGDSG--GVGGVNGDG-----
Mb3541|M.bovis_AF2122/97            ---------DPLLAAQDGGQGGTGGTGGNAGAGGTGFTQGADGNA-----
MSMEG_0868|M.smegmatis_MC2_155      ---------GTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGN----
TH_3810|M.thermoresistible__bu      -----------------ALDGGHGGN------GGNVGFFSLFNLG-----
MAB_4284c|M.abscessus_ATCC_199      ---------------NAGLAGNAGLAG-----------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------LAYSAVGEEDAESPTVVIEKLFLPEDSEPRRR----
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----------ETGTTGGAGGVGGQG-----------TAGGTGGVGGIGG
Mvan_1264|M.vanbaalenii_PYR-1       -----------ETGVTGGVGGIGGQG-----------TEGGTGGVGGVGG
MMAR_3763|M.marinum_M               GADATAAGASGENGGDGGAGGMGGAGGMG-------GVLGGHGGAGGIGG
Rv3508|M.tuberculosis_H37Rv         -----------GAGGAGGKGGTGGAGGSGADNPTGAGFAGGAGGTGGAAG
MUL_4367|M.ulcerans_Agy99           -----------GAGGGGGRGGDGGSSTS----TSGVGGAGGAGGNGGNAG
Mb3541|M.bovis_AF2122/97            -----------GNGGDGGVGGNGGNGADN-TTTAAAGTTGGAGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155      ----------NGAVSGTATGGRGGDG-----------IDGGTGGAGGMGE
TH_3810|M.thermoresistible__bu      -----------------GAGGWGGSG-----------VDG----------
MAB_4284c|M.abscessus_ATCC_199      -----------NAGLAGNAGLAGNAG-----------LAGNAGLAG----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----------PVLLVGSGLAVVGISAVLALEIALAIGIRTTGTVALQPTP
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --AGSTG---------------AVGGVGGKGIQ-----------------
Mvan_1264|M.vanbaalenii_PYR-1       --VGATG---------------GAGGVGGKGIQ-----------------
MMAR_3763|M.marinum_M               --VGATG---------------GSGGLGATGAEGVTGGNL----------
Rv3508|M.tuberculosis_H37Rv         --AGGAGGATGTGGTGGVVGATGSAGIGGAGGRGGDGGDGASGLGLGLSG
MUL_4367|M.ulcerans_Agy99           --FGVSAGGTG-----------GSAGDGGAGG------------------
Mb3541|M.bovis_AF2122/97            --TGGTGGAAGTG-TGGQQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAA
MSMEG_0868|M.smegmatis_MC2_155      IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPT-------
TH_3810|M.thermoresistible__bu      -----------------------VDVVGGN--------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----------GGQGLQGGKGGDGGAGGKGGDADSMGSAG----------
Mvan_1264|M.vanbaalenii_PYR-1       -----------GGQGLQGGQGGDGGTGGTGGDATSMGEAG----------
MMAR_3763|M.marinum_M               -------HGGDGGNGGKGGIGGAGGDGGAGGKAQAAGFAD----------
Rv3508|M.tuberculosis_H37Rv         FDGGQGGQGGAGGSAGAGGINGAGGAGGNGGDGGDGATGA----------
MUL_4367|M.ulcerans_Agy99           ---------------GAGGVDGVGGASGNGGAAGAGGAGG----------
Mb3541|M.bovis_AF2122/97            QDGGQGGTGGTGGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGNGADNTT
MSMEG_0868|M.smegmatis_MC2_155      ----TGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGA----------
TH_3810|M.thermoresistible__bu      ---------------------PDGGTPG----------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------NAGLAGNAGLAGNAGLAGNAGLAG----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------------NQHLIVPTEQAPAPPPVQASAPQPK----------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --ATGGKGGNGGNGGRGGLFGKGGN-----------AGNGADGGTGGAGG
Mvan_1264|M.vanbaalenii_PYR-1       --ATGGKGGNGGNGGRGSLFGRGGN-----------AGNGGNGGTGGNGG
MMAR_3763|M.marinum_M               --GTEGAGGAGGEGGAGGVAGDGGKGADAAAFSGAAGGNGGHGGDNGAGG
Rv3508|M.tuberculosis_H37Rv         -AGLGDNGGVGGDGGAGGAAGNGGN---AGVGLTAKAGDGGAAGNGGNGG
MUL_4367|M.ulcerans_Agy99           -SGIG----AGIDGGAGGAGGTGGA---AGF-----PGGGGTTGAWGTGG
Mb3541|M.bovis_AF2122/97            TAAAGTTGGAGGAGGAGGTGGTGGA---AGTGTGGQQGNGGNGGNGGTGG
MSMEG_0868|M.smegmatis_MC2_155      ---TGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSG
TH_3810|M.thermoresistible__bu      -------------------------------------AHG----------
MAB_4284c|M.abscessus_ATCC_199      ------NAGLAGNAGLAGNAGLAG--------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---ISVPEPVAAPKPLSPPVAAPLP-------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          AGGTGGTG------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       NGGTGGTG------------------------------------------
MMAR_3763|M.marinum_M               AGGTGGAGSTVGAHGADGFSPTTGGNGGDGGSGGSGFQGVKGGAGGVGGD
Rv3508|M.tuberculosis_H37Rv         AGGAGGAGDNNFNGGQGGA--GGQGGQGGLGGASTTSINANGGAGGNGGT
MUL_4367|M.ulcerans_Agy99           AGGAGGAG------------------------------------------
Mb3541|M.bovis_AF2122/97            KGGTGGDGALAGSSGGAGGKGGNGGDAGKAGTGSAPGTAGTGGDGGKGGN
MSMEG_0868|M.smegmatis_MC2_155      HGGAAQGGNG----------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ------------GAGGTGGTGGTGGIG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1       ------------GNGGTGGTGGTGGIG-----------------------
MMAR_3763|M.marinum_M               GGL--------YGNGGTGGTGGTGGIGFNGSTTIGG--------------
Rv3508|M.tuberculosis_H37Rv         GGKGGAGGAGTLGVGGSGGTGGDGGDAGSGGGGGFG--GAAGKAGGGGNG
MUL_4367|M.ulcerans_Agy99           ------------GAGDHGGVGVNPGDSGTAG-------------------
Mb3541|M.bovis_AF2122/97            GGIGAAGTTGPVGTGASGGTGGSGGAGGTGGDGGAANGGTAGAGGAGGNG
MSMEG_0868|M.smegmatis_MC2_155      ------------GNGGNGWVQAYDPNGPAGTTIDKGK-------------
TH_3810|M.thermoresistible__bu      --------------------ESHTP----GVYTDRQ--------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -------------------GAGSTGGTGGTGGTGGTG----GTGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1       -------------------GAGSTGGTGGTGGTGGTG----GTGGTGGTG
MMAR_3763|M.marinum_M               ----------------GNGGDGHTGLTGGDGGAGGKGGALAGHGGDGGTG
Rv3508|M.tuberculosis_H37Rv         GRGGDGGDGASGLGLGLSGFDGGQGGQGGAGGSAGAG----GINGAGGAG
MUL_4367|M.ulcerans_Agy99           -------------------WAGGAGGAGGAGGSAAFN----GVNGAGGAG
Mb3541|M.bovis_AF2122/97            GKGGDGGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAG----ATPGANGIA
MSMEG_0868|M.smegmatis_MC2_155      ----------------------AAGGNGGDGGFNGTG------GATGGRG
TH_3810|M.thermoresistible__bu      ----------------------------GEDGEDGTG------TGIGGRG
MAB_4284c|M.abscessus_ATCC_199      ----------------------NAGLAGNAGLAGNAG-----LAGNAGLA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----------------------AAPPPAAPPLPEAPP-----IPAAPPVV
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGT-GGKGGTG-------GTGGAGGTGGDGGTGGTGGTG------
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGT-GGKGGTG-------GTGGDGGTGGTGGTGGTGGTG------
MMAR_3763|M.marinum_M               GVGGTGGT-GGSGGTGTSGIFSSANGGDGGNGGDGGTGGTGGVGGLGGQA
Rv3508|M.tuberculosis_H37Rv         GNGGDGGD-GATGAAGLGDNGGVG--GDGGAGGAAGNGGNAGVGLT----
MUL_4367|M.ulcerans_Agy99           GNGGAGGG-GGAGASGIG-AGVAG--GDGGTGGTGG--------------
Mb3541|M.bovis_AF2122/97            GNGGDGGD-GAAGAVGISGATGAGDGGHGGTGGAGGNGGTGGAGGSG---
MSMEG_0868|M.smegmatis_MC2_155      GDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAG
TH_3810|M.thermoresistible__bu      GNGG-----SSSGTHPMAE-------------------------------
MAB_4284c|M.abscessus_ATCC_199      GNAGLAGNAGLAGNAGLAG-------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                PVPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVP---
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ----------GTGGTGGTGGTGG-AGDG----------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----------GTGGTGGTGGTGG-AGDG----------------------
MMAR_3763|M.marinum_M               QAAGFADGTQGVGGAGGVGGTGGNAGNGGHGAN-----------------
Rv3508|M.tuberculosis_H37Rv         -------AKAGDGGAAGNGGNGGAGGAGGAGDNNFNGGQGGAGGQGGQGG
MUL_4367|M.ulcerans_Agy99           --------AAGTGGAAGTGGTGGAAGAAGS--------------------
Mb3541|M.bovis_AF2122/97            ----IDGVGGGTGGTGGNGGNGAIGGAGGDAGGSGNSGGNGGTGGKGGNA
MSMEG_0868|M.smegmatis_MC2_155      GVSEGEGGTGGHGGDGGRGGDGALGGNGGT--------------------
TH_3810|M.thermoresistible__bu      ------------DGEHVKALDGRPGLDG----------------------
MAB_4284c|M.abscessus_ATCC_199      --------NAAVAGNAAVAGNAAVAGNAAVG-------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----------QPPSPPQVGGTVPQSPPQ----------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3763|M.marinum_M               -ADVGSGKAGGNGGDGGDPGVGGIGGQGGAGSIAGVEGAAGVAPTSGGNG
Rv3508|M.tuberculosis_H37Rv         LGGASTTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGGDGGDAGS
MUL_4367|M.ulcerans_Agy99           ---------------AGDGGAGGAGGAGDDGSAGVVS--------GDPG-
Mb3541|M.bovis_AF2122/97            GAGGAAGSNGGTVGANGTGGDGGNGGAAGAATAGSNGGAGTGSAGGNGGT
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3763|M.marinum_M               GDGGNGASGATGVNGGAGGSGGDGGLYGNGGDGGDGGNGGKGQVGSTGPV
Rv3508|M.tuberculosis_H37Rv         GGGGGFG-----GAAGKAGGGGNGGVGGDGGEGASGLGLGLSGFDGGQGG
MUL_4367|M.ulcerans_Agy99           -------------TAGKAGGAG---------------------------G
Mb3541|M.bovis_AF2122/97            GGRGGSGGAGGDGIGGVGGGKGGNGADGEVGGAGGAGGSGPNTSPGGNGG
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          TGGTGGTGGTGGQGGQGGQGGTG---------------------------
Mvan_1264|M.vanbaalenii_PYR-1       LGGTGGTGGTGGFGGQGGQGGTG---------------------------
MMAR_3763|M.marinum_M               AGSAGGTGGTGGTGGQGGAGGSGG--------------------------
Rv3508|M.tuberculosis_H37Rv         QGGAGGSAGAGGINGAGGAGGTGGAGGDGAPATLIGGPDGGDGGQGGIGG
MUL_4367|M.ulcerans_Agy99           AGGVGGNGVAGGVNGSGGAGGAG---------------------------
Mb3541|M.bovis_AF2122/97            QGGQGGSGGAGGAAGAGGAGGGAN--------------------------
MSMEG_0868|M.smegmatis_MC2_155      GGVGLGNGGKGGNGGNGGNGGTYV--------------------------
TH_3810|M.thermoresistible__bu      -----GNGSHGGNGGHGGRGG-----------------------------
MAB_4284c|M.abscessus_ATCC_199      --GVLNTGVSGAIGGSSHVGGAIN--------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                HQTPPGEGTPPKPDGPGNYGGGHVP-------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ----------------------------GTGGQGGLGGGGGTGGQGGTG-
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------GTGGQGGLGGVGGTGGTGGTG-
MMAR_3763|M.marinum_M               -------------------------ALAGHGGDGGSGGDGGTGGTGGTGR
Rv3508|M.tuberculosis_H37Rv         DGGNAGFGAGVPGDGGDGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGD
MUL_4367|M.ulcerans_Agy99           -------------------------------------GAGGTGGAGASGV
Mb3541|M.bovis_AF2122/97            --GTAGNGGQGGAGGTGGAGAASSATNGGSGGAGGTGGAGGTGGAGGDGV
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------DPSHTGAGGNGGNGGAGR
TH_3810|M.thermoresistible__bu      -----------------------------------FLGIGGSGGWG----
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------ESLGGSGSVGGST-
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------------------------------TPGAGGSGGSGGGHV
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----------------------------------------GTGGQGGTG
Mvan_1264|M.vanbaalenii_PYR-1       -----------------------------------------GTGGQGGTG
MMAR_3763|M.marinum_M               NGANGITG----------------------------ADIDGGSGGKGGNG
Rv3508|M.tuberculosis_H37Rv         PSIDGGQGGAGGHGGQGGKGG---------LNSTGLASAASGDGGNGGAG
MUL_4367|M.ulcerans_Agy99           P--------------------------------------ASVDGGDGGAG
Mb3541|M.bovis_AF2122/97            GGAGGGNGGHGGDAGDGGNGANGNNRSSGSFLAAGGTGGAAGDGGQGGQG
MSMEG_0868|M.smegmatis_MC2_155      IRVNNGTA---------------------------TGTATGGNGGNGGNG
TH_3810|M.thermoresistible__bu      -----------------------------------------GHGGNGGDT
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------------AVGGGAHT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                P-----------------------------------------TPGAGGSG
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GTGG-----------TGGTGG----------------TGGAGGDGGLGGL
Mvan_1264|M.vanbaalenii_PYR-1       GTGG-----------TGGTGG----------------TGGAGGDGGLGGL
MMAR_3763|M.marinum_M               GTGG-----------AGGAGGQGGQAQAAGYSDGTQGVGGAGGDGGTAGI
Rv3508|M.tuberculosis_H37Rv         GAGGNGGDGDGFIGGSGGTGGTGGDA----GVGGLANTGGTAGNAGIGGA
MUL_4367|M.ulcerans_Agy99           GAGG-----------AAGTGGSG----------------GSAGNTGAGGA
Mb3541|M.bovis_AF2122/97            GAGG-GAGGQGGAGGAGGTGGNGGN-----ITGGTAGTAGAAGNGGAAGK
MSMEG_0868|M.smegmatis_MC2_155      DADG----------HRGGKGGDGGEA-----LIRATVIGSNASGTATGGD
TH_3810|M.thermoresistible__bu      DADG----------GNGGDGGNGG----------------------SAGR
MAB_4284c|M.abscessus_ATCC_199      GVGG------------GVSTGVG--------------VGSHVGGGISESL
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                GSGG-----------------------------------GHVPTPGTGGP
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GGFGGSGG------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       GGFGGVGG------------------------------------------
MMAR_3763|M.marinum_M               GGDGGDGANAVAGSGERGGDGGHGGDPGNAGAGGQAGAGPTSGGNGKAGS
Rv3508|M.tuberculosis_H37Rv         GGRGGDGGAGDSGALS----------QDGNGFAGGQGGQGGVGGNAGAGG
MUL_4367|M.ulcerans_Agy99           GGAGGAGGSAASTGVN----------GDG---------------------
Mb3541|M.bovis_AF2122/97            GGAGGQGGTGGGTGGQGG--------AGGDGGAGGTGGDRTVGGGTVPAG
MSMEG_0868|M.smegmatis_MC2_155      GGNGGTLGATNGTGGAAT------------IVAYNVVQANPQASGTATDG
TH_3810|M.thermoresistible__bu      GGTGGLRGVF----------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GGSGSVGGSTAVGG------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                GGTGGSGG------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ---TGGQGGLGGPGGS----------TGGAGGAGGQAGTAGKGGLFGGSG
Mvan_1264|M.vanbaalenii_PYR-1       ---TGGQGGQGGPGGS----------TGGAGGAGGQAGVAGKGGLFGGSG
MMAR_3763|M.marinum_M               GVTTGGNGGDGGDGGSG-----AIGVKGGAGGAGGDGGLYGNGGNGGDGG
Rv3508|M.tuberculosis_H37Rv         INGAGGTGGTGGAGGDGQNGTTGVASEGGAGGQGGDGGQGGIGGAGGNAG
MUL_4367|M.ulcerans_Agy99           --GAGGAGGVGGLGGDS-------AATAGGGGAGGDGGKGGAGGAGVNGV
Mb3541|M.bovis_AF2122/97            SGGQGGNAGGGGAGGQG-------GADGGSGGDGGDAGTGGNGGNGGNRN
MSMEG_0868|M.smegmatis_MC2_155      HGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGG
TH_3810|M.thermoresistible__bu      ----GINGGNGR------------------------------AGLGGRGX
MAB_4284c|M.abscessus_ATCC_199      ----GAHTGVGGGVSTG-------------VGVGSHVGGGISESLGGSGS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -------------------------------GHVPTPGAGTPGGSGGGHL
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          SAGK------------------AGATG----------AAGASGGKGAQG-
Mvan_1264|M.vanbaalenii_PYR-1       SAGT------------------AGVTG----------ASGASGGKGAQG-
MMAR_3763|M.marinum_M               TGGKGTVGDSGATLSADGDRGGAGATGGVGGAGGDGGAKGGNGGLGGSG-
Rv3508|M.tuberculosis_H37Rv         FGAG---------------VPGDGGIG----------GTGGAGGAGGAG-
MUL_4367|M.ulcerans_Agy99           GG-------------------GDGGKG----------GTGGAGGAGGAG-
Mb3541|M.bovis_AF2122/97            SGNG---------------TGGAGGNG----------GGGANGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155      DGVVNT-------------TANAANPGSA--------TGTATGGDGGKAT
TH_3810|M.thermoresistible__bu      X-------------------------------------------XXGGGV
MAB_4284c|M.abscessus_ATCC_199      VGGS-----------------------------------TAVGGGAHTGV
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                PFPG------------------------------------AGSTPGGSGG
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ATGAQGATGAQG-------------ATGATGAAG----------------
Mvan_1264|M.vanbaalenii_PYR-1       ATGAQGATGAQG-------------ATGATGASG----------------
MMAR_3763|M.marinum_M               GTGGMGGTGGDG-------------AHGADMASGSGANGGYGGYGGFGGV
Rv3508|M.tuberculosis_H37Rv         ADGDPSIDGGQG---------------GAGGHGGQGGKGGLNSTGLASAA
MUL_4367|M.ulcerans_Agy99           SDGIIPSNGGLG---------------GNGGNGGNGGQ-----------A
Mb3541|M.bovis_AF2122/97            SGGGTGGNGGAGGDAGDAGNGGNGNGTGNGGNGGNGGIAGMGGNGGAGTG
MSMEG_0868|M.smegmatis_MC2_155      GTASQGGNGGPS--------------WVQSGYGSTLGG----------NA
TH_3810|M.thermoresistible__bu      GAAVRSGNG------------------VFSGGG-----------------
MAB_4284c|M.abscessus_ATCC_199      GGGVNTGVGVGS--------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                GHLPTPGAGTPG--------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -KAGATGAAG----------------------AAGAAGSAGTTGAQGSAG
Mvan_1264|M.vanbaalenii_PYR-1       -AQGSAGSAG----------------------SAGVAGSAGTTGAQGSAG
MMAR_3763|M.marinum_M               GGAGGTGGVGGQAHAAGF---------TDGATGAGGDGGQGGTGGLGAWG
Rv3508|M.tuberculosis_H37Rv         SGDGGNGGAGGAGGNG--------GDGDGFIGGSGGTGGTGGDAGVGGLA
MUL_4367|M.ulcerans_Agy99           FGDG--------------------------VGGAGGIGGKGGNAAIGTIV
Mb3541|M.bovis_AF2122/97            SGNGGNGGSGGNGGNAGMGGNSGTGSGDGGAGGNGGAAGTGGTGGDGGLT
MSMEG_0868|M.smegmatis_MC2_155      TGTATAGKGG--------------------EASNGGVAGNGGNALVMAAG
TH_3810|M.thermoresistible__bu      -GTPSAGFGV--------------------PTT---IQFPAGSCTSRAVS
MAB_4284c|M.abscessus_ATCC_199      ------------------------------HVGGGISESLGGSGSVGGST
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -------------------------------GGLGGFGGGHAPAPGGGLG
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          TNGANGANGSQ---------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       TNGANGANGSQ---------------------------------------
MMAR_3763|M.marinum_M               GNGGDGADGSISGPPQNGGKGGDGGGGGP---------------------
Rv3508|M.tuberculosis_H37Rv         NTGGTAGNAGIGGAGGRGGDGGAGDSGAL----SQDGNGFAGGQGGQGGV
MUL_4367|M.ulcerans_Agy99           ING-----------------------------------------------
Mb3541|M.bovis_AF2122/97            GTGGTGGSGGTGGDGGNGGNGGNGADNTANMTAQAGGDGGNGGDGGFGGG
MSMEG_0868|M.smegmatis_MC2_155      TTGVATGNTATG--------------------------------------
TH_3810|M.thermoresistible__bu      REGIMPSSRAAS--------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AVGGGAHTSAIN--------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                GGGGHAPAPGGG--------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ----GAAGKAGATGTTGATGAAGEDGDA----------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----GAAGKAGATGTTGATGAAGDAGDP----------------------
MMAR_3763|M.marinum_M               ---GGLGGQGGLSGDGSSTGAAGELGTF----------------------
Rv3508|M.tuberculosis_H37Rv         GGNAGAGGINGAGGTGGTGGAGGDGQNGTTG-------------------
MUL_4367|M.ulcerans_Agy99           -------GVGGAGGSGGLGGATEDG-------------------------
Mb3541|M.bovis_AF2122/97            AGAGGGGLTAGANGTGGQGGAGGDGGNGAIGGHGPLTDDPGGNGGTGGNG
MSMEG_0868|M.smegmatis_MC2_155      -------GDGGAATTAGATGGAGGFSNIAAIHG-----------------
TH_3810|M.thermoresistible__bu      -------ARAGAACASSTSRSRRSFCCSRA--------------------
MAB_4284c|M.abscessus_ATCC_199      ------DALGGSGSVGGSTAVGGGAHTSAIN-------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----LGGFGGGHSGGGLGGLGGGHK------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -------------------------------------GSGGSGINGGAG-
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------------------GSEAVDINGGAG-
MMAR_3763|M.marinum_M               -------------------------------------GNGGSGGNGGIGG
Rv3508|M.tuberculosis_H37Rv         -VASEGGAGGQGGDGGQGGIGGAGGNAGFGAGVPGDGGIGGTGGAGGAGG
MUL_4367|M.ulcerans_Agy99           --------------------------------------VGGVGCAGGAG-
Mb3541|M.bovis_AF2122/97            GTGGTGGAGIGSLGGGTGGDGGNGGTGGNGGTGGEGGEVGGAGGTGGAAG
MSMEG_0868|M.smegmatis_MC2_155      --------------------------AITDSTAISGHGGAGNGGNGGKGA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------------------------ESMNSSINASHS-
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ---------------------GAGGAG------------GEGGEGGDGGK
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------GAGGAG------------GEGGEGGAGGA
MMAR_3763|M.marinum_M               NATGFNAP-------------GTGGAG------------GNGGNGAFGGS
Rv3508|M.tuberculosis_H37Rv         AGADGDPS-IDGGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGA
MUL_4367|M.ulcerans_Agy99           ---------------------GNGGRGDMLFT-----------VGGSGGT
Mb3541|M.bovis_AF2122/97            NGGDGGTGGTGGGDGGAGGTGGTGGTGGLGDPRVGGSG-GDGGTGGSGGA
MSMEG_0868|M.smegmatis_MC2_155      DGWVQAYD-----------PAGPVGSKIANSSAVAGNGGDGGVNGTGGAS
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------------------------------SSMNESFGSS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GGAGAEGG--------AGGGGGAGGSGAGGAGGAGGSGG-----------
Mvan_1264|M.vanbaalenii_PYR-1       GGDGSEGG--------AGGSGGAGGSGTGGAGGAGGSGG-----------
MMAR_3763|M.marinum_M               GGTGGRGGSSSVGTGGAGGDGGDGGMGFGGIGGGGGTGGQGGSGVDAQGI
Rv3508|M.tuberculosis_H37Rv         GGNGGAGGLG-------GGGGTGGTNGNGGLGGGGGNGGAGGAGGTPTGS
MUL_4367|M.ulcerans_Agy99           GGDGGGGGSA-------SGSGTGGSGGTGGVGGIGGDGKLG---------
Mb3541|M.bovis_AF2122/97            AGNGGNGGNAG-----AGGNGNGGTGGAGGIGGTGGNGGDAEPGVPPGAG
MSMEG_0868|M.smegmatis_MC2_155      GGDGGNGGNTS--VWKSGGQTADGEHNTGGNGGNGGDGSEPGPG------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      MGSHGAAGTG----FEAQGHAQGHASETAHTTLPGAEHH-----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          ------------------------------------------------SG
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------------------SG
MMAR_3763|M.marinum_M               GGAGNGGVGGNGGDGGDGWDAPGGQGGKGGQGGNGGDGSPPVPPFGGSSG
Rv3508|M.tuberculosis_H37Rv         GTEGTGGDGGDAGAGGNGGSATGV-----------------------GNG
MUL_4367|M.ulcerans_Agy99           --------------------------------------------------
Mb3541|M.bovis_AF2122/97            GAGGAGTTGGKGGTGGNGSGTGSG-----------------------GTG
MSMEG_0868|M.smegmatis_MC2_155      ------------------------------------------------GN
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          GSGGSGGSGGAAGD--SDD-------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       GSGGAGGSGGAAGD--SD--------------------------------
MMAR_3763|M.marinum_M               GTGGTGGTGGAGGDRFVDTELVG--IGGAGHGGVTGGGPTGPALVDGGTG
Rv3508|M.tuberculosis_H37Rv         GNGGDGGNGGDGGNGAPGGFG-----GGAGAGGLGGSGAGGGTDGDDGNG
MUL_4367|M.ulcerans_Agy99           GFGGDGGDGGDGGFGVIGGQG-----GGGGFGGLGGTGAGG-APSDKGIN
Mb3541|M.bovis_AF2122/97            GDGGTGGGGGNGGTGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGGAG
MSMEG_0868|M.smegmatis_MC2_155      GAGGAGGNGGTGGTT----------AGGSGNGGNGGNGGNGGADGTPGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_5091|M.gilvum_PYR-GCK          -----------
Mvan_1264|M.vanbaalenii_PYR-1       -----------
MMAR_3763|M.marinum_M               GAGGSGGTGAH
Rv3508|M.tuberculosis_H37Rv         GSPGTDGS---
MUL_4367|M.ulcerans_Agy99           GEPGNPG----
Mb3541|M.bovis_AF2122/97            GKGGSGGV---
MSMEG_0868|M.smegmatis_MC2_155      GTTGANNP---
TH_3810|M.thermoresistible__bu      -----------
MAB_4284c|M.abscessus_ATCC_199      -----------
MLBr_01183|M.leprae_Br4923          -----------
MAV_4827|M.avium_104                -----------