For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
GRLLHSLSTAFLVFVAVVVLCVSTSMPTAAHLLLNHPHALVIGGTGTPVPPPEYVNGQTDNYIGAEFPGE YRYAVHTPQNFWPVYGSMSFDESTVAGLAALQAEMAKEGHFGSPLVILGYSSSTRILTADKNRRIADGDY AVDINYVLVSDVAKGNGGVMARFPGWHIPILGVTFDGATRTDSDGYAFDTKSISFVHDGWSDFPVYPLNV LALANAVAGIAVLHPTYPELDRPDLVPVGSTGDTEYFVIGTDIMPLLMPLETIGVPRPILLAVDEPLRVL VEAGYRRDIAPGAPTPARLIPIVNPITLTRNFIAAIPVGVDDAMEELGHGRPLGTQPSGVFGVGGEDTEL KGLPAGVISLAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPVVEDEPAVEDETPVADTKKASPKPLRPKV RGPISFDAPKLPTIRKATGDRPLKRLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPAARADDAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5455 | - | - | 100% (487) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_4734 | - | 2e-50 | 31.51% (568) | hypothetical protein MSMEG_4734 |
| M. smegmatis MC2 155 | MSMEG_2737 | - | 7e-30 | 27.30% (575) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 5e-42 | 32.65% (392) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 8e-57 | 36.56% (424) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv1430 | PE16 | 5e-42 | 32.65% (392) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 4e-07 | 29.46% (129) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 1e-28 | 27.13% (527) | PE/PPE family protein |
| M. marinum M | MMAR_0384 | - | 3e-41 | 34.09% (308) | PE family protein, PE4 |
| M. avium 104 | MAV_1760 | - | 4e-10 | 26.69% (311) | hypothetical protein MAV_1760 |
| M. thermoresistible (build 8) | TH_4029 | - | 5e-72 | 36.15% (509) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 2e-40 | 33.77% (308) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4815 | - | 2e-54 | 31.68% (524) | hypothetical protein Mvan_4815 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1465|M.bovis_AF2122/97 -----MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAAD
Rv1430|M.tuberculosis_H37Rv -----MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAAD
MMAR_0384|M.marinum_M -----MSYVLTAPDLLASAATDVDGIAATLQVANSAAAAPTSGLLAAAQD
MUL_1034|M.ulcerans_Agy99 -----MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQD
MSMEG_5455|M.smegmatis_MC2_155 ----------------------MGRLLHSLSTAF---------------L
TH_4029|M.thermoresistible__bu --------------------------VRSAVLVG---------------C
Mflv_1918|M.gilvum_PYR-GCK MGKGDFGLKASEFTGRSSTRFADSVRRRPGGATYGLYRHDGLGVGTWAWV
Mvan_4815|M.vanbaalenii_PYR-1 ----------------------MRLIIRPLAALF---------------L
MLBr_01232|M.leprae_Br4923 ----------------------MKRLLATTLAALTVG------------T
MAV_1760|M.avium_104 ----------------------MKQLLAGVTALLSVS------------T
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1465|M.bovis_AF2122/97 EVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANA
Rv1430|M.tuberculosis_H37Rv EVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANA
MMAR_0384|M.marinum_M EVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAEAANA
MUL_1034|M.ulcerans_Agy99 EVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAEAANA
MSMEG_5455|M.smegmatis_MC2_155 VFVAVVVLCVSTS-------MPTAAHLLLNHPHALVIGGTGTPVPPPE--
TH_4029|M.thermoresistible__bu VLTTVLALAWVSP-------MPAMVQVLAKT--MLVIGGTGHPLVDPSGP
Mflv_1918|M.gilvum_PYR-GCK FARSSRSFPRSRRCWRYPRGVPTPVAVLVANTTALVMGGTFHPLTGPRDS
Mvan_4815|M.vanbaalenii_PYR-1 VLASVAALPLS---WTLSG----VVVALTSNTTALIMGGSFHPLAEPADA
MLBr_01232|M.leprae_Br4923 VSGFGSTVASSEPGEPWLPPSPVPVRENSPAKIVYALGGARPPTFDWD--
MAV_1760|M.avium_104 AGYFGIGTAAADGGPIGGPPTPGAPGD----QTAYALGGAHVLGIPYD--
MAB_4141|M.abscessus_ATCC_1997 -MAGQYSVPGKRHSLRRYVATITAVAATCTVLAPLAMESRTIASTLAS--
.
Mb1465|M.bovis_AF2122/97 ALVDTAAT--------------GASELGSGGR------------------
Rv1430|M.tuberculosis_H37Rv ALVDTAAT--------------GASELGSGGR------------------
MMAR_0384|M.marinum_M SLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPV
MUL_1034|M.ulcerans_Agy99 SLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPV
MSMEG_5455|M.smegmatis_MC2_155 --------------------------------------------------
TH_4029|M.thermoresistible__bu GRPVDGWPYPSRPLGEPGMATEGDGAP-----------------------
Mflv_1918|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4815|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1465|M.bovis_AF2122/97 TALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWT--
Rv1430|M.tuberculosis_H37Rv TALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWT--
MMAR_0384|M.marinum_M VALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQALFTPEQFWPVTP-
MUL_1034|M.ulcerans_Agy99 VALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQALFTPEQFWPVTP-
MSMEG_5455|M.smegmatis_MC2_155 -------YVNGQTDNYIGAEFPGEYRY---------AVHTPQNFWPVYG-
TH_4029|M.thermoresistible__bu -----AGYVLLVHDNFVVPGGTDGHRYR------AVAVYTPQEFFPVAG-
Mflv_1918|M.gilvum_PYR-GCK -----PEFVTAYLDNAVDNQISAAYGYA---VTNAVAVYTPEEFFPLG--
Mvan_4815|M.vanbaalenii_PYR-1 -----PPFVTAYLDNAVTGHLDPAFADASGPVTNAVAVYTPEQFFPIG--
MLBr_01232|M.leprae_Br4923 ------YYTIRAGDEFFPDVNRKLIDYP----ARAPFRYVPTFLVPGP--
MAV_1760|M.avium_104 ------QYIRMEGADWFPGQQRQIVRYP----AGQVQGHVLERLFPGIGK
MAB_4141|M.abscessus_ATCC_1997 -------YVIGIGGNNDGASANIPRKLGGAYSVDYHPVSYPGAIWPVSG-
: *
Mb1465|M.bovis_AF2122/97 --------GIPSLTYDQSVAEGAGYLHTAIMQQVA---------------
Rv1430|M.tuberculosis_H37Rv --------GIPSLTYDQSVAEGAGYLHTAIMQQVA---------------
MMAR_0384|M.marinum_M --------GLGNLTFNQSVAQGVTLLNDAINTQLA---------------
MUL_1034|M.ulcerans_Agy99 --------GLGNLTFNQSVAQGVTLLNDAINTQLA---------------
MSMEG_5455|M.smegmatis_MC2_155 -----------SMSFDESTVAGLA-ALQAEMAKEG---------------
TH_4029|M.thermoresistible__bu -----------SRTFNDSVTDGFANTVNCAHSSAGCIAHIYPDTDVGLTD
Mflv_1918|M.gilvum_PYR-GCK -----------GLTFDDSVAEGLANLGRCLRAEPGCVFNADPAVAARV-G
Mvan_4815|M.vanbaalenii_PYR-1 -----------QLTFARSVAEGLVNLHRCLGAETDCVFNDDPAIRP---H
MLBr_01232|M.leprae_Br4923 ---------RDEVTIGEAIAVATKNLNQAIHRGTE---------------
MAV_1760|M.avium_104 LDESFPGLGMDGPSVGESVAEGIDNLDAAIRTTGR---------------
MAB_4141|M.abscessus_ATCC_1997 ---------LTAPTFKTSVAQGRTNLNDEIVTAGN---------------
: : . .
Mb1465|M.bovis_AF2122/97 -----AGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGN
Rv1430|M.tuberculosis_H37Rv -----AGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGN
MMAR_0384|M.marinum_M -----LGNKVVAFGYSQSATIVNNEILALMAMGTG-APDPGDLSFIMVGA
MUL_1034|M.ulcerans_Agy99 -----LGNKVVAFGYSQSATIVNNEILALMAMGTG-APDPGDLSFIMVGA
MSMEG_5455|M.smegmatis_MC2_155 ----HFGSPLVILGYSSSTRILTADKNRRIADGD----YAVDINYVLVSD
TH_4029|M.thermoresistible__bu PVADDDGSGVVVVGYSQSAVIASLVKQHLLDNPD----RAPGTSFVLLGN
Mflv_1918|M.gilvum_PYR-GCK TVAPRHDDTFVVFGYSQSAAVASLLKRQLIDAPGP---EPAATTFMLAAN
Mvan_4815|M.vanbaalenii_PYR-1 AVAPRAGDAMMAFGYSQSAVIASLAKLDLIQRYQP---GDPSVSFMLVAN
MLBr_01232|M.leprae_Br4923 --------PAAVVGLSQGSLALDTEQEQLATDPTAP--PPDQLTFNTFGD
MAV_1760|M.avium_104 --------PGTAIGLSEGAFVVDGEQARLANDPTAP--PPNTLNFATFGD
MAB_4141|M.abscessus_ATCC_1997 -------QPITIVGYSLGAVVVSKSHSDLLQRYPG---GNPNIQFVLMGS
.* * .: : .
Mb1465|M.bovis_AF2122/97 PNNPNGG----ILARFP-GLYLQSLGLTFNGATPDTD---------YATT
Rv1430|M.tuberculosis_H37Rv PNNPNGG----ILARFP-GLYLQSLGLTFNGATPDTD---------YATT
MMAR_0384|M.marinum_M PNNPDGG----LLARFP-GFYIPFLDVSFNGATPAANP--------YPTS
MUL_1034|M.ulcerans_Agy99 PNNPDGG----LLARFP-GFYIPFLDVSFNGATPAANP--------YPTS
MSMEG_5455|M.smegmatis_MC2_155 VAKGNGG----VMARFP-GWHIPILGVTFDGATRTDS-----DGYAFDTK
TH_4029|M.thermoresistible__bu PMRPNGG----LLQRLPRGMTIPILDVTAFGPTPTNSCDEQGENCAHPTL
Mflv_1918|M.gilvum_PYR-GCK PMRPNGG----VLGRFP-ALTIPILGITFHGATPTAG---VDG--AYRTV
Mvan_4815|M.vanbaalenii_PYR-1 PMRPNGG----ILMRLHGWPTIPILEIPFPGASPTDSAVLPDGRHVYPTV
MLBr_01232|M.leprae_Br4923 PSGYHGFGKSVLASIFRPGDYIPLIDYTMPQRMDSQYD----------SN
MAV_1760|M.avium_104 PIGRHAFGQSFLTAMFGVGSVVPALDYTMPPPYESQYD----------TN
MAB_4141|M.abscessus_ATCC_1997 ANTPNGG----IFARFP-WLKIPLADIESNGAWEPDQ---------FKTK
.. : : : :
Mb1465|M.bovis_AF2122/97 IYTTQYDGFA-DFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIV
Rv1430|M.tuberculosis_H37Rv IYTTQYDGFA-DFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIV
MMAR_0384|M.marinum_M IFTAQYDGIA-HAPQYPLNILSDINAIMGYFYVHGNYPDLMSGQAIQ---
MUL_1034|M.ulcerans_Agy99 IFTAQYDGIA-HAPQYRLNILSDINAIMGYFYVHGNYPDLMSGQAIQ---
MSMEG_5455|M.smegmatis_MC2_155 SISFVHDGWS-DFPVYPLNVLALANAVAGIAVLHPTYPELDRPDLVP---
TH_4029|M.thermoresistible__bu DVAVQHDALGGDFPIYPLHLPAVANSLLSYALLHGTMPEQHLDDAVP---
Mflv_1918|M.gilvum_PYR-GCK DVVRQYDGLGGDFPVRPLNLLATVNALLGYGIMHGETVDVPFAQARF---
Mvan_4815|M.vanbaalenii_PYR-1 DVARQYDGLGGDFPVRPLNLVATVNALLGYALLHGSAVDIPLAQARF---
MLBr_01232|M.leprae_Br4923 RVVAAYDGLS-EFPDRADNLLAQLNCFAGGAISHTPSGFFNPEDVPPQNI
MAV_1760|M.avium_104 RFVAAYDSIA-DFPDRPDNMFALANTLMGLATGHTAVAFTNPSMVPPQNI
MAB_4141|M.abscessus_ATCC_1997 VINTEYDTYG-DFPAY-FNPLALANSIAAIQYAHPDAYYDRIDPAALDDP
:* . . * : : * . . *
Mb1465|M.bovis_AF2122/97 --LPVSSPDT-NTTYILLPNEDLPLLQPLRGI----VPEPLLDLIEPDLR
Rv1430|M.tuberculosis_H37Rv --LPVSSPDT-NTTYILLPNEDLPLLQPLRGI----VPEPLLDLIEPDLR
MMAR_0384|M.marinum_M --LPTSPGYTGNTDYYMYLTQDLPLVQPIRDIPY--AGPPLADLIQPQLR
MUL_1034|M.ulcerans_Agy99 --LPTSPGYTGNTDYYMYLTQDLPLVQPIRDIPY--AGPPLADLIQPQLR
MSMEG_5455|M.smegmatis_MC2_155 ------VGSTGDTEYFVIGTDIMPLLMPLETIG---VPRPILLAVDEPLR
TH_4029|M.thermoresistible__bu ------QGVHGDTTYYLLPTDLVPLLMPFEGV----VPRPILVALDEPLR
Mflv_1918|M.gilvum_PYR-GCK ------QGREGDTDYYLIGTDLLPLLQPLLLF----VPRPILSALDAPLR
Mvan_4815|M.vanbaalenii_PYR-1 ------QGRQGDTGYYLVETDLVPLLQPFAFF----VPRPILKAIDAPLR
MLBr_01232|M.leprae_Br4923 --RTTVNSRGAKTTTYLIPVNHLPLTLPLRYLG---WSDALVDQIDAVLQ
MAV_1760|M.avium_104 --RTTINSRGAKDTTIMIPEKHLPLVMPLKYIG---IDENTLNKLDAILT
MAB_4141|M.abscessus_ATCC_1997 DNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDLTNPIGASFVLDAIEPTLR
. : . :** *: . :: *
Mb1465|M.bovis_AF2122/97 AIIELGYDRTG----YADVPTPAALFPVHIDPIAVPPQIGAAIGGPLTAL
Rv1430|M.tuberculosis_H37Rv AIIELGYDRTG----YADVPTPAALFPVHIDPIAVPPQIGAAIGGPLTAL
MMAR_0384|M.marinum_M VLVDLGYSDYGPGLSYADVPTPAGLLSVP-NPFAVSYYL---LKGSLQAP
MUL_1034|M.ulcerans_Agy99 VLVDLGYSDYGPGLSYADVPTPAGLLSVP-NPFAVSYYL---LKGSLQAP
MSMEG_5455|M.smegmatis_MC2_155 VLVEAGYRRDIA----PGAPTPARLIPIV-NPITLTRNFIAAIPVGVDDA
TH_4029|M.thermoresistible__bu VLIEGGYRRDIS----PGEPTPAYLIPVI-NPVSLTVNLIRSVPVGLDNG
Mflv_1918|M.gilvum_PYR-GCK VLVEDAYDRDAG----PGDPTTARWWPVK-DFAGTAAKLIASVPVAVDNL
Mvan_4815|M.vanbaalenii_PYR-1 VVIEDAYDRDVG----PGVATRASWRPIK-DIVGLAARLVASIPVAVDNL
MLBr_01232|M.leprae_Br4923 PKIDAAYAYNDN-----PLNKPISVDPVN---------------------
MAV_1760|M.avium_104 PRVNAGYSRNDD-----PATAPVQVDPVH---------------------
MAB_4141|M.abscessus_ATCC_1997 VFIDMAYDRDTG----PGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHNV
:: .* .
Mb1465|M.bovis_AF2122/97 DGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQV
Rv1430|M.tuberculosis_H37Rv DGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQV
MMAR_0384|M.marinum_M --------------------YGAAVEIGVEAG------------LLGPES
MUL_1034|M.ulcerans_Agy99 --------------------YGAAVEIGVEAG------------LLGPES
MSMEG_5455|M.smegmatis_MC2_155 MEELGHGRPLGTQPSGVFGVGGEDTELKGLPAGVISL----AKPTLPVSS
TH_4029|M.thermoresistible__bu IEELTGERPLGTTDPGPYGVGGDDADLRGLPAGLVPLGSTSPTPILPETA
Mflv_1918|M.gilvum_PYR-GCK TEGFGLGRVLGTPVPGVFGVGGPDLPDVDEGGAVTSD---IDEDAVAQRD
Mvan_4815|M.vanbaalenii_PYR-1 TEGLGLGRVLGTTEPGAFGVGGPDLPAEPEP-AVPDE---SVEPAVPEQD
MLBr_01232|M.leprae_Br4923 ----------------------------------------------GMDP
MAV_1760|M.avium_104 ----------------------------------------------GFDP
MAB_4141|M.abscessus_ATCC_1997 ENGLAGATPKQSASPEKPASPPVPQPGPTNPGSATTQIPAPEAPTPSVVS
Mb1465|M.bovis_AF2122/97 LPILVEGPGALVTADTHYLVDAIQDL------------AAGDLSGFNQNL
Rv1430|M.tuberculosis_H37Rv LPILVEGPGALVTADTHYLVDAIQDL------------AAGDLSGFNQNL
MMAR_0384|M.marinum_M FPDTYPWVPSLNPGLNFYLGQPSVTL------------LSLLSGGLGDIF
MUL_1034|M.ulcerans_Agy99 FPDTYPWVPSLNPGLNFYLGQPSVTL------------LSLLSGGLGDIF
MSMEG_5455|M.smegmatis_MC2_155 HTTVVEKTERKDLAKPAAEPEPVVED------------EPAVEDETPVAD
TH_4029|M.thermoresistible__bu APAAEKPAMRVDSGTPKPIIRTAAPS------------APLLRTPRPPAG
Mflv_1918|M.gilvum_PYR-GCK SASSTERSAPAEESRSAVGGADSDGR------------DDVVDPEPAAPE
Mvan_4815|M.vanbaalenii_PYR-1 PESVEYDGGRAAGEGSAGEGSAGAES------------VDRVEPDAAPVE
MLBr_01232|M.leprae_Br4923 ----IAGIDAELR---DSILNVFAQL------------RSILPPPPG---
MAV_1760|M.avium_104 AEVTAPANQATFGGGADPLSQIMAGA------------MSVLSHGAGEAD
MAB_4141|M.abscessus_ATCC_1997 LSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDPKSTPPP
Mb1465|M.bovis_AF2122/97 QLIPATNIALLVFAAGIPAVAAVAILTGQDFPV-----------------
Rv1430|M.tuberculosis_H37Rv QLIPATNIALLVFAAGIPAVAAVAILTGQDFPV-----------------
MMAR_0384|M.marinum_M HLIPPP-----VFP------------------------------------
MUL_1034|M.ulcerans_Agy99 HLIPPP-----VFP------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 TKKASPKPLRPKVRGPISFDAPKLPTIRKATGDRPLKRLLSALTPKRPKP
TH_4029|M.thermoresistible__bu ERLGERLGERLNQRRGPILDASRLLRPGRAAAGR------GVTDTGRPGP
Mflv_1918|M.gilvum_PYR-GCK AETS---------EAETVTET------EADDADD--------ADDGADAD
Mvan_4815|M.vanbaalenii_PYR-1 SDPAPVEADPAPVEADPAPEKSDPAPVEADPAPEK-------SDPGSDAS
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 H-------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 TKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNHLKSVPG
Mb1465|M.bovis_AF2122/97 -----------------------------------------
Rv1430|M.tuberculosis_H37Rv -----------------------------------------
MMAR_0384|M.marinum_M -----------------------------------------
MUL_1034|M.ulcerans_Agy99 -----------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 ASSHDAGPAAGNKDTDNADKPAARADDAA------------
TH_4029|M.thermoresistible__bu V---DAAPNP-ESDTKSQEQP--------------------
Mflv_1918|M.gilvum_PYR-GCK DEDIDADGADADGEDTAG------NTAEAA-----------
Mvan_4815|M.vanbaalenii_PYR-1 ADDGEAGAATTPTETDEADEPPDEDTAEAA-----------
MLBr_01232|M.leprae_Br4923 -----------------------------------------
MAV_1760|M.avium_104 -----------------------------------------
MAB_4141|M.abscessus_ATCC_1997 LSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA