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SFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSAAIAELFGGFGREYQAMGARVAL LHDDFVRALTAGGSAYGQAEALNMWPLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGI LWGNGGNGGLGAAGANGGAGGSAGLIGTGGVGGAGGVGAAGMTGGSGGAGGGGGWLWGAGGSGGAAGAGG SGGSGGWLWGNAGQTAGAGVGGAGGAGGAGDAGDQGVSGVAPGEAGAVGFAGGAGGAGGAGGNGVGGGVN GAGGAGGAGGVGGGGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGTGGTGGAAGVAGTGGDGGDGGAG GAGSDASLAGQAGFAGGSGGAGGVGGSAGAGGVNGSGGDGGAGAAGGAGGASATVAGSGGVGGDGGAGGA AGGGVGAASLGGDGGHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAGGTGGDSGGVGGVNGDGGAGGGGGR GGDGGSSTSTSGVGGAGGAGGNGGNAGFGVSAGGTGGSAGDGGAGGGAGGVDGVGGASGNGGAAGAGGAG GSGIGAGIDGGAGGAGGTGGAAGFPGGGGTTGAWGTGGAGGAGGAGGAGDHGGVGVNPGDSGTAGWAGGA GGAGGAGGSAAFNGVNGAGGAGGNGGAGGGGGAGASGIGAGVAGGDGGTGGTGGAAGTGGAAGTGGTGGA AGAAGSAGDGGAGGAGGAGDDGSAGVVSGDPGTAGKAGGAGGAGGVGGNGVAGGVNGSGGAGGAGGAGGT GGAGASGVPASVDGGDGGAGGAGGAAGTGGSGGSAGNTGAGGAGGAGGAGGSAASTGVNGDGGAGGAGGV GGLGGDSAATAGGGGAGGDGGKGGAGGAGVNGVGGGDGGKGGTGGAGGAGGAGSDGIIPSNGGLGGNGGN GGNGGQAFGDGVGGAGGIGGKGGNAAIGTIVINGGVGGAGGSGGLGGATEDGVGGVGCAGGAGGNGGRGD MLFTVGGSGGTGGDGGGGGSASGSGTGGSGGTGGVGGIGGDGKLGGFGGDGGDGGDGGFGVIGGQGGGGG FGGLGGTGAGGAPSDKGINGEPGNPG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_4367 | - | - | 100% (1077) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_0572 | - | 0.0 | 47.82% (918) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_3062 | - | 0.0 | 49.21% (884) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3538 | PE_PGRS54 | 0.0 | 49.77% (1302) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 47.42% (852) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3514 | PE_PGRS57 | 0.0 | 53.25% (1232) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 5e-13 | 40.22% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-60 | 37.04% (459) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_5294 | - | 0.0 | 71.60% (1081) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 4e-26 | 47.34% (169) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-161 | 40.57% (1092) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 4e-42 | 39.26% (326) | PUTATIVE - |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 49.54% (769) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mb3538|M.bovis_AF2122/97 MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGADEVSAR Rv3514|M.tuberculosis_H37Rv MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGADEVSAR MUL_4367|M.ulcerans_Agy99 MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSAA MMAR_5294|M.marinum_M MSFVSVAPSLLDAAARDLAGLGAGLREANLAAAGATMGVLPAAGDEVSAA TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -----------------------------------MHERLRERAGGVRKT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------MMFLAPPGGPGPISAA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------MSIIDFILNLFRDPVEAA MAV_4827|M.avium_104 --------------------------------MNIVLGVSMAPSSIQMVV Mb3538|M.bovis_AF2122/97 IAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEA------AA Rv3514|M.tuberculosis_H37Rv IAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEA------AA MUL_4367|M.ulcerans_Agy99 IAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALNMWPLQE MMAR_5294|M.marinum_M IAELFGGFGREYQAVGARMALLHDDFVRALTAGGSAYGQAEALNMWPLQE TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 LSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPESPLPDLKPRWERPTTA Mflv_5091|M.gilvum_PYR-GCK ---------------MVTFGGGATPTPTSLGAAAVDLSGTSCGLICNGQD Mvan_1264|M.vanbaalenii_PYR-1 IQLTSTGSEATEPWYVVSFGGSGAPTPNNLAASLVDLSGTSCGLICNGQD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNP MAV_4827|M.avium_104 LEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQ Mb3538|M.bovis_AF2122/97 AEQIVLGVINAPTQALLGRPLIGDGANATTPGG-AGGAGGLLFGNGGAGA Rv3514|M.tuberculosis_H37Rv AEQIVLGVINAPTQALLGRPLIGDGANATTPGG-AGGAGGLLFGNGGAGA MUL_4367|M.ulcerans_Agy99 LEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILWGNGGNGG MMAR_5294|M.marinum_M LEQQALGVVNAPSMALFGRPLIGNGVDGVAGTGQAGGAGGILWGNGGNGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PDSETPSITQPQ-----GRDTAADPAEQQATS--TNTTDQPTSDSLGAQP Mflv_5091|M.gilvum_PYR-GCK GTGQNGGILFGN-----GGSGWNSDVVGMDGG--NGGNGGLFGGNGGNGG Mvan_1264|M.vanbaalenii_PYR-1 GTGQNGGILFGN-----GGSGWNSEIAGVSGG--NGGNAGLFGGNGGNGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 IHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIAS MAV_4827|M.avium_104 LSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMG Mb3538|M.bovis_AF2122/97 AGAPGQAGGPGGPAGLWGNGGPGGAGGSGGGTGGAGGAGGWLFGVGGAGG Rv3514|M.tuberculosis_H37Rv AGAPGQAGGPGGPAGLWGNGGPGGAGGSGGGTGGAGGAGGWLFGVGGAGG MUL_4367|M.ulcerans_Agy99 LGAAGANGGAGGSAGLIGTGGVGGAGGVGA-------------------- MMAR_5294|M.marinum_M SGAAGANGGAGGSAGLIGTGGVGGAGGVGA-------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TAQVARQVQAPATDPAPAAPSLRPISGLLS-------------------- Mflv_5091|M.gilvum_PYR-GCK NGLGGGNGGNGGNAGAFALFGNGGNGGNGG-------------------- Mvan_1264|M.vanbaalenii_PYR-1 NGLGSGDGGNGGDAGLFSLFGRGGNGGNGG-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GNQVMSPSGNVDSFNRGPLLDLSFGDLQFGN------------------- MAV_4827|M.avium_104 YERTAVLLVEPDTATLAVVETSDGS------------------------- Mb3538|M.bovis_AF2122/97 VGGAGGGTGGAGGPGGLIWGGGGAGGVGGAGGGTGGAGG----------- Rv3514|M.tuberculosis_H37Rv VGGAGGGTGGAGGPGGLIWGGGGAGGVGGAGGGTGGAGG----------- MUL_4367|M.ulcerans_Agy99 -AGMTGGSGGAGGGGGWLWGAGGSG------------------------- MMAR_5294|M.marinum_M -VGMAGGSGGAGGSGGWLWGAGGAGGVGGAGGVGAGAGGIGGHGGAGGAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -VVTLGTTLIPNAPT----EPADMP------------------------- Mflv_5091|M.gilvum_PYR-GCK -VGVVGATGAVGAPG----VAGATG------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -VGIAGATGAVGAPG----VAGATG------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -RDTTAIGDGAVAVGGSNSGP----------------------------- MAV_4827|M.avium_104 IPDVYKQQIRAESYG----------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GVARSLLFGTGGAGGAGGVGGGGVAGVDSGTPGGAGGGGGVGGAGGAGGV TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 --------------------------------------RAELLFGAGGAG Rv3514|M.tuberculosis_H37Rv --------------------------------------RAELLFGAGGAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------G MMAR_5294|M.marinum_M GGGSRSLLFGAGGVGGEGASGGLGGGGGAGASGVGFDMAGGAGGDGGAGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------------GV Mflv_5091|M.gilvum_PYR-GCK ------------------------------------------------AT Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------------AT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------------IAS MAV_4827|M.avium_104 -----------------------------------------------DAA Mb3538|M.bovis_AF2122/97 GAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGAGGAGGQGGAGGAGSD Rv3514|M.tuberculosis_H37Rv GAG---TDGGPGATGGTGGHGGVGGDGGWLAPGGAGGAGGQGGAGGAGSD MUL_4367|M.ulcerans_Agy99 AAGAGGSGGSGGWLWGNAGQTAGAGVGGAGGAGGAGDAGDQGVSGVAPGE MMAR_5294|M.marinum_M AAGAGGAGGSGGWLWGNAGQTAGAGVGGAGGAGGAGGAGDHGVSSIAPGE TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 WAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDPTQIVNWLIYQ Mflv_5091|M.gilvum_PYR-GCK GVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAGAVGSAGAAGEAGET Mvan_1264|M.vanbaalenii_PYR-1 GVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAGAVGSAGTAGSAGAP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GQGSTAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADID MAV_4827|M.avium_104 GQLSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEP Mb3538|M.bovis_AF2122/97 GGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGGTGGAGGD Rv3514|M.tuberculosis_H37Rv GGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGGTGGAGGD MUL_4367|M.ulcerans_Agy99 AGAVGFAGGAGGAGGAGGNGVGGGVNGAGGAGGAGGVGGGGGAGASGVGA MMAR_5294|M.marinum_M AGAVGFAGGAGGAGGAGGNGVGGGVNGAGGVGGAGGAGGGGGAGASGVGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 P--LHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTADNPNGGTG Mflv_5091|M.gilvum_PYR-GCK G--TWGNAGLPGKAGDAGGAGAVGAAGAAGTVGTAGATGGTGTGANGGAG Mvan_1264|M.vanbaalenii_PYR-1 G--VWGNAGLPGAAGAAGGAGAIGTAGVAGAAGTAGATGGTGVGGNGGAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 KSVTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIGSHNQANIGTS MAV_4827|M.avium_104 ETALARGAALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVPVD Mb3538|M.bovis_AF2122/97 GVLGGVGGTGGKGGVGGVAGLGGAGGAAG--------------------- Rv3514|M.tuberculosis_H37Rv GVLGGVGGTGGKGGVGGVAGLGGAGGAAG--------------------- MUL_4367|M.ulcerans_Agy99 GVAGGDGGTGGAGGAAGVGGAAGTGGTG---------------------- MMAR_5294|M.marinum_M GVAGGDGGTGGAGGAAGVGGAAGSGGVGGAAGVAGTGGDGGAGGSGGASD TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GLLFGDGGHGYDGSAAGLAGGNGG-------------------------- Mflv_5091|M.gilvum_PYR-GCK -GVGGVGGTGAAG-AAGGAGGLGE-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -QAGGIGGTGAAG-AAGQAGTAGE-------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TSAGGSAAVGGNAGLAGNAGLAGN-------------------------- MAV_4827|M.avium_104 PEPGDDELAYSAVGEEDAES------------------------------ Mb3538|M.bovis_AF2122/97 ------------------------QLFSAGGAAGAVGVG----------- Rv3514|M.tuberculosis_H37Rv ------------------------QLFSASGAAGNAGVGGAGGQGGDGGA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M QGAAGVNPGEAGAVGFAGGAGGAGGAGGDSGAGGVNGSGGVGGAGGAGGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -----------------------------------------GTGGQGGAG Rv3514|M.tuberculosis_H37Rv GGAGADADQPGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGQGGAG MUL_4367|M.ulcerans_Agy99 --------------------------------------GAAGVAGTGGDG MMAR_5294|M.marinum_M GGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGSGGVGGAAGVAGTGGDG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------NAGLFGNGGNG Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------TGTTGGAGGVG Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------TGVTGGVGGIG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------AGLAGNAGLA MAV_4827|M.avium_104 ----------------------------------------PTVVIEKLFL Mb3538|M.bovis_AF2122/97 GMGGSGADNASG--------IGADGGAGGTGGNAGAGGAGGAAGTGGTGG Rv3514|M.tuberculosis_H37Rv GAGGAGADNPTG--------IGGTGGDGGTGGAAGAGGAGGAAGTGGTGG MUL_4367|M.ulcerans_Agy99 GDGGAGGAGSDASLAGQAGFAGGSGGAGGVGGSAGAGGVNGSGGDGGAGA MMAR_5294|M.marinum_M GDGGAGGAGSDASVAGQAGFAGGSGGAGGVGGSAGAGGVNGSGGDGGAGA TH_3810|M.thermoresistible__bu ----VDGD-------------GGSGGRTGLFSKLSRGGDGG--------- MSMEG_0868|M.smegmatis_MC2_155 GVGWAGLD-------------GGNGGSGGLLMGIGGAGGAGGVGADGTSA Mflv_5091|M.gilvum_PYR-GCK GQGTAGGT-------------GGVGGIGGAGSTGAVGGVGGKGIQGGQG- Mvan_1264|M.vanbaalenii_PYR-1 GQGTEGGT-------------GGVGGVGGVGATGGAGGVGGKGIQGGQG- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GNAGLAGN-------------AGLAGNAGLAGNAGLAGNAGLAGNAGLAG MAV_4827|M.avium_104 PEDSEPRR-------------RPVLLVGSGLAVVGISAVLALEIALAIG- Mb3538|M.bovis_AF2122/97 VVGAAG----KAGIGGTGGQGGAGGAGSAG--------------TDATAT Rv3514|M.tuberculosis_H37Rv MIGTTG----NAGVGGAGGQGGDGGAGGAG--------------ADADQP MUL_4367|M.ulcerans_Agy99 AGGAGGASATVAGSGGVGGDGGAGGAAG-----------------GGVGA MMAR_5294|M.marinum_M AGGAGGASATVAGSGGVGGDGGAGGAAG-----------------GGVGA TH_3810|M.thermoresistible__bu -------------DGGLGGNGGHGGGTG--------------------II MSMEG_0868|M.smegmatis_MC2_155 H-----------VDGGTGGTGGTGGGTGGTGGIGGTGGGLFGLLGHSGST Mflv_5091|M.gilvum_PYR-GCK ------------LQGGKGGDGGAGGKGG-----------------DADSM Mvan_1264|M.vanbaalenii_PYR-1 ------------LQGGQGGDGGTGGTGG-----------------DATSM MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------NAGLAGNAGLAGNAG--------------------LA MAV_4827|M.avium_104 --------------IRTTGTVALQPTPN-----------------QHLIV Mb3538|M.bovis_AF2122/97 GATGGTGFSGGAGGAGGAGG--NTGVGGTNGSGGQGGTGGAGGAGGAGGV Rv3514|M.tuberculosis_H37Rv GATGGTGFAGGAGGAGGAGG--SSGAGGTNGSGGAGGTGGQGGAGGAGGA MUL_4367|M.ulcerans_Agy99 ASLGGDGGHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAGGTGGD------ MMAR_5294|M.marinum_M AGLGGDGGHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAGGTGGD------ TH_3810|M.thermoresistible__bu SLLSLAG-NGGNGGNG---------YRTTDNNALDGGHGGNGG------- MSMEG_0868|M.smegmatis_MC2_155 GAAGAAG-NGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGG------- Mflv_5091|M.gilvum_PYR-GCK GSAGATGGKGGNGGNGGRGG--LFGKGGNAGNGADGGTGGAGG------- Mvan_1264|M.vanbaalenii_PYR-1 GEAGATGGKGGNGGNGGRGS--LFGRGGNAGNGGNGGTGGNGG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG------- MAV_4827|M.avium_104 PTEQAPAPPPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAP------ Mb3538|M.bovis_AF2122/97 GADNPTGIGGAGGTGGAGGTGGTGGAAGAGGAGGAVGTGGTGGVVGDVGN Rv3514|M.tuberculosis_H37Rv GADNPTGIG------GTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGN MUL_4367|M.ulcerans_Agy99 -------------------SGGVGGVNGDGGAGGGGGRGGDGGS------ MMAR_5294|M.marinum_M -------------------SGGVGGVNGDGGAGGGGGRGGDGGSSTTVAG TH_3810|M.thermoresistible__bu -------------------NVGFFSLFNLG--GAGGWGG--SGVDG---- MSMEG_0868|M.smegmatis_MC2_155 -------------------TGGQSTAAGPGKGGGGGGGG--GGAIL---- Mflv_5091|M.gilvum_PYR-GCK -------------------AGGTGGTGGAGGTGGTGGTGGIGGAGS---- Mvan_1264|M.vanbaalenii_PYR-1 -------------------NGGTGGTGGNGGTGGTGGTGGIGGAGS---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------NAGLAGNAAVAGNAAVAGNAAVAG------- MAV_4827|M.avium_104 -------------------PPAAPPLPEAPPIPAAPPVVPVPVVVP---- Mb3538|M.bovis_AF2122/97 AGIGG--------------------------------------------- Rv3514|M.tuberculosis_H37Rv AGVGG--------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M VGGAGGAGGAGGDSGMVAGAGGTGGQAGDGGFGGFGGAGIDGGGAAGARG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GDGGAGGVGGAAEATGTGGAGGSGGAAGGGGSGASAVGAGLAGGAGGDGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M IGGAAGAGGSGFVAGADGNGGFGGAGGAGGAGDQGVSGAAPGEAGAVGFA TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GGAGGAGGAGGNGVGGGVNGAGGVGGAGGAGGGGGAGASGVGAGVAGGDG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GAGGAGGAAGVGGAAGSGGVGGAAGVAGTGGDGGAGGSGGASDQGAAGVN TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M PGEAGAVGFAGGAGGAGGVGGDSGAGGVNGSGGVGGAGGAGGGGGAGASG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M VGAGVAGGDGGTGGAGGAAGVGGAAGTGGVGGAAGVAGTGGDGGAGGSGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M ASDQGAAGVNPGEAGAVGFAGGAGGAGGAGGDSGAGGVNGSGGVGGAGGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GGGGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGTGGVGGAAGVAGTG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GDGGAGGSGGASDQGAAGVNPGEAGTVGFAGGAGGAGGVGGDSGAGGVNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M SGGVGGAGGAGGGGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGSGGV TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GGAAGVAGTGGDGGDGGAGGAGSDASVAGQAGFAGGSGGAGGVGGSAGAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GVNGSGGDGGAGGTGGIGGASATTAGVGGAGGAGGAGGTTGGGVGAAGLG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------TGGKGG----------------AGG Rv3514|M.tuberculosis_H37Rv -------------------------AGGQGGDGGAGGAGADADQPGATGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GDGGHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAGGTGGDSGGVGGVNGD TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 TGFAGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQGGAGGAGGAGADNPTG Rv3514|M.tuberculosis_H37Rv TGFAGGAGGAGKAGGSSSAGGTNSSGSAGGTGRQSGTGGAGGAGADNPTG MUL_4367|M.ulcerans_Agy99 ---------------STSTSGVGGAGGAGGNGGNAGFGVS-------AGG MMAR_5294|M.marinum_M GGAGGIGGRGGDGGSSTSTSGVGGAGGAGGNGGNAGFGVG-------AGG TH_3810|M.thermoresistible__bu ---------------VDVVGGNPDGGTPGAHGESHTPGV--------YTD MSMEG_0868|M.smegmatis_MC2_155 ---------------IGANGGTVDGHAIGGNGGNGGNGS--------TTA Mflv_5091|M.gilvum_PYR-GCK ---------------TGGTGGTGGTGGTGGTGGTGGTGG--------TGG Mvan_1264|M.vanbaalenii_PYR-1 ---------------TGGTGGTGGTGGTGGTGGTGGTGG--------TGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------NAAVGGVLNTGVSGAIGGSSHVGG---------AI MAV_4827|M.avium_104 ---------------PVPVPVPVRIPVPDPVSPPQLLAP--------PRL Mb3538|M.bovis_AF2122/97 IGGAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSVGNAGIGGTGGTGGVG Rv3514|M.tuberculosis_H37Rv IGGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVG--------- MUL_4367|M.ulcerans_Agy99 TGGSAGDGGAG--------------------------------------- MMAR_5294|M.marinum_M TGGSAGDGGAGGFGGAGIDGSGAAGARGG--------------------- TH_3810|M.thermoresistible__bu RQGEDGEDGTG--------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 AGGNGGTGGTGRVIAEGTGSTAEGTATGG--------------------- Mflv_5091|M.gilvum_PYR-GCK TGGTGGKGGTG--------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGKGGTG--------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NESLGGSGSVG--------------------------------------- MAV_4827|M.avium_104 SVPQPVQPPVR--------------------------------------- Mb3538|M.bovis_AF2122/97 GAGGAGAAAAAGSSATGGAGFAGGAGGEGGAGGNSGVGGTNGSGGAGGAG Rv3514|M.tuberculosis_H37Rv -----------------------------GAGGSSGAGGTNGSGGAGGTD MUL_4367|M.ulcerans_Agy99 -------------------------------------GGAGGVDGVGGAS MMAR_5294|M.marinum_M ------------------------------DGGAGGGGGAGGVDGVGGAS TH_3810|M.thermoresistible__bu -------------------------------------TGIGGRG------ MSMEG_0868|M.smegmatis_MC2_155 ------------------------------DGGHSTGTGIGGNGGIGSVY Mflv_5091|M.gilvum_PYR-GCK --------------------------------GTGGAGGTGGDGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------GTGGDGGTGGTGGTGGTG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------GSTAVGGGAH MAV_4827|M.avium_104 ------------------------------------------------VP Mb3538|M.bovis_AF2122/97 GKGGTGGAGGSGADNPTGAGFAGGAGGTGGAAGAGGAG------------ Rv3514|M.tuberculosis_H37Rv GQGGAGGAGGAGADNPTGIGGTGGDGGTGGAAGAGGAG------------ MUL_4367|M.ulcerans_Agy99 GNGGAAGAGGAGGSG-IGAGIDGGAGGAGGTG------------------ MMAR_5294|M.marinum_M GNGGAAGAGGAGGSG-IGAGIDGGAGGDGGIG------------------ TH_3810|M.thermoresistible__bu --GNGGSSSGTHPMAEDGEHVKALDGRPG--------------------- MSMEG_0868|M.smegmatis_MC2_155 AYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGD Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTGGTGGAGDGTGGTGGTGG--------------------- Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTGGTGGAGDGLGGTGGTGG--------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TGVGGGVSTGVGVGSHVGGGISESLGGSG--------------------- MAV_4827|M.avium_104 QPPSPPQVGGTVPQSPPQHQTPPGEGTPP--------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 ---------------------------------------------GATGT Rv3514|M.tuberculosis_H37Rv ---------------------------------------------GAAGT MUL_4367|M.ulcerans_Agy99 ------------------------------------------------GA MMAR_5294|M.marinum_M ------------------------------------------------GA TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGS Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GGTGGVVGATGSAGIGGAGGRGGDGGDGASGLG------LGLSGFDGGQG Rv3514|M.tuberculosis_H37Rv GGTGGMIGTTGNAGVGGAGGQGGDGGAGGAGADADQPGATGGTGFAGGAG MUL_4367|M.ulcerans_Agy99 AGFPGGGGTTGAWGTGGAGGAGGAGGAGDHGGVGVNPGDSGTAGWAGGAG MMAR_5294|M.marinum_M AGFPGGGGTTGAWGTGGAGGAGGSGGAGDHGGVGVNPGDSGTAGWAGGAG TH_3810|M.thermoresistible__bu -------------LDGGNGSHGGN----------------------GGHG MSMEG_0868|M.smegmatis_MC2_155 ITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNG Mflv_5091|M.gilvum_PYR-GCK --------------TGGQGGQGGQG-------------------GTGGTG Mvan_1264|M.vanbaalenii_PYR-1 --------------TGGFGGQGGQG-------------------GTGGTG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------SVGGSTAVGGG--------------------AHTGVG MAV_4827|M.avium_104 -------------KPDGPGNYGGGHVP------------------TPGAG Mb3538|M.bovis_AF2122/97 GQGGDGGSAGAGGINGAGGAGGDGGDGGDGATGAAG-LGDNGGVG----- Rv3514|M.tuberculosis_H37Rv GAGGSGGSSCAGGTNGSGGAGGTCGQVVAGGAGISFSNGSNGGTG----- MUL_4367|M.ulcerans_Agy99 GAGGAGGSAAFNGVNGAG-------------------------------- MMAR_5294|M.marinum_M GAGGAGGSAAVNGVNGAG-------------------------------- TH_3810|M.thermoresistible__bu GRGGFLGIG----------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGT Mflv_5091|M.gilvum_PYR-GCK GQGGLGGGG----------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GQGGLGGVG----------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGVSTG-------------------------------------------- MAV_4827|M.avium_104 GSGGSGGGHVP--------------------------------------- Mb3538|M.bovis_AF2122/97 ----GDGGAGGAAGNGGNAGVGLTAKAGDGGAAGNGGNGGAGGAGGAGDN Rv3514|M.tuberculosis_H37Rv ----GTGGVGGTGGDGGNAGTG-AGDPGKGGTGGTGGTGGSGGAGGSGGA MUL_4367|M.ulcerans_Agy99 ----GAGGNGGAGGGGGAGASG-IGAGVAGGDGGTGGTGGAAGTGGAA-- MMAR_5294|M.marinum_M ----GAGGNGGAGGGGGAGASG-IGAGVAGGDGGTGGTGGAAGTGGAA-- TH_3810|M.thermoresistible__bu ----GSGGWGGHGGNGGD-------TDADGGNGGDGGNGGSAGRGGTG-- MSMEG_0868|M.smegmatis_MC2_155 FVNAGANGNGGAGGAGGV-------SEGEGGTGGHGGDGGRGGDGALG-- Mflv_5091|M.gilvum_PYR-GCK ----GTGGQGGTGGTGGQGG-----TGGTGGTGGTGGTGGAGGDGGLG-- Mvan_1264|M.vanbaalenii_PYR-1 ----GTGGTGGTGGTGGQGG-----TGGTGGTGGTGGTGGAGGDGGLG-- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------VGVGSHVGGGISES-----LGGSGSVGGSTAVGGGAHTGVGG-- MAV_4827|M.avium_104 -----TPGAGGSGGSGGG-------HVPTPGTGGPGGTGGSGGGHVPTP- Mb3538|M.bovis_AF2122/97 NFNGGQGGAGGQGGQGGLG------------------------------- Rv3514|M.tuberculosis_H37Rv NFNGGTGGTGGTGGKGGLN------------------------------- MUL_4367|M.ulcerans_Agy99 ----GTGGTGGAAGAAG--------------------------------- MMAR_5294|M.marinum_M ----GTGGTGGAAGAAG--------------------------------- TH_3810|M.thermoresistible__bu ----GLRGVFGINGGNG--------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ----GNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAG Mflv_5091|M.gilvum_PYR-GCK ----GLGGFGGSGGTGG--------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----GLGGFGGVGGTGG--------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----GVNTGVGVGSHVG--------------------------------- MAV_4827|M.avium_104 ----GAGTPGGSGG------------------------------------ Mb3538|M.bovis_AF2122/97 -----------GASTTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGT Rv3514|M.tuberculosis_H37Rv -----------TDGLSSATS--GTGGTGGTGGKGGTGGAGDDSAGGTGGT MUL_4367|M.ulcerans_Agy99 --------------------------SAGDGGAGGAGG------------ MMAR_5294|M.marinum_M --------------------------TAGDGGAGGAGG------------ TH_3810|M.thermoresistible__bu -----------------------------RAGLGGRGX------------ MSMEG_0868|M.smegmatis_MC2_155 RIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSN Mflv_5091|M.gilvum_PYR-GCK -----------------------------QGGLGGPGG------------ Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------QGGQGGPGG------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------GGISESLGGSGS------------ MAV_4827|M.avium_104 ----------------------------GHLPFPGAGS------------ Mb3538|M.bovis_AF2122/97 GGDGGDAGAGGGGGFGG----------------------AAGKAGGGGNG Rv3514|M.tuberculosis_H37Rv GGAGGNAGAGGLANTGG----------------------TAGNAGIGGDG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GVGGDGGEGATGLGLD-LSGFAGGQGGQGGAGGNAGAGGING-AGGTGGT Rv3514|M.tuberculosis_H37Rv GQGGNGGQGDSGSGLGGQPGFAGGAGGKGGAGGSSGAGGTNG-SGGAGGA MUL_4367|M.ulcerans_Agy99 -----AGDDGSAGVVSGDPGTAGKAGGAGG-AGGVGGNGVAGGVNGSGGA MMAR_5294|M.marinum_M -----AGDDGSAGVVSGDPGTAGKAGGAGG-AGGAGGNGVAGGANGSGGA TH_3810|M.thermoresistible__bu ---------------------XXXGGGVG--AAVRSGNGVFS---GGGGT MSMEG_0868|M.smegmatis_MC2_155 SGINGGHGGNGGQGTIEANGPSAVASGIG--AGGNGGDGIDG---GLGGN Mflv_5091|M.gilvum_PYR-GCK --------------------STGGAGGAGGQAGTAGKGGLFG---GSGSA Mvan_1264|M.vanbaalenii_PYR-1 --------------------STGGAGGAGGQAGVAGKGGLFG---GSGSA MLBr_01183|M.leprae_Br4923 ---------------------MPLFLNAEPQALTAAANTLEG--LSAATV MAB_4284c|M.abscessus_ATCC_199 ---------------------VGGSTAVGGGAHTSAINDALGGSGSVGGS MAV_4827|M.avium_104 -----------------------TPGGSGGGHLPTPGAGTPG-----GGL . . Mb3538|M.bovis_AF2122/97 GGAGGDG-APATLIGGPDGGDGGQGGIG---GDGGNAGFGAGVPGDGGIG Rv3514|M.tuberculosis_H37Rv GGQGGAGGAGISFSNGSNGGTGGTGGVGGTGGDGGNAGTGAGDPGKGGTG MUL_4367|M.ulcerans_Agy99 GGAGGAGGTGGAGASGVPASVDGGDGGAGGAG------GAAGTGGSGGSA MMAR_5294|M.marinum_M GGAGGAGGTGGAGASGVPASVAGGDGGAGGAGGAAGSGGAAGTGGSGGSA TH_3810|M.thermoresistible__bu PSAGFGVPTTIQFPAGSCTSRAVSREG----------------------- MSMEG_0868|M.smegmatis_MC2_155 GGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYG Mflv_5091|M.gilvum_PYR-GCK GKAGATGAAGASGGKGAQGATGAQGATG---------------------- Mvan_1264|M.vanbaalenii_PYR-1 GTAGVTGASGASGGKGAQGATGAQGATG---------------------- MLBr_01183|M.leprae_Br4923 ASNAAAAQLTTEIAPPAADDVSILLAHF---------------------- MAB_4284c|M.abscessus_ATCC_199 TAVGGGAHTSAINESMNSSINASHSSSMN--------------------- MAV_4827|M.avium_104 GGFGGGHAPAPGGGLGGGGGHAPAPGGG---------------------- . Mb3538|M.bovis_AF2122/97 GTGGAGGAGGAGGAGDAGADGDPSIDGGQGGAGGHGGQGGKGGLNSTGLA Rv3514|M.tuberculosis_H37Rv GTGGTGGSGGAGGSGGANFNG------GTGGTGGTGGTGGKGGMGGIAGD MUL_4367|M.ulcerans_Agy99 GNTGAGGAGG---------------------------------AGGAGGS MMAR_5294|M.marinum_M GNTGAGGAGGDGGVGGA--------GGNAEGPGLFGYDGGMGGAGGAGGS TH_3810|M.thermoresistible__bu ------------------------------------------------IM MSMEG_0868|M.smegmatis_MC2_155 STLGGNATGTATAGKGG--------EASNGGVAGNGGNALVMAAGTTGVA Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------------AQGA Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------------AQGA MLBr_01183|M.leprae_Br4923 ----------------------------------------------FSGH MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------------ESF MAV_4827|M.avium_104 -------------------------------------------------L Mb3538|M.bovis_AF2122/97 SAASGDGGNGGAGGAGGNGGDGDGFIGGSGGTGGTGGDAGAGG------- Rv3514|M.tuberculosis_H37Rv GGPGGDGGNAGVGGKGGTNGNGG--SGGTGGTGGAGGNAGAGG------- MUL_4367|M.ulcerans_Agy99 AASTGVNGDGGAGGAGGVGGLGGD-SAATAGGGGAGGDG----------- MMAR_5294|M.marinum_M AGSTGVNGDGGAGGAGGVGGLGGD-SAATAGGGGAGGDGGAGGAAGAGAG TH_3810|M.thermoresistible__bu PSSRAASARAGAACASSTSRSRRS-FCCSRA------------------- MSMEG_0868|M.smegmatis_MC2_155 TGNTATGGDGGAATTAGATGGAGG-FSNIAAIHGAITDS----------- Mflv_5091|M.gilvum_PYR-GCK TGATGAAGKAGATGAAGAAGAAGS-AGTTGAQGSAGTN------------ Mvan_1264|M.vanbaalenii_PYR-1 TGATGASGAQGSAGSAGSAGVAGS-AGTTGAQGSAGTN------------ MLBr_01183|M.leprae_Br4923 GRQYQAHASQGATNHQDLIQSLLTSSSAYAGTETANHDSL---------- MAB_4284c|M.abscessus_ATCC_199 GSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH------------ MAV_4827|M.avium_104 GGFGGGHSGGGLGGLGGGHK------------------------------ . * Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M IAGSAGDGGHAGAGGAGGAGLSGGFNTGAAGGIGGAGGAGGTGGDSGGVG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GVNGDGGAGGIGGHGGDGGSSTSTPGVGGAGGAGGDGGSAGIGVGVAGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GDAGAGGAGGSGGAGIDGSAATGAHGGAGGSGGVGGQATNSAGVGGDGGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GGAGGNGGAGANGTASPGVPGPGAGGDAGAGGNGGAGGGSGARNGDGGDG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3514|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5294|M.marinum_M GVGGRGGDGHIHPGGSRINGGDGGVGGAAGLAGVNGASAAGNAGHGGDGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 ----------------------------LANTGGTAGNAGIGGAGGRGGD Rv3514|M.tuberculosis_H37Rv ----------------------------LANTGGTAGNAGIGGDGGQGGN MUL_4367|M.ulcerans_Agy99 ------------------------------GKGGAGGAGVNGVGGGDGGK MMAR_5294|M.marinum_M AGGNGSVGAAGADGVGAGATGGFGSQGGDGGKGGAGGAGVNGVGGGDGGK TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------TAISGHGGAGNGGN Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------GANGAN Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------GANGAN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GGAGDSGALSQDGNGFAGGQGGQGGAGGNAGAGGING--AGGTGGTGGAG Rv3514|M.tuberculosis_H37Rv GGQGDSGSGLGGQPGFAGGPGGKGGAGGNAGTGGTNGSGAGGAGGQGGAG MUL_4367|M.ulcerans_Agy99 GG---TGGAGGAGGAGSDGIIPSNGGLG---------------------- MMAR_5294|M.marinum_M GGSGGTGGAGGAGGAGSDGILPSNGGLGGLGGSGGLGGAGGAGTDGGASG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGKGADGWVQAYDPAGPVGSKIAN-------------------------- Mflv_5091|M.gilvum_PYR-GCK GSQGAAGKAGATGTTGATG------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GSQGAAGKAGATGTTGATG------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GDGAPAT-----LIGGPD--GGDGGQGGGAGFGSGVAGAAGAGGNGGKGG Rv3514|M.tuberculosis_H37Rv GAGISFSNGSNGGTGGTGGVGGTGGDGGNAGTGAGDPGKGGTGGTGGTGG MUL_4367|M.ulcerans_Agy99 ----------------------------GNGGNGGNGGQAFGDGVGGAGG MMAR_5294|M.marinum_M ATGTYGNGGTGGAGGAGGNATGGAGEGGGLGGNGGTGGQAFGDGVGGAGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------SSAVAGNGGDGG Mflv_5091|M.gilvum_PYR-GCK -----------------------------------------AAGEDGDAG Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------------AAGDAGDPG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 DGGTGGTGGTNFAGGQGGAGGRGGAGGNGANGVGDNAAGGDGGNGGAGGL Rv3514|M.tuberculosis_H37Rv SGGAGGSGGANFNGGTGGTGGTGGTGGKGGMGG----IAGDGGPGGDGGN MUL_4367|M.ulcerans_Agy99 IGGKGGNAAIGTIVINGGVGGAGGSGGLGGATE--DGVGGVGCAGGAGGN MMAR_5294|M.marinum_M IGGKGGNAAIGTLVVNGGVGGAGGSGGLGGATE--NGVGGVGGAGGAGGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 VNGTGG--------ASGGDGGNGGNTSVWKSGG--QTADGEHNTGGNGGN Mflv_5091|M.gilvum_PYR-GCK SGGSG---------INGGAGGAGG-------------AGGEGGEGGDGGK Mvan_1264|M.vanbaalenii_PYR-1 SEAVD---------INGGAGGAGG-------------AGGEGGEGGAGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GGGGGTGGTNGNGGLGGGGGNGGAGGAGGTPTGSGTEGTGGDGGDAGAGG Rv3514|M.tuberculosis_H37Rv AGVGGKGGTNGNGGSGGTGGTGGPGGSGGAPTGSGTGGKGGAGGDGGDGA MUL_4367|M.ulcerans_Agy99 GGRGDM-----LFTVGGSGGTGGDGGGGGSASGSGTGGSGGTGGVGGIGG MMAR_5294|M.marinum_M GGRGDT-----LFTAGGSGGTGGHGGGGGSASGSGTGGSGGTGGVGGIGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGDG---------SEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGG Mflv_5091|M.gilvum_PYR-GCK GGAG---------AEGGAGGGGGAGGSGAGGAG-------GAGGSGGSGG Mvan_1264|M.vanbaalenii_PYR-1 GGDG---------SEGGAGGSGGAGGSGTGGAG-------GAGGSGGSGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 NGGSATGVGNGGNGGDGGNGGDGGN--GAPGGFGGGAGAGGLGGSGAGGG Rv3514|M.tuberculosis_H37Rv DGGAATGVGDGGDGGNGGNGGNGGTGVGSPGGLGGAGGTGGLGGAGAGGG MUL_4367|M.ulcerans_Agy99 DGK------LGGFGGDGGDGGDGGFGVIGGQGGGGGFGGLGGTGAGGAPS MMAR_5294|M.marinum_M DGK------VGGSGGDGGDGGDGGSGVIGGQGGGGGIGGFGGTGAGGAPS TH_3810|M.thermoresistible__bu -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGG------ADGTPGTAGTTGANNP------------------------- Mflv_5091|M.gilvum_PYR-GCK SGG------SGGSGGAAGDSDD---------------------------- Mvan_1264|M.vanbaalenii_PYR-1 SGG------AGGSGGAAGDSD----------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 TDGDDGNGGSPGTDGS Rv3514|M.tuberculosis_H37Rv ADGDDGDDGQPGNNGS MUL_4367|M.ulcerans_Agy99 DKGINGEPGNPG---- MMAR_5294|M.marinum_M DNGTNGEPGNPG---- TH_3810|M.thermoresistible__bu ---------------- MSMEG_0868|M.smegmatis_MC2_155 ---------------- Mflv_5091|M.gilvum_PYR-GCK ---------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------------- MLBr_01183|M.leprae_Br4923 ---------------- MAB_4284c|M.abscessus_ATCC_199 ---------------- MAV_4827|M.avium_104 ----------------